Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: rheumatoid arthritis + tweak inhibition + new  Related to the article below (Last Update: 7/8/2008)

Medication and exercise treat rheumatoid arthritis
The Star-Ledger - NJ.com, NJ -
My mother has rheumatoid arthritis and I wanted to know about the medications used to treat this problem. Rheumatoid arthritis is a chronic disease ...
New MedPredict Report Highlights Trend Toward Early Diagnosis and ...
Earthtimes (press release), UK -
In this report, entitled Thought Leader Insight & Analysis: Rheumatoid Arthritis Q2 2008, MedPredict's global Thought Leader Panel reviews progress in ...

St. Louis Post-Dispatch
A joint effort in woman's fight against rheumatoid arthritis
St. Louis Post-Dispatch,  United States - Jul 7, 2008
She was diagnosed with rheumatoid arthritis in 2000. "We were living in Naples, Fla., at the time, and I was used to jogging three miles a day," Janson says ...
Tools, devices help arthritis patients get on with tasks
Atlanta Journal Constitution,  USA - Jul 7, 2008
Diagnosed at age 29 with rheumatoid arthritis 10 years ago, the Dacula mom of three was racked with pain and fatigue for almost a year before doctors ...
UCB: European submission for rheumatoid arthritis treatment
Pharmaceutical Business Review - Jul 7, 2008
... (EMEA) requesting the approval of certolizumab pegol as a subcutaneous treatment for adults with moderate to severe active rheumatoid arthritis (RA). ...

MSN India
Heavy Birthweight Increases Risk Of Developing Rheumatoid Arthritis
Science Daily (press release) - Jun 30, 2008
ScienceDaily (June 30, 2008) ? People who have a birthweight over 10 pounds are twice as likely to develop rheumatoid arthritis when they are adults ...
High Birth Weight Doubles Risk of Rheumatoid Arthritis Washington Post
Rheumatoid arthritis 'linked to heavy birthweight' Hindu
Heavy babies prone to arthritis as adults Reuters India
guardian.co.uk - Medscape (subscription)
all 64 news articles »
Rheumatoid arthritis may be a bigger risk for big babies
Los Angeles Times, CA - Jul 4, 2008
This is not to say that heavier birth weight causes rheumatoid arthritis, Mandl says -- both may have the same underlying cause. "The same stressors that ...
Genentech shares drop on renewed Rituxan concerns
Reuters - Jul 7, 2008
Last month, a rheumatoid arthritis patient being treated with Rituxan died after developing progressive multifocal leukoencephalopathy, a central nervous ...DNA
Drinking cuts rheumatoid arthritis risk
The Punch, Nigeria - Jul 3, 2008
By Agency Reporter People who drink alcohol regularly may cut their risk of developing rheumatoid arthritis, a new study finds. Alcohol has been shown to ...
Girls State governor proves self as leader
The Tennessean, TN -
"She has been very active in community service, receiving national recognition from the Juvenile Rheumatoid Arthritis Foundation, and will serve as vice ...
Source: Google News

… human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis … -
PH Wooley - The Journal of Immunology, 1993 - Am Assoc Immnol
... Atkins, DM Findlay, TS Zheng, and H. Hess TWEAK Is a ... Home page DA Fox Cytokine Blockade
as a New Strategy to Treat Rheumatoid Arthritis: Inhibition of Tumor ...

… of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK … -
Y Chicheportiche, R Chicheportiche, I Sizing, J … - Arthritis Res, 2002 - arthritis-research.com
... Group: Infliximab and methotrexate in the treatment of rheumatoid arthritis. ... Arthritis
Rheum 1990, 33:1807-1814 ... Studies on the interaction between TWEAK and the ...
-

The Apoptotic Ligands TRAIL, TWEAK, and Fas Ligand Mediate Monocyte Death Induced by Autologous … -
MJ Kaplan, EE Lewis, EA Shelden, E Somers, R … - The Journal of Immunology, 2002 - Am Assoc Immnol
... with active SLE, inactive SLE, and rheumatoid arthritis (RA) were ... anti-TWEAK also
gave significant inhibition (p < 0.05 ... of anti-FasL, TRAIL, and TWEAK was not ...

