… reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria … -
MP Mallampalli, G Huyer, P Bendale, MH Gelb, S … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences
... EG Nabel Mechanisms of Cardiovascular Disease in Accelerated ... Farnesyltransferase
Inhibitor Ameliorates Disease in a Mouse Model of Progeria Science, March 17 ...

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson?Gilford progeria … -
R Varga, M Eriksson, MR Erdos, M Olive, I Harten, … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences
... of some symptoms associated with normal aging, most notably cardiovascular disease
that eventually ... We have created a mouse model for progeria by generating ...

[CITATION] Hutchinson-Gilford progeria syndrome -
RL Pollex, RA Hegele - Clinical Genetics, 2004 - Blackwell Synergy
... would have the same respiratory, cardiovascular, and arthritic ... is the Lmna
L530P/L530P progeria mouse model ... evidence of having atherosclerotic disease, which ...

… of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome -
BC Capell, MR Erdos, JP Madigan, JJ Fiordalisi, R … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences
... Gilford progeria syndrome (HGPS) is a rare genetic disorder that is characterized
by dramatic premature aging and accelerated cardiovascular disease. ...

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient … -
LG Fong, JK Ng, M Meta, N Cote, SH Yang, CL … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences
... In that mouse model, heterozygotes were phenotypically ... New Approaches to Progeria
Pediatrics, October ... Nabel Mechanisms of Cardiovascular Disease in Accelerated ...

Aging and nuclear organization: lamins and progeria -
LC Mounkes, CL Stewart - Current Opinion in Cell Biology, 2004 - Elsevier
... in such diverse tissue-specific diseases, including progeria. ... These models are not,
however, mutually ... to arthrosclerosis and cardiovascular disease [31.], as ...

… , and progeria?new evidence suggesting that protein farnesylation could be important for disease … -
SG Young, LG Fong, S Michaelis - J. Lipid Res, 2005 - ASBMB
... model for human progeroid syndromes, explain the ... classic human progeroid syndrome,
Hutchinson-Gilford progeria ... commonly suggested that muscle and heart disease ...

… of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria … -
RD Goldman, DK Shumaker, MR Erdos, M Eriksson, AE … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences
... before 24 months of age (Progeria Research Foundation's ... the final stages of disease,
most children ... and dilated hearts because of atherosclerotic heart disease. ...

Histological and Ultrastructural Features of Atherosclerosis in Progeria -
WE Stehbens, SJ Wakefield, E Gilbert-Barness, RE … - Cardiovascular Pathology, 1999 - Elsevier
... pronounced than in brown atrophy of the heart. ... may also account for cerebrovascular
disease (24 ... evidence that vascular changes in progeria are atherosclerotic 6 ...

… improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome … -
SH Yang, MO Bergo, JI Toth, X Qiao, Y Hu, S … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences
... us confident that this model could be ... M. Kleinman New Approaches to Progeria Pediatrics,
October 1 ... EG Nabel Mechanisms of Cardiovascular Disease in Accelerated ...