Today's Health, Science, Technology, Personal Finance News
(please report bugs and errors: suzanne@liveinfospace.com)
| apples |
Protects your heart |
prevents constipation |
Blocks diarrhea |
Improves lung capacity |
Cushions joints |
| apricots |
Combats cancer |
Controls blood pressure |
Saves your eyesight |
Sheilds against Alzheimer's |
Slows aging process |
| artichokes |
Aids digestion |
Lowers cholesterol |
Protects your heart |
Stabilizes blood sugar |
Guards against liver disease |
| avocadoes |
Battles diabetes |
Lowers cholesterol |
Helps stops strokes |
Controls blood pressure |
Smoothes skin |
| bananas |
Protects your heart |
Quiets a cough |
Strengthens bones |
Controls blood pressure |
Blocks diarrhea |
| beans |
Prevents constipation |
Helps hemorroids |
Lowers cholesterol |
Combats cancer |
Stabilizes blood sugar |
| beets |
Controls blood pressure |
Combats cancer |
Strengthens bones |
Protects your heart |
Aids weight loss |
| blueberries |
Combats cancer |
Protects your heart |
Stabilizes blood sugar |
Boosts memory |
Prevents constipation |
| broccoli |
Strengthens bones |
Saves eyesight |
Combats cancer |
Protects your heart |
Controls blood pressure |
| cabbage |
Combats cancer |
Prevents constipation |
Promotes weight loss |
Protects your heart |
Helps hemorroids |
| canteloupe |
Saves eyesight |
Controls blood pressure |
Lowers cholesterol |
Combats cancer |
Supports immune system |
| carrots |
Saves eyesight |
Protects your heart |
Prevents constipation |
Combats cancer |
Promotes weight loss |
| cauliflower |
Protects against Prostate Cancer |
Combats Breast Cancer |
Strengthens bones |
Banishes bruises |
Guards against heart disease |
| cherries |
Protects your heart |
Combats Cancer |
Ends insomnia |
Slows aging process |
Sheilds against Alzheimer's |
| chestnuts |
Promotes weight loss |
Protects your heart |
Lowers cholesterol |
Combats Cancer |
Controls blood pressure |
| chili peppers |
Aids digestion |
Soothes sore throat |
Clears sinuses |
Combats Cancer |
Boosts immune system |
| figs |
Promotes weight loss |
Helps stops strokes |
Lowers cholesterol |
Combats Cancer |
Controls blood pressure |
| fish |
Protects your heart |
Boosts memory |
Protects your heart |
Combats Cancer |
Supports immune system |
| flax |
Aids digestion |
Battles diabetes |
Protects your heart |
Improves mental health |
Boosts immune system |
| garlic |
Lowers cholesterol |
Controls blood pressure |
Combats cancer |
kills bacteria |
Fights fungus |
| grapefruit |
Protects against heart attacks |
Promotes Weight loss |
Helps stops strokes |
Combats Prostate Cancer |
Lowers cholesterol |
| grapes |
saves eyesight |
Conquers kidney stones |
Combats cancer |
Enhances blood flow |
Protects your heart |
| green tea |
Combats cancer |
Protects your heart |
Helps stops strokes |
Promotes Weight loss |
Kills bacteria |
| honey |
Heals wounds |
Aids digestion |
Guards against ulcers |
Increases enery |
Fights allergies |
| lemons |
Combats cancer |
Protects your heart |
Controls blood pressure |
Smoothes skin |
Stops scurvy |
| limes |
Combats cancer |
Protects your heart |
Controls blood pressure |
Smoothes skin |
Stops scurvy |
| mangoes |
Combats cancer |
Boosts memory |
Regulates thyroid |
aids digestion |
Sheilds against Alzheimer's |
| mushrooms |
Controls blood pressure |
Lowers cholesterol |
Kills bacteria |
Combats cancer |
Strengthens bones |
| oats |
Lowers cholesterol |
Combats cancer |
Battles diabetes |
prevents constipation |
Smoothes skin |
| olive oil |
Protects your heart |
Promotes Weight loss |
Combats cancer |
Battles diabetes |
Smoothes skin |
| onions |
Reduce risk of heart attack |
Combats cancer |
Kills bacteria |
Lowers cholesterol |
Fights fungus |
| oranges |
Supports immune systems |
Combats cancer |
Protects your heart |
Stregthens respiration |
|
| peaches |
prevents constipation |
Combats cancer |
Helps stops strokes |
aids digestion |
Helps hemorroids |
| peanuts |
Protects against heart disease |
Promotes Weight loss |
Combats Prostate Cancer |
Lowers cholesterol |
Aggravates
diverticulitis |
| pineapple |
Strengthens bones |
Relieves colds |
Aids digestion |
Dissolves warts |
Blocks diarrhea |
| prunes |
Slows aging process |
prevents constipation |
boosts memory |
Lowers cholesterol |
Protects against heart disease |
| rice |
Protects your heart |
Battles diabetes |
Conquers kidney stones |
Combats cancer |
Helps stops strokes |
| strawberries |
Combats cancer |
Protects your heart |
boosts memory |
Calms stress |
|
| sweet potatoes |
Saves your eyesight |
Lifts mood |
Combats cancer |
Strengthens bones |
|
| tomatoes |
Protects prostate |
Combats cancer |
Lowers cholesterol |
Protects your heart |
|
| walnuts |
Lowers cholesterol |
Combats cancer |
boosts memory |
Lifts mood |
Protects against heart disease |
| water |
Promotes Weight loss |
Combats cancer |
Conquers kidney stones |
Smooths skin |
|
| watermelon |
Protects prostate |
Promotes Weight loss |
Lowers cholesterol |
Helps stops strokes |
Controls blood pressure |
| wheat germ |
Combats Colon Cancer |
prevents constipation |
Lowers cholesterol |
Helps stops strokes |
improves digestion |
| wheat bran |
Combats Colon Cancer |
prevents constipation |
Lowers cholesterol |
Helps stops strokes |
improves digestion |
| yogurt |
Guards against ulcers |
Strengthens bones |
Lowers cholesterol |
Supports immune systems |
Aids digestion |
MIT Researcher Mimics Photosynthesis To Turn Water Into Hydrogen And Oxygen
Posted on 29 October 2008

A MIT researcher has demonstrated a reaction which resembles the photosynthesis process that plants make each day which means that from now on solar power could be deployed at world scale. Using catalysts developed by the chemist, he showed a video where oxygen was generated from water, just like plants do it in photosynthesis.
“I’m going to show you something I haven’t showed anybody yet,” said Daniel Nocera, the MIT chemist. After the lights were tuned off, he pointed to the video and asked - “Can you see that?” Then he explained - “Oxygen is pouring off of this electrode. This is the future. We’ve got the leaf.” This means that the most difficult obstacle was overcame as from now on we efficiently produce hydrogen gas by splitting water thanks to his catalysts.
This is very important as solar power could be deployed at worldwide and it could remove our dependence on fossil fuels. Solar power cannot replace oil with solar panels as solar cells are not very efficient and the sun doesn’t shine all day long. All this can change now, and we could use the catalysts and light to split water to generate hydrogen fuel which could power our cars. Also, according to Nocera, the catalysts could split seawater and if the hydrogen will be processed in a fuel cell then it will produce fresh water.
During recent history many scientists tried to get energy from the sun by resembling photosynthesis and their attempts were successful. The problem is that this process requires high temperatures, expensive catalysts, and harsh alkaline solutions, so it cannot be deployed at world-scale. Well, this will change as Nocera’s catalysts are cheap and they split water in oxygen and hydrogen at room temperature.
