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Recent News and Articles on the Keywords: syndrome + metabolic + treatment  Related to the article below (Last Update: 8/5/2008)

A Practical "ABCDE" Approach to the Metabolic Syndrome
RedOrbit, TX -
The first step in treatment is recognition of the condition. Clinical definitions of the metabolic syndrome vary only slightly (Table 2), ...
Intensive Lipid Lowering With Atorvastatin in Patients With ... RedOrbit
all 2 news articles »
Excessive and Binge Drinking May Increase Risk for Metabolic Syndrome
Medscape (subscription) -
Definitions of the metabolic syndrome were based on the National Cholesterol Education Program Adult Treatment Panel III guidelines, with at least 3 of the ...
Growth Hormone Reduces Abdominal Fat, Cardiovascular Risk In HIV ...
Science Daily (press release) -
Previous research has shown that growth hormone secretion is reduced in substantial number of those with the syndrome. High doses of growth hormone did ...
BELLUS Health moves forward on nutraceutical and pharmaceutical ...
Canada NewsWire (press release), Canada -
The Company is also developing NC-503 (eprodisate) for the treatment of Type II diabetes and certain features of metabolic syndrome. ...BLUS
Cold-fX safe for kids: maker
Calgary Herald,  Canada -
The company is also researching how the proprietary technology, designed to boost the immune system, can treat metabolic syndrome, high cholesterol and ...
VIVUS Inc. Q2 2008 Earnings Call Transcript
Seeking Alpha, NY -
In addition, the majority of patients in this trial had multiple cardiovascular comorbidities, typical of those with metabolic syndrome. ...VVUS
Intensive Lipid Intervention in the Post-ENHANCE Era
RedOrbit, TX -
Importance and management of dyslipidemia in the metabolic syndrome. Am J Med Sci. 2005;330(6):295-302. 20. Lavie CJ, Milani RV. ...
Oral Glucose Tolerance Test May Predict Risk for Type 2 Diabetes
Medscape (subscription) - Jul 31, 2008
A model using 1-hour plasma glucose concentration, Adult Treatment Panel III criteria for the metabolic syndrome, and fasting plasma glucose level ...
Switch to atazanavir does not reduce belly fat
Aidsmap, UK -
Accumulation of this type of fat increases the risk of heart disease when it occurs in the context of other metabolic changes like elevated levels of ...
Regular Meals Reduce Risk Of Developing Metabolic Syndrome, Study ...
Science Daily (press release) - Jul 22, 2008
The scientists believe that the results can help to improve dietary advice regarding the prevention or treatment of metabolic syndrome. ...
Source: Google News

Prevalence of the Metabolic Syndrome Among US Adults Findings From the Third National Health and … -
ES Ford, WH Giles, WH Dietz - JAMA, 2002 - Am Med Assoc
... the transition from impaired glucose tolerance to type 2 diabetes mellitus and provide
relevant treatment paradigms for patients with the metabolic syndrome. ...

… National Cholesterol Education Program Adult Treatment Panel Definition of the Metabolic Syndrome … -
CE Tan, S Ma, D Wai, SK Chew, ES Tai - Diabetes Care, 2004 - Am Diabetes Assoc
... Article. Can We Apply the National Cholesterol Education Program Adult Treatment
Panel Definition of the Metabolic Syndrome to Asians? ...

… National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome -
DB Carr, KM Utzschneider, RL Hull, K Kodama, BM … - Diabetes, 2004 - Am Diabetes Assoc
... Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education
Program Adult Treatment Panel III Criteria for the Metabolic Syndrome. ...

… Linoleic Acid Causes Isomer-Specific Insulin Resistance in Obese Men With the Metabolic Syndrome -
U Riserus, P Arner, K Brismar, B Vessby - Diabetes Care, 2002 - Am Diabetes Assoc
... Treatment With Dietary trans10cis12 Conjugated Linoleic Acid Causes Isomer-Specific
Insulin Resistance in Obese Men With the Metabolic Syndrome. ...

… of the Adult Treatment Panel III Diagnostic Criteria for Identification of the Metabolic Syndrome -
KL Cheal, F Abbasi, C Lamendola, T McLaughlin, GM … - Diabetes, 2004 - Am Diabetes Assoc
... KR Bailey, GL Schwartz, and ST Turner Correspondence Between the Adult Treatment
Panel III Criteria for Metabolic Syndrome and Insulin Resistance Diabetes Care ...

