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Recent News and Articles on the Keywords: new + schizophrenia + risk  Related to the article below (Last Update: 8/5/2008)

Schizophrenia risk gene identified
News Wales, UK -
Scientists from Cardiff University have identified a risk gene associated with the mental health disorder schizophrenia. An international group of ...
Missing DNA chunks tied to risk of schizophrenia
Jackson Clarion Ledger, MS -
In the past, scientists have found specific genes and deletions linked to schizophrenia risk. But the new work is notable because two large studies ...

eMaxHealth.com
A rare glimpse of schizophrenia's genetic roots
eMaxHealth.com, NC -
In addition, changes at two new sites in the genome were identified as risk factors, bringing the total number of solid genetic links to the disorder to ...

Oneindia
Irish teams play key role in genetic finding
Irish Times, Ireland -
"For the vast majority with schizophrenia, these are relatively minor risk factors but there might be a small group of people for whom these will be more ...
Genetic Factors Behind Schizophrenia Identified Oneindia
all 2 news articles »

AFP
New gene clues to schizophrenia risk
AFP - Jul 30, 2008
"But since only a small amount of the genetic risk for schizophrenia has been accounted for, they are not ready to be applied for genetic testing. ...

BBC News
New Studies Reveal Genes That Increase Schizophrenia Risk
dBTechno, MA - Jul 30, 2008
Boston (dbTechno) - Three new studies were published on Wednesday which reveal genes that may lead to an increased risk of developing schizophrenia. ...
Researchers find 3 new genes for schizophrenia Reuters
Researchers Discover DNA Link To Schizophrenia RedOrbit
New Genetic Clues to Schizophrenia Discovered HealthNews
Science Now - GenomeWeb News (subscription)
all 433 news articles »
SFI funded Researchers Contribute to Important Genetic Findings in ...
Science Foundation Ireland, Ireland -
In addition, the study uncovered two new specific genomic areas that, when altered, significantly increase the risk of developing the disease. ...
Advance in MS research; Research facility planned for Liverpool ...
FierceBioResearcher, DC -
Report Structural changes in DNA apparently increase the risk of schizophrenia. Story The FDA has approved a new test that can identify the type of cancer ...
Certain chromosomes may up risk of having schizophrenia
ABC Online, Australia - Jul 30, 2008
New research into schizophrenia shows abnormalities in certain chromosomes can increase the risk of people developing the disease. Researchers in Queensland ...
Study finds genetic link to schizophrenia Brisbane Times
all 4 news articles »
Gene mutations reveal schizophrenia's complexity
New Scientist (subscription), UK - Jul 31, 2008
"Together, the new studies show that many of us carry some risk genes for schizophrenia, but the people that have the illness simply carry more of them. ...
Source: Google News

… and Motor Skills as Childhood Predictors of Schizophrenia-Related Psychoses: The New York High-Risk … -
L Erlenmeyer-Kimling, D Rock, SA Roberts, M Janal, … - American Journal of Psychiatry, 2000 - Am Psychiatric Assoc
... and L. Erlenmeyer-Kimling A New MMPI-Derived Indicator of Liability to Develop
Schizophrenia: Evidence from the New York High-Risk Project Assessment, June 1 ...

… data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia -
I Chumakov, M Blumenfeld, O Guerassimenko, L … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
... The association of both DAAO and a new gene G72 from 13q34 with ... Identification in
2 Independent Samples of a Novel Schizophrenia Risk Haplotype of the ...

Evidence of a Dose-Response Relationship Between Urbanicity During Upbringing and Schizophrenia Risk -
CB Pedersen, PB Mortensen - Archives of General Psychiatry, 2001 - Am Med Assoc
... View larger version (45K): [in this window] [in a new window]. Figure 1. Relative
risk of schizophrenia associated with age and change of the municipality (A ...

Identification in 2 Independent Samples of a Novel Schizophrenia Risk Haplotype of the Dystrobrevin … -
NM Williams, A Preece, DW Morris, G Spurlock, NJ … - Archives of General Psychiatry, 2004 - Am Med Assoc
... View this table: [in this window] [in a new window]. ... the hypothesis that the protective
haplotype of DTNBP1 modifies the risk of schizophrenia by influencing ...

Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study -
L Arseneault? - BMJ, 2002 - pubmedcentral.nih.gov
... Swedish study 1 and add three new pieces of evidence. Firstly, cannabis use is
associated with an increased risk of experiencing schizophrenia symptoms, even ...

… Between Childhood Behavioral Disturbance and Later Schizophrenia in the New York High-Risk Project -
GP Amminger, S Pape, D Rock, SA Roberts, SL Ott, E … - American Journal of Psychiatry, 1999 - Am Psychiatric Assoc
... Regular Article. Relationship Between Childhood Behavioral Disturbance
and Later Schizophrenia in the New York High-Risk Project. ...