According to Nocera, this process could be used in two ways - one would use solar panels to capture the light coming from the sun and the electricity that will be generated will power an electrolyzer which will split water thanks to these new and cheap catalysts. The other way would require a system that resembles a leaf as the catalysts will be positioned near dye molecules. How will this work? Well, the dye molecules will capture the sunlight and then the catalysts will do their job and split the water to get hydrogen for a later use.
Although there were many scientists and chemists who questioned Nocera’s catalysts, he is very confident of the success of his system.
“With this discovery, I totally change the dialogue. All of the old arguments go out the window,” explained Nocera.
For the moment, solar power provides only 1 percent of the energy demand in the US and if the demand will grow up to 10 percent then utility companies will have to do something when the sun doesn’t shine. According to Ryan Wiser, scientist at the Lawrence Berkeley National Laboratory in Berkeley, CA, utilities could invest a lot of money in energy storage, however, the companies also have a cheaper option in developing natural gas plants that will replace solar power when it’s not available.
“Electrical storage is just too expensive,” concluded Wiser.
The situation changes when we talk about 20 percent of the energy demand as then solar power will contribute to the base load power which is the amount of power required for the minimum energy demand. For the moment, the base load power is supplied by coal power plants. In order to replace coal, solar power needs to be harnessed 24/7 even if the weather is cloudy. As the sun doesn’t shine 24 hours a day, solar power cannot become the most important source of energy in the country.
Another problem is that the solar power-generated electricity cannot be stored efficiently. A good comparison was made by Nathan Lewis from Caltech who said that one kilogram of water pumped uphill, then sent through a turbine would store one kilojoule of energy, meanwhile one kilogram of oil stores 45,000 kilojoules. Lewis added that batteries are also expensive and very inefficient as they store 300 watts per kilogram, meanwhile oil stores 13,000 watts per kilogram.
“The numbers make it obvious that chemical fuels are the only energy-dense way to obtain massive energy storage,” concluded Lewis.
Nocera began studying the process of photosynthesis as of 1984, however, he didn’t start to mimic the process right away. This happened in 2004 when chemists from the Imperial College London discovered a very important protein which was responsible for the release of oxygen from water.
“As soon as we saw this, we could start designing systems,” said Nocera.
In order to fully understand the process, Nocera tried a very different approach - he reversed the reaction and combined oxygen with electrons and protons to get water and he noticed that cobalt-based compounds were the best catalysts so he used them to also split water. When these catalysts failed, he said “let’s forget all the elaborate stuff and just use cobalt directly.”

Nocera was surprised to see that the cobalt worked so good and the success of the experiment made him realize how lucky he was.
“There was no reason for us to expect that just plain cobalt with phosphate, versus cobalt being tied up in one of our complexes, would work this well. I couldn’t have predicted it. The stuff that was falling out of the compounds turned out to be what we needed,” admitted the chemist.
However, Nocera was intrigued by the fact that cobalt worked so well and he wanted to understand why.
“I want to know why the hell cobalt in this thin film is so active. I may be able to improve it or use a different metal that’s better. We were really interested in the basic science. Can we make a catalyst that works efficiently under the conditions of photosynthesis? The answer now is yes, we can do that. Now we’ve really got to get to the technology of designing a cell.”
Despite Nocera’s scientific proof, many scientists questioned his discovery and they said it’s overrated. Even Nocera’s mentor, Thomas Meyer said that “the claim that this is the answer for artificial photosynthesis is crazy” because there is “no guarantee that it can be scaled up or even made practical” and he also added that this is only a “research finding” rather than a breakthrough.
Nocera was also chaffed by John Turner, a researcher at the National Renewable Energy Laboratory in Golden, CO who said that “at least what he’s published so far would never work for a commercial electrolyzer, where the current density is 800 times to 2,000 times greater.” Another fellow researcher who questioned Nocera’s finding, was Ryan Wise who said that “electrolysis is inefficient, so why would you do it?”

One of the scientists who believed in Nocera’s discovery was Michael Grätzel, chemistry and chemical engineering professor at the École Polytechnique Fédérale in Lausanne, Switzerland. Grätzel said that Nocera was very excited and that “he took me to a restaurant and bought a tremendously expensive bottle of wine.”
Grätzel says that he has a way to make Nocera’s discovery practical as in 1991 he developed a futuristic solar cell where the electrons were collected by a titanium-oxide film to generate electricity, instead of setting them off during the electrolysis. Using his cell and Nocera’s catalysts, Grätzel believes that he develop an artificial leaf that would capture sunlight and split water in a process that resembles photosynthesis.
Nocera is very confident that soon we will “make fuels from a glass of water.” Although most of the scientists today don’t agree with Nocera, from where I’m looking this could be possible. Hopefully, the MIT chemist will manage to find a practical use for his catalysts and solar power will replace fossil fuels.
Optimal Dose of Vitamin E Maximizes Benefits, Minimizes Risk
Corvallis, Oregon – October 29, 2008 -- Vitamin E has been heralded for its ability to reduce the risk of blood
clots, heart attack, and sudden death. Yet in some people, vitamin E causes
bleeding. Scientists have known for more than 50 years that excess vitamin E
promotes bleeding by interfering with vitamin K, which is essential in blood
clotting. However, they haven’t been able to pinpoint how the two vitamins
interact. Nutrition researcher Maret Traber of Oregon State University reviews
studies of possible explanations of the interaction in an article published
recently in Nutrition Reviews.
One of the most compelling studies of the
benefits of vitamin E is the Women’s Health Study, in which 40,000 healthy
women, 45 and older, took 600 IU vitamin E supplements or a placebo every other
day for 10 years. Women taking the supplements had 24 percent fewer deaths from
heart disease. Vitamin E’s protective effect appeared even stronger in women 65
and older. Those taking the vitamin experienced a 26 percent reduction in
cardiovascular events and a 49 percent reduction in cardiovascular deaths.
“That’s a significant benefit,” Traber said.
Yet, she added, “In some people high doses of vitamin E increase the tendency to
bleed. Women enrolled in the study had an increase in nose bleeds.”
To lessen the bleeding risk, the U.S.-based
Food and Nutrition Board in 2000 set the upper tolerable limit for daily vitamin
E intake at 1500 I.U.
Research Traber reviewed suggests that a shared
metabolic pathway in the liver causes vitamins E and K to interact. Vitamin K in
the liver appears to diminish as vitamin E increases.
“Several different explanations could account
for the interaction between the two vitamins,” Traber said. “We need more
research to understand the delicate balance between vitamins E and K.”
_________________________________________________________________
This study is
published in the November 2008 issue of Nutrition Reviews. Media wishing
to receive a PDF of this article may contact professionalnews@bos.blackwellpublishing.net.
To view the
abstract for this article, please click
here.
Maret Traber is
affiliated with Oregon State University and can be reached for questions at maret.traber@oregonstate.edu.
Nutrition
Reviews is a highly cited journal devoted to keeping academic researchers,
students, and professionals abreast of the latest research in the field with
authoritative and critical reviews of significant developments in all areas of
nutrition science and policy.
Media Contact
Amy Molnar
Publicity Associate
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St.
Hoboken, NJ 07030
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(fax)
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Drinking milk to ease milk allergy?
Hopkins Children's oral immunotherapy study shows promise,
but do not try this at home
Giving children with milk allergies increasingly higher doses of milk over
time may ease, and even help them completely overcome, their allergic reactions,
according to the results of a study led by the Johns Hopkins Children's Center
and conducted jointly with Duke University.