[CITATION] New vessels, new approaches: angiogenesis as a therapeutic target in musculoskeletal disorders -
SC Ballara, JM Miotla, EM Paleolog - Int. J. Exp. Path., 1999 - Blackwell Synergy
... of disorders such as rheumatoid arthritis (RA), in ... named vascular endothelial growth
inhibitor (VEGI, also ... the recently identified protein TWEAK, can stimulate ...

Inhibition of TWEAK activity as a new treatment for inflammatory and degenerative diseases -
M Yepes, JA Winkles - Drug News Perspect, 2006 - journals.prous.com
... and rheumatoid arthritis, making it a promising strategy for the treatmentof patients
with these diseases. Inhibition of TWEAK Activity as a New Treatment for ...

TWEAK Is a Novel Arthritogenic Mediator -
SJ Perper, B Browning, LC Burkly, S Weng, C Gao, K … - The Journal of Immunology, 2006 - Am Assoc Immnol
... by synovial fibroblasts derived from rheumatoid arthritis (RA) patients. ... during mouse
collagen-induced arthritis (CIA) and ... repair, suggesting that TWEAK may be ...

[PDF] The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity -
S Campbell, J Michaelson, L Burkly, C Putterman - Front Biosci, 2004 - bioscience.org
... tissue from patients with rheumatoid arthritis and osteoarthritis ... In response to
incubation with TWEAK, PGE2, MMP ... 8 (but not tissue inhibitor of metalloproteinase ...

Update on cytokines in rheumatoid arthritis. -
F Brennan, J Beech - Current Opinion in Rheumatology, 2007 - co-rheumatology.com
... cytokines implicated in pathogenesis of rheumatoid arthritis TOP. ... arthritis exacerbates
autoimmune arthritis by enhancing ... inflammation, and that TWEAK may be a ...

TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL … -
T Ando, J Ichikawa, M Wako, K Hatsushika, Y … - Arthritis Research & Therapy, 2006 - biomedcentral.com
... PD98059 abrogated TWEAK inhibition of BMP-2-induced ALP ... bone from a patient with
rheumatoid arthritis expressed Fn14. ... C, Garcia I, Browning JL :TWEAK, a new ...
-

Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
U M?ller-Ladner, C Ospelt, S Gay, O Distler, T Pap - Arthritis Research & Therapy, 2007 - arthritis-research.com
... L, Crowell T, Rajman L, et al.: TWEAK is a ... Arthritis Res Ther 2006, 8:R80 ... vascular
endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts ...

Source: Google Scholar
 
 

Inhibition of TWEAK may provide a new approach to rheumatoid arthritis therapy

 
 
Researchers at Biogen Idec reported in the Journal of Immunology that activation of a recently discovered inflammation pathway may play an important role in the disease process that causes rheumatoid arthritis.
The studies demonstrate that inhibiting the TWEAK molecule may provide a new approach to developing rheumatoid arthritis treatments.

Discovered by Biogen Idec and University of Geneva researchers, TWEAK belongs to a family of molecules called tumor necrosis factor ( TNF ) that plays an important role in normal immune system and inflammatory responses.
TNF-inhibiting therapies are currently used to treat a number of diseases including rheumatoid arthritis, a chronic, autoimmune disease that causes inflammation and swelling of the joints and the surrounding synovial tissue, resulting in progressive damage to the cartilage and bone.

TWEAK stimulates blood vessel growth ( angiogenesis ) and production of inflammatory proteins called cytokines and chemokines.
The published studies found that TWEAK promotes a number of events that are hallmarks of rheumatoid arthritis, including joint inflammation and synovial angiogenesis.

" Despite considerable progress, many rheumatoid arthritis patients do not adequately respond to current treatments, indicating that other pathways are involved in this complex disease," said Timothy Zheng, at Biogen Idec. " Our investigative research suggests that TWEAK contributes to the disease through multiple mechanisms, and inhibiting the TWEAK pathway may represent a new set of opportunities for treatment."

Specifically, the Biogen Idec researchers found that TWEAK promotes joint inflammation by stimulating the production of several types of inflammatory proteins, triggers joint damage by stimulating the production of damaging metalloprotease enzymes and promoting bone breakdown, and contributes to joint tissue disease by directly promoting angiogenesis in synovial tissue. The studies also suggest that TWEAK may impede normal bone repair mechanisms.

Source: Biogen Idec, 2006
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With:News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page