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Recent News and Articles on the Keywords: may represent + treatment of + strategy  Related to the article below (Last Update: 7/1/2008)

Algebra Progress Monitoring and Interventions for Students With ...
RedOrbit, TX - 45 minutes ago
Analysis of think-aloud data from students as they solved problems revealed their use of the instructed strategy. Comparisons of students in the treatment ...
The Effects of Tier 2 Intervention on the Mathematics Performance ... RedOrbit
all 2 news articles »
Sangamo BioSciences Announces Nature Biotechnology Study ...
Earthtimes (press release), UK -
... for the treatment of HIV/AIDS, strategic partnerships with collaborators and clinical trials of ZFP Therapeutics. Actual results may differ materially ...SGMO
Aradigm Reports Successful Top-line Phase 2 Data with Inhaled ...
Business Wire (press release), CA -
Study demonstrates significant reduction in bacterial infection and improvement in lung function following two weeks of treatment. Once daily dosing regimen ...OTC:ARDM
First Subjects Enrolled in Epigenomics sponsored PRESEPT ...
FOXBusiness -
"Adherence to current colorectal cancer screening options poses one of the greatest challenges to colorectal cancer detection and treatment. ...FRA:ECX
Raptor Pharmaceuticals Closes $10 Million Private Placement
FOXBusiness -
The Company intends to use the net proceeds to fund programs for its drug product candidates and execute its corporate strategy. ...OTC:RPTP - OTC:CMTX
More gambling poor strategy
The Herald-Times (subscription), IN -
But the pull tab legislation represents a bigger issue: the continued expansion of gaming as an economic strategy of our state. Indiana?s resources would be ...
InvestSource Inc.: Elleipsis Global Travel Solutions Powers New ...
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Two studies of migraineurs who reported that they had poor response to, or did not tolerate, short-acting triptans, showed that treatment with Treximet ...SE - SWC - SAP
Intensive Intervention for Students With Mathematics Disabilities ...
RedOrbit, TX - 45 minutes ago
Nevertheless, most typically developing students are well on their way toward automatic retrieval of number combinations as their major solution strategy by ...

Energy Bangla
Lionei Sippel ? Her Visions for Australia
Energy Bangla, Bangladesh - Jun 30, 2008
Leonie mentioned government must explain the treatment process in simpler ways to greater portion of society as in not too distant future PRW may become the ...
A 12-step program for Canada
Globe and Mail, Canada - Jun 27, 2008
Commit to a national mental-health plan ? now Canada is the only Group of Eight country without a mental-health strategy. We need a plan that lays out ...
Source: Google News

Primary Prevention of Sudden Death as a Novel Treatment Strategy in Hypertrophic Cardiomyopathy -
BJ Maron, NAM Estes, MS Maron, AK Almquist, MS … - Circulation, 2003 - Am Heart Assoc
... 30 mm), even in the absence of important arrhythmias, may represent a sole ... It is
our expectation that this contemporary treatment strategy will prevent most of ...

Comprehensive Strategy for the Evaluation and Triage of the Chest Pain Patient -
JL Tatum, RL Jesse, MC Kontos, CS Nicholson, KL … - Annals of Emergency Medicine, 1997 - Elsevier
... Failure to recognize these patients may occur if the ... However, these high-risk patients
represent only a ... through to final diagnosis and appropriate treatment. ...

Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. -
C Boni, A Bertoletti, A Penna, A Cavalli, M Pilli, … - Journal of Clinical Investigation, 1998 - pubmedcentral.nih.gov
... Since lamivudine treatment can overcome T cell hyporeactivity, combining ... to stimulate
the T cell response may represent an effective strategy to induce ...

Acetylcysteine and contrast agent-associated nephrotoxicity -
C Briguori, F Manganelli, P Scarpato, PP Elia, B … - Journal of the American College of Cardiology, 2002 - Am Coll Cardio Found
... high-risk patients, transient dialysis may be required ... Brackets represent the standard
deviation ... concentration from baseline and the treatment strategy (F = 0.026 ...