Despite the small number of patients in the trial – 19 – the findings are
illuminating and encouraging, investigators say, because this is the first-ever
double-blinded and placebo-controlled study of milk immunotherapy. In the study,
the researchers compared a group of children receiving milk powder to a group of
children receiving placebo identical in appearance and taste to real milk
powder. Neither the patients nor the investigators knew which child received
which powder, a rigorous research setup that minimizes the chance for error and
bias.
The findings of the study are reported online ahead of print, Oct. 28, in the Journal of Allergy & Clinical Immunology
"Our findings suggest that oral immunotherapy gradually retrains the immune
system to completely disregard or to better tolerate the allergens in milk that
previously caused allergic reactions," says Robert Wood, M.D., senior
investigator on the study and director of Allergy & Immunology at Hopkins
Children's. "Albeit preliminary and requiring further study, these results
suggest that oral immunotherapy may be the closest thing yet to a 'true'
treatment for food allergy."
Currently, food allergy management involves complete avoidance of the trigger
foods, waiting for the child to outgrow the allergy or treating allergic
reactions if and when they occur. The latter could be dangerous, investigators
say, because these common foods are difficult to avoid and some reactions can be
severe and even life-threatening.
In a report released Oct. 22, the Centers for Disease Control and Prevention
estimates that food allergies are on the rise with three million children in the
United States now having at least one food allergy, an 18 percent jump from 10
years ago. Milk allergy is the most prevalent type of food allergy.
"Given that the quality of life of a child with a food allergy is comparable
to the quality of life of a child with diabetes, we urgently need therapies that
go beyond strict food avoidance or waiting for the child to outgrow the
allergy," Wood says.
Researchers followed allergic reactions over four months among 19 children
with severe and persistent milk allergy, 6 to 17 years of age. Of the 19
patients, 12 received progressively higher doses of milk protein, and seven
received placebo. At the beginning of the study, the children were able to
tolerate on average only 40 mg (.04 ounces or a quarter of a teaspoon) of milk.
At the end of the four-month study, both groups were given milk powder as a
"challenge" to see what dose would cause reaction after the treatment. The
children who had been receiving increasingly higher doses of milk protein over a
few months were able to tolerate a median dose of 5, 140 mg (over 5 ounces) of
milk without having any allergic reaction or with mild symptoms, such as mouth
itching and minor abdominal discomfort. Those who had been getting the placebo
remained unable to tolerate doses higher than the 40 mg of milk powder without
having an allergic reaction. In the group receiving milk protein, the lowest
tolerance dose was 2, 540 mg (2.5 ounces) and the highest was 8,140 mg (8
ounces). Lab tests showed the children who regularly drank or ate milk had more
antibodies to milk in their blood, yet were able to better tolerate milk than
those who took the placebo. Researchers say, tolerance in children treated with
milk continued to build over time, and recommend that these children continue to
consume milk daily to maintain their resistance. The researchers caution that it
remains unclear whether the children would maintain their tolerance once they
stop consuming milk regularly. "It may very well be that this tolerance is lost
once the immune system is no longer exposed to the allergen daily," Wood
says.
The Hopkins group is currently studying oral immunotherapy in children with
egg allergy to determine whether increasingly higher doses of egg protein can
help resolve their allergy, and have recently started another study of milk
immunotherapy.
Wood emphasizes the findings require further research and advises parents and
caregivers not to try oral immunotherapy without medical supervision.
###
Other Hopkins investigators in the study: Justin Skripak, M.D., Hannah
Rowley, R.D., Nga Brereton, R.D., Susan Oh, R.D., Robert Hamilton, M.D.,
Elizabeth Matsui, M.D. M.H.S.
Duke University co-investigators: Scott Nash, M.D., and A. Wesley Burks,
M.D.
The research was funded by the National Institutes of Health and The Eudowood
Foundation.
Can rectal vitamin E induce remission in patients with mild to
moderate ulcerative colitis?
It is believed that the generation of an exaggerated intestinal immune
response to otherwise innocuous stimuli along with generation of oxygen free
radicals plays a key role in the pathophysiology of UC. However, no
disease-specific treatment for UC has yet emerged. Vitamin E is a major
lipophilic antioxidant in cellular membranes with excellent antioxidant
activities which protects membrane lipids from peroxidation by scavenging not
only chain carrying peroxyl radicals but also singlet oxygen and superoxide
anion radicals. This is especially interesting in case of UC, considering the
pivotal role of oxygen free radicals in the genesis of mucosal damage. Given the
recent evidence suggesting anti-inflammatory properties for Vitamin E, one may
ask whether d-alpha tocopherol, as the dominant vitamin E isomer in plasma with
the highest biopotency, can be expected to reduce the development of tissue
injury in UC.
A research article to be published on October 21, 2008 in the World
Journal of Gastroenterology addresses this question. The research team led
by Dr. Mirbagheri from Department of Internal Medicine of Amir Alam hospital in
Tehran-Iran, report for the first time the preliminary results of an on-going
open-label case-series study on clinical and endoscopic changes of disease
severity in patients with active UC who received daily rectal doses of d-alpha
tocopherol for at least 12 wk.
All 15 participating patients responded dramatically to therapy after 12
weeks, with 9 of them going to clinical remission. The average score of Mayo
disease activity index (DAI) started to decrease after second week and remained
significantly lower for the remainder of the study. Besides, there was no case
of worsening disease activity or report of serious adverse event during the
course of study. The observed effect are probably due to antioxidant and
anti-inflammatory effects of vitamin E which potently takes effect by local
route of administration. At the end of this interesting article the authors
suggest that rectal administration of d-alpha tocopherol might be used safely as
a new therapeutic modality to reduce the clinical severity of ulcerative colitis
without major side effects or complications of current therapies.
###
Reference: Mirbagheri SA, Nezami BG, Assa S, Hajimahmoodi M. Rectal
administration of d-alpha tocopherol for active ulcerative colitis: A
preliminary report. World J Gastroenterol 2008; 14(39): 5990-5995
http://www.wjgnet.com/1007-9327/14/5990.asp
Correspondence to: Seyed Amir Mirbagheri, MD, Depart-ment of Internal
Medicine, Amir-Alam Hospital, North Sa'adi Street, Tehran 13145-784, Iran. mirbagherimd@yahoo.com Telephone:
+98-216-6708688 Fax: +98-216-6704805
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international
journal in gastroenterology and hepatology, has established a reputation for
publishing first class research on esophageal cancer, gastric cancer, liver
cancer, viral hepatitis, colorectal cancer, and H pylori infection. It provides
a forum for both clinicians and scientists. WJG has been indexed and abstracted
in Current Contents/Clinical Medicine, Science Citation Index Expanded (also
known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus,
MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts
Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB
Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and
0.993. WJG is a weekly journal published by WJG Press. The publication dates are
the 7th, 14th, 21st, and 28th of every month. The WJG is supported by The
National Natural Science Foundation of China, No. 30224801 and No. 30424812, and
was founded with the title China National Journal of New Gastroenterology on
October 1, 1995, and renamed WJG on January 25, 1998.
About The WJG Press
The WJG Press mainly publishes World Journal of Gastroenterology.
How did glycine significantly decrease liver injury?
The nonessential amino acid glycine has been shown to be anti-inflammatory in
several animal injury models. Recent studies demonstrated that dietary glycine
protected both the lung and liver against lethal doses of endotoxin in rat or
other animals and improved graft survival after liver transplantation. The
influence of dietary glycine on oxidant-induced or cholestatic liver injury was
not known.
