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What does Iconocast do? We receive health and science press releases from major research institutes, government agencies, and universities daily. These are articles and press releases that are sent to all publishers regularly. Do we also borrow news from other publishers? Yes, we do and so do many other major Internet publishers such as SeattleTimes.com (from almost all publishers), Washingtonpost.com (from all publishers) and CBS News (from WebMD.com and many other websites and blogs). However, contrary to these publishers, Iconocast adds value to the content presented. The new Iconocast technology provides the most accurate updates on important and valuable health and science news inside a (green-border) table (Google News). Are past news or articles worth searching? Yes, we believe past articles are still valuable if they are effectively updated. Majority of these articles are truly timeless.
How does it work for today's article? Before showcasing today's article, the new Iconocast algorithm also presents links to substantially more views, articles, and news inside a Green Border Table in regards to the article on the page. In most cases the first or second links provided by Google News inside the table is to the original source of the article. Most people click on those links and land on the page where the original article is located. Website that participate in Google news and their articles show up in Iconocast have experienced an increase in traffic (also from the back-links or the link popularity that Iconocast provides). If you are not participating in Google news, Google will be happy to consider your site. We also strongly believe the more views and news about the same article, the more information, intelligence, and much more trustworthy is that article. This is an effective way for the reader to expand on the information and make sure that the article has validity and is reliable. Let us examine some examples. Take a look at this article: The Associated Press : Ad gives hot dogs a bum rap, experts say. If you examine both Google News and Google Scholar results, you get much more important news on what really causes colon cancer, what might help, what prevents, and what is more risky than the poor Hot Dogs. Of course we can never compete with a company as larger as the The Associated Press, however, we strongly believe we have justifiably added value over what they are presenting. Here is another example : CIA, FBI push 'Facebook for spies' If you examine the Google News Table, you get an expanded view of the activities (private social networking system for the CIA, the FBI and the National Security Agency called A-Space), and Google Scholar will give you important legal issues, privacy issues, and other important intellectual views.
Here is another example: Sarah Jessica Parker Removes Trademark Mole. Notice there are more than 100 articles that validate the news about the mole disappearance. After seeing the links to all these 100 article, don't you feel a bit more confident that the mole is really gone? Or check out this one : Miley Cyrus Without Clothes On in the Shower ; is this true? Fake? If you examine the information and news inside the Green Border Table on the page, you will quickly realize they are fake. These two examples and many, many other examples we can bring justify a system of check and balances to examine the validity of what people actually put out on the Internet. One can confidently say that Iconocast is based on our correct system of "Check (- the article) and Balances (- Google News)". No other News Agency provides the same service as Iconocast does. Everyday, Iconocast is viewed, searched and utilized by FBI, CIA, US Military (more than 54,000 hits so far for September), US Government (more than 29000 hits for September; see the table below), NSA, almost all private background checking agencies, NBC News, Apple Computer, Government News Agencies, Department of Health, CDC, and many other health related websites.
| September: US Government & US Military Usage of Iconocast.com |
| Hits |
Files |
KBytes |
Organization |
29151 |
20715 |
7154415 |
US Government |
54188 |
20219 |
2593282 |
US Military |
What is the significance of our system? To do a quick search in Google News on the relevant keywords of the article, we are able to identify what each article is about by just examining the title of the article. How reliable is our system? Look at this example : How much risk can you handle? Making better investment decisions. The system correctly identifies the keywords: "you + risk + investment" right at the top of the Green Border Table. This is not an easy task. There are just too many other words in that title such as: How + much + can + handle + Making + better + decision. All these words were correctly eliminated. We strongly believe we have achieved something substantial here.
In addition, Iconocast is the very first International Multimedia News Library, providing updated archived news translated to more than 7 languages.

It is now well known that satellite dish (tv) and the start of the Internet were very instrumental in break up of the tyrannical regime of Soviet Union. I say why stop there? Why not translate our good values (healthy living, healthy eating, quality arts, book reviews, green living, ..... ) in the western free society for everyone in the world? Compared to racy television programs that are translated today (e.g. Bachelorette, Lipstick Jungle), isn't this a better representation of the western values? Iconocast main focus are health, science, technology, and arts. In some cases we have also collected business, real estate, books review, entertainment, gossip, and
movie review.
Iconocast acts only as a library for these collections. What does it mean by library? It means we do not present these articles on daily basis (contrary to the news we receive from Universities and research institutes; there is no gossip news on today.htm page). We only save them for future reference and of course these articles can always be searched inside Iconocast by using the Google Search below on this page. In reality we recycle the past content (gossips and entertainment news) with today Google News. We do not intend to violate any copyright laws. If we have missed a link to the original article, we will correct this error. Iconocast is the very first Internet Library that is capable of recycling (value added) the past content. Just not too long ago there was a news (gossip) regarding the iPod effect on Heart Pacemaker. Two weeks later it was known that iPod has absolutely no effect on Pacemaker. Iconocast is the only Internet Library that corrected this content (gossip and rumors) by providing recent Google News at the top of the mentioned article which refuted the iPod harm on pacemaker. I wish someone could have calculated the loss to Apple computer for that period of doubt and more important the loss to the society for temporarily losing its trust on one of the best gadgets ever invented. Take a look at this one: Leaked Document Shows Verizon's Psyops Anti-iPhone Propagands. Now if you examine the Google News Table, you get a better, fair and expanded view on iPhone and all the neat things it can do. Isn't this more fair? You also get competitive analysis, and news on future Google Cell Phone Android. This is what we call check, expand, fair, and balance. Because there are so many wild and unchecked information on the Internet, some people joke that WWW stand for Wild Wild Web. We just like to hopefully remove the sarcasms.
I personally love the music of Amy Winehouse. It is a shame how much garbage is written on the Internet about Amy (e.g.:Amy Winehouse's hair extentions harvested from corpse). It is just as if we love to destroy and tear apart personalities and characters if they are famous or talented. We should wait another 100 years until someone with her talents give us enjoyment.
We strongly believe there is a justified opportunity for correcting gossips and false accusations, and it is to the advantage of the society for a healthy rule of mass communication and intelligence. Iconocast can also be used as an instrument that can remove burden of the liability of the shoulders of those who distribute false news and gossips unknowingly. How important is this effort? Recent article such as "Lawsuits Against Bloggers Seen Rising; Since 2004, 159 Court Actions Have Targeted Citizen Journalists for Libel and Other Charges" is a good indication.
In summary, there is really no difference between Iconocast and your city library with one unique advantage that Iconocast adds value by recycling the news with today's content.
And finally, I like to dedicate this website to the loving memory and honor of Tim Russert and his inspiring legacy. Just like us, he loved the News. He used to say if it's Sunday, it's meet the press. We like to say, if it's in the Internet, it is either expanded, updated, validated or refuted in Iconocast, not just in English, but in Spanish, Portuguese, German, Japanese, Italian, ......
Creative People
Here are the steps to creativity and secrets of creative people. No one has ever got off the bed and was a Picasso. No one!
My suggestions to those who like to be creative is to find something, a task, hobby, or profession that you find purified, noble and virtuous. Then copy your favorite leader, teacher, master or mentor. We all have to start with copying before we are creative in our fields. Even the most successful surfer, surgeon, rock climber had to copy his/her first teacher. At first, Picasso also copied. It does not matter how long you have to imitate, copy, plagiarize (give the credit of course), duplicate, or replicate. It does not matter. Don't forget you have to find what you do purified, noble and virtuous. If you don't, it will not work for you. It never works. What about those who have been copied? The smart and open minded have a saying: "Imitation is the highest form of flattery". The closed minded who were lucky once, complain.....This closed mindedness impedes creativity in our great country. Should you be happy that you copy? No! Absolutely not, and through this unhappiness that is the motivation you gain to become creative.
OK, you might think we are a bit unorthodox here and claim things (copying and plagiarizing) that might make people roll their eyes. So we like to bring some great and unique examples. We truly believe copying and plagiarizing will only help those who are true to their tasks and truly find what they do noble and virtuous. We strongly believe these are the people who will eventually become creative and will lead greatly. Do we have an example? Yes we do. Boston University, where Dr. King got his Ph.D. in systematic theology, conducted an investigation and found that he plagiarized major portions of his doctoral thesis. We do not mention this to diminish Dr. King's accomplishments. Totally contrary. We only mention this to foster our own argument. We strongly believe the creativity will eventually come to people once they gathered more insights. And, so did Dr. King. How do you think Japanese did it? How did they become so creative? They copied in 50s and 60s. When they were able to accumulate enough insights into building Cars, TVs,....they stormed out with creativity and ingenuity. Ronald Reagan enjoyed quoting Thomas Paine ("We have it in our power to begin the world over again."! ). Kelsey Grammer was imitating Bob Hope in Frasier and his Dad was John Wayne. Now imagine putting these two characters in one show. What do you get? Cheers! I like to make sure I am clear on the fact that it is the task that must be found noble and virtuous and not copying or plagiarizing. Copying is never noble, however, if you find the task noble, we believe copying will help and will lead toward creativity. Barak Obama also quotes Thomas Paine when he says I am Citizen Of The World! Did anyone notice? Of course they do. But since they have so much respect for Barak or even they, themselves, copy (I mean the so called elite themselves) they shot their mouth. Does Barak ever says Thomas Paine said it first in sometimes around 1774 (giving credit)? No! The moral of the story? Everyone copies. Only those who truly find the task, the occupation, the career noble and virtuous and will concentrate to perfect it and develop insights, will be creative. Why did entrepreneurship and creativity flourished in Ronald Reagan Era? Because Ronald Reagan was himself creative and a political entrepreneur. Lucky those who find serving their community and this great country noble and virtuous.
