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Recent News and Articles on the Keywords: cystic + web + 7,750  Related to the article below (Last Update: 8/5/2008)

Cypress Consulting Captures New Niche in Fast Growing, Tech Savvy ...
Market Wire (press release) -
"Our researchers now have an improved, web-based system to support submission, review and feedback for cystic fibrosis clinical trial protocols. ...
Web Exclusive: Good News!
Florida Times-Union, FL - Aug 1, 2008
By BRANDIS JEST , The Times-Union - San Marco's Dance Trance Fitness recently raised more than $500 for the Cystic Fibrosis Foundation. ...
Race against time
Lake City Reporter, FL -
?Breakthroughs in Cystic Fibrosis were made by parents who didn?t stop fighting for their children.? To help the Prockos raise money and DMD awareness, ...
Tricia B. Bowley
Baltimore Sun, United States - Jul 7, 2008
Her image also became one of the "Faces of the Cystic Fibrosis" displayed on the foundation's Web site. In June, she was awarded a Governor's Citation for ...
OSU athletes meet, greet, sign
Daily O'Collegian, OK - Aug 3, 2008
... Stone gets the coaches and athletes to sign items that are auctioned to benefit organizations such as American Red Cross and Cystic Fibrosis. ...
Web Exclusive: Good News!
Florida Times-Union, FL - Jul 25, 2008
The Cystic Fibrosis Foundation (CFF) raised $210000 during its annual Northeast Florida Great Strides Walks; a 31 percent increase from last year's efforts. ...

Wall Street Journal
Putting Drug Development In Patients' Hands
Wall Street Journal - Jul 28, 2008
And the Cystic Fibrosis Foundation, started by a group of parents who had children with the disease, recently announced that a drug it is paying a biotech ...
Biking for a cure
Bugle-Observer, Canada - Jul 7, 2008
Siblings Alley and David Watson dip their rear bike tires in the Pacific Ocean before heading across Canada to raise money for Cystic Fibrosis. ...
FoldRx Technology Enables Discovery of Novel Therapeutic Approach ...
Business Wire (press release), CA - Jul 8, 2008
... cystic fibrosis, based on its broad, proprietary, yeast-based drug discovery platform. For more information on FoldRx, please visit the company?s web ...
Strength within: Man beats odds after double lung transplant
Northern Virginia Daily, VA - Jul 22, 2008
... according to a Web site of the Cystic Fibrosis Foundation and a press release from NetLife Health, a nonprofit agency that coordinates organ and tissue ...
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Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel … -
KA Burton, BD Johnson, ZE Hausken, RE Westenbroek, … - Proceedings of the National Academy of Sciences, 1997 - National Acad Sciences
... of Washington School of Medicine, Box 357750, Seattle, WA 98195-7750; and Howard ...
and RA Frizzell Protein Kinase A Associates with Cystic Fibrosis Transmembrane ...

The effect of extracorporeal shock wave lithotripsy on the rat spinal cord
A Karatas, M Dosoglu, T Zeyrek, A Kayikci, A Erol, … - Spinal Cord, 2008 - nature.com
Full text access provided to Googlebot Access by Web Services. ... d, g, i?l) 6000;
(e) 7750; (h) 4646 ... imaging study showed enlargement of the cystic cavity after ...

Application of Immunohistochemistry to Cytology
D Sources - Archives of Pathology and Laboratory Medicine, 2008 - arpa.allenpress.com
... We would strongly recommend using a Web-based antibody ... pancreatoblastoma, and solid
cystic (papillary-cystic) tumor. ... Floyd Curl Dr, Mail Code #7750, San Antonio ...
-

[PDF] Indexing Large Archives of Pathology Images Using the Unified Medical Language System (UMLS) G. …
JJ Berman - PATHOLOGY EDUCAT ION, 2000 - peir.path.uab.edu
... Finally, web-based distribution of GRIPE materials is anticipated in the future ... Roger
Geiss University of Mississippi 3 rdPlace Aorta?Cystic Medial Necrosis ...

Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a … -
JM Perez-Victoria, A Di Pietro, D Barron, AG … - Curr. Drug Targets, 2002 - ingentaconnect.com
... trials have shown an overall cure rate greater than 90% (Web site http ... resistance-
associated protein 1 (MRP1) and the cystic fibrosis transmembrane conductance ...

