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Recent News and Articles on the Keywords: rheumatoid arthritis + new + arthritis  Related to the article below (Last Update: 8/5/2008)

Stroke rehab may be poorer for arthritis patients
Reuters UK, UK -
By Michelle Rizzo NEW YORK (Reuters Health) - People with rheumatoid arthritis who suffer a stroke are likely to have lower functional ability subsequently ...
Behavioral Comorbidities in Rheumatoid Arthritis
Psychiatric Times, NY -
While tremendous therapeutic advancements have been made, patients with rheumatoid arthritis (RA) have a myriad of comorbidities, including fatigue, ...

ChattahBox
FDA Panel Recommends New Arthritis Drug Approval
eFluxMedia - Jul 30, 2008
By Raoul Railey An FDA panel voted Tuesday 10 to 1 for the approval of a new drug that fights against rheumatoid arthritis. Even thought the Food and Drug ...
New athritis drug gets approval recommendation The Associated Press
Roche wins US panel support for arthritis drug Reuters
FDA Panel Backs Rheumatoid-Arthritis Drug Wall Street Journal
dBTechno - CNNMoney.com
all 147 news articles »  OTC:RHHBY - SWF:RO - SWF:HUE
In Good Health ? Respect your elders ... keep them cool
Frederick News Post (subscription), MD -
The Arthritis & Osteoporosis Center of Maryland is looking for volunteers to participate in a study of an investigational drug for rheumatoid arthritis. ...

Oneindia
Arthritis May Double Heart Attack
Oneindia, India - Jul 31, 2008
Patients with rheumatoid arthritis are twice as likely to suffer a heart attack, suggests a new study. Rheumatoid arthritis, lupus, and related autoimmune ...
Joint Inflammation and Heart Disease Linked Newswise (press release)
all 12 news articles »
FDA: Roche's Actemra Appears Effective in Rheumatoid Arthritis
Wall Street Journal - Jul 25, 2008
By JARED A. FAVOLE and ANITA GREIL Roche Holding AG's Actemra appears effective at treating rheumatoid arthritis, a disease that can destroy joints and ...
Roche arthritis drug works: FDA staff Reuters
Place Your Biotech Bets Motley Fool
Roche arthritis drug works - US FDA staff Forbes
Reuters
all 26 news articles »  OTC:RHHBY - SWF:RO - SWF:HUE
Genetics, lifestyle affect bone density
Daytona Beach News-Journal, FL - Aug 3, 2008
Even though you can't change your race, your genes, or the fact that you have rheumatoid arthritis, there are risk factors that you can avoid and treatment ...

BBC News
Outcry at Government drug watchdog's plan to cut arthritis treatments
Telegraph.co.uk, United Kingdom - Jul 21, 2008
Many rheumatoid arthritis patients live with the disease for decades. They argue that cutting down the options will leave them needlessly living in agony ...
UK?s Nice Nixes Second Tries With Rheumatoid Arthritis Meds Wall Street Journal Blogs
Restricting arthritis drugs ?a prescription for pain? Times Online
Arthritis drug access 'curbed' BBC News
Reuters - The Press Association
all 151 news articles »
Training in high temperatures
Cyclingnews.com -
I have read the answer to a question in 2005 but it related to Rheumatoid Arthritis and so am not sure whether it is applicable.
Cooking series may help arthritis
Indianapolis Star, United States - Jul 31, 2008
Many people living with rheumatoid arthritis lack the time, strength, and ability to prepare healthy and nutritious food for themselves or their families. ...
Source: Google News

… American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis … -
FC Arnett, SM Edworthy, DA Bloch, DJ McShane, JF … - Arthritis Rheum, 1988 - ncbi.nlm.nih.gov
... The new criteria are as follows: 1) morning stiffness in and ... metacarpophalangeal,
or wrist joints; 4) symmetric swelling (arthritis); 5) rheumatoid nodules; 6 ...

The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. -
DA Fox - Arthritis Rheum, 1997 - ncbi.nlm.nih.gov
Arthritis Rheum. 1997 Apr;40(4):598-609. The role of T cells in the
immunopathogenesis of rheumatoid arthritis: new perspectives. Fox DA. ...

… of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis -
C Bombardier, L Laine, A Reicin, D Shapiro, R … - New England Journal of Medicine, 2000 - content.nejm.org
... Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis," N Engl
J ... Selecting new drugs for pain control: Evidence-based decisions or clinical ...