In the process of copying, you will concentrate on the task. Then you develop insights about the task. The trick is to combine finding nobility, concentration and developing insights in a spiral circle. Each will strengthen the other in a spiral manner on a circle. In other words, the more you find the task purified, noble and virtuous, the more you will concentrate and the more you will develop insights. The more you concentrate, the more you will find it virtuous and the more you will develop insights. The more you develop insights, the more you will concentrate and the more you will find it virtuous. Each must help the other grow and become stronger and stronger. This is essential in the process. We call this the tornado process. Nobility, concentration and insights are the winds of the tornado and each wind pushes the other to make the tornado stronger and stronger. If the tornado process does not happen, the creativity is not there.
Inside the tornado process you need to develop good observation techniques. You will develop more intuition about the task and how to do it even better than your mentor or master. This will be the turning point from just copying to becoming creative.
Hopefully, it will come the day that you will realize you can be creative. It will just come to you. Believe me it will. One day you will find yourself in a Picasso kind position. It might take 5 years or 5 weeks or 5 days. It all depends how much natural talents you have, how powerful is your tornado, and how much you love what you do. We can not say for certain what talent is. Is it a byproduct of the tornado effect? We don't know. We believe it is. We like to believe we are all talented. We are. We just need to discover our own tornado process. Each one of us has a tornado process hidden somewhere. You need to find your own tornado process.
What are the sign of the tornado process?
If you find yourself doing something nonstop with an amazing energy you never thought you possessed, you are experiencing the tornado. Say, you can not stop playing the piano. You can not stop climbing that rock. You can not stop writing that novel.
These are all the signs of the tornado. Some jobs you do for 5 minutes and you want to die. Say, cleaning your kitchen. Believe me you are not born to clean kitchens or mowing the lawn. And that is good news.
An interesting question would be: How can I find what I am good at? What is my tornado?
I was not introduced to Argentine Tango music and dance until I was 38 years old. Then I discovered some sort of tornado process when I started learning and copying my Argentine dance masters. You need to look for original signs and clues. When I was 25 or even younger I saw an Argentine Tango dance show conducted by Leslie Caron (she was in Father Goose with Cary Grant). I truly found it purified, noble and virtuous. Did I take the second step and the third step (concentration and developing insights into this dance) at 25? No! Unfortunately not. Sad!
Was I too old at age 38? Maybe. The moral of the story is this: If you find something immediately virtuous and noble, do not let go. Here is your clue. If you watch a surfer surfing and you find it immediately noble, do not give up. Go learn surfing. If you find a rock climber, climbing and you find it virtuous, do not just pass by. Go learn rock climbing. If you watch a piano concert and you think you have been mesmerized, do not just say it was just a show. Go learn piano.
Some 15 or 20 years ago, there was a TV show called LA Law. Then, I read in Wall Street Journal, that the application to Law Schools had tripled because of LA Law TV show. This might sound funny to you. But, this is the real tornado process in action for some of the young talented lawyers. There are so may Doctor shows on TV. From Gray Anatomy to ER and Hopkins. They are the best examples of developing tornado process for very young future doctors. So are shows like criminal justice or CSI.
Why are we talking about creativity on this page?
When I started our news publishing business I had no choice but to copy the big and successful Internet news publishers like seattletimes.com or Yahoo News. I had no journalism background. I worked nonstop for 5 years. Sometimes I put like 18 hours or more a day to run this website. Was I happy I could not contribute something new, creative? Of course I was not happy. But this is the price you pay until you get there and become creative. Hopefully there will be a point when you have gatherer enough insights and intuition. When I had enough intuition that I could be creative, I developed our Google news table at the top of every news we publish. I invented a very unique and effective algorithm to discover the keywords from the title of the news. Up to 5 months ago, every news was handled one by one. Now everything is an automatic process done by a software engineered by me. I only hope you find it useful and you also find it creative. One more thing; do I still work 18 hours or more. Sadly the answer is yes. The tornado will never go away. This is the amazing part of the process. Like it or not, once the tornado gets going, you can not stop the tornado. YOU CAN NOT!
Who invented the Tornado Process? The Tornado process (only named by me) is more than 5000 year old method used by Buddhist Monks to meditate. If you think about it, it really applies to anything we do and why we do. Imagine courting a woman. Every man find his woman purified, noble and virtuous. I have met few women who have told me they have never been in love. Tornado is the process of finding love. The first step in finding love is to find a woman or man that you find totally purified, noble and virtuous. You will define the nobility and the ways you believe someone is virtuous. Then you concentrate on that person and then you find insights about her/him. This is the part that every woman says I like him to notice the detail about me. That really mean that she/he wants him/her to develop insights about the opposite. When the tornado develops about a woman or man, love is created.
Who is currently the most famous Tornado man? Perhaps the most famous Tornado man is Michael Phelps. Michael does nothing but swim, eat and sleep. And he has been doing it for more than 8 years now. Last thing I heard was that swimming pools all over the country are filled with kids.
Today I heard they are not going to allow soft baseball in the next Olympics. Why? Because US is too good. This is again the sign of closed mindedness. Next they will ban Basketball and then Swimming,.....
If you like to know more about the tornado process, see www.motivationbook.com.
Looking at beautiful art can act as a painkiller
By Richard Alleyne
Beauty is truth, the English romantic poet John Keats once
wrote, but according to the latest scientific research it is also a
painkiller.
Looking at a beautiful piece of art has long been said to have
the power to heal emotional wounds but the new research also claims it offers a
distraction from physical pain.
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Works by Vincent Van Gogh, such as Starry Night [left] and Sandro
Botticelli's Birth of Venus were deemed beautiful while paintings by Fernando
Botero [inset] were viewed as ugly
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The research carried out by the University of Bari in Italy
could help vindicate hospitals who are accused of wasting money on art and decor
as it suggests a pleasant environment helps patients overcome discomfort and
pain.
A team headed by Professor Marina de Tommaso at the
Neurophysiopathology Pain Unit asked a group of men and women to pick the 20
paintings they considered most ugly and most beautiful from a selection of 300
works by artists such as Leonardo da Vinci and Sandro Botticelli.
They were then asked to contemplate either the beautiful
paintings, or the ugly painting, or a blank panel while the team zapped a short
laser pulse at their hand, creating a sensation as if they had been pricked by a
pin.
The subjects rated the pain as being a third less intense while
they were viewing the beautiful paintings, compared with when contemplating the
ugly paintings or the blank panel.
Electrodes measuring the brain's electrical activity also
confirmed a reduced response to the pain when the subject looked at beautiful
paintings.
While distractions, such as music, are known to reduce pain in
hospital patients, Prof de Tommaso says this is the first result to show that
beauty plays a part.
The findings, reported in New Scientist, also go a long way to
show that beautiful surroundings could aid the healing process.
"Hospitals have been designed to be functional, but we think
that their aesthetic aspects should be taken into account too," said the
neurologist who published her findings in the paper Aesthetic Value of Paintings
(And) Affects on Pain Thresholds.
"Beauty obviously offers a distraction that ugly paintings do
not. But at least there is no suggestion that ugly surroundings make the pain
worse.
"I think these results show that more research is needed into
the how a beautiful environment can alleviate suffering."
The 12 volunteers, six female and six male, were picked randomly
from the student body at the university and were aged between 22 and 38. They
were asked to choose their favourite paintings from the website
http://wwar.com/artists/.
Pictures they liked included Starry Night by Vincent Van Gogh
and Botticellis Birth of Venus. Pictures they found ugly included works by Pablo
Picasso, the Italian 20th century artist Anonio Bueno and Columbian Fernando
Botero.
One of the problems with the study for those wishing to reduce
pain is the subjective nature of beauty.
Edvard Munch's The Scream was deemed by some people as
beautiful.
"These people were not art experts so some of the pictures they
found ugly would be considered masterpieces by the art world," said Prof de
Tommaso. |
Today's Health, Science, Technology, Personal Finance News
(please report bugs and errors: suzanne@liveinfospace.com)
Novel Anti-Cancer Mechanism Found in Long-Lived Rodents
Biologists at the University of Rochester have found that small-bodied
rodents with long lifespans have evolved a previously unknown anti-cancer
mechanism that appears to be different from any anticancer mechanisms employed
by humans or other large mammals. The findings are published in today's issue of Aging Cell.