A research article to be published on October 21, 2008 in the World
Journal of Gastroenterology addresses this question. The research team led
by Prof. Thurman from the University of North Carolina used a dietary and
cholestatic model thru BDL in rats to address this question. They could
demonstrate that hepatic injury due to BDL is significantly reduced by dietary
glycine in rats. Moreover, the data indicated that glycine decreases liver
injury under the conditions of experimental cholestasis thru a direct effect on
hepatocytes. Surprisingly, Kupffer cells did not appear to play a major role in
the pathological changes caused by cholestasis.
It is best known that Kupffer cells, the resident macrophages of the liver,
are involved in several disease states, such as endotoxin shock, alcoholic liver
diseases, and other toxicant-induced liver injury by releasing eicosanoids,
inflammatory cytokines, and free radical species. Furthermore, in previous
studies of the research team, a glycine-dependent chloride channel on the cell
membrane of Kupffer cells and other macrophages that influence the activation
process of these cells could be detected. But in the actual used cholestatic
model no significant influence of this cell line on liver injury could be
detected.
###
Reference: Froh M, Zhong Z, Walbrun P, Lehnert M, Netter S, Wiest R,
Conzelmann L, Gäbele E, Hellerbrand C, Schölmerich J, Thurman RG. Dietary
glycine blunts liver injury after bile duct ligation in rats. World J
Gastroenterol 2008; 14(39): 5996-6003
http://www.wjgnet.com/1007-9327/14/5996.asp
Correspondence to: Matthias Froh, Department of Internal Medicine I,
University of Regensburg, Regensburg 93042, Germany. froh.science@mac.com Telephone:
+49-941-9447012 Fax: +49-941-9447011
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in
gastroenterology and hepatology, has established a reputation for publishing
first class research on esophageal cancer, gastric cancer, liver cancer, viral
hepatitis, colorectal cancer, and H pylori infection. It provides a forum for
both clinicians and scientists. WJG has been indexed and abstracted in Current
Contents/Clinical Medicine, Science Citation Index Expanded (also known as
SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE
and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals,
Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and
Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a
weekly journal published by WJG Press. The publication dates are the 7th, 14th,
21st, and 28th of every month. The WJG is supported by The National Natural
Science Foundation of China, No. 30224801 and No. 30424812, and was founded with
the title China National Journal of New Gastroenterology on October 1, 1995, and
renamed WJG on January 25, 1998.
About The WJG Press
The WJG Press mainly publishes World Journal of Gastroenterology.
With Halloween falling on a Friday this year, it’s safe
to say trick-or-treaters of all ages will be staying out even later that usual.
These costumed creatures of the night are often draped in dark clothing, dressed
more for scares than visibility. Taking extra care for both pedestrians and
drivers is important for the neighborhood. After all, not only are the injury
risks greater on Halloween, chances are you may know the victim or driver.
(Watch our video on
the dangers of driving at dusk.)
Scary statistics from the U.S. Department of Transportation (USDOT) show that
fatal collisions between motor vehicles and young pedestrians occur most
frequently between 4 and 8 p.m. year round – prime trick-or-treating hours on
Halloween. And the Centers for Disease Control and Prevention (CDC) reports that the
number of deaths among young pedestrians (ages 5-14) is four times higher on
Halloween evening than any other evening of the year.
Take your time
when driving and be alert. Better yet, if you don’t need to drive, so much the
better. Put off that errand for another day.
Here are some more tips to improve your safety this Halloween:
Driving:
- As always, be aware of school buses. Children may be distracted by their
costumes and/or wearing masks that limit their vision.
- Don’t use a cell phone while driving.
- Stay below the posted speed limit in residential areas.
- Wet leaves can be as slippery as ice; watch out for wet patches on the road.
- Keep a vigilant eye out for kids who may dart out into traffic. In fact, you
should expect it.
- Try to park in a spot where you won’t need to back up; but if you must, have
an adult outside the car to watch for wee ghouls.
- Be extra careful pulling in and out of driveways.
- If you’re attending an adult Halloween party, designate a driver. Two-thirds
of highway fatalities on Halloween are alcohol-related.
- Don’t wear that scary mask while you’re driving!
Trick or treating:
- Be sure your children are escorted by a responsible adult.
- Help drivers see kids by putting reflective tape (available in hardware and
sporting goods stores) on their costumes and treat bags. Have them carry
flashlights and glowsticks.
- Make sure children know how to cross a street safely: before entering the
crosswalk, look left, right, and left again before crossing the street.
- Always cross inside crosswalks when available. According to the USDOT, 84
percent of deaths of young pedestrians happen at non-intersection locations.
- Remind kids not to run out between parked cars.
- Walk on sidewalks or on the far edge of the road facing traffic.
- Make sure costumes and shoes fit properly to avoid falls. If wearing a mask,
make sure it fits securely and has large eye holes. Better yet, wear makeup to
avoid obscured vision.
- Remind children to walk (not run!) as they make their rounds ringing
doorbells.
- Remind children to look for cars before walking in front of a driveway.
- Buckle up all children in their car seats or seat belts even if you’re
making short trips from house to house.
Recommended Halloween reading:
See the additional Halloween
tips on our Safety
blog, including ways to
keep cats and dogs safe. Learn the
safest way to carve a pumpkin. And if you need to whip up a last-minute
costume, see our Home
blog for DIY ideas.
Happy Halloween!
—Desiree Calamari
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With Halloween falling on a Friday this year, it’s safe to say
trick-or-treaters of all ages will be staying out even later that usual. These
costumed creatures of the night are often draped in dark clothing, dressed more
for scares than visibility. Taking extra care for both pedestrians and drivers
is important for the neighborhood. After all, not only are the injury risks
greater on Halloween, chances are you may know the victim or driver. (See video
on right on the dangers of driving at dusk.)
Scary statistics from the U.S. Department of Transportation (USDOT) show that
fatal collisions between motor vehicles and young pedestrians occur most
frequently between 4 and 8 p.m. year round--prime trick-or-treating hours on
Halloween. And the Centers for Disease Control
and Prevention (CDC) reports that the number of deaths among young
pedestrians (ages 5-14) is four times higher on Halloween evening than any other
evening of the year.
Take your time when driving and be alert. Better yet, if you don’t need to
drive, so much the better. Put off that errand for another day.
For more tips to improve your family's safety this Halloween, see the rest of
this post on our Cars
blog, and see more safe Halloween
tips on our Safety blog.
Like diapers, the cost of formula can add up. In fact, if your baby is
strictly formula-fed, you’re likely to shell out $2,000 for formula by her first
birthday. Fortunately, there are ways to save. Here are four of our top formula
thrift tips:
Shop at mass merchandisers. Your formula costs will vary by
where you shop, according to a USDA report. Formula sold by mass merchandisers
costs the least. Supermarket prices will make a bigger dent in your budget. And
drugstores charge substantially more, so don’t wait to shop for formula until
the all-night drugstore is the only outlet open.
Buy milk-based formula. It tends to cost less than soy-based
formula, so don’t buy soy or another type of special formula unless your
pediatrician recommends it.
Sign up for savings. Some formula companies offer exclusive
offers and savings on their Web sites. At www.verybestbaby.com, Nestle promises up
to $319 in savings and free offers, including money-saving checks for their Good
Start formula. A caveat: This includes “partner offers” on products you might
not want, so you might save less, and you must provide your e-mail address.
Similarly, at www.enfamil.com you can
enroll in Enfamil Family Beginnings to receive special offers and promotions,
including up to $60 in formula checks.