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis -
JM Bathon, RW Martin, RM Fleischmann, JR Tesser, … - New England Journal of Medicine, 2000 - content.nejm.org
... 2005). Rheumatoid Arthritis: An Overview of New and Emerging Therapies.
J Clin ... 2004). New Drugs for Rheumatoid Arthritis. NEJM 350 ...

New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study -
F Cornelis, S Faure, M Martinez, JF Prud'homme, P … - Proceedings of the National Academy of Sciences, 1998 - National Acad Sciences
Vol. 95, Issue 18, 10746-10750, September 1, 1998. Genetics New susceptibility locus
for rheumatoid arthritis suggested by a genome-wide linkage study. ...

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis -
PE Lipsky, DMFM van der Heijde, EW St Clair, DE … - New England Journal of Medicine, 2000 - content.nejm.org
... Will our current success in treating rheumatoid arthritis hinder new drug development? ...
Rheumatoid Arthritis: An Overview of New and Emerging Therapies. ...

New Drugs for Rheumatoid Arthritis -
NJ Olsen, CM Stein - The New England Journal of Medicine, 2004 - nejm.org
PreviousPrevious, Volume 350:2167-2179, May 20, 2004, Number 21. Next Next. New
Drugs for Rheumatoid Arthritis. Nancy J. Olsen, MD, and C. Michael Stein, MB, Ch ...
-

… recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis … -
ME Weinblatt, JM Kremer, AD Bankhurst? - New England Journal of Medicine, 1999 - content.nejm.org
... Ann Rheum Dis 63: 755-758 [Full Text]; Olsen, NJ, Stein, CM (2004). New Drugs
for Rheumatoid Arthritis. ... A New Approach to Rheumatoid Arthritis. ...

… vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis The CLASS Study … -
FE Silverstein, G Faich, JL Goldstein, LS Simon, T … - JAMA, 2000 - Am Med Assoc
... FDA) for symptomatic treatment of rheumatoid arthritis (RA) and ... in this window]
[in a new window]. ... that are not associated with your arthritis?" All affirmative ...

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)-Fc … -
LW Moreland, SW Baumgartner, MH Schiff, EA Tindall … - New England Journal of Medicine, 1997 - content.nejm.org
... New Drugs for Rheumatoid Arthritis. ... Cytokine Blockade as a New Strategy to Treat
Rheumatoid Arthritis: Inhibition of Tumor Necrosis Factor. ...

Source: Google Scholar
 
 

Inhibition of TWEAK may provide a new approach to rheumatoid arthritis therapy

 
 
Researchers at Biogen Idec reported in the Journal of Immunology that activation of a recently discovered inflammation pathway may play an important role in the disease process that causes rheumatoid arthritis.
The studies demonstrate that inhibiting the TWEAK molecule may provide a new approach to developing rheumatoid arthritis treatments.

Discovered by Biogen Idec and University of Geneva researchers, TWEAK belongs to a family of molecules called tumor necrosis factor ( TNF ) that plays an important role in normal immune system and inflammatory responses.
TNF-inhibiting therapies are currently used to treat a number of diseases including rheumatoid arthritis, a chronic, autoimmune disease that causes inflammation and swelling of the joints and the surrounding synovial tissue, resulting in progressive damage to the cartilage and bone.

TWEAK stimulates blood vessel growth ( angiogenesis ) and production of inflammatory proteins called cytokines and chemokines.
The published studies found that TWEAK promotes a number of events that are hallmarks of rheumatoid arthritis, including joint inflammation and synovial angiogenesis.

" Despite considerable progress, many rheumatoid arthritis patients do not adequately respond to current treatments, indicating that other pathways are involved in this complex disease," said Timothy Zheng, at Biogen Idec. " Our investigative research suggests that TWEAK contributes to the disease through multiple mechanisms, and inhibiting the TWEAK pathway may represent a new set of opportunities for treatment."

Specifically, the Biogen Idec researchers found that TWEAK promotes joint inflammation by stimulating the production of several types of inflammatory proteins, triggers joint damage by stimulating the production of damaging metalloprotease enzymes and promoting bone breakdown, and contributes to joint tissue disease by directly promoting angiogenesis in synovial tissue. The studies also suggest that TWEAK may impede normal bone repair mechanisms.

Source: Biogen Idec, 2006
 
 
 
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