Understanding this mechanism may help prevent cancer in humans because many
human cancers originate from stem cells and similar mechanisms may regulate stem
cell division.
"We haven't come across this anticancer mechanism before because it doesn't
exist in the two species most often used for cancer research: mice and humans,"
says Vera Gorbunova, assistant professor of biology at the University of
Rochester, a principal investigator of this study. "Mice are short-lived and
humans are large-bodied. But this mechanism appears to exist only in small,
long-lived animals."
Gorbunova believes that cells of long-lived, small-bodied rodents are
hypersensitive to cues from the surrounding tissue. If the cells sense that
conditions are inappropriate for growth, they slow down cell division. Such a
mechanism would arrest tumor growth and prevent metastases.
Gorbunova's team has worked at length investigating the links between body
size and lifespan in rodents because rodents range in size from tiny field mice
to the human-sized capybara of Brazil. She can use them to compare size and
lifespan across several different-sized but closely related animals. She
discovered that telomerase—an enzyme that can lengthen the lives of cells, but
can also increase the rate of cancer—is highly active in small rodents, but not
in large ones.
Until Gorbunova's research, the prevailing wisdom has assumed that an animal
that lived as long as we humans do needed to suppress telomerase activity to
guard against cancer. Telomerase helps cells reproduce, and cancer is
essentially runaway cellular reproduction, so an animal living for 70 years has
a lot of chances for its cells to mutate into cancer. A mouse's life expectancy
is shortened by other factors in nature, such as predation, so it was thought
the mouse could afford the slim cancer risk to benefit from telomerase's ability
to speed healing.
But Gorbunova and colleagues showed that it was not life expectancy, but body
mass that regulated the expression of telomerase. Simply having more cells
increases the likelihood that one will become cancerous. We humans, as large
animals, would likely develop cancer much more often and much earlier if we
didn't suppress our telomerase.
While the findings were a surprise, they revealed another question: What
about small animals like the common grey squirrel that live for 24 years or
more? With telomerase fully active over such a long period, why isn't cancer
rampant in these creatures?
Gorbunova found that the squirrel, naked mole-rat, chipmunk, muskrat, and
chinchilla express high levels of telomerase, which would be expected to
increase their cancer risk over their long lifetimes. But these species have
developed a mechanism to counteract the high telomerase activity and remain
cancer free for the duration of their lifespans.
"Squirrels know a cure for cancer," says Gorbunova. "Short-lived small
species display continuous rapid proliferation of their cells, but these
long-lived rodents have somehow found a way to slow down that proliferation when
they need to."
Gorbunova thinks that squirrels and similar rodents have evolved a strict
monitoring function within their cells that may be able to sense appropriate and
inappropriate cell division—i.e., healthy reproduction and runaway cancerous
reproduction—and slow or inhibit the division if necessary.
Gorbunova is now looking to isolate and understand this mechanism with the
hope that it may be applicable to help human cells thwart the onset of tumor
growth.
Along with Gorbunova and the first author Andrei Seluanov, the paper was
co-authored by their long-time collaborator Daven Presgraves, all from the
University of Rochester; members of the Gorbunova laboratory: Chris Hine,
Michael Bozzella, and Amelia Hall; and Tais Sasahara and Antonio Ribeiro from
the University of San Paulo, and Ken Catania from Vanderbilt
University.
'Baby' fat cells may be key to treating obesity, say UT
Southwestern researchers
Dr. Jonathan Graff, associate professor of
developmental biology and molecular biology, has shown in mice that immature fat
cells in the walls of the blood vessels that nourish fatty tissue...
Click here for more information.
|
DALLAS – Sept. 18, 2008 – Immature, or "baby," fat cells lurk in the walls of
the blood vessels that nourish fatty tissue, just waiting for excess calories to
help them grow into the adult monsters responsible for packing on the extra
pounds, researchers at UT Southwestern Medical Center have found in mice.
Researchers have long known that such cells were probably located near blood
vessels, but they didn't know exactly where. Discovering their existence, their
identity and their lair may direct future research to find ways to stop these
cells from creating undesired fat – or to use these immature cells for such
clinical treatments as filling in a woman's breast after a lumpectomy.
"There's both intellectual and clinical importance in this discovery," said
Dr. Jonathan Graff, associate professor of developmental biology and molecular
biology at UT Southwestern and senior author of the study, which appears in
today's online edition of the journal Science. "Identifying the
progenitor cells and finding where they live gives us an exciting therapeutic
opportunity.
"Since we can now isolate the progenitor cells, we can interrogate them
molecularly and gain insight not only into how they function but also how to
harness their powers to help in a variety of human conditions. And because we
have found their location, we might be able to develop therapies that can help
people with obesity, diabetes or other metabolic challenges."
Dr. Graff said it might soon be possible to isolate immature cells from each
person’s own fat and move those cells into other parts of the body, where they
might be medically useful. For example, progenitor fat cells from the belly or
thighs could be moved to a soldier’s wounds or scars from breast cancer surgery.
These cells might even be moved for purely cosmetic reasons.
Ordinarily, the progenitor cells, called adult stem cells, create new fat
cells in several situations, such as when the young body is growing and needs to
form fat cells. They are also necessary when weight is stable; as fat cells die
and must be replaced by new ones, as with most tissues in the body.
When caloric intake exceeds use, however, not only do existing fat cells get
larger to store more fat, but progenitor cells also create entirely new fat
cells.
To locate the progenitor cells, the researchers engineered mice so that the
stem cells would glow green, making them easy to follow as they transformed from
progenitors into fully developed fat cells.
The researchers found that the progenitor cells were embedded within the
walls of the blood vessels that run through fat tissue.
"They're not just attached to the vessel wall, they're an integral part of
it," Dr. Graff said.
This arrangement makes sense, Dr. Graff said, because it allows the cells to
respond to the nutrients such as glucose that are present in the blood after a
meal. When they sense excess caloric intake, they drift out of the vessel walls
and mature into fat cells. This helps to ensure that they reside in the
appropriate location among other fat cells.
The green glow also allowed the researchers to separate the progenitor cells
from other cells using a technique that isolates only the glowing cells.
They then grew the cells in culture to analyze some of their properties and
found that the progenitor cells have a distinct set of molecules on the surface,
which could allow the cells to be isolated easily for transplant or study.
In future research, the scientists plan to characterize the cells more fully
and to isolate the progenitors just by removing unwanted fat. These cells then
can be moved to other locations in that same person for reconstructive purposes,
to treat a variety of diseases, and also paradoxically to treat obesity and
diabetes.
###
Other UT Southwestern researchers involved in the study were lead author Dr.
Wei Tang, postdoctoral fellow in developmental biology; graduate student Daniel
Zeve; Dr. Jaemyoung Suh, postdoctoral researcher in developmental biology; Dr.
Bob Hammer, professor of biochemistry; Dr. Michelle Tallquist, assistant
professor of molecular biology; Dr. Darko Bosnakovski, former postdoctoral
research fellow in developmental biology; and Dr. Michael Kyba, former assistant
professor of developmental biology.
The study was funded by the National Institutes of Health and the Excellence
for Education Foundation.
This news release is available on our World Wide Web home page at
http://www.utsouthwestern.edu/home/news/index.html
To automatically receive news releases from UT Southwestern via e-mail,
subscribe at http://www.utsouthwestern.edu/receivenews
Dr. Jonathan Graff -- http://www.utsouthwestern.edu/findfac/professional/0,2356,20367,00.html
New study: Overbearing parents foster obsessive children
New Université de Montréal study correlates parenting and a
child’s relationship to his or her hobby
A new study has found that parental control directly influences whether a
child will develop a harmonious or obsessive passion for their favorite hobby.
Conducted by Professor Geneviève Mageau, of the Université de Montréal's
Department of Psychology, the study will be published this fall edition of the Journal of Personality.
Mageau focused on 588 musicians and athletes between the ages of six and 38
who practice their hobby at different levels (beginner, intermediate and
expert). Mageau used a Likert-type scale to measure how parents support the
autonomy of their child.
She also evaluated the psychological well being of the child regarding their
hobby, which in this case was piano, saxophone, skiing or swimming.
"The more controlling parents are, the harder it is for the child to have a
harmonious passion for their favorite activity," says Mageau. Her concept of
supporting autonomy means allowing a child to face up to his or her
responsibilities, while considering the child's point of view and also providing
answers to their questions without being authoritative.
"Youngsters with a harmonious passion had parents or an entourage that
supported them, while those with an obsessive passion were raised in an
oppressive environment," she says.
According to Mageau, adults often admit exercising abusive authority over
their children and sometimes forcing their offspring to pursue an activity
against their will. "The child learns that by obeying their parents they will be
loved," she says. "The risk is that as adults they continue to pursue the
activity to maintain their self-esteem."
