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Recent News and Articles on the Keywords: bone marrow + heart attack + cells  Related to the article below (Last Update: 7/1/2008)


Daily Mail
Why is my skin all hot and blotchy?
Daily Mail, UK -
Another controversial area is the source of stem cells. The bone marrow and blood of both adults and children contain stem cells, however the richest ...
Stem cell treatment in clinical trial at Texas Heart Institute at ...
Pearland Journal, TX - Jun 25, 2008
In stem cell therapy, stem cells are typically removed from another part of the patient?s body?usually the bone marrow or the blood, both of which contain a ...
Stem cells ? hope or hype?
Health24.com, South Africa - Jun 26, 2008
At this stage, adult stem cells are used in bone-marrow transplants only. This is applied in the treatment of several diseases, but mainly in the treatment ...
A special thanks, done in person
Attleboro Sun Chronicle, MA - Jun 24, 2008
Bone marrow is the soft tissue in the cavities of bones involved in the production of blood cells. In August 2006, Donahue, went to Massachusetts General ...
New Discoveries Get To The Heart Of Cardiovascular Disease
Science Daily (press release) - Jun 18, 2008
Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice. The FASEB Journal, 2008; DOI: 10.1096/fj.08-108829 ...
CellCyte Genetics Corporation Announces Launch of Comprehensive ...
news aktuell (Pressemitteilung), Germany - Jun 26, 2008
... CCG-TH30, is being developed to send autologous bone marrow-derived (adult) stem cells to the heart of patients after a heart attack. ...OTC:CCYG
Geron Presents Data at ISSCR Showing That Its Embryonic Stem Cell ...
Business Wire (press release), CA - Jun 12, 2008
Human cells were detected at 14 days and there was a significant increase in newly mineralized tissue compared to controls, demonstrating bone regeneration ...GERN
Sick and tired?
Health24.com, South Africa - Jun 22, 2008
If the disease also affects vital organs such as the lungs, bone marrow or heart muscle, the fatigue may be even worse. Examples of such diseases are ...
CellCyte Genetics Corporation Selects Washington University School ...
euro adhoc (Pressemitteilung), Germany - Jun 4, 2008
... product in development, CCG-TH30, is designed to send autologous bone marrow-derived (adult) stem cells to the heart of patients after a heart attack. ...OTC:CCYG

BBC News
Birth defect test guru knighted
BBC News, UK - Jun 13, 2008
There are also CBEs for practice nurse Rosemary Cook; breast cancer expert Professor William George; bone marrow transplant specialist Anthony Goldstone, ...
Source: Google News

Stem cells: Lost in translation -
KR Chien - Nature, 2004 - nature.com
... colleagues 1 suggesting that stem cells derived from bone marrow can replace heart
muscle lost as a result of heart attack, and can improve cardiac function. ...

Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction -
H Oh, SB Bradfute, TD Gallardo, T Nakamura, V … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences
... Bioenergetic and Functional Consequences of Bone Marrow-Derived Multipotent Progenitor ...
Cardiac Progenitor Cells in a Donor Heart Model Stem Cells, April 1 ...

Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart -
S Davani, A Marandin, N Mersin, B Royer, B … - Circulation, 2003 - Am Heart Assoc
... RD, et al. Autologous transplantation of bone marrow cells improves damaged
heart function. Circulation. 1999; 100: II247?256. ...

Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children … -
EM Horwitz, PL Gordon, WKK Koo, JC Marx, MD Neel, … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences
... engraftment in one or more sites, including bone, skin, and marrow stroma, and ... marker
gene suggested the potential for immune attack against therapeutic ...

Helping the heart to heal with stem cells -
N Rosenthal, L Tsao - Nature Medicine, 2001 - nature.com
... thoracic delivery, obtaining adequate autologous cells from a heart attack victim
in ... cytokine activation of the patient's bone-marrow cells alone would ...

[PDF] Climate and amphibian declines -
JA Pounds - Science, 1999 - environment.stanford.edu
... combination of characteristics makes bone-marrow-derived cells uniquely suited to
the task of restoring structure and function in the wake of a heart attack. ...
-

Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure Syndromes -
DE Dunn, P Tanawattanacharoen, P Boccuni, S … - Annals of Internal Medicine, 1999 - annals.highwire.org
... their relative insusceptibility to autoimmune attack (6, 10 ... clinic at the National
Heart, Lung, and ... diagnosed or previously treated bone marrow failure syndromes ...

[PDF] Hearts and bones -
M Sussman - Science, 1999 - cmbi.bjmu.edu.cn
... combination of characteristics makes bone-marrow-derived cells uniquely suited to
the task of restoring structure and function in the wake of a heart attack. ...
-

CELL THERAPY: Renovating the Heart -
J Couzin, G Vogel - Science, 2004 - sciencemag.org
... from the university's ethics review board to infuse bone marrow cells into heart
patients. On 25 March 2001, a 46-year-old heart attack survivor signed on to ...

Dendritic cells and the control of immunity -
J Banchereau, RM Steinman - Nature, 1998 - nature.com
... 6, 7, 8, 9, 10 : bone-marrow cultures stimulated ... isolated from blood, lung, spleen,
heart, kidney, and ... to eliminate infected cells and attack transplants and ...

Source: Google Scholar
 
 

Bone Marrow Cells Can Repair Damaged Heart

 

 

Bone marrow cells can be used to repair a heart damaged by a heart attack, according to U.S. researchers.

The cells, genetically engineered to make them stronger and more likely to survive, restored the heart?s pumping capacity by 80 percent to 90 percent in animal models in rats, the team at Brigham and Women?s Hospital in Boston said.

Writing in the September issue of the journal Nature Medicine, they said they hoped their experiments will someday lead to a treatment for human patients whose hearts are irreparably damaged by heart attacks. "This is a very positive development that we think holds immense promise," Dr. Victor Dzau, who led the study, said. "But there is certainly more work to do."

His team used bone marrow cells called mesenchymal stem cells. These cells are already used to repair cartilage and bone defects.

They should, in theory, be able to generate new heart tissue but experiments in pigs have failed so far because the cells die. So the team added a gene called Akt1, which can prevent transplanted cells from dying.

It worked.

"The results were truly remarkable," Dzau said in a statement. "The hearts that received the stem cells modified with Akt1 exhibited an amazing amount of reparative growth, significantly, if not completely, restoring cardiac function."

When injected into the hearts or rats given artificial heart attacks, the stem cells hooked up with the heart cells and generated more heart-like cells, the team reported.

"The hope is this sort of process can be turned into a gene therapy for humans," added Dr. Abeel Mangi, formerly of Brigham and Women?s and now at Massachusetts General Hospital.

 
 
 
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