Buy online. Some retailers, including many mass
merchandisers like Target and Wal-Mart, don’t sell formula through their Web
sites, so you’ll have to go shopping and then schlep the stuff home. But you can
purchase formula online at many sites including www.samsclub.com (Member’s Mark, the store
brand), www.costco.com (national brands and
Kirkland Signature, Costco’s store brand), www.naturesonedirect.com (Baby’s
Only), www.earthsbest.com (Earth’s
Best), and www.amazon.com. Amazon offers
Enfamil, Similac, Nestle Good Start, and Member’s Mark, as well as free shipping
on some quantities, which will save you a trip to the store. Amazon also sells
some organic brands, such as Earth’s Best and Baby’s Only. You can sign up for
Amazon Prime, which entitles you to unlimited “free” standard and two-day
shipping on eligible items, as well as other benefits, for an annual membership
fee of $79.
See our full report on baby
formula, as well as our reports on baby
bottles without BPA and breast
pumps, for more information.
About one in five women going through menopause have symptoms severe enough to make their lives miserable from time to time. No woman, after
all, wants to start sweating profusely in public after a hot flash. And night
sweats and difficulty sleeping can leave a woman tired, groggy, irritable, and
less than productive for days on end.
But the main drugs used to treat such problems —the hormones estrogen
and progestin—have long had a bad rap. They have been linked since 2002 to a
broad array of serious risks, including breast cancer, heart attack, and stroke.
In our research, we found that new studies of hormone use often get wide media
attention, and add to an already confusing topic for women. Our Consumer
Reports Best Buy Drugs project has taken a careful look at the evidence on
hormone products in a new
report that cuts through the confusion and gives women straightforward
advice.
The good news is that hormone drugs are now deemed to be a viable option for
younger, healthy women who have severe symptoms and desperately need relief. In
particular, women under the age of 60 who are at a low risk for breast cancer
and heart problems may not increase their risk of heart disease when they take
hormones. However—and it’s a big however—they still face an increased risk of
breast cancer, blood clots, and stroke. So, hormones still need to be prescribed
and taken with extreme care, even for women who have severe
symptoms.
The report advises women with mild symptoms to avoid hormones and seek relief through
lifestyle and habit changes, such as quitting smoking, exercising regularly,
sleeping in a cool room, and dressing in loose-fitting clothes. Women who have
heart disease or are at high risk of it, as well as women who may be at high
risk of breast cancer, are also advised to steer clear of the drugs.
The new report also examines the cost of hormone drugs. Most are reasonably
priced. Even so, we recommend asking your doctor to prescribe a generic. Most
generic estradiol pills, for example, cost less than $15 a month, and could save
you up to $400 over brand-name Premarin. The full report lists 14 Best Buy
hormone products, including pills, patches, and vaginal creams and rings.
Read
the full report to learn more.
—Steve Mitchell, associate editor, Best Buy Drugs
Red meat, milk lovers more susceptible to E. Coli
Last Updated: 2008-10-30 11:00:54 -0400 (Reuters
Health)
HONG KONG (Reuters Life!) - Lovers of red meat and milk may be
more susceptible to a major strain of Escherichia coli (E. coli), which causes
severe diarrhea, researchers in Australia said.
In an article published in Nature, they said red meat and cow's milk contain
a type of sugar that the Shiga toxigenic E. coli bacterium binds readily to,
making people sick.
"Frequent consumption of (red meat and milk) would allow incorporation of the
sugar into our cells and when we eat meat infected with E. coli, it sensitizes
our cells to attack by this toxin," said Travis Beddoe, a research fellow at the
Protein Crystallography Unit of Australia's Monash University.
Using human gut and kidney tissues, the researchers found that toxins from E.
coli would only bind to tissues that were flushed with the sugar.
"The toxins couldn't bind to human tissues in the absence of the sugar, but
when we fed human cells with this (sugar) ... there was strong binding and
increase in virulence and toxicity," Beddoe told Reuters in a telephone
interview.
The sugars can reside anywhere along the human digestive tract, although they
tend to concentrate in the stomach and kidneys -- sometimes for up to a few
days.
"If we drink milk or have a lot of red meat intake we would be replenishing
those sugars, they would be there all the time," Beddoe said.
The Shiga toxigenic E. coli is a major pathogenic form of E. coli. The sugar,
called N-glycolylneuraminic acid-containing saccharides, is abundant in cow's
milk and red meat, but low or absent in poultry and fish.
Copyright © 2008 Reuters Limited. All rights reserved.
Republication or redistribution of Reuters content, including by framing or
similar means, is expressly prohibited without the prior written consent of
Reuters. Reuters shall not be liable for any errors or delays in the content, or
for any actions taken in reliance thereon. Reuters and the Reuters sphere logo
are registered trademarks and trademarks of the Reuters group of companies
around the world.
Gum disease common with rheumatoid
arthritis
Last Updated: 2008-10-30 10:00:54 -0400 (Reuters
Health)
By Karla Gale
NEW YORK (Reuters Health) - Symptoms of gum disease are common in
patients with rheumatoid arthritis (RA) and may be an independent marker of RA
disease activity, according to research presented this week at the American
College of Rheumatology meeting in San Francisco.
About 20 million people worldwide have RA -- an autoimmune disease caused
when the body confuses healthy tissues for foreign substances and attacks
itself. The disease causes pain, stiffness and swelling in multiple joints, and
inflammation can develop in other organs as well. Studies have suggested that RA
raises heart risks.
Dr. Clifton O. Bingham, III, and colleagues at Johns Hopkins University,
Baltimore, surveyed the oral health of 153 patients with RA between 45 and 84
years old and found that patients with more active RA had more symptoms of gum
disease.
The results also suggest that the prevalence of gum disease in patients with
RA is at least twice that seen in the general population, and that "more than 30
percent have severe periodontal disease according to the 2007 CDC criteria,
which may need surgical intervention," Bingham said.
"The relationship between RA disease activity with periodontal disease
suggests that periodontal disease may serve as a disease-modifying factor for
RA," he added.
"These findings should prompt more attention to oral health in this patient
population," Bingham said.
The rheumatologist pointed out that treatment of periodontal disease has been
linked to improved control of other systemic diseases, including diabetes and
cardiovascular disease. The possibility exists, therefore, that treatment of
periodontal disease could even "improve outcomes for patients with RA."
Copyright © 2008 Reuters Limited. All rights reserved.
Republication or redistribution of Reuters content, including by framing or
similar means, is expressly prohibited without the prior written consent of
Reuters. Reuters shall not be liable for any errors or delays in the content, or
for any actions taken in reliance thereon. Reuters and the Reuters sphere logo
are registered trademarks and trademarks of the Reuters group of companies
around the world.
Childhood anxiety can be effectively treated:
study
Last Updated: 2008-10-30 14:30:21 -0400 (Reuters
Health)
By Karla Gale
NEW YORK (Reuters Health) - Most children with anxiety disorders
benefit from a type of "talk therapy" called cognitive behavioral therapy (CBT)
and antidepressant medication, either in combination or alone, according to
results of a study funded by the National Institute of Mental Health (NIMH).
"Anxiety disorders are among the most common mental disorders affecting
children and adolescents. Untreated anxiety can undermine a child's success in
school, jeopardize his or her relationships with family, and inhibit social
functioning," Dr. Thomas R. Insel, director of the National Institute of Mental
Health said in a statement issued by the institute.
"This study provides strong evidence and reassurance to parents that a
well-designed, two-pronged treatment approach is the gold standard, while a
single line of treatment is still effective," Insel added.
The study involved 488 children ages 7 years to 17 years with a variety of
anxiety disorders - some with moderate to severe anxiety. Many of the children
also had attention deficit hyperactivity disorder and behavior problems.