###
On the Web:
About the Université de Montréal: http://www.umontreal.ca/english/index.htm.
Media contact:
Sylvain-Jacques Desjardins
International press attaché
Université de Montréal
Telephone:514-343-7593
Email: sylvain-jacques.desjardins@umontreal.ca
Walnut Trees Emit Aspirin-Like Chemical to Deal With
Stress
Discovery may help scientists better understand air quality, farm
crops
September 18, 2008
Walnut trees respond to stress by producing significant amounts of a chemical
form of aspirin, scientists have discovered.
The finding, by scientists at the National Center for Atmospheric Research
(NCAR) in Boulder, Colo., opens up new avenues of research into the behavior of
plants and their impacts on air quality, and also has the potential to give
farmers an early warning signal about crops that are failing.
"Unlike humans, who are advised to take aspirin as a fever suppressant,
plants have the ability to produce their own mix of aspirin-like chemicals,
triggering the formation of proteins that boost their biochemical defenses and
reduce injury," says NCAR scientist Thomas Karl, who led the study. "Our
measurements show that significant amounts of the chemical can be detected in
the atmosphere as plants respond to drought, unseasonable temperatures, or other
stresses."
For years, scientists have known that plants in a laboratory may produce
methyl salicylate, which is a chemical form of acetylsalicylic acid, or aspirin.
But researchers had never before detected methyl salicylate in an ecosystem or
verified that plants emit the chemical in significant quantities into the
atmosphere.
The team of scientists reported its findings last week in the journal Biogeoscience. The research was funded by the National Science
Foundation (NSF), NCAR's sponsor.
"Biosphere-atmosphere interactions are important to the understanding of the
Earth system," said Cliff Jacobs, program director in NSF's Division of
Atmospheric Sciences. "This fortuitous discovery of methyl salicyclate in
quantities not anticipated adds to an already important study."
Researchers had not previously thought to look for methyl salicylate in a
forest, and the NCAR team found the chemical by accident. They set up
specialized instruments last year in a walnut grove near Davis, Calif., to
monitor plant emissions of certain volatile organic compounds (VOCs).
These hydrocarbon compounds are important because they can combine with
industrial emissions to affect pollution, and they can also influence local
climate.
When the NCAR scientists reviewed their measurements, they found to their
surprise that the emissions of VOCs included methyl salicylate.
The levels of methyl salicylate emissions increased dramatically when the
plants, which were already stressed by a local drought, experienced unseasonably
cool nighttime temperatures followed by large daytime temperature increases.
Instruments mounted on towers about 100 feet above the ground measured up to
0.025 milligrams of methyl salicylate rising from each square foot of forest per
hour.
Karl and his colleagues speculate that the methyl salicylate has two
functions. One of these is to stimulate plants to begin a process known as
systemic acquired resistance, which is analogous to an immune response in an
animal.
This helps a plant to both resist and recover from disease. The methyl
salicylate also may be a mechanism whereby a stressed plant communicates to
neighboring plants, warning them of the threat. Researchers in laboratories have
demonstrated that a plant may build up its defenses if it is linked in some way
to another plant that is emitting the chemical.
Now that the NCAR team has demonstrated that methyl salicylate can build up
in the atmosphere above a stressed forest, scientists are speculating that
plants may use the chemical to activate an ecosystem-wide immune response.
"These findings show tangible proof that plant-to-plant communication occurs
on the ecosystem level," says NCAR scientist Alex Guenther, a co-author of the
study. "It appears that plants have the ability to communicate through the
atmosphere."
The discovery raises the possibility that farmers, forest managers, and
others may eventually be able to start monitoring plants for early signs of a
disease, an insect infestation, or other types of stress. At present, they often
do not know if an ecosystem is unhealthy until there are visible indicators,
such as dead leaves.
"A chemical signal is a very sensitive way to detect plant stress, and it can
be an order of magnitude more effective than using visual inspections," Karl
says.
"If you have a sensitive warning signal that you can measure in the air, you
can take action much sooner, such as applying pesticides. The earlier you detect
that something's going on, the more you can benefit in terms of using less
pesticides and managing crops better."
The discovery also can help scientists resolve a central mystery about VOCs.
For years, atmospheric chemists have speculated that there are more VOCs in the
atmosphere than they have been able to find. Now it appears that some fraction
of the missing VOCs may be methyl salicylate and other plant hormones.
This finding can help scientists better track the impact of VOCs on the
behavior of clouds and the development of ground-level ozone, an important
pollutant.
-NSF-

Media Contacts
Cheryl Dybas, NSF (703) 292-7734 cdybas@nsf.gov
David Hosansky, NCAR (303)
497-8611 hosansky@ucar.edu

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Vitamin D drug useful for kidney disease
Last Updated: 2008-09-17 16:48:23 -0400 (Reuters
Health)
By Megan Rauscher
NEW YORK (Reuters Health) - Treatment with paricalcitol, a drug
that activates the cell receptor for vitamin D, can reduce the inflammation and
the protein loss that occurs with chronic kidney disease, the results of a small
study suggest. This may help explain why activation of the vitamin D receptor
has been linked to improved survival.
"Larger studies are underway to confirm whether these encouraging findings
should result in a change in the way we treat patients with chronic kidney
disease," Dr. Rajiv Agarwal, from Indiana University School of Medicine,
Indianapolis, noted in comments to Reuters Health.
"Vitamin D receptor activation is associated with improved survival in
patients with chronic kidney disease, but the (reason for) this benefit is
unclear," Agarwal and colleagues note in Hypertension: Journal of the American
Heart Association.
In the new study, the researchers randomly assigned 24 patients with chronic
kidney disease to treatment with paricalcitol or inactive "placebo" for 1 month.
All of the study subjects were vitamin D deficient.
Short-term exposure to paricalcitol produced marked anti-inflammatory effects
and a 50 percent reduction in urine levels of a protein called albumin-- two
factors linked to progression of chronic kidney disease, the investigators
report.
By contrast, treatment with paricalcitol did not affect blood pressure.
The authors note that two larger studies are underway that should help
clarify the benefits that paricalcitol provides for patients with chronic kidney
disease.
SOURCE: Hypertension, September 2008.
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similar means, is expressly prohibited without the prior written consent of
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around the world.
Heart attack risk rises with intensity of
exercise
Last Updated: 2008-09-17 17:08:53 -0400 (Reuters
Health)
By Michelle Rizzo
NEW YORK (Reuters Health) - Physical exertion may trigger the
onset of heart attack in a "dose-response fashion", that is, the risk increases
with the intensity of physical exertion, according to study published in the
European Heart Journal.
Depending on the patient's initial risk, cardiac events can be triggered by
transient exposure to stress, including physical, psychological, or chemical
stressors," note Dr. Stephanie von Klotz, at the German Research Center for
Environmental Health, Neuherberg, and colleagues.
The researchers examined factors associated with a sudden heart attack in
1,301 patients, who were interviewed regarding levels of activity and time spent
outdoors on the day of the event and the 3 preceding days.
The risk of heart attack was increased 5.7-fold within 2 hours of an episode
of strenuous exertion and 1.6-fold within 2 hours of moderate exertion, compared
to very light or no exertion.
"This suggests a graded exposure-response relationship between physical
exertion intensity and triggering of heart attack onset," von Klot told Reuters
Health. However, she added, "Regular physical exertion was protective against
the risk associated with moderate and strenuous exertion episodes."
Of interest, was that strenuous activity performed outside was associated
with a 4-fold greater risk of heart attack symptom onset compared with
activities performed indoors, the researcher noted. "This was not observed for
moderate exertion and was not explained by outdoor temperature," she said.
The risk of heart attack onset with moderate exertion was "particularly
elevated" in patients with high blood pressure or those who reported very low
levels of physical activity, von Klot pointed out.
"These findings emphasize the importance of increasing endurance very
carefully prior to introducing a cardio-protective training program to sedentary
or hypertensive patients."
SOURCE: European Heart Journal, August 2008.
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similar means, is expressly prohibited without the prior written consent of
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for any actions taken in reliance thereon. Reuters and the Reuters sphere logo
are registered trademarks and trademarks of the Reuters group of companies
around the world.
Flu vaccine in pregnancy benefits mother and
child
Last Updated: 2008-09-17 12:15:51 -0400 (Reuters
Health)
NEW YORK (Reuters Health) - In a study conducted in Bangladesh,
pregnant women who were give an inactivated influenza vaccine during their third
trimester of pregnancy provided "a considerable two-for-one benefit" to mothers
and their infants, according to researchers.
Influenza vaccination reduced the rate of influenza illness by nearly two
thirds in infants up to 6 months of age and averted roughly one third of all
respiratory illnesses with fever in mothers and young infants, report Dr. Mark
C. Steinhoff from Cincinnati Children's Hospital, Ohio, who conducted the study
along with colleagues in Dhaka and Baltimore.
