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Recent News and Articles on the Keywords: arthritis + rheumatology + web  Related to the article below (Last Update: 8/5/2008)

Genetics, lifestyle affect bone density
Daytona Beach News-Journal, FL - Aug 3, 2008
... been practicing in this area since 1993. Send questions to Dr. Tsai in care of accent@news-jrnl.com. You also can check his Web site: arthritis-allergy.net.
New treatment guidelines for rheumatoid arthritis introduced
Ortho SuperSite, NJ - Jul 25, 2008
However, the new recommendations ? which appear on the American College of Rheumatology's Web site ? do not strive to replace individualized medical ...
Health Canada approves ORENCIA(R) (abatacept) for the treatment of ...
Canada NewsWire (press release), Canada - Jul 29, 2008
Rheumatology. 2006;45:972-974. (4) American College of Rheumatology Web site. Arthritis in Children. ...BMY
More News related to Press Releases
StreetInsider.com (subscription), MI - Jul 15, 2008
American College of Rheumatology (ACR) scores were also assessed in the COMET study and were comparable to the DAS clinical remission data. ...AMGN - WYE
Former Olympian speaks on living with rheumatoid arthritis
OCRegister, CA - Jul 22, 2008
The Web site and surveys were funded by Centocor, a pharmaceutical company that makes drugs to treat rheumatoid arthritis. According to the survey of 1000 ...
Hospital for Special Surgery Ranked No. 1 by US News & World Report
MarketWatch - Jul 10, 2008
Hospital for Special Surgery also ranked fourth in the nation for rheumatology. For the 18th consecutive year, HSS has ranked above all other hospitals in ...
Incyte Reports Progress in Multiple Clinical Programs; Announces ...
WELT ONLINE, Germany - Jul 29, 2008
Preliminary results from this Phase IIa trial have been accepted for oral presentation at the American Rheumatology Meeting, October 24-29, 2008. ...INCY
Insurance companies play doctor
The Register-Guard, OR - Jul 18, 2008
This is becoming a major problem for the care of arthritis patients. Rheumatologists are specialists in arthritic and musculoskeletal diseases. ...
Amgen's Second Quarter 2008 Adjusted Earnings Per Share Increased ...
Trading Markets (press release), CA - Jul 28, 2008
However, sales growth continued in both rheumatology and dermatology, and ENBREL continues to maintain a leading position in both segments. ...AMGN
Cell Count and Differential of Aspirated Fluid in the Diagnosis of ...
Journal of Bone and Joint Surgery (subscription) - Aug 1, 2008
Arthritis Rheum. 2005;52:3928-33.[CrossRef][Medline] Phillips JE, Crane TP, Noy M, Elliott TS, Grimer RJ. The incidence of deep prosthetic infections in a ...
Source: Google News

Diagnostic Accuracy of the Anti-Citrulline Antibody Assay for Rheumatoid Arthritis -
N Bizzaro, G Mazzanti, E Tonutti, D Villalta, R … - Clinical Chemistry, 2001 - Am Assoc Clin Chem
... Home page SMJ Harney, C. Meisel, AM Sims, PY Woon, BP Wordsworth, and MA Brown Genetic
and genomic studies of PADI4 in rheumatoid arthritis Rheumatology, July 1 ...

New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study -
F Cornelis, S Faure, M Martinez, JF Prud'homme, P … - Proceedings of the National Academy of Sciences, 1998 - National Acad Sciences
... Hinks, and W. Thomson SNPs in the FOXP3 gene region show no association with Juvenile
Idiopathic Arthritis in a UK Caucasian population Rheumatology, August 1 ...

… vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis The CLASS Study … -
FE Silverstein, G Faich, JL Goldstein, LS Simon, T … - JAMA, 2000 - Am Med Assoc
... JAMA-EXPRESS Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal
Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis ...

Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to … -
JJ Gomez-Reino, L Carmona, VR Valverde, EM Mola, … - Arthritis & Rheumatism, 2003 - doi.wiley.com
... SER Web page, 3) notes in the Web distribution list ... dose methotrexate therapy in
a patient with rheumatoid arthritis. Rheumatology (Oxford) 2001;40:341?2. 11 ...

Socio-economic consequences of rheumatoid arthritis in the first years of the disease -
JM Albers - Rheumatology, 1999 - Br Soc Rheumatology
... N. Erb, KM Douglas, DL Mitton, and GD Kitas Cardiovascular disease and psychological
morbidity among rheumatoid arthritis patients Rheumatology, February 1 ...