The metabolic syndrome?a new worldwide definition -
KGMM Alberti, P Zimmet, J Shaw - The Lancet, 2005 - Elsevier
... needed. There is no specific treatment for the metabolic syndrome so
individual abnormalities will have to be attended to. Again ...

[PDF] National Cholesterol Education Program -
AT Panel III - … panel on detection, evaluation, and treatment of high blood …, 1994 - health.utah.gov
... therapy ? Initiate or intensify lifestyle therapies ? Initiate or intensify
LDL-lowering drugs ? Treatment of metabolic syndrome ? Emphasize weight ...

Definition of Metabolic Syndrome Report of the National Heart, Lung, and Blood Institute/American … -
SM Grundy, HB Brewer, JI Cleeman, SC Smith, C … - Circulation, 2004 - Am Heart Assoc
... that therapeutic lifestyle change, with emphasis on weight reduction, constitutes
first-line therapy for metabolic syndrome. Drug treatment to directly reduce ...

The Metabolic Syndrome and Total and Cardiovascular Disease Mortality in Middle-aged Men -
HM Lakka, DE Laaksonen, TA Lakka, LK Niskanen, E … - JAMA, 2002 - Am Med Assoc
... The long-term effectiveness of such interventions clinically and at the population
level in the treatment and prevention of the metabolic syndrome and its ...

… treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome -
CJ Glueck, R Papanna, P Wang, N Goldenberg, L … - Metabolism, 2003 - Elsevier
Page 1. Incidence and Treatment of Metabolic Syndrome in Newly Referred
Women With Confirmed Polycystic Ovarian Syndrome CJ Glueck ...

Source: Google Scholar
 
 

Patients With Metabolic Syndrome Need More Aggressive Treatment

 
 
More aggressive treatment with statins is necessary to lower LDL (low-density lipoprotein) cholesterol in patients with coronary heart disease and metabolic syndrome, a syndrome composing of three cardiovascular risk factors (see notes) according to an Article published online September 5, 2006 by The Lancet.

The Treating to New Targets (TNT) study was a prospective, double blind, parallel-group trial which was done at 256 sites in 14 countries between 1998 and 2004, with a median follow-up of 4.9 years. The analysis by Prakash Deedwania and colleagues (University of California, San Francisco, USA) involved 5584 patients with metabolic syndrome and clinically evident coronary heart disease aged 35--75 years.

The patients were randomly assigned to receive either atorvastatin 10mg per day or 80mg per day (aggressive treatment). At 3 months patients on 10mg per day had mean LDL cholesterol concentrations of 2.5mmol/L, compared with 1.9mmol/L in the aggressively treated patients. Major cardiovascular events occurred in 13% patients receiving atorvastatin 10mg, compared with 9.5% receiving 80mg. Irrespective of treatment, significantly more patients with metabolic syndrome (11.3%) had a major cardiovascular event than those without metabolic syndrome (8%). This increased risk was significantly reduced by intensive therapy with atorvastatin 80mg beyond that achieved with 10mg. The analysis suggests that the risk of major cardiovascular events increases with the presence of each component of the metabolic syndrome, and patients with diabetes also have a much higher risk.

By focusing aggressive statins therapy (80mg a day instead of 10mg a day) on patients with metabolic syndrome or diabetes in a population with stable coronary heart disease, allows the number needed to treat to be reduced significantly, which gains a significant improvement in the cost-effectiveness of high statin dose.

###

Metabolic Syndrome--Although there is some disagreement about the criteria for metabolic syndrome, it is generally described as the clustering of at least three cardiovascular risk factors, such as insulin resistance, obesity, large waist circumference, hypertension, and dyslipidiaemia*. The metabolic syndrome has been closely linked to diabetes and cardiovascular disease.

*Dislipidaemia--A disorder of lipoprotein metabolism, including lipoprotein overproduction or deficiency. Dyslipidaemia may be manifested by elevation of the total cholesterol, LDL cholesterol and the triglyceride concentrations, and a decrease in the "good" high-density lipoprotein (HDL) cholesterol concentration in the blood.

Professor Prakash C Deedwania, Professor of Medicine, University of California, San Francisco, VA Central California Healthcare System, 2615 E Clinton Avenue, Fresno CA 93703, USA.

Contact: Joe Santangelo
Lancet
 
 
 
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