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Recent News and Articles on the Keywords: prostate cancer + cancer cells + cancer  Related to the article below (Last Update: 7/1/2008)


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Cancer 'cure' in mice to be tested
Times of India, India - Jun 29, 2008
The team has tested human cancer-fighting cells from healthy donors against human cervical, prostate and breast cancer cells in the laboratory - with ...
Toward a Cure? Miller-McCune.com
Study Provides Clues to Preventing and Treating Cancer Spread Newswise (press release)
Cancer cure trials move from mice to men Independent
CTV.ca - Greensboro News Record
all 75 news articles »
Accidental fungus leads to promising cancer drug
Reuters - Jun 29, 2008
Tests in mice showed it worked against a range of tumors, including breast cancer, neuroblastoma, ovarian cancer, prostate cancer, brain tumors known as ...
What's new
Indianapolis Star, United States -
Men -- and those who care about them -- can join the fifth annual Unite 2 Fight Race Against Prostate Cancer at 8 am July 12 Downtown. ...
First Subjects Enrolled in Epigenomics sponsored PRESEPT ...
FOXBusiness -
The Septin 9 gene encodes a protein involved in cell division and is thought to play a role in the onset of cancer. Epigenomics has demonstrated in multiple ...FRA:ECX
Cytokinetics Announces Clinical Data Regarding Ispinesib in ...
FOXBusiness -
To date, clinical activity with ispinesib has been observed in breast cancer as well as in ovarian and non-small cell lung cancer, with the most robust ...CYTK - CLDA - OTC:CMTX
Prevent prostate cancer with checkups
Paragould Daily Press, AR - Jun 29, 2008
He said if caught early, prostate cancer is treatable. He said options include a robotic surgery method, X-Ray therapy, radiation pellets and cryogenics. ...
From Infectious Diseases to Cancer: 60 Years of Pharmaceutical Growth
MidwestBusiness.com, IL -
This incidence, however, shifts in certain countries such as the US where prostate cancer now exceeds breast cancer, Japan where stomach cancer is high and ...
Odanacatib, an Investigational Cathepsin K Inhibitor, Reduced ...
FOXBusiness -
In cancer that has spread to the bones, tumour cells speed up the normal process of bone breakdown and formation, which in turn results in further tumour ...MRK
Baby to be born free of breast cancer after
Times Online, UK - Jun 28, 2008
In addition to breast cancer, women carrying the gene also have a higher risk of ovarian cancer and male carriers are at greater risk of developing prostate ...
Effectiveness Of Contrast Agent Cytate In Detecting Prostate Cancer
Science Daily (press release) - Jun 26, 2008
Cytate, a contrast agent that conjugates to receptors on prostate cancer cells, exhibited greater fluorescence when applied to cancerous prostate tissue as ...
Source: Google News

… , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer -
J Li, C Yen, D Liaw, K Podsypanina, S Bose, SI … - Science, 1997 - sciencemag.org
... In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma
cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6 ...

… 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis …
H Zhong, K Chiles, D Feldser, E Laughner, C … - Cancer Research, 2000 - AACR
... Factor 1 Expression by the Epidermal Growth Factor/Phosphatidylinositol
3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for ...
-

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers … -
AJ Raffo - Cancer Research, 1995 - AACR
... ARTICLES. Overexpression of bcl-2 protects prostate cancer cells from apoptosis
in vitro and confers resistance to androgen depletion in vivo. ...

… (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells -
R Rodriguez - Cancer Research, 1997 - AACR
... ARTICLES. Prostate attenuated replication competent adenovirus (ARCA) CN706: a
selective cytotoxic for prostate-specific antigen-positive prostate cancer cells. ...

Specific association of human telomerase activity with immortal cells and cancer -
NW Kim, MA Piatyszek, KR Prowse, CB Harley, MD … - Science, 1994 - sciencemag.org
... cells examined to date, TRF analysis has shown that the chromosomes lose about 50
to 200 nucleotides of telomeric sequence per cell division (4-6), consistent ...

… Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2 -
AL Hsu, TT Ching, DS Wang, X Song, VM Rangnekar, … - Journal of Biological Chemistry, 2000 - ASBMB
... The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation
in Human Prostate Cancer Cells Independently of Bcl-2 *. ...

… : A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells -
S Yeh, HK Lin, HY Kang, TH Thin, MF Lin, C Chang - Proceedings of the National Academy of Sciences, 1999 - National Acad Sciences
... Neu signal cascade to androgen receptor and its coactivators: A novel pathway by
induction of androgen target genes through MAP kinase in prostate cancer cells. ...

In vivo amplification of the androgen receptor gene and progression of human prostate cancer -
T Visakorpi, E Hyytinen, P Koivisto, M Tanner, R … - Nature Genetics, 1995 - nature.com
... ISI | ChemPort |; Thompson, TC Growth factors and oncogenes in prostate cancer.
Cancer Cells 2, 345-354 (1990). | PubMed | ISI | ChemPort |; Kallioniemi, A. et ...

Prostate cancer in a transgenic mouse -
NM Greenberg, F DeMayo, MJ Finegold, D Medina, WD … - Proc Natl Acad Sci US A, 1995 - pubmedcentral.nih.gov
... system to study the molecular basis of transformation of normal prostatic cells
and the factors influencing the progression to metastatic prostate cancer. ...

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells -
S Haldar - Cancer Research, 1996 - AACR
... Association for Cancer Research. ARTICLES. Taxol induces bcl-2 phosphorylation
and death of prostate cancer cells. S Haldar, J Chintapalli ...

Source: Google Scholar
 
 

Vitamin D Mimic May Improve Prostate Cancer Therapy

 

Treating prostate cancer cells with a vitamin D-like compound appears to make them more susceptible to the destructive effects of radiation, lab experiments show.

If this research holds up, pretreating prostate cancer patients with the vitamin D "analog" could offer two benefits. It might allow the radiation dose to be reduced, resulting in fewer side effects, or it could enhance the effectiveness of standard dose radiation.

However, "our findings first need to be verified in animal studies followed by testing in humans," Dr. Constantinos Koumenis, from Wake Forest University in Winston-Salem, North Carolina, told.

The analog, which is produced by Abbott Labs under the name Zemplar, is already approved by the FDA as treatment for an overactive parathyroid gland "which should expedite testing in prostate cancer patients," Dr. Koumenis noted.

Optimistically, "testing in humans could begin in a year," he added.

In the new study, the researchers irradiated human prostate cancer cells that were exposed to Zemplar, calcitriol (the active form of vitamin D), or were untreated. The results are published in the online issue of the British Journal of Cancer.

The killing effect of radiation was stronger when the cells were first exposed to Zemplar or calcitriol. In addition, the enhanced destruction was fairly selective, leaving normal prostate cells relatively unscathed.

"The reason for the synergy between Zemplar and radiation is unclear," Dr. Koumenis noted. However, vitamin D by itself has been shown to slow the growth of prostate cancer cells, he added.

Although calcitriol was effective in these experiments, it has one major drawback: it tends to cause high calcium levels in the blood, which can lead to a number of problems. Zemplar, by contrast, appears much less likely to produce this metabolic disturbance.

 
 
 
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