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Recent News and Articles on the Keywords: brain tumor + tumor development + tumor  Related to the article below (Last Update: 8/5/2008)

YM BIOSCIENCES REPORTS PHASE II DATA FOR NIMOTUZUMAB IN METASTATIC ...
FOXBusiness -
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AVANT focuses on the use of tumor-specific targets and human monoclonal antibodies (mAbs) to precisely deliver therapeutic agents through its novel ...
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Kommersant, Russia - Aug 2, 2008
And then the tomography showed a brain tumor, in a place that is hard to operate on. It penetrates from the fourth ventricle in the brainstem. ...
Brain Cancer Study: Magnitude Of Post-vaccine Immune Response ...
Science Daily (press release) - Jul 15, 2008
While other studies have suggested a link, this is believed to be the first to show direct and continual proportionality between the strength of anti-tumor ...
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However, he died a few years later from a brain tumor when Smith was 4, so she and her brothers went to the home. Smith became involved in motorcycle riding ...

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... disabilities such as Downs Syndrome, autism, and traumatic brain injury from, for example, a car accident, stroke, brain tumor, or near drowning. ...
Source: Google News

Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain … -
D Barba, J Hardin, M Sadelain, FH Gage - Proceedings of the National Academy of Sciences of the …, 1994 - pubmedcentral.nih.gov
... Copyright notice. Development of anti-tumor immunity following thymidine
kinase-mediated killing of experimental brain tumors. D ...

… -beta is induced during tumor development and upregulated during tumor progression in endothelial … -
KH Plate, G Breier, CL Farrell, W Risau - Lab Invest, 1992 - ncbi.nlm.nih.gov
... beta is induced during tumor development and upregulated during tumor progression
in ... cells proliferate during brain development, are quiescent in ...

Tumor Necrosis Factor Alpha, Interleukin 1 and Related Cytokines in Brain Development: Normal and … -
JE Merrill - Logo, 1992 - content.karger.com
... Tumor Necrosis Factor Alpha, Interleukin 1 and Related Cytokines in Brain Development:
Normal and Pathological Jean E. Merrill Department of Neurology, Reed ...

Induction versus progression of brain tumor development: differential functions for the pRB-and p53- … -
MTS Robles, H Symonds, J Chen, T Van Dyke - Molecular and Cellular Biology, 1994 - pubmedcentral.nih.gov
... notice. Induction versus progression of brain tumor development: differential functions
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PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate … -
J Li, C Yen, D Liaw, K Podsypanina, S Bose, SI … - Science, 1997 - sciencemag.org
... a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and ...
This change appears to occur late in tumor development: although rarely seen ...

Development of an Animal Brain Tumor Model and Its Response to Therapy with 1, 3-Bis (2-chloroethyl) … -
M Barker, T Hoshino, O Gurcay, CB Wilson, SL … - Cancer Research, 1973 - AACR
Page 1. [CANCER RESEARCH 33,976-986, May 1973] Development of an Animal Brain Tumor
Model and Its Response to Therapy with IjS-Bisil-chloroethylVl-nitrosourea1 ...

Tumor Necrosis Factor-Alpha Potentiates Glutamate Neurotoxicity in Human Fetal Brain Cell Cultures -
CC Chao, S Hu - Logo, 1994 - content.karger.com
... Using human fetal brain cell cultures, we investigated whether ... Tumor necrosis factor
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The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor … -
KO Cho, CA Hunt, MB Kennedy - Neuron, 1992 - ncbi.nlm.nih.gov
1992 Nov;9(5):929-42. Click here to read The rat brain postsynaptic density fraction
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Antitumor Effect of Immunizations With Fusions of Dendritic and Glioma Cells in a Mouse Brain Tumor … -
Y Akasaki, T Kikuchi, S Homma, T Abe, D Kofe, T … - Journal of Immunotherapy, 2001 - immunotherapy-journal.com
... Against Parental Cell Challenge in the Brain TOP. As an experimental treatment
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… of Vascular Endothelial Growth Factor/Vascular Permeability Factor in Brain Tumor Tissue and Cyst … -
K Weindel, JR Moringlane, D Marm?, HA Weich - Neurosurgery, 1994 - neurosurgery-online.com
... growth factor (aFGF) is present in the fluid of brain tumour pseudocysts. ... derived
growth factor receptor-? is induced during tumor development and upregulated ...

