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Recent News and Articles on the Keywords: rheumatoid arthritis + cholesterol level + early  Related to the article below (Last Update: 7/8/2008)

Rheumatoid arthritis is a risk factor for cardiovascular disease
Hindu, India - Jun 14, 2008
Paris: The risk of cardiovascular disease (CVD) for people with rheumatoid arthritis (RA) has been found to be comparable to the risk of CVD in people with ...
Arthritis trial to test out heart drugs
Bournemouth Daily Echo,  UK - Jun 11, 2008
"This may be due to early and more advanced blood vessel damage due to high levels of inflammation in rheumatoid arthritis." Most previous trials of statins ...
Fatty liver may raise heart disease risk in obese kids
The Post, Pakistan - Jul 2, 2008
In particular, she said, the research holds potential for lupus, rheumatoid arthritis and other autoimmune diseases ? conditions in which the body uses the ...
Alive in the cold
New Straits Times, Malaysia - Jun 9, 2008
Probiotics also helps those with lactose intolerance, Irritable Bowel Syndrome, yeast infections and even rheumatoid arthritis. ...
Source: Google News

… activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritis -
M Boers, MT Nurmohamed, CJA Doelman, LR Lard, AC … - British Medical Journal, 2003 - ard.bmj.com
... Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum
1981;24:1308?15.[Medline ... of the serum cholesterol levels; third consensus ...

High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by … -
I Del Rincon, K Williams, MP Stern, GL Freeman, A … - Arthritis & Rheumatism, 2001 - doi.wiley.com
... Arthritis Longitudinal Evaluation; RA rheumatoid arthritis; NA not ... surgery between
participants enrolled early or late ... we found that cholesterol levels in the ...

Atherosclerosis in Rheumatoid Arthritis -
YB Park, CW Ahn, HK Choi, SH Lee, BH In, HC Lee, … - ARTHRITIS & RHEUMATISM, 2002 - doi.wiley.com
... LDL cholesterol level (mg/dl) 122.5 29.6 132.5 33.9 0.138 ... Homocysteine level (
moles/liter) 11.27 3.00 9.03 2.95 0.001 ... SD. RA rheumatoid arthritis; NS not ...

Cardiovascular Morbidity and Mortality in Women Diagnosed With Rheumatoid Arthritis -
DH Solomon, EW Karlson, EB Rimm, CC Cannuscio, LA … - Circulation, 2003 - Am Heart Assoc
... deficient blood folate levels and hyperhomocysteinemia ... therapy for rheumatoid arthritis:
implications for ... Cholesterol-lowering effect of hydroxychloroquine in ...

Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of … -
PM Ridker, N Rifai, L Rose, JE Buring, NR Cook - Obstetrical & Gynecological Survey, 2003 - obgynsurvey.com
... of Coffee and Caffeine on Cholesterol, Fibrinogen and C ... Rheumatoid Arthritis Is
Associated With Increased Aortic Pulse ... C-Reactive Protein Levels for Predicting ...

Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled … -
DW McCarey, IB McInnes, R Madhok, R Hampson, O … - The Lancet, 2004 - Elsevier
... 80% power at the 5% significance level. ... major cause of morbidity and mortality in
rheumatoid arthritis. ... substantially reduced LDL-cholesterol and triglyceride ...

… therapy on serum lipid levels in patients with rheumatoid arthritis: a prospective study -
YB Park, HK Choi, MY Kim, WK Lee, J Song, DK Kim, … - The American Journal of Medicine, 2002 - Elsevier
... Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 38
(1995), pp. ... acid in men with low high-density lipoprotein cholesterol levels. ...

Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor-Deficient Mice -
ME Burleigh, VR Babaev, JA Oates, RC Harris, S … - Circulation, 2002 - Am Heart Assoc
... to decrease atherosclerosis in cholesterol-fed rabbits. ... cardiovascular events in
rheumatoid arthritis patients treated ... for measuring rofecoxib levels, and Rory ...

Coronary artery disease and rheumatoid arthritis. -
N Goodson - Current Opinion in Rheumatology, 2002 - co-rheumatology.com
... a cohort of 186 patients with early arthritis [23 ... We can see that the rheumatoid
patient is ... RA patients had significantly lower cholesterol levels than controls ...

Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk … -
M Wong, L Toh, A Wilson, K Rowley, C Karschimkus, … - Arthritis & Rheumatism, 2003 - doi.wiley.com
... terol, high-density lipoprotein cholesterol, LDL choles- ... smoking status, and education
level, becoming of ... in patients with rheumatoid arthritis (solid circles ...

Source: Google Scholar
 
 

Heart Risk High in Arthritis Patients
 

When rheumatoid arthritis is active, often in the early stages, cholesterol levels shift into a danger zone where they could start causing plaque buildup in the arteries, new findings show.

Patients with rheumatoid arthritis often have levels of total cholesterol that are actually slightly below normal, Dr. M. T. Nurmohamed, from the VU University Medical Center in Amsterdam, and associates note in their article in the Annals of the Rheumatic Diseases.

The problem is that the "good" component of cholesterol (HDL) is decreased to a greater extent than the total level. So the ratio of total cholesterol to HDL, known as the "atherogenic index," is usually greater than 4, which raises the risk of atherosclerosis.

The new findings are based on a study of 47 patients with early active rheumatoid arthritis, 112 patients with long-standing rheumatoid arthritis, and another 134 patients who were enrolled in a trial comparing treatment with sulfasalazine for rheumatoid arthritis to a combination regimen containing steroids.

Patients with established arthritis, regardless of disease activity, had total cholesterol levels that were slightly increased, Nurmohamed’s team found. In contrast, patients with early rheumatoid arthritis had total cholesterol levels that were on the low side of normal.

All of the patient groups had HDL-cholesterol levels that were below normal, and the lowest atherogenic index at the start of the study was 5.1.

Among the patients taking part in the treatment trial, both treatments led to an improvement in the atherogenic index. However, steroid-containing combination therapy produced a much more rapid improvement than did sulfasalazine, the researchers report.

However, steroid therapy is a two-edged sword, they point out. Ultimately, harmful cardiovascular effects from long-term steroid therapy -- for example, increased blood pressure and greater resistance to insulin -- would probably offset the improvement in atherosclerosis risk.
 
 
 
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