The study results were released Wednesday online, in advance of print in the
October 9th issue of The New England Journal of Medicine, to coincide with
presentation of the results before the National Vaccine Advisory Committee at
the US Department of Health and Human Services.
In the study, 340 women in the third trimester of pregnancy were randomly
assigned receive either the inactivated influenza vaccine or a 23-valent
pneumococcal polysaccharide vaccine (the control group).
Steinhoff's team observed fewer cases of laboratory-confirmed influenza
before 24 weeks of age among the infants of influenza-vaccinated mothers than
among infants in the control group (6 vs. 16), for a vaccine effectiveness of 63
percent.
There were also fewer cases of respiratory illness with fever in infants in
the influenza-vaccinated group than among infants in the control group (110 vs.
153), for a vaccine effectiveness of 29 percent.
Among the mothers, there was also a reduction in the rate of respiratory
illness with fever of 36 percent.
"In a tropical setting of perennial transmission of influenza virus," write
Steinhoff and colleagues, "maternal influenza immunization for much of the year
had a substantial protective effect in both mothers and their young infants."
The researchers point out that in regions with limited financial resources,
the strategy of immunizing pregnant women is widely used for tetanus prevention
and prenatal immunization programs are in place.
Based on the study findings, they suggest that the strategy of maternal
immunization "should be evaluated further for the prevention of influenza."
The investigators also remind healthcare providers that infection with
influenza virus is associated with serious illness and hospitalization among
pregnant women and young infants.
The inactivated trivalent influenza vaccine has been recommended for pregnant
women in the U.S. for more than a decade, yet "few mothers" receive it. The
vaccine is also recommended for infants between 6 months and 23 months of age.
SOURCE: The New England Journal of Medicine, October 9, 2008.
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similar means, is expressly prohibited without the prior written consent of
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are registered trademarks and trademarks of the Reuters group of companies
around the world.
Study explains how Listeria attacks mother,
fetus
Last Updated: 2008-09-18 9:33:27 -0400 (Reuters
Health)
CHICAGO (Reuters) - French researchers have discovered how
food+borne bacteria can make the jump from a pregnant mother to her unborn
child, a finding that may lead to new ways of protecting a fetus from
potentially deadly infections.
Researchers at the Institut Pasteur in Paris studied Listeria monocytogenes,
a pathogen that infects 2,500 people a year in the United States, killing 500
each year.
Pregnant women are about 20 times more likely than other healthy adults to
get listeriosis, an infection that can often result in miscarriage and
stillbirth.
About one-third of listeriosis cases happen during pregnancy, according to
the U.S. Centers for Disease Control and Prevention.
People get listeriosis from eating contaminated food. Listeria can cross from
the intestine into the blood stream. But how it crosses the placental barrier
and into the fetus has been unclear.
A team led by Marc Lecuit studied listeria in both gerbils and mice and found
two bacterial invasion proteins, InlA and InlB, are needed for listeria to cross
the placental barrier and infect the fetus, the team reported in the journal
Nature on Wednesday.
Lecuit and colleagues think by blocking one or both of these pathways, it may
be possible to keep a mother from passing the infection to her fetus.
In addition to pregnant women, listeriosis affects older people, newborns and
adults with weakened immune systems.
Symptoms include fever, muscle aches, and sometimes nausea or diarrhea. If
infection spreads to the nervous system, it can cause headache, confusion, loss
of balance or convulsions.
Copyright © 2008 Reuters Limited. All rights reserved.
Republication or redistribution of Reuters content, including by framing or
similar means, is expressly prohibited without the prior written consent of
Reuters. Reuters shall not be liable for any errors or delays in the content, or
for any actions taken in reliance thereon. Reuters and the Reuters sphere logo
are registered trademarks and trademarks of the Reuters group of companies
around the world.
No such thing as a safe tan: scientists
Last Updated: 2008-09-18 9:30:06 -0400 (Reuters
Health)
LONDON (Reuters) - There is no such thing as a safe tan, U.S. and
British researchers said on Thursday.
They said in their review of published studies that tans and skin cancer both
begin with DNA damage caused by exposure to ultraviolet light but many people,
especially the young, ignore or are unaware of this danger in a quest for a
bronzed body.
"The signals in the cells that induce sun tanning appear to be DNA damage,"
said Dorothy Bennett, a cell biologist at St. George's, University of London,
who wrote one of the papers.
"DNA damage is the first step in getting a mutation in cells that could lead
to cancer, so there can't be anything like a safe tan."
The World Health Organization estimates that as many as 60,000 people each
year die from too much ultraviolet light, mostly from malignant melanoma -- the
deadliest form of skin cancer.
The link between skin cancer and damage from ultraviolet light from the sun
or tanning booths is well known but the review published in the journal Pigment
Cell & Melanoma Research suggests that even a little exposure is
dangerous.
Another problem is that while genetic and other factors also contribute to
skin cancer risk, mixed messages about the safety of ultraviolet light confuses
the public, Bennett added in a telephone interview.
Getting some sunshine is important because ultraviolet light spurs the body
to produce vitamin D. But people need far less ultraviolet exposure for this
than it takes to tan, she said.
"A lot of young people don't know about the scientific evidence," she said.
"Anything that causes mutations in your cells increases your risk of
cancer."
Copyright © 2008 Reuters Limited. All rights reserved.
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similar means, is expressly prohibited without the prior written consent of
Reuters. Reuters shall not be liable for any errors or delays in the content, or
for any actions taken in reliance thereon. Reuters and the Reuters sphere logo
are registered trademarks and trademarks of the Reuters group of companies
around the world.
Calcium in pregnancy shields fetus from lead
risks
Last Updated: 2008-09-18 13:00:51 -0400 (Reuters
Health)
By Anne Harding
NEW YORK (Reuters Health) - Taking calcium supplements during
pregnancy reduces a woman's blood levels of lead, and thus the danger that her
fetus will be exposed to the toxic metal, new research conducted in Mexico
shows.
"You could actually see the more a person took, the more their blood levels
went down," Dr. Adrienne S. Ettinger of the Harvard School of Public Health in
Boston, who helped conduct the study, told Reuters Health.
During pregnancy, women need more calcium to help build fetal bones, and
their bodies may boost reabsorption of their own bone tissue to get it. This in
turn can cause any lead stored in the bones to enter the blood circulation,
exposing the fetus to lead, which can impair neurological development and cause
lasting damage to the brain.
There is evidence that calcium can help prevent the release of lead from the
bones, Ettinger and her team note in their report in Environmental Health
Perspectives. The researchers previously found that lactating women who took
calcium supplements had significantly less lead in their blood and breast milk.
To investigate the effects of calcium supplementation during pregnancy, "the
period of greater relevance for maternal-fetal transfer of lead," they randomly
assigned 670 pregnant women to take 1,200 mg of calcium daily or a placebo.
Thirty-five percent of the study participants said they used lead-glazed pottery
to serve, store or prepare food.
Blood lead levels fell by 11 percent, on average, in women who took calcium.
Women who consumed the most had the most benefit; those who took 75 percent or
more of the recommended number of calcium pills had a 24-percent drop in blood
lead.
Women who started out with the most lead in their blood had an average
17-percent reduction in blood lead levels. For women with high initial blood
lead levels who also reported using lead-glazed pottery, calcium reduced lead
levels by 31 percent.
The U.S. phased out leaded gasoline in the early 1970s, so the great majority
of reproductive-age women in this country don't have significant amounts of lead
in their bones, Ettinger said in an interview. But those working in battery
manufacturing, mining or other occupations involving lead exposure are still at
risk, she added.
"It's not a lot of women, but the women who are exposed occupationally could
be very highly exposed," the researcher said. Women in many parts of the
developing world, where leaded gas is still in use or was only recently phased
out and occupational and household exposure to lead tends to be more common, are
also at risk, according to Ettinger.
The reduction in blood lead levels she and her colleagues saw were relatively
modest, the researcher noted. "We're not suggesting that people just take a pill
and think everything is fine," she said. "In addition to decreasing exposure
sources this may be an important preventive method."
Women in the U.S. are typically instructed to take prenatal vitamins, but
their calcium content varies widely, she added. "I think it's important to be
aware of how much you're getting with the supplement and figure out with your
doctor if you have risk factors for lead, and if so maybe additional calcium
would be necessary," Ettinger advised.
SOURCE: Environmental Health Perspectives, September 2,
2008.
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similar means, is expressly prohibited without the prior written consent of
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are registered trademarks and trademarks of the Reuters group of companies
around the world.
C-section affects mothers' brain response to
baby
Last Updated: 2008-09-18 12:30:27 -0400 (Reuters
Health)
By Amy Norton
NEW YORK (Reuters Health) - Women who deliver by cesarean section
may not experience the same brain alterations during childbirth as do women who
deliver vaginally and this, in turn, may affect their response to their infants'
cries, a small study suggests.
