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Recent News and Articles on the Keywords: anabolic steroids + myocardial infarction + steroids  Related to the article below (Last Update: 7/8/2008)

Bigger, Stronger, Faster*
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And no, this isn't an argument for pot, but rather a drug that we just don't think much about -- anabolic steroids. With this film, director and bodybuilder ...
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Source: Google News

Acute myocardial infarction in a 22-year-old world class weight lifter using anabolic steroids. -
RA McNutt, GS Ferenchick, PC Kirlin, NJ Hamlin - Am J Cardiol, 1988 - ncbi.nlm.nih.gov
Acute myocardial infarction in a 22-year-old world class weight lifter using anabolic
steroids. McNutt RA, Ferenchick GS, Kirlin PC, Hamlin NJ. ...

An acute myocardial infarction occurring in an anabolic steroid user. -
MJ HUIE - Medicine & Science in Sports & Exercise, 1994 - acsm-msse.org
... McNu'rr, RA, GS Ferenchick, PC Kirlin, and NJ Ham- lin. Acute myocardial infarction
in a 22-year-old world class weightliftcr using anabolic steroids. Am. ...

Myocardial infarction associated with anabolic steroid use in a previously healthy 37-year-old … -
GS Ferenchick, S Adelman - Am Heart J, 1992 - ncbi.nlm.nih.gov
Click here to read Myocardial infarction associated with anabolic steroid
use in a previously healthy 37-year-old weight lifter. ...

Anabolic steroid abuse and cardiac death. -
MC Kennedy, C Lawrence - Med J Aust, 1993 - ncbi.nlm.nih.gov
... uses for anabolic steroids but they are widely abused by athletes in attempts to
alter lean body mass and strength. Acute non-fatal myocardial infarction was ...

Anabolic steroid abuse and cardiac sudden death: a pathologic study.
V Fineschi, G Baroldi, F Monciotti, L Paglicci … - Arch Pathol Lab Med, 2001 - ncbi.nlm.nih.gov
... CONTEXT: Androgenic anabolic steroids (AAS) used for improving physical performance
have been considered responsible for acute myocardial infarction and sudden ...

Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters -
MS Nieminen, MP Ramo, M Viitasalo, P Heikkila, J … - European Heart Journal, 1996 - Eur Soc Cardiology
... [9] Lyndberg KK. Myocardial infarction and death of a body builder after using anabolic
steroids. Ugersk Laeger 1991; 153: 587-8. [10] Gaede JT, Montine TJ. ...

Myocardial infarction with extensive intracoronary thrombus induced by anabolic steroids. -
M Fisher, M Appleby, D Rittoo, L Cotter - Br J Clin