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Recent News and Articles on the Keywords: new + bacterial + solution  Related to the article below (Last Update: 8/5/2008)

OK, everybody out of the water
TheChronicleHerald.ca, Canada -
He said there had been no positive bacteria tests at either beach. Coun. Sue Uteck (Northwest Arm-South End) said the new sewage system can handle up to ...
Harbour beaches closed as heavy rains raise bacteria fears CBC.ca
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New York Daily News
Anthrax suspect was a prolific scientific author
The Associated Press -
Ivins' detailed knowledge of the anthrax bacteria proved valuable in developing a new vaccine prototype and in devising tests to see if it would work on ...
AssociatedPress
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BigHospitality.co.uk
Green and clean showerheads for hotels
BigHospitality.co.uk, UK -
Hotels dedicated to both cleanliness and saving the environment may want to check out Enviroflow Solutions? anti-bacterial Ag+ showerhead for use in their ...
HUL launches Aviance Men?s Solutions
Moneycontrol.com, India - Aug 4, 2008
Bacteria Combat Refreshing Bath Gel (Rs. 750, 195ml) ensures that your skin smells fresh and clean all day long. Aviance Men?s Solution now is available in ...
SpongeTech? Delivery Systems, Inc. New Uncle Norman?s? Pet Sponge ...
PR.com (press release), NY - Aug 4, 2008
The show?s segments are solution-rich, in a ?news-you-can-use? style with branded storytelling dedicated to creating new opportunities and ideas for women. ...
Company hopes to combat superbugs
abc7news.com, CA -
"We are doing that topically, by pouring the solution or gel ointment of top of bacteria and eventually, we can deliver more of this molecule than the white ...
Bacteria probe under way at Tufts
Worcester Telegram, MA -
Water is used to suspend the toxin in the solution. ?Our thinking is that the water evaporated, leaving the toxin in the residue,? said Mr. McManus, ...
New 18.8 Tesla nuclear magnetic resonance system is a powerful ...
Indiana University, IN - Aug 4, 2008
... are important for the replication of human viral and bacterial pathogens," said IU Bloomington biochemist David Giedroc, who will use the new system. ...
SAPREF (Shell and BP South African Petroleum Refineries (Pty) Ltd ...
Earthtimes (press release), UK - Aug 4, 2008
In Durban, South Africa, SAPREF decided to first try a new solution on contaminated water stored in a 5000 cubic meter tank. ...NIG:APET
The search for the source of Erie County beach bacteria
Sandusky Register,  USA -
Other possible solutions might include putting in a local sewer system to serve the area or improving the efficiency of the private sewage systems serving ...
Source: Google News

Bacterial solutions to the iron-supply problem -
V Braun, H Killmann - Trends in Biochemical Sciences, 1999 - Elsevier
... 0004(99)01359-6 How to Cite or Link Using DOI (Opens New Window) Copyright ? 1999
Elsevier Science Ltd. All rights reserved. Review. Bacterial solutions to the ...

A New Method for the Extraction of R Lipopolysaccharides -
C Galanos, O Luderitz, O Westphal - European Journal of Biochemistry, 1969 - Blackwell Synergy
... The supernatant solution after ultracentrifugation conta,ined negligible ... and R. frie-
demu T, form bacteria were mbjected to the new extraction method ...

Detection and in situ identification of representatives of a widely distributed new bacterial phylum -
W Ludwig, SH Bauer, M Bauer, I Held, G Kirchhof, R … - FEMS Microbiology Letters, 1997 - Blackwell Synergy
... The hybridization solution contained 35% formamide. ... This two species branch was then
discussed as a new line of descent within the bacterial domain. ...

Biosynthesis and characterization of a new bacterial copolyester of 3-hydroxyalkanoates and 3- …
Y Doi, C Abe - Macromolecules, 1990 - pubs.acs.org
... The 125-MHz l3C NMR spectra were recorded at 27 "C in a CDC13 solution of polyester
(25 mg/mL) with a ... 15, 1990 Biosynthesis of a New Bacterial Copolyester 3707 ...

GeneMark. hmm: new solutions for gene finding -
AV Lukashin, M Borodovsky - Nucleic Acids Research - Oxford Univ Press
... 26, No. 4 GeneMark.hmm: new solutions for gene finding ... ABSTRACT The number of
completely sequenced bacterial genomes has been growing fast. ...

LIVE/DEAD? BacLight?: application of a new rapid staining method for direct enumeration of viable … -
L Boulos, M Pr?vost, B Barbeau, J Coallier, R … - Journal of Microbiological Methods, 1999 - Elsevier
... for drinking water applications of a new fluorescent stain ... their ability to penetrate
viable bacterial cells (Molecular ... are contained in a solution of anhydrous ...