… of functional disability in patients with rheumatoid arthritis. Associations with rheumatology … -
MM Ward, JP Leigh, JF Fries - Archives of Internal Medicine, 1993 - Am Med Assoc
... browser does not support basic Web standards. ... of functional disability in patients
with rheumatoid arthritis. Associations with rheumatology subspecialty care. ...

Cytokine production by synovial T cells in rheumatoid arthritis -
G Steiner, M Tohidast-Akrad, G Witzmann, M Vesely, … - Rheumatology, 1999 - Br Soc Rheumatology
... Smolen, WB Graninger, and P. Emery Leflunomide, a new disease-modifying anti-rheumatic
drug and the never ending rheumatoid arthritis story Rheumatology, July 1 ...

Serious bacterial infections in patients with rheumatoid arthritis under anti-TNF-a therapy -
S Kroesen, AF Widmer, A Tyndall, P Hasler - Rheumatology, 2003 - Br Soc Rheumatology
... Graninger, JS Smolen, and M. Aringer Listeria-Associated Arthritis in a ... Rheumatology,
January 1, 2004; 43(1): 114 - 115. ... Similar articles in ISI Web of Science. ...

… and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis A Randomized Controlled … -
LS Simon, AL Weaver, DY Graham, AJ Kivitz, PE … - JAMA, 1999 - Am Med Assoc
... a day or 200 mg once daily, and for the treatment of rheumatoid arthritis (RA) at ...
in the study if they fulfilled the American College of Rheumatology (ACR-20 ...

A Genomewide Screen in Multiplex Rheumatoid Arthritis Families Suggests Genetic Overlap with Other … -
D Jawaheer, MF Seldin, CI Amos, WV Chen, R Shigeta … - The American Journal of Human Genetics, 2001 - Elsevier
... gathered by the North American Rheumatoid Arthritis Consortium (NARAC ... the 1987 American
College of Rheumatology criteria for ... through links at the NARAC Web site ...

Source: Google Scholar
 
 

New Approach To Rheumatoid Arthritis

 
 
Rheumatoid arthritis drugs work better, at least in arthritic rats, when delivered into the central nervous system, Gary Firestein and colleagues (University of California San Diego) now report in the international open-access medical journal PLoS Medicine.

Rheumatoid arthritis (RA) is a disease marked by chronic inflammation, leading to joint pain and destruction. Pain and inflammation in the joints are constantly monitored by the central nervous system (CNS, i.e. the brain and spinal cord). Scientists have long suspected that the CNS can regulate inflammation and immune responses in the body's "periphery", but little is known about how this works. Firestein and colleagues focused on a protein called p38, which is involved in a number of cellular processes critical to the development of RA. Several substances that block the action of p38 are effective in animal models of arthritis and are currently being tested in clinical trials in patients with RA.

Based on the observation by other scientists that p38 is activated in the CNS in response to peripheral pain, and on Firestein and colleagues' own finding that this is true in response to inflammation as well, the researchers blocked p38 with drugs directly delivered to the spinal cord of the arthritic rats. They found that the treated rats had substantially less inflammation, arthritis, and joint destruction, compared with rats that had undergone the same treatment but received no active drug. Treatment of arthritic rats with the same amount of drugs given directly under the skin (the "systemic treatment" that is currently being tested in RA patients, but with much higher doses) did not have any beneficial effect on the joints.

These findings suggest that spinal cord administration might reduce the side effects (and possibly the costs) of p38 inhibitors without compromising the benefits to patients. And if future studies confirm that the action of these drugs on the CNS is essential to achieve a response even when administered as a systemic treatment, designing drugs that get into the CNS easier might improve the effectiveness and/or make it possible to use lower doses systemically.

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PLEASE MENTION THE OPEN-ACCESS JOURNAL PLoS MEDICINE (http://www.plosmedicine.org/ AS THE SOURCE FOR THESE ARTICLES AND PROVIDE A LINK TO THE FREELY-AVAILABLE TEXT. THANK YOU.

All works published in PLoS Medicine are open access. Everything is immediately available without cost to anyone, anywhere--to read, download, redistribute, include in databases, and otherwise use--subject only to the condition that the original authorship is properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.

Citation: Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, et al. (2006) Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med 3(9): e338. DOI: 10.1371/journal.pmed.0030338.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030338

Contact:
Gary Firestein
San Diego School of Medicine
Rheumatology, Allergy and Immunology
9500 Gilman Dr.
La Jolla, CA 92093
United States of America
gfirestein@ucsd.edu

About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://dx.doi.org/10.1371/journal.pmed.0030337

About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org/

Contact: Andrew Hyde
Public Library of Science
 
 
 
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