Using brain imaging scans, researchers found that, compared with women who'd
had a c-section, those who'd delivered vaginally showed greater activity in a
number of brain regions in response to their own infants' crying.
The brain regions in question are thought to be involved in emotional
regulation, empathy and habitual behaviors, among other things.
The findings, published in the Journal of Child Psychology and Psychiatry,
raise the question of whether the method of delivery can affect a new mother's
mood or behavior soon after giving birth.
However, no one knows whether this is in fact the case.
"We don't know yet what this means," lead researcher Dr. James E.
Swain, of Yale University's Child Study Center, said in an interview.
There is no evidence, he said, that women who have c-sections tend to have
more difficulty bonding with their babies, for instance.
Instead, the little that is known often comes from animal research, with
experiments showing that surgical delivery seems to alter how mothers tend to
their pups. Some studies of women have linked c-section delivery to a higher
risk of postpartum depression -- but this relationship is controversial and not
proven, Swain pointed out.
It is known that vaginal delivery triggers the release of a hormone called
oxytocin, which is key in breast milk production and, in animals, has been shown
to affect maternal behaviors like licking and grooming.
In theory, c-sections could -- by altering the hormonal milieu of childbirth
-- affect human mothers' brain responses shortly after birth, according to Swain
and his colleagues.
To test this idea, the researchers performed functional MRI brain scans on 12
healthy women who had given birth 2 to 4 weeks earlier. Half of the women had
delivered vaginally and half underwent an elective c-section.
The scans charted changes in each woman's brain blood flow as she listened to
either a recording of her own baby crying or to static-like sounds.
In general, the study found, the mothers who'd delivered vaginally showed
greater activity in response to their babies' cries within several regions of
the brain.
Much more research will be necessary to sort out what all of this means,
according to Swain. He and his colleagues are continuing to follow the women in
their study to see whether differences in brain activity persist.
There is also a need for larger studies that include not only healthy women,
as this one did, but mothers with postpartum depression as well, Swain pointed
out.
If c-sections do affect maternal brain activity and behavior, the researcher
noted, it would stand as one more factor for women and their doctors to consider
when deciding whether to have an elective cesarean.
It would also suggest, Swain said, that doctors, husbands and families should
"give a little extra consideration and care to moms who have c-sections."
SOURCE: Journal of Child Psychology and Psychiatry, October
2008.
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similar means, is expressly prohibited without the prior written consent of
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around the world.
New Stem Cell Centre Gives Hope For Stroke Damage
Researchers within the University of Adelaide's new Centre for Stem Cell
Research are aiming by the end of this year to show repair in stroke-damaged
brains using stem cells taken from adult teeth.
The world-leading
research using dental pulp stem cells from extracted human teeth and
stroke-affected rat brain tissue were outlined as part of the launch on 16
September, 2008 of the Centre for Stem Cell Research.
The focus of the
new Centre will be on turning novel basic research into potential life-saving
treatments and cures for serious conditions and diseases.
The Centre
will draw together almost 100 research scientists and 80 research students from
18 research groups based at the University of Adelaide, the Women's and
Children's Hospital, the Institute of Medical and Veterinary Sciences (IMVS),
Hanson Institute and the Queen Elizabeth Hospital.
University of
Adelaide Vice-Chancellor and President Professor James McWha said the new Centre
would help put South Australian researchers at the forefront of stem cell
research in Australia.
"The members of the Centre undertake
internationally recognised and awarded research on areas such as the isolation
of adult and cord blood stem cells, clinical applications including potential
cures for stroke damage and cardiac repair, and novel approaches to diseases
such as cystic fibrosis and leukaemia," said Professor McWha.
Centre
Director and University of Adelaide Principal Research Fellow, Associate
Professor Mark Nottle, said: "The focus of the Centre is on translating basic
research into clinical and commercial outcomes through collaboration between
members and with external partners."
The stroke research project is a
collaboration between Dr Simon Koblar, University of Adelaide, and Associate
Professor Stan Gronthos, IMVS and Hanson Institute. Last week they started
injecting adult dental pulp stem cells into stroke-damaged rat brains and should
have preliminary results on therapeutic outcomes by the end of the year.
"Stroke is the leading cause of disability in Australia with 270,000
Australians left with the residue of strokes every year," said Dr Koblar.
"Even if all we can do is get someone's hand function to improve that
would be a magnificent advance."
----------------------------
Article adapted by Medical News Today
from original press release.
----------------------------
Dental
pulp stem cells are highly promising as precursors of replacement neurons (brain
cells) because they are easily accessible, can be taken from the patient needing
treatment, and they have similar properties to cranial neural crest cells that
normally make brain cells and other cranial tissues.
The launch of the
Centre for Stem Cell Research took place at 3pm at the National Wine Centre on
Tuesday 16 September.
The Centre's main aims are to:
- undertake and foster world-class stem cell research;
- establish and maintain collaborative links in stem cell research within
Australia and internationally;
- provide higher degree and research training opportunities;
- to build public awareness of stem cell research in South Australia.
The Centre will provide Early Career Research Fellowships to attract
and retain the brightest young minds to Adelaide, and to continue to build the
already substantial critical mass of stem cell researchers within Adelaide.
Initial funding from the Fellowships has come from the University and Bellberry
Limited, a not-for-profit company that manages the only private human research
ethics committees in Australia.
Source: Dr. Simon Koblar
University of
Adelaide
New Tool For Early Diagnosis Of Breast Cancer
Scientists from Finland, Germany and the ESRF have developed a new X-ray
technique for the early detection of breast cancer. This allows a 3D
visualization of the breast with a high spatial resolution and is extremely
sensitive to alterations in the tissue, such as those generated by cancer. This
technique could be used in the next years in hospitals. It may help doctors to
detect tumours with greater precision than is possible using current X-ray
mammography.
Breast cancer is the most frequent form of cancer affecting
women in industrialized countries, according to the World Health Organization.
It is widely recognized that the early detection of breast cancer is directly
linked to a successful treatment of the disease.
Although X-ray
mammography is currently the most widely used tool in diagnostic radiology, it
fails to identify about 10 to 20% of palpable breast cancers. This is because
some breasts, especially in young women, are very dense. Therefore, on
mammograms, glandular tissues can mask cancer lesions.
Better results are
obtained using X-ray computed tomography (CT). CT imaging could produce accurate
3D images of the entire breast, improving the detection of early diseases in
dense breasts. However, its use in breast imaging is limited by the radiation
dose delivered to a radiosensitive organ such as the breast.
A new CT
technique has allowed scientists to overcome this problem. The teams from the
Helsinki University Central Hospital, Turku University Central Hospital
(Finland), the Radiation and Nuclear Safety Authority (Finland), the University
Hospital of Grenoble (France), the European Molecular Biology Laboratory in
Hamburg (Germany) and the Biomedical experimental station (beamline) at the ESRF
have managed to visualize breast cancer with an unprecedented contrast
resolution and with clinically compatible doses.
The researchers,
including physicists, surgeons, radiologists and pathologists, used the
technique, called Analyzer-Based X-ray Imaging (ABI), on an in vitro specimen at
the ESRF, using a radiation dose similar to that of a mammography examination.
The dose corresponded to a quarter of that required for imaging the same sample
with conventional CT scanner, and the spatial resolution of the ABI images was
seven times better.
For the experiment, researchers chose a particularly
challenging specimen: a breast invaded by a lobular carcinoma (a diffusely
growing cancer), the second most common form of breast cancer, which is also
very difficult to visualize in clinical mammography. In this kind of sample, the
determination of the extension of the cancer frequently fails in X-ray
mammograms and ultrasonographs of the breast.
The results showed that
high-spatial-resolution ABI-CT makes visible small-size and low-contrast
anatomic details that could otherwise only be seen by the microscopic study of
an extracted sample of the breast tissue (histopathology).
"We can
clearly distinguish more microcalcifications -small deposits of minerals which
can indicate the presence of a cancer- than with radiography methods and improve
the definition of their shapes and margins", explains Jani Keyriläinen, main
author of the paper. "If we compare the images with X-ray mammograms and
conventional CT images, we can confirm that this technique performs extremely
well", he adds.
Clinical future
Despite having studied only
in vitro samples, the team is very optimistic that the technique will be applied
in the future in clinics. "The technique does not require sophisticated and
expensive synchrotron radiation facilities", explains Alberto Bravin, scientist
in charge of the biomedical beamline at the ESRF. However, "it would not be
viable to use X-ray tubes, as exposure times would be too long and this would be
incompatible with clinical practice".
Scientists hope that current
worldwide development of compact, highly intense X-ray sources will enable the
clinical use of this technique. The Biomedical beamline at the ESRF is directly
involved in one of these projects, with the role of developing synchrotron
techniques for clinical application on compact sources (e.g. the tabletop X-FEL
machine of the Munich Advanced Center for Photonics- MAP).