The children were randomly assigned to one of four groups: CBT -- a specific
type of therapy that, for this study, taught children about anxiety and helped
them face and master their fears by guiding them through structured tasks; the
antidepressant (sertraline; Zoloft); the combination of the two; or placebo.
Among those in combination treatment, 81 percent improved. Sixty percent in
the CBT-only group improved, and 55 percent in the sertraline-only group
improved. Among those on placebo, 24 percent improved.
Study investigator Dr. John Walkup from Johns Hopkins in Baltimore said this
study "clearly showed that combination treatment is the most effective for these
children. But sertraline alone or CBT alone showed a good response rate as
well."
"This suggests that clinicians and families have three good options to
consider for young people with anxiety disorders, depending on treatment
availability and costs," he added.
Results also showed that the treatments were safe. Children taking sertraline
alone showed no more side effects than the children taking placebo and few
children discontinued the trial due to side effects. In addition, no child
attempted suicide, a rare side effect sometimes associated with antidepressant
medications in children.
The findings of the study, slated for publication in the December 25 print
issue of the New England Journal of Medicine, were released early to coincide
with a presentation Thursday at the annual meeting of the American Academy of
Child and Adolescent Psychiatry in Chicago.
SOURCE: The New England Journal of Medicine, online October 30,
2008.
Copyright © 2008 Reuters Limited. All rights reserved.
Republication or redistribution of Reuters content, including by framing or
similar means, is expressly prohibited without the prior written consent of
Reuters. Reuters shall not be liable for any errors or delays in the content, or
for any actions taken in reliance thereon. Reuters and the Reuters sphere logo
are registered trademarks and trademarks of the Reuters group of companies
around the world.
ADHD tied to more severe nicotine
dependence
Last Updated: 2008-10-30 12:00:28 -0400 (Reuters
Health)
By Amy Norton
NEW YORK (Reuters Health) - Young people with attention-deficit
hyperactivity disorder (ADHD) may be particularly vulnerable to serious nicotine
addiction if they start smoking, a new study suggests.
Past research has shown that kids with ADHD are more likely than their peers
without the disorder to start smoking. These latest findings suggest that once
they do take up the habit, they also tend to become more severely
nicotine-dependent, researchers report in the Journal of Pediatrics.
"The nicotine dependence appears to be about twice as bad," said lead
researcher Dr. Timothy E. Wilens of Massachusetts General Hospital in
Boston.
The study, which included 166 15- to 25-year-olds with and without ADHD,
found that those with the disorder scored significantly higher on a
questionnaire that gauges physical dependence on nicotine.
Their average score was double that of smokers without ADHD.
ADHD was not the only factor that influenced nicotine dependence, however.
Young people who had a parent who smoked, friends who smoked or who lived with a
smoker all tended to have more-severe nicotine addiction.
Importantly, Wilens told Reuters Health, these environmental factors all had
a greater impact on study participants with ADHD. This suggests that a mix of
biology and environment is at work, according to Wilens.
It's not clear why ADHD and smoking are linked, he explained, but there is
evidence that nicotine affects brain systems believed to be involved in ADHD.
One study, for example, found that nicotine and the ADHD drug Ritalin each had
similar effects on a protein that regulates levels of the brain chemical
dopamine.
Some recent studies have also suggested that nicotine can help alleviate ADHD
symptoms.
It's possible, Wilens said, that some young people with ADHD are using
cigarettes as a way to self-medicate.
The bottom line for parents of children with ADHD, he noted, is that they
should discuss the importance of not smoking with their children, and make sure
that their ADHD symptoms are minimized to the extent possible.
Parents should also be aware of the environmental factors that push some kids
to smoke, Wilens pointed out. "If parents smoke, themselves," he said, "they
should certainly stop."
SOURCE: Journal of Pediatrics, September 2008.
Copyright © 2008 Reuters Limited. All rights reserved.
Republication or redistribution of Reuters content, including by framing or
similar means, is expressly prohibited without the prior written consent of
Reuters. Reuters shall not be liable for any errors or delays in the content, or
for any actions taken in reliance thereon. Reuters and the Reuters sphere logo
are registered trademarks and trademarks of the Reuters group of companies
around the world.
Bipolar Disorder Involves A Lower Quality Of Both Mental And Physical Life, Even
In Periods Of Normality
A study carried out in the Institute of Neurosciences of the University of
Granada (Spain) and the Mental Health Unit of the Hospital Neurotraumatológico
of Jaen (Spain) has evaluated the quality of life of patients suffering from
bipolar disorder (BD), in comparison with the general population, and which
variables are connected with patients with a lower quality of life. Part of the
results of this research work has been included in a scientific paper of the
August 2008 issue of the renowned international journal Bipolar Disorders. In
addition, the Headlines review of the American Psychiatric Association has
selected such article, among those published by the highest-impact psychiatric
journal, as the relevant paper of the month as regards psychiatric disorders and
their treatment.
To carry out this work, UGR researchers Luis Gutiérrez
Rojas and Manuel Gurpegui Fernández de Legaria, together with other scientists,
analysed 108 patients with BD, against a comparative group made up of 1,210
persons from a general population sample. Inside the group of patients, 48 of
them were euthymic, this is, without active symptoms of the disease; the
remaining 60 patients (non-euthymic) presented relevant symptoms during the
evaluation.
BD, known in the past as manic-depressive psychosis, affects
approximately 3 of every 100 persons and consists of suffering recurrent
depression episodes (depressive phases) alternating with periods of euphoria
(manic phases). The patients swing intensely (usually in weeks or months) from
happiness to sadness, besides enjoying periods of normality
(euthymia).
A lower quality of physical life
The scientists
from Granada have found out that, as it was to be expected, patients with BD
present a worse mental health than the general population; but, in addition,
they have discovered that they have a poorer quality of life at a physical
level. This could be due to a higher consumption of addictive substances such as
alcohol and tobacco, the long-term secondary effects of the pharmacological
treatment and a more sedentary way of life.
From this research we can
also gather that BD patients who suffer a lower quality of mental life are those
who started to suffer the disease before 20 years old, who have been suffering
it for a longer time, who suffer the II subtype of the disease, who are
dependent on tobacco and who are suffering depressive symptoms at present. In
addition, the researchers from Granada have proved that having a high social
support (such as that of the family) is connected with a better quality of life
for the patient.
Besides it, their work has made clear that depressive
symptoms (sadness, listlessness, tiredness, concentration difficulty, insomnia,
poor appetite, etc.) have a higher impact in the quality of life than maniac
symptoms (excessive self-esteem, lack on inhibition, verbosity, hyperactivity,
increase of sexual appetite, etc.). And they also produce more disability or
negative repercussion for working capacity andfamily and social life; this is
probably due to that maniac symptoms are usually shorter in time and have a good
response to medication, whereas depressive ones are usually more difficult to
eliminate.
A more active intervention
Luis Gutiérrez Rojas
insists that, at the sight of the results of this work, there should be a more
active intervention to help those people who present depressive symptoms or a
high tobacco dependence. However, other variables which could seem less relevant
a priori, such as having a family history of the disease, having suffered many
apisodes of the disorder or having carried out suicide attempt, are not
variables significantly conected with a bad quality of life.
Reference:
Luis Gutiérrez Rojas. Institute of Neurosciences of the University of
Granada
UNIVERSITY OF GRANADA - COMMUNICATIONS DEPARTMENT
Secretariado
de Comunicación - Universidad de Granada
Hospital Real - Cuesta del Hospicio
s/n
http://www.ugr.es
Examining The Relationship Between Anger And Alcohol Abuse
Research suggests that alcoholics are more likely to experience emotions such as
annoyances, frustrations and anger compared to non-alcoholics.