Cost of relapse in schizophrenia -
PJ Weiden, M Olfson - Schizophr Bull, 1995 - pt.wkhealth.com
... Luke's-Roosevelt Hosp Ctr, New York; Columbia Univ, New York); Schizophr ... issue in
estimating the costs of treating schizophrenia is the risk and associated ...

[BOOK] Children at Risk for Schizophrenia: A Longitudinal Perspective
NF Watt - 1984 - Cambridge University Press
-

… children with velocardiofacial syndrome: usefulness as phenotypic indicators of schizophrenia risk -
C Feinstein, S Eliez, C Blasey, AL Reiss - Biological Psychiatry, 2002 - Elsevier
... Pertinent to this discussion is the recently reported analysis of findings from
the New York High-Risk Longitudinal Study for Schizophrenia (Erlenmeyer-Kimling ...

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia -
MF Egan, TE Goldberg, BS Kolachana, JH Callicott, … - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences
... View larger version (14K): [in this window] [in a new window], Fig. ... The effect of
COMT genotype on risk for schizophrenia was analyzed by using both case ...

Source: Google Scholar
 
 

New Genetic Risk Factor Linked To Schizophrenia, Particularly In Females

 
 
UCLA scientists have discovered that infants who possess a specific immune gene that too closely resembles their mothers' are more likely to develop schizophrenia later in life. Reported in the October issue of the American Journal of Human Genetics, the study suggests that the genetic match may increase fetal susceptibility to schizophrenia, particularly in females.

HLA-B is one of a family of genes called the human leukocyte antigen (HLA) complex, which helps the immune system distinguish the body's own proteins from those made by foreign invaders, such as viruses and bacteria. The developing fetus inherits one copy of the HLA-B gene from each parent.

“Our findings clearly suggest that schizophrenia risk rises, especially in daughters, when the child's HLA-B gene too closely matches its mother's,” explained Christina Palmer, Ph.D, UCLA associate professor of psychiatry and human genetics and a researcher at the Semel Institute for Neuroscience and Human Behavior. “We don't know whether sons who match are not affected -- or are more affected and less likely to come to term.”

In 2002, Palmer and her colleagues discovered that infants are twice as likely to develop schizophrenia later in life when they possess a cell protein called Rhesus (Rh) factor that their mothers lack. Later studies found that male babies were more vulnerable to the consequences of Rh incompatibility than female infants.

The UCLA team hypothesized that females must possess a different fetal risk factor that predisposes them to schizophrenia. They decided to focus on HLA-B, which previous studies had linked to prenatal complications, like preeclampsia and low birth weight, that in turn have been associated with schizophrenia.

The researchers studied a group of 274 Finnish families in which at least one child had been diagnosed with schizophrenia or a related psychosis. In this group, 484 offspring had been diagnosed with the disease.

The scientists drew blood samples from everyone and performed DNA analysis, identifying cases in which children's HLA-B genes closely matched their mothers'.

Analysis of the entire sample revealed that daughters whose HLA-B genes matched their mothers' were 1.7 times more likely to develop schizophrenia than children who don't match their mothers'. If this risk could be removed, the researchers calculated that up to 12 percent of the cases of schizophrenia in daughters could be prevented.

“Our findings point out a paradox in pregnancy,” said Palmer. “Why doesn't the mother's immune system reject her fetus when it inherits a copy of the HLA gene from the father that substantially differs from hers?

“It seems pretty clear that it's a good thing for the HLA genes of a mother and her fetus to not match,” she added. “We suspect that HLA-matching increases a woman's susceptibility to pregnancy complications, which in turn predispose her child to schizophrenia. This is one more piece in the puzzle of identifying genetic markers for the disease.”

The UCLA findings will enhance scientists' ability to detect genes that promote adverse prenatal conditions and deepen understanding of how these genes and the prenatal environment act separately and together to increase vulnerability to schizophrenia.

“In the future, we also may be able to produce tailored risk assessments for individuals with personal or family histories of schizophrenia,” said Palmer.

Palmer's co-authors included Hsin-Ju Hsieh, Elaine Reed and Janet Sinsheimer of UCLA; J. Arthur Woodward of UC Merced; and Jouko Lonnqvist and Leena Peltonen from the National Public Health Institute and the Department of Medical Genetics at the University of Helsinki. The National Institute of Mental Health, Center of Excellence in Disease Genetics of the Academy of Finland and Helsinki-based Biocentrum funded the study.

The Semel Institute for Neuroscience and Human Behavior is an interdisciplinary research and education institute devoted to the understanding of complex human behavior, including the genetic, biological, behavioral and sociocultural underpinnings of normal behavior, and the causes and consequences of neuropsychiatric disorders. In addition to conducting fundamental research, the institute faculty seeks to develop effective treatments for neurological and psychiatric disorders, improve access to mental health services and shape national health policy regarding neuropsychiatric disorders. See http://www.npi.ucla.edu/ for more information.

University of California, Los Angeles (UCLA), Health Sciences

924 Westwood Blvd., Ste. 350
Los Angeles, CA 90095
United States
http://www.npi.ucla.edu/
 
 
 
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