Source: Google Scholar
 
 

Immune response protects against brain tumor development

Researchers at The University of Texas M. D. Anderson Cancer Center have found that allergies and asthma that stimulate inflammation may be protective, but use of antihistamines to control the inflammation could eliminate that protection.

In this study, the researchers also associated chicken pox infection with a significantly reduced risk of developing brain tumors.

The researchers say the findings suggest that a small amount of inflammation in the brain may rev up the immune system enough to protect against brain tumor development. But they stress that no one should give up antihistamines or shun use of a chicken pox vaccine because of this study.

" Brain tumors are exceedingly rare, and many, many people use antihistamines, so we certainly are not suggesting a direct connection between the two, or between chicken pox and tumors," says the study's lead author, Melissa Bondy. " What this study may do is help us begin to understand if the immune system plays a role in development of different kinds of brain tumors."

" Our long-term goal is to look at genes that may be increasing or reducing risk of developing these tumors, and then to assess whether some individuals might be genetically susceptible," says Michael E. Scheurer.
 
In this study, Scheurer and Bondy combined data from their large Harris County, Texas, epidemiological study of brain tumor patients with information collected on patients in the San Francisco area by researchers at the University of California - San Francisco ( UCSF ).
Together, they compared medical histories of 830 brain tumor patients matched to a control group of 831 individuals. Within the patient group were 339 cases of glioblastoma, the most aggressive and lethal type of brain tumor, as well as 117 cases of midgrade anaplastic astrocytoma and 154 cases of low-grade gliomas.
The research team considered recent studies that suggest immune system activity in the brain may protect against brain tumor development and that people who have allergies or asthma have a reduced risk of developing a glioma.

" It could be that allergies and asthma produce enough inflammation in the brain to keep immune system cells active, and that this surveillance works to eliminate cancer beginning to develop in the brain," Scheurer says. " So we wondered whether use of antihistamines that counter that inflammation eliminates the protective effect."

They found that, indeed, a history of allergies and asthma was significantly protective for the three different kinds of brain tumors examined in the study. Individuals with the disorders had a 35 percent reduced risk of developing glioblastoma, a 51 percent reduced risk of midgrade anaplastic astrocytoma, and a 36 percent reduced risk of low-grade glioma.

They also found that participants who used antihistamines were more likely to develop brain tumors. Participants who used antihistamines had three times the risk of developing an midgrade anaplastic astrocytoma and two times the risk of developing low-grade glioma, compared to those who did not use antihistamines. The risk of developing a glioblastoma was also increased by 26 percent, but that was not statistically significant, the researchers say.

" This suggests that among people who are susceptible, those who have allergies and don't do anything about it may be protected to some degree against brain tumors," Bondy says. " But those who use antihistamines could decrease that protection and increase their risk. The real question is if there are particular gene variants that would make a person susceptible."

The researchers also asked participants about their history of chicken pox. A latent infection is known to promote low level inflammation in the brain, which could also provide an immune response that protects against tumor development.
They found that a history of chicken pox significantly reduced the risk of developing midgrade anaplastic astrocytoma. The risk of developing the other two kinds of tumors studied was also reduced ( 40 percent for glioblastoma and 22 percent for low-grade glioma ), but not significantly so.

Finally, the researchers looked at use of anti-inflammatory ( Cox-2 inhibitors ) drugs among study participants and found a significant reduction ( 31 percent ) in development of glioblastoma among those who used them.

" There are three pathways that lead to inflammation in the brain, and reducing one with a Cox-2 inhibitor may be beneficial," Bondy says.

" These are all interesting signals that may give us a clue as to the role of inflammation and development of different kinds of brain tumors," Scheurer says.

Source: University of Texas M. D. Anderson Cancer Center, 2006
 
 
 
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