A new and improved microassay to determine 2-keto-3-deoxyoctonate in lipopolysaccharide of gram- … -
YD Karkhanis, JY Zeltner, JJ Jackson, DJ Carlo - Analytical Biochemistry, 1978 - Elsevier
... Institute for Therapeutic Research, Rahway, New Jersey 07065 ... present in
lipopolysaccharide (LPS) of gramnegative bacteria. ... formed is kept in solution at ...

… of competent Escherichia coli: transformation and storage of bacterial cells in the same solution -
CT Chung, SL Niemela, RH Miller - Proceedings of the National Academy of Sciences of the …, 1989 - JSTOR
... function of the transformation solution (transforma- tion ... be widely applicable for
bacterial transformation and ... Linear Regression Analysis (Wiley, New York), pp ...

High microbial turnover rate preventing atopy: a solution to inconsistencies impinging on the … -
PM Matricardi, S Bonini - Clinical and Experimental Allergy, 2000 - Blackwell Synergy
... High microbial turnover rate preventing atopy: a solution to inconsistencies ... Indeed,
cross-infections with new bacterial strains, rather than a specific and ...

A rapid boiling method for the preparation of bacterial plasmids -
DS Holmes, M Quigley - Analytical Biochemistry, 1981 - Elsevier
... Restriction enzymes were purchased from New England Biolabs and used ... The majority
of the bacterial RNA and plasmids remain in solution alter removal of the ...

Source: Google Scholar
 
 

Solution To Bacterial Mystery Promises New Drugs

 
 
A 25-year quest to identify the first biochemical step that many disease-causing bacteria use to build their membranes has led to a discovery that holds promise for effective, new antibiotics against these bacteria, according to investigators at St. Jude Children's Research Hospital. The finding is significant because the biochemical step the antibiotic would block is not used by humans. Therefore, such a drug would not cause dangerous side effects.

A report on this finding appeared in the September 1 issue of Molecular Cell.

The discovery also demonstrated that current textbooks use the wrong type of bacterium as a model to explain a critical biochemical step that most disease-causing bacteria use to make their membranes, according to Charles Rock, Ph.D., a member of the St. Jude Department of Infectious Diseases and senior author of the paper. As bacteria grow in size or divide, they must make additional membrane using a series of biochemical reactions. The first step in this process is the transfer of a fatty acid to a molecule called G3P. Bacteria then convert this molecule into a variety of other molecules called phospholipids, which are the building blocks of membranes.

"We identified a biochemical process that uses a previously unrecognized molecule as a raw material to make phospholipid," Rock said. "That discovery solved a mystery that has puzzled researchers for 25 years."

Scientists have used E. coli bacteria for many years as a model to understand how disease-causing bacteria make membrane phospholipids, but E. coli is an unsuitable model for most pathogens (disease-causing bacteria), according to Rock.

First, E. coli is a so-called gram-negative bacterium, while many of the pathogens researchers are interested in are gram-positive, Rock noted. Among those gram-positive organisms are Staphylococcus aureus, which causes skin infections and serious blood infections, and Streptococcus pneumoniae, which causes pneumonia. The terms "gram-positive" and "gram-negative" refer to the response of bacteria to a standard laboratory process by which they are stained as a first step in identification.

Laboratory strains of E. coli do not cause disease; and the enzyme E. coli uses during the first step in making membranes does not exist in most other bacteria, including gram-positive pathogens. Therefore, the way gram-positive bacteria make phospholipid building blocks remained a mystery for over more than two decades. Now, however, the St. Jude team reports that the gram-positive pathogens use two enzymes, called PlsX and PlsY, to kick off phospholipid synthesis.

"In fact, the biochemical pathway that uses PlsX and PlsY is the most widely distributed bacterial pathway for initiating the production of phospholipids," explained the study's first author, Ying-Jie Lu, Ph.D., of the St. Jude Department of Infectious Diseases. "It turns out that E. coli is more of an oddball rather than in the mainstream when it comes to how it makes membranes."

E. coli fuses a molecule called G3P with a fatty acid in a single step. Rock's team showed that gram-positive pathogens first use PlsX to synthesize a compound called fatty acyl-phosphate, then use PlsY to transfer the fatty acid to G3P. These steps initiate membrane phospholipid formation required for cell growth.

"Our discovery of PlsX and PlsY not only solved a troublesome mystery," Rock said. "It's also important because identifying the essential components required for disease-causing bacteria to grow and multiply is a key part of developing new strategies for controlling infections."

###

Other authors of the study include Yong-Mei Zhang (St. Jude) and Kimberly Grimes, Jianjun Qi and Richard Lee (University of Tennessee).

This work was supported in part by the National Institutes of Health, a Cancer Center (CORE) Grant and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fund-raising organization. For more information, please visit http://www.stjude.org/.

Contact: Bonnie Kourvelas
St. Jude Children's Research Hospital
 
 
 
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