Antiretroviral Therapy in Adults Updated Recommendations of the International AIDS Society-USA Panel -
CCJ Carpenter, DA Cooper, MA Fischl, JM Gatell, BG … - JAMA, 2000 - Am Med Assoc
... Recommendations herein represent the panel's consensus opinion as of ... in naive CD4 +
cells) may be achieved ... to those concerning treatment complexity, monitoring ...

CARDIOMYOPATHY: Arrhythmogenic right ventricular cardiomyopathy: diagnosis, prognosis, and treatment -
D Corrado, C Basso, G Thiene - British Medical Journal, 2000 - heart.bmj.com
... empirically by antiarrhythmic drug treatment, which is ... directed catheter ablation
may be attempted ... automatic cardioverter defibrillator represents the first ...

Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives -
A Bazarbachi, O Hermine - Virus Research, 2001 - Elsevier
... the selection of an HTLV-I positive donor may improve the ... IFN in acute ATL, we recommend
that this combination should represent the first treatment option. ...

Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV … -
C Marzolini, A Telenti, LA Decosterd, G Greub, J … - AIDS, 2001 - aidsonline.com
... drug monitoring (TDM) strategy may be useful for individualizing the treatment.
According to Joshi et al. [11], trough plasma levels represent an important ...

Liver Transplantation for the Treatment of Moderately or Well-Differentiated Hepatocellular … -
U Cillo, A Vitale, M Bassanello, P Boccagni, A … - Annals of Surgery, 2004 - annalsofsurgery.com
... at the time of transplantation represents a direct ... also in terms of postoperative
treatment and follow ... 9,18,26 that tumor differentiation may accurately reflect ...

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics -
J Hardy, DJ Selkoe - Science, 2002 - sciencemag.org
... but not monomers or insoluble amyloid fibrils, may be responsible ... Treatment Strategies
Based on A Biology. If AD represents the effects of a chronic imbalance ...

Source: Google Scholar
 
 

Inhibition of LDH-A may represent a rational and safe strategy for treatment of cancer

 
 
Although researchers have known for nearly 90 years that cancer cells commonly display altered glucose metabolism, the molecular significance of this phenomenon is not completely understood.

Now, a study reveals a functional connection between carbohydrate-driven energy production and tumor maintenance.
Importantly, the results suggest that inhibition of a specific aspect of glucose metabolism may represent an attractive and potentially well-tolerated approach to interfering with tumor growth.
Normal cells produce most of the ATP they need to power cellular functions through an oxygen-dependent process known as oxidative phosphorylation.
In contrast, cancer cells commonly switch to what is known as a "glycolytic phenotype," producing ATP through a process that can occur in the absence of oxygen and involves conversion of glucose to lactate.
Researchers believe that the glycolytic phenotype enables rapidly proliferating tumor cells to survive even when environmental oxygen levels are not optimal.
In addition, perturbations of the normal physiology of mitochondria, cellular structures involved in oxygen-dependent ATP production, have also been linked to cancer.

Valeria Fantin, at Harvard Medical School, and colleagues examined whether blocking the conversion of glucose to lactate in mammary tumor cells might help shed light on the association between tumor survival and the interplay between glycolytic phenotype and mitochondrial metabolism.

The researchers used a sophisticated genetic technique to reduce levels of lactate dehydrogenase A ( LDH-A ), an enzyme required for the glucose to lactate pathway that is elevated in human breast and lung cancers.
Inhibition of LDH-A stimulated mitochondrial function and drastically compromised the ability of the tumor cells to proliferate in low oxygen conditions.
Restoration of LDH-A activity reestablished the glycolytic phenotype of the tumor cells.

These data suggest that alterations in glucose metabolism in cancer cells are linked with changes in mitochondrial physiology and that LDH-A plays a critical role in tumor growth.
The researchers propose that inhibition of LDH-A may represent a rational and safe strategy for treatment of cancer.

" Because individuals with complete hereditary deficiency of LDH-A do not show any symptoms under ordinary circumstances, the genetic data suggest that inhibition of LDH-A activity may represent a relatively nontoxic approach to interfere with tumor growth," explains Fantin.

Source: Cancer Cell, 2006
 
 
 
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