Once the
technique has been confirmed and tabletop synchrotrons are on the market, the
progression could be very straightforward. "With these machines it would
definitely be possible to apply this technique to clinical practice", explains
Bravin, "and, in this way, contribute actively to a more efficient detection of
breast cancer", he concludes.
EUROPEAN SYNCHROTRON RADIATION FACILITY
(ESRF).
BP 220.
F-38043 Grenoble Cedex.
http://www.esrf.fr
Blood Clot Drug May Be Less Effective When Taken With Commonly Used Acid-Reducer
Clopidogrel, a drug used in treating coronary artery disease and marketed as Plavix®, may be less effective when it interacts with acid
reducing proton pump inhibitors (PPIs) (e.g., Prilosec®, Nexium®)
according to an Aetna (NYSE:AET) analysis published in the September 16th issue
of the Journal of the American College of Cardiology. Initial results
showed (a) a one year acute myocardial infarction (MI) of 5.03 percent in the
group taking PPIs often; (b) a 3.08 percent one year acute MI rate in the group
taking PPI some of the time; and (c) a one year acute MI rate of 1.38 percent in
the group with no PPI use.*
"This is one study, one piece of the data
puzzle, but it certainly suggests that we may be able to help promote improved
patient safety through outreach and education," said Ed Pezalla, MD, national
medical director for Aetna Pharmacy Management and co-author of the analysis.
"We have notified the FDA of our findings and are making physicians aware of the
potential risks of taking these medications together."
Aetna is
currently working to create a clinical alert to physicians and pharmacists when
these two medications are prescribed concurrently.
Aetna Pharmacy
Management's (APM) Pharmacy Outcomes Research team conducted the analysis
following a previous report on clopidogrel in the Journal's January 2008 issue,
which suggested PPIs can have a negative influence on the antiplatelet action of
clopidogrel. Following the publication of this report, the team analyzed Aetna's
medical and pharmacy claims information to see if the data showed a difference
in MI event rates for Aetna members taking clopidogrel depending on whether they
were also taking a PPI.
"Because proton pump inhibitors are prescribed
in almost half of all patients receiving clopidogrel, we felt this study was
needed to evaluate the significance of the risk when both drugs were
simultaneously used," said David Day, MS, RPh, head of Pharmacy Outcomes
Research for Aetna and co-author of the analysis. "We're evaluating any
additional communication that may be necessary."
Aetna identified 1,010
members less than 65 years old that were continuously eligible for Aetna medical
and pharmacy benefits from January 2005 through December 2006 and were newly
started on clopidogrel during the month of January 2006. Aetna then associated
these members with concurrent pharmacy claims for PPIs, medical claims for
hospital admission with diagnoses indicative of MI co-morbidities, and internal
measures of severity of illness at the time of first clopidogrel use.
*
Those members who received >182 days supply of clopidogrel throughout 2006
without evidence of PPI use were assigned to the control group. Those members
who received >182 days supply of clopidogrel throughout 2006 and <182 days
supply of PPI were assigned to the low PPI exposure group, and finally, those
members who received >182 days supply of clopidogrel throughout 2006 and
>182 days supply of PPI were assigned to the high PPI exposure group.
Aetna is one of the nation's (USA) leading diversified health
care benefits companies, serving approximately 37.2 million people with
information and resources to help them make better informed decisions about
their health care. Aetna offers a broad range of traditional and
consumer-directed health insurance products and related services, including
medical, pharmacy, dental, behavioral health, group life and disability plans,
and medical management capabilities and health care management services for
Medicaid plans. Our customers include employer groups, individuals, college
students, part-time and hourly workers, health plans, governmental units,
government-sponsored plans, labor groups and expatriates.
Aetna
Carpal Tunnel Syndrome: Knowing When To Refer For Testing Is As Easy As 1,
2, 3
Does your physician know when it is appropriate to refer you to a specialist to
diagnose carpal tunnel syndrome (CTS)? Due to a high prevalence of CTS, and the
number of other conditions that mimic symptoms of CTS, a team of researchers set
out to develop an easy screening questionnaire to help physicians determine when
it is appropriate to refer a patient for nerve conduction studies and needle
electromyography (EMG) - the two electrodiagnostic tests, most commonly used to
diagnose CTS.
The carpal tunnel is a small tunnel made of bones and
ligaments in the wrist. The median nerve runs down the forearm through the
tunnel into the hand on the palm side of the hand and provides feeling to the
hand and fingers. The median nerve can become irritated by inflammation in this
tunnel, which leads to carpal tunnel syndrome. CTS can be a result of many
factors arising from work and lifestyle, health, injuries, and even genetic
predisposition. The most common cause of CTS is repetitive hand motion. Common
symptoms include tingling, numbness and pain in the hand, which are typically
worse at night and can even cause people to awaken from sleep.
A simple
seven item screening questionnaire was used to screen patients with possible CTS
prior to referral for electrodiagnostic testing. The questionnaire was completed
by 100 consecutive patients. Three key questions were found to predict the
diagnosis of CTS: 1) tingling in at least two of the first four digits; 2)
symptoms worse during the night/on awakening; and 3) improvement on shaking the
hand. With at least two affirmative responses to three questions the sensitivity
of the questionnaire to predict abnormal electrodiagnostic test was 97% (p <
0.001). According to Dr. Simon Podnar, "It seems that only patients with the
most advanced CTS may be missed by the questionnaire; therefore looking for
muscle atrophy and abnormal skin sensation in the hand is not to be skipped on
physical examination by the doctor."
This simple questionnaire proved to
be a useful screening tool with a high sensitivity for predicting
electrodiagnostic abnormalities typical for CTS. Used by clinicians in
combination with physical examination, the questionnaire can result in more
timely referrals for electrodiagnostic testing, diagnosis, and treatment for
patients with CTS.
The complete findings and results of this study are
being presented at the American Association of Neuromuscular &
Electrodiagnostic Medicine (AANEM) 55th Annual Meeting in Providence, Rhode
Island, September 17-20, 2008. The AANEM is the largest organization worldwide,
with over 5000 members dedicated to advancing neuromuscular, musculoskeletal,
and electrodiagnostic medicine.
American Association of Neuromuscular and
Electrodiagnostic Medicine (AANEM)
2621 Superior Dr. NW
Rochester, MN
55901
United States
http://www.aanem.org
Older People Who Diet Without Exercising Lose Valuable Muscle Mass
A group of sedentary and overweight older people placed on a four-month exercise
program not only became more fit, but burned off more fat, compared to older
sedentary people who were placed on a diet but did not exercise.
The new
study also showed that when older people diet without exercising, they lose more
lean muscle compared to those who exercise, said senior researcher Bret H.
Goodpaster. When they combined weight loss with exercise, it nearly completely
prevented the loss of lean muscle mass. The results are important because older
people tend to lose muscle mass as they age and too much muscle loss may
interfere with activities of daily living.
The study, "Separate and
combined effects of exercise training and weight loss on exercise efficiency and
substrate oxidation," appears in the current issue of the Journal of Applied
Physiology, published by The American Physiological Society. Francesca
Amati, John J. Dube, Chris Shay and Goodpaster, all of the University of
Pittsburgh, carried out the study.
Study looks at exercise
efficiency
The researchers wanted to know the best way to get better
(more efficient) at completing a defined exercise task. In particular, they
wanted to know if greater fitness could be achieved through exercise training,
weight loss (through dieting), or both. In addition, they wanted to know which
fuel source the body would draw upon, carbohydrates or fats, under these
different conditions.
The 64 participants were 60-75 years of age and
were either overweight or obese. All of the participants were sedentary at the
outset of the study. The researchers divided the participants into three
groups:
-- exercise only
-- diet only
-- exercise plus
diet
Those who exercised could either walk on a treadmill or ride a
stationary bicycle, although most chose to walk. The dieters reduced their
caloric intake to achieve a 10% weight loss by the end of the four-month study
period. The final group combined both the daily exercise and the
diet.
Exercise increases efficiency, burns more fat
The
researchers measured how many calories the participants expended during a set
work load on a stationary bicycle at the beginning and at the end of the
experiment. They found that the:
-- Exercise group expended fewer
calories (became more efficient) on the exercise task at the end of the study
compared to the beginning.
-- Exercise group drew more on fat stores as
the source of their body's fuel.
-- Diet-only group did not gain
efficiency in performing the exercise task, even though they weighed less at the
end of the experiment.
-- Diet-only group's weight loss resulted from a
loss of both muscle and fat.
-- Exercise plus diet group was the most
efficient at the exercise task at the end of the experiment. This shows an
additive effect of both dieting and exercise, but most of that benefit was due
to exercise.
-- Exercise plus diet group, like the exercise-only group,
drew more on fat stores as an energy source.
"The take-home message is
that, even among older people and during a fairly short period of time, exercise
produces metabolic changes that require the expenditure of fewer calories during
physical activity," Goodpaster said. Exercise also allowed older people to more
preferentially burn fat, which may be healthier metabolically."