A new
study at the University at Buffalo's Research Institute on Addictions (RIA) will
investigate these anger emotions and how they might be addressed in outpatient
alcoholism treatment. In this study, researchers will develop a treatment
specifically focused on anger management for use with individuals with drinking
problems and will then examine the effects of the new treatment protocol in a
pilot clinical trial.
The study is funded by a $1.8 million grant from
the National Institute of Alcohol Abuse and Alcoholism and will run through
2013.
"We have seen that alcoholics score higher on various measures of
anger emotions than non-alcoholics," explained Kimberly S. Walitzer, Ph.D., lead
investigator on the study. "Furthermore, anger emotions can play a role in
relapse to drinking following a period of abstinence from alcohol use. If we can
help individuals to manage anger emotions differently, we should be able to help
them cope in different ways other than drinking."
Walitzer is a senior
research scientist and deputy director of RIA, as well as research associate
professor in the Department of Psychology in the UB College of Arts and
Sciences.
Walitzer's research team includes two senior research
scientists at RIA. Paul R. Stasiewicz, Ph.D. is director of RIA's Clinical
Research Center and research associate professor in UB's Department of
Psychiatry in the School of Medicine and Biomedical Sciences. Gerard J. Connors,
Ph.D. is RIA's director, professor in the Department of Psychology and research
professor in the Department of Psychiatry in the School of Medicine and
Biomedical Sciences.
The Research Institute on Addictions has been a
national leader in the study of addictions since 1970 and a research center of
the University at Buffalo since 1999.
The University at Buffalo is a premier research-intensive public university, a flagship institution in the
State University of New York system and its largest and most comprehensive
campus. UB's more than 28,000 students pursue their academic interests through
more than 300 undergraduate, graduate and professional degree programs. Founded
in 1846, the University at Buffalo is a member of the Association of American
Universities.
University at Buffalo
Cancer Requires Support From Immune System To Develop
Tumors that grow around nerves in a rare genetic disease need cooperation from
cells from the immune system in order to grow, reports a team of scientists,
including researchers from UT Southwestern Medical Center.
Treating mice
with a drug that attacks the immune cells not the tumor greatly reduced the size
and metabolism of the tumors, the scientists reported. A clinical trial of the
treatment in humans has begun.
"It was not the tumor being treated, but
its environment," said Dr. Luis Parada, chairman of developmental biology at UT
Southwestern and co-senior author of the study, which appears in the Oct. 31
issue of the journal Cell. "This insight has led to a very promising
therapy of a previously untreatable tumor.
"This is the first time a
mouse model has been used to gain insight into a cancer that could not be
derived from patient studies," said Dr. Parada, director of the Kent Waldrep
Center for Basic Research on Nerve Growth and Regeneration.
The
researchers were studying tumors called plexiform neurofibromas, which occur
around peripheral nerves. In humans, they occur as part of a genetic disease
called neurofibromatosis-1. About 25 percent to 40 percent of people with the
disease develop the tumors, which are generally benign but can grow large enough
to cause disfigurement or disability and can sometimes become
malignant.
These tumors are complex structures that include many
different types of cells, particularly Schwann cells, which provide a fatty
coating that makes nerve cells electrically efficient, and mast
cells.
Because of their complexity, plexiform neurofibromas are difficult
to remove surgically, and there is currently no cure for
them.
Neurofibromatosis-1 is caused by a mutation in a single gene called
Nf1. About 250,000 people in the U.S., Europe and Japan have this mutation. The
mutation is dominant, meaning that people with one normal gene and one mutated
gene develop the disease.
The UT Southwestern researchers had previously
found in mice that plexiform neurofibromas develop from Schwann cells that have
two mutated copies of Nf1. In addition, they discovered that even before a
plexiform neurofibroma begins to form around a nerve, mast cells migrate into
the area.
In the current study, the scientists used genetically
engineered mice to confirm first that the animals need two mutated copies of Nf1
in their Schwann cells to develop neurofibromas, which the rest of their cells
can still have one normal and one mutant Nf1 gene.
In addition, a bone
marrow transplant from normal mice with two normal Nf1 genes prevented 90
percent of the engineered mice from developing neurofibromas, confirming that
even with two mutated genes in the Schwann cells, a mutated copy must also be
present in other cells. Bone marrow is the source of mast cells, blood cells and
many other types of cells that circulate through blood vessels.
The
researchers then focused on the role of mast cells in tumor formation,
particularly a molecule on the cells' surface called c-kit, which controls many
functions, including migration and proliferation.
The mice engineered to
develop tumors were given the drug imatinib mesylate, also known as Gleevec. The drug, known to inhibit c-kit, currently is used
to treat chronic myelogenous leukemia and other cancers.
Positron
emission tomography scans showed that Gleevec halved the metabolic activity of
the tumors, while later examination confirmed that the tumors were much smaller
than in placebo-treated mice.
"We found there was a requirement from the
immune system to interact with the tumor for the tumor to grow," Dr. Parada
said. "When mast cells are blocked, the tumor cannot grow."
During the
course of these experiments, the researchers learned about a girl who had a
large neurofibroma that could not be removed surgically because too many blood
vessels were involved. Because Gleevec is already approved for other conditions,
the girl's doctor treated her under "compassionate use" guidelines.
The
girl's tumor shrank by 70 percent with no apparent side effects during the first
three months of a six-month treatment under "compassionate use" regulations. The
mass has remained dormant in the six months afterward, the researchers
reported.
While this was only a single case, it was consistent with the
one-year study of the tumor and its action in mice, Dr. Parada said, and the
child's treatment was tailored to reflect the findings from the animal
study.
A phase 2 clinical trial of this treatment in people with
neurofibromatosis has been approved and is under way.
Dr. Parada
cautioned, however, that further research is needed. A single human case, while
encouraging, is not enough to prove the long-term effectiveness of the
treatment, and Gleevec might be exerting other actions in addition to inhibiting
mast cells.
Other UT Southwestern researchers involved in the study were
Dr. Yuan Zhu, former instructor of developmental biology, and Dr. Dennis Burns,
professor of pathology. Researchers from Indiana University School of Medicine,
including co-senior author Dr. D. Wade Clapp, also participated.
The
study was funded by the Department of Defense and the National Institutes of
Health.
Dr. Luis Parada -- http://www.utsouthwestern.edu/findfac/professional/0,2356,15510,00.html
UT
Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas
TX
75390-9060
United States
http://www.utsouthwestern.edu
Optimal Dose Of Vitamin E Maximizes Benefits, Minimizes Risk
Vitamin E has been heralded for its ability to reduce the risk of blood clots,
heart attack, and sudden death. Yet in some people, vitamin E causes bleeding.
Scientists have known for more than 50 years that excess vitamin E promotes
bleeding by interfering with vitamin K, which is essential in blood clotting.
However, they haven't been able to pinpoint how the two vitamins interact.
Nutrition researcher Maret Traber of Oregon State University reviews studies of
possible explanations of the interaction in an article published recently in Nutrition Reviews.
One of the most compelling studies of the
benefits of vitamin E is the Women's Health Study, in which 40,000 healthy
women, 45 and older, took 600 IU vitamin E supplements or a placebo every other
day for 10 years. Women taking the supplements had 24 percent fewer deaths from
heart disease. Vitamin E's protective effect appeared even stronger in women 65
and older. Those taking the vitamin experienced a 26 percent reduction in
cardiovascular events and a 49 percent reduction in cardiovascular deaths.
"That's a significant benefit," Traber said. Yet, she added, "In some
people high doses of vitamin E increase the tendency to bleed. Women enrolled in
the study had an increase in nose bleeds."