Molecular genetics of autism spectrum disorder -
J Veenstra-VanderWeele, EH Cook Jr - Molecular Psychiatry, 2004 - nature.com
Full text access provided to Googlebot Access by Web Services. ... many different mutations
in a single gene (CFTR) have been described in cystic fibrosis, some of ...

[PDF] Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug … -
CA Hrycyna, LE Airan, UA Germann, SV Ambudkar, I … - Biochemistry, 1998 - chem.purdue.edu
... ATP, [ R - 32 P]-8-azidoadenosine 5???-triphosphate; CFTR, cystic fibrosis transmembrane ...
Published 1998 by the American Chemical Society Published on Web 09/09 ...
-

[PDF] Topic 3.11 Significance of experimental studies for assessing adverse effects of endocrine- … -
LE Gray Jr, PMD Foster - Pure Appl. Chem, 2003 - old.iupac.org
... Corresponding author: Tel.: 919-541-7750; E-mail ... OECD) (de- scribed at the following
Web site: <http ... ligaments 3. Note if ovaries are small, cystic-fluid filled ...

Effects of Serine/Threonine Protein Phosphatases on Ion Channels in Excitable Membranes -
S Herzig, J Neumann - Physiological Reviews, 2000 - Am Physiological Soc
... Citation Map. Similar articles found in: Physiological Reviews Online ISI Web of
Science PubMed. ... Search for citing articles in: ISI Web of Science (57). ...

[CITATION] In press
SJ Mitchell, WJ Beese - The retention system: reconciling variable retention with …

Source: Google Scholar
 
 

Cystic fibrosis: stopping inhaled corticosteroid use causes no problems

 
 
In comparison to cystic fibrosis patients who regularly use inhaled corticosteroid, those who did not use these drugs for six months exhibited no positive or negative effects in terms of major disease factors. Such factors include amount of lung function decline, number of antibiotics prescribed, time to onset of acute chest exacerbation or frequency of using a bronchodilator.

The findings appear in the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Ian M. Balfour-Lynn, at Royal Brompton Hospital in London, and six associates concluded that it is safe for cystic fibrosis patients to stop using inhaled corticosteroids in order to lower their drug burden, to reduce potential adverse side effects, and to save money.

According to the authors, 52 percent of children and 55 percent of the adults with cystic fibrosis in Great Britain have been prescribed inhaled corticosteroid medication for their illness.

Cystic fibrosis, an inherited disorder, is characterized by the production of thick, sticky mucus that frequently obstructs the lungs. The problem can lead to life-threatening lung infections and difficulties with the pancreatic ducts, preventing normal digestion and causing patient malnutrition. Because of improved treatment techniques in recent years, however, patient survival has increased from 25 to 33 years.

" Oral corticosteroids slow the progression of cystic fibrosis lung disease, but long-term use is precluded by unacceptable side effects," said Balfour-Lynn. " A systematic review of inhaled corticosteroid use in cystic fibrosis revealed 10 randomized controlled trials, with six having been published. The trials studied 293 adults and children. Although there was variable methodological quality among the studies, the conclusion was that there was 'no evidence from existing trials to support the practice of prescribing inhaled steroids in cystic fibrosis.'"

The authors noted that 52 percent of the patients were on high-dose inhaled corticosteroids ( 1,000 micrograms or more per day ). At those levels, the drug can lead to significant symptoms related to adrenal suppression and insufficiency. Also, among pediatric patients, slowing of linear growth has been a problem for individuals taking the drug for a year or more.

Over a 6-month period, the researchers studied 84 cystic fibrosis patients ( median age 14.6 years ) who were using an inhaled corticosteroid ( Fluticasone ) and 87 cystic fibrosis patients ( median age 15.8 years ) who were not.

" Replacing the inhaled corticosteroids with a placebo was found to be safe as there was no significant increase in lung-related adverse effects leading to withdrawal from the study, nor an increased need for oral corticosteroids," said Balfour-Lynn.

The researchers stressed that they were not advocating stopping inhaled corticosteroid use in all cystic fibrosis patients, but urging clinicians to assess the need in each individual.

" If there is objective evidence that a patients benefited when inhaled corticosteroids were first started, then it is likely they should be continued on the drug," said Balfour-Lynn.

Source: American Thoracic Society, 2006
 
 
 
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