American
Physiological Society (APS)
9650 Rockville Pike
Bethesda, MD
20814
United States
http://www.the-aps.org
93% Of Brits Are Scared Of Going To The Dentist, UK
Men are worst offenders behind nation's criminal dental record
A shocking
93 per cent of people in the UK are scared of going to the dentist, with men
worse worriers than women.
That's according to a new survey of more than
1,500 dental patients carried out by the Cosmetic Dentistry Guide - the leading
website that offers guidance and advice for anyone considering dental treatment.
There is help at hand for petrified patients at
www.cosmeticdentistryguide.co.uk which has a panel of experts available online.
Dr Kalpesh Bohara, one of the experts, has a 100% record of successfully
treating patients with dental anxiety.
"Everyone knows that some people
are scared of visiting the dentist but I don't think anyone realises the true
extent of the problem," says Dr Bohara. "I would say it is the main cause of
dental problems in the UK today."
Another leading dentist, Dr Kailesh
Solanki, also featured on the Cosmetic Dentistry Guide advisory panel, says
scared patients are hiding behind excuses to avoid sorting out their smiles.
"People like to blame a lack of NHS dentists or high private costs for
their avoidance of dental care rather than admit that they are simply too
scared," says Dr Solanki.
The survey, of 1,586 patients at Dr Solanki's
Kissdental clinic, also showed that men are more scared than women, and less
likely to confront their fears.
"Men are definitely more scared," says
Dr Solanki. "The difference is that women might be worried too but take more
pride in their appearance and are willing to accept the 'pain' for the gain."
"But people have nothing to fear. A trip to the dentist can be like a
relaxing spa treatment. We have chill-out lounges, massages, DVD glasses, even a
champagne bar. What's there to be scared of?"
About The Cosmetic
Dentistry Guide
The Cosmetic Dentistry Guide is a website that acts
as a portal to leading cosmetic dentistry practitioners based across the UK.
Visitors to the website get professional expertise and information about
cosmetic dental procedures. The Cosmetic Dentistry Guide ensures that people get
expert advice before they make any decisions about visiting a dental
practitioner.
The Cosmetic Dentistry Guide offers advice and the shared
experiences of procedures through an online forum, and also has experts online
to answer people's questions.
Cosmetic Dentistry Guide
New Approach To Detect Rare Genetic Variants Aims To Help Women Evaluate Hormone
Replacement Therapy And Breast Cancer Risk
Perlegen, a leader in discovering clinically important genetic variations that
affect patients' drug response and predisposition to disease, announced today
that it has launched a new, proprietary approach to discovering rare genetic
variations. The company is now employing this approach in a study of women who
have received hormone replacement therapy, to survey a large proportion of the
expressed genome for the presence of rare genetic variants that alter women's
risk of developing breast cancer.
Perlegen has already identified common
genetic variants with proven, quantifiable associations to disease risk and drug
response profiles, including common variants related to the risk of developing
breast cancer. But while common variants can provide valuable information, they
do not explain all of the genetic factors associated with a particular clinical
outcome. This new approach will enable Perlegen to efficiently identify more of
the genetic basis behind the differences in patients' disease risks and response
to drugs.
Common variants can be found by "genotyping," or studying the
most prevalent genetic variants, called single nucleotide polymorphisms (or
"SNPs"). Rarer variants, however, must be found through "sequencing," a more
involved process that looks at the entire genetic code in a region of interest
to discover not only any single-base changes from its known sequence, but also
any insertions or deletions of code. Perlegen's sequencing approach targets the
sections of the genome that are expressed as proteins, since even with fast,
second-generation sequencing, addressing the entire genome in hundreds of cases
and controls remains prohibitively expensive. Perlegen's new approach uses an
innovative sample preparation method, automated processing on a next-generation
sequencing discovery platform and advanced data analysis methods.
"Perlegen's pioneering use of sequencing to discover rarer genetic
variants associated with increased risk of disease or drug side effects will
make clinical testing an even more powerful tool," said Bryan Walser, M.D., CEO
of Perlegen. "This new information will build upon our earlier work in common
variants for breast cancer to allow physicians and patients to make
better-informed choices about treatment options based on information associated
with the individual's particular genetics, enabling medicine that's truly
tailored to each individual. For a woman who has some identified risk factors
for breast cancer, such as immediate family history, and is considering hormone
replacement therapy to ameliorate the symptoms of menopause, this additional
information could be extremely valuable."
The data for the Perlegen
study of hormone replacement therapy and breast cancer risk comes from the
Women's Health Initiative (WHI), a long-term national health study that focuses
on strategies for preventing heart disease, breast and colorectal cancer and
fracture in postmenopausal women. Since 1993, the WHI study has involved more
than 161,000 women ages 50-79 in one of the most definitive, far-reaching
programs of research on women's health ever undertaken in the United States.
Perlegen expects to complete its breast cancer study in early 2009. The
company will continue to apply this sequencing technology to identify markers
that help to guide other key healthcare decisions.
About Perlegen
Perlegen's mission is to discover and commercialize genetic
variations that can make a difference to patients and physicians. The company's
expertise is in understanding human genetic variation within and across diverse
patient populations and in conducting studies aimed at identifying those
variations that are predictive of drug response, including both toxicity and
efficacy.
Perlegen
Open Alternative To WeightWatchers Launched
Lack of access to effective dieting programs is likely one reason why the
obesity epidemic hits lower income families hardest. Many can not afford
effective weight loss programs such as WeightWatchers.
Slimlet.com, a new free online
diet, has been launched providing guidance and tools free of charge to
everyone who wishes to lose weight. The open initiative is based on a diary type
diet. The application calculates the users' daily energy consumption and assists
the user to stay under this limit which has proven very effective.
"I
have been overweight myself but found that through simple steps, guidance and
discipline I was able to lose weight" Patricia Feddersen, founder of Slimlet.com
said. She added that the diet actively supports and guides the user in the
process of losing weight but that a certain amount of motivation is needed.
Ambitions of Slimlet.com are to provide all overweight individuals with
equal opportunities to become healthier regardless of financial resources.
Patricia Feddersen is committed to help stopping the obesity epidemic and expect
that the service has hundred thousand members during the fourth quarter.
Slimlet.com
Survey Shows 'Grey's Anatomy' Viewers Gained HIV Knowledge
Many viewers of an episode of ABC's prime-time medical drama "Grey's Anatomy"
that included a story about mother-to-child HIV transmission gained awareness of
the issue, according to a survey released on Tuesday by the Kaiser Family Foundation, USA Today reports.
For the study, the
Foundation worked with writers of the show to embed in the episode the story of
an HIV-positive pregnant woman. According to USA Today, the woman
is "distraught" before being told by her physician that with proper treatment,
her child has a 98% chance of being born HIV-negative. The Foundation conducted
three national random surveys of regular viewers of the show one week before,
one week after and six weeks after the episode. The surveys combined had 1,505
respondents.
Victoria Rideout, vice president and director of the
Foundation's program for the Study of Media and Health, said the goal of the survey was to
measure the "impact of the message about mother-to-child HIV transmission"
(Marcus, USA Today, 9/17). One week before the show, 15% of the
viewers surveyed said that they were aware of the mother-to-child HIV
transmission risk. One week after the show, 61% of viewers of the episode were
aware of the risk. Six weeks after the show, 45% of viewers
remembered the information correctly (Childs, ABC News, 9/17). According to the survey, the
increase from 15% to 61% awareness of the risk of mother-to-child HIV
transmission translates to more than eight million people learning correct
information on the issue from watching the episode. The survey also found that
the percentage of viewers who said it was "irresponsible for a woman who knows
she is HIV-positive to have a baby" dropped from 61% to 34% after the episode
aired, and then increased to 47% six weeks after the show (Kaiser Family
Foundation release, 9/16). Rideout said she was "astounded" by the number
of viewers who "picked up on factual health info about HIV embedded in the show,
and that they remembered it weeks later."
The Foundation and the
University of Southern California's Annenberg Norman Lear Center also
released a second study of top-10 prime time television shows, finding that six
out of 10 episodes from 2004 to 2006 included at least one health-related
storyline. "People are very hungry for information about health," Linda
Rosenstock, dean of the University of California-Los Angeles School of Public Health, said,
adding that entertainment media do "societal good" by putting accurate health
information into shows. Jay Bernhardt of CDC said that embedding information accurately into TV content
could "help change behaviors about health" (USA Today,
9/17).
The studies, and a Kaisernetwork.org webcast of a briefing
discussing them, are available online.
Reprinted with kind permission
from http://www.kaisernetwork.org. You can view the entire Kaiser
Daily Health Policy Report, search the archives, or sign up for email delivery
at http://www.kaisernetwork.org/dailyreports/healthpolicy. The
Kaiser Daily Health Policy Report is published for kaisernetwork.org, a free
service of The Henry J. Kaiser Family Foundation.
© 2008 Advisory
Board Company and Kaiser Family Foundation. All rights reserved.
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