To lessen the bleeding risk,
the U.S.-based Food and Nutrition Board in 2000 set the upper tolerable limit
for daily vitamin E intake at 1500 I.U.
Research Traber reviewed
suggests that a shared metabolic pathway in the liver causes vitamins E and K to
interact. Vitamin K in the liver appears to diminish as vitamin E increases.
"Several different explanations could account for the interaction
between the two vitamins," Traber said. "We need more research to understand the
delicate balance between vitamins E and K."
This
study is published in the November 2008 issue of Nutrition Reviews.
To view the abstract for this article, please click here.
Maret Traber is affiliated with Oregon
State University .
Nutrition Reviews is a highly cited journal
devoted to keeping academic researchers, students, and professionals abreast of
the latest research in the field with authoritative and critical reviews of
significant developments in all areas of nutrition science and policy.
Wiley-Blackwell was formed in February 2007 as a result of the
acquisition of Blackwell Publishing Ltd. by John Wiley & Sons, Inc., and its
merger with Wiley's Scientific, Technical, and Medical business. Together, the
companies have created a global publishing business with deep strength in every
major academic and professional field. Wiley-Blackwell publishes approximately
1,400 scholarly peer-reviewed journals and an extensive collection of books with
global appeal. For more information on Wiley-Blackwell, please visit
www.wiley-blackwell.com or http://interscience.wiley.com. Wiley-Blackwell was
formed in February 2007 as a result of the acquisition of Blackwell Publishing
Ltd. by John Wiley & Sons, Inc., and its merger with Wiley's Scientific,
Technical, and Medical business. Together, the companies have created a global
publishing business with deep strength in every major academic and professional
field. Wiley-Blackwell publishes approximately 1,400 scholarly peer-reviewed
journals and an extensive collection of books with global appeal. For more
information on Wiley-Blackwell, please visit http://www.blackwellpublishing.com/ or http://interscience.wiley.com/.
Source: Amy Molnar
Wiley-Blackwell
Vigorous Activity Protects Against Breast Cancer
Normal-weight women who carry out lots of vigorous exercise are approximately
30% less likely to develop breast cancer than those who don't exercise
vigorously. A study of more than thirty thousand postmenopausal American women,
reported in BioMed Central's open access journal Breast Cancer Research,
has revealed that a sedentary lifestyle can be a risk factor for the disease -
even in women who are not overweight.
While an Investigator at the
National Cancer Institute of the U.S. National Institutes of Health, Michael F.
Leitzmann led a team of researchers who followed the 32,269 women for eleven
years and found that vigorous activity may protect against breast cancer,
independent of body weight control. Vigorous activity was judged to include
things like heavy housework (scrubbing floors, washing windows, heavy yard-work,
digging, chopping wood) and strenuous sports or exercise (running, fast jogging,
competitive tennis; aerobics, bicycling on hills, and fast dancing).
Leitzmann said, "Notable strengths of our study include its large sample
size, prospective design, high follow-up rate, and availability of relevant
known or suspected breast cancer risk factors. These features enabled us to
minimize any effects from other factors apart from exercise."
Interestingly, the authors found that non-vigorous activity, such as
light housework (vacuuming, washing clothes, painting, general gardening) and
light sports or exercise (walking, hiking, light jogging, recreational tennis,
bowling) was not protective. Furthermore, vigorous activity was only protective
in lean women and not those who were overweight or obese. According to
Leitzmann, "Possible mechanisms through which physical activity may protect
against breast cancer that are independent of body mass include reduced exposure
to growth factors, enhanced immune function, and decreased chronic inflammation,
variables that are related both to greater physical activity and to lower breast
cancer risk".
The authors added, "An alternative explanation for the
stronger apparent effect of vigorous activity among lean over heavy women is
that heavier women may misreport non-vigorous activities as vigorous ones".
Notes
1. Prospective study of physical activity and risk of
postmenopausal breast cancer
Michael F Leitzmann, Steven C Moore, Tricia M
Peters, James V Lacey, Arthur Schatzkin, Catherine Schairer, Loiuse A Brinton
and Demetrius Albanes
Breast Cancer Research (in press)
Article
available at journal website: http://breast-cancer-research.com/
All
articles are available free of charge, according to BioMed Central's open access
policy.
2. Breast Cancer Research is an international,
peer-reviewed online journal, publishing original research, reviews,
commentaries and reports. Research articles of exceptional interest are
published in all areas of biology and medicine relevant to breast cancer,
including normal mammary gland biology, with special emphasis on the genetic,
biochemical, and cellular basis of breast cancer. In addition, the journal
publishes clinical studies with a biological basis, including Phase I and Phase
II trials.
3. BioMed Central (http://www.biomedcentral.com/) is an independent
online publishing house committed to providing immediate access without charge
to the peer-reviewed biological and medical research it publishes. This
commitment is based on the view that open access to research is essential to the
rapid and efficient communication of science.
Source: Graeme Baldwin
BioMed
Central
Israel's CorAssist Keeps A Weak Heart Pumping
CorAssist has already started human clinical trials using a small device that
restores power to weakened heart muscles. According to Loshakove, there are two
major conditions related to heart failure, namely, systolic and diastolic heart
failure.
First to market
While some devices to treat
systolic heart failure (SHF) are already in clinical trials, no devices to treat
diastolic heart failure (DHF) are available. CorAssist's solution presents the
first device-based approach to treat DHF, being a one-of-its-kind product in the
market.
After a heart attack, or with heart muscle disease due to
obesity and other conditions such as genetic defects, the heart muscles have a
difficult time squeezing blood to the body (the systolic phase), and then back
again into the heart (the diastolic phase). CorAssist is focusing on the second
condition - DHF - where a person's heart inadequately relaxes, and is impaired
in its capability to return blood from the body back to the heart.
According to the New York Heart Association, over five million people in
the US suffer from heart failure. About half of these people suffer from
diastolic heart failure, for which there is no effective treatment. Affecting
mainly women, the overweight, smokers, and people with diabetes and other
predisposing diseases and conditions, DHF results in the stiffening of the heart
muscles.
Don't still my beating heart
CorAssist's main
product is the ImCardia, which works from outside the heart. It's a
self-expanding device that attaches to the external surface of the left
ventricle. When the heart muscle squeezes, energy is loaded into the device,
which absorbs this energy, and releases it to the left ventricle in the
diastolic phase. This keeps the muscles elastic, giving it a small "work out" to
improve heart health.
So far, safety studies on three people - in South
America and Eastern Europe - have found the ImCardia safe for implantation. Next
year, the company is gearing up for a larger trial. And it could take as little
as two years for the company to get FDA approval, allowing the much-needed
solution to be available in the US.
CorAssist is a 14-person company
based in Herzylia, Israel. Founded in 2003 by three Israeli physicians - Yair
Feld, Yotam Reisner and Shay Dubi - it keeps a number of world-renowned heart
specialists and scientists on its advisory team, and includes Prof. William
Little, from Wake Forest University School of Medicine, North Carolina; Prof.
Michael Zile from the Medical University of South Carolina, and Prof. Mitchell
Krucoff from Duke University Medical Center.
Written by By Karin
Kloosterman
CorAssist
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Sources Of News: |
Consumer Report http://www.consumerreports.org/cro/news/index.htm |
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| Medical News Today http://www.medicalnewstoday.com/ |
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| Reuters Health http://www.reuters.com/news/health'type=healthNews |
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| Daily Mail http://www.dailymail.co.uk/pages/live/ |
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| Telegraph |
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| Newswise http://www.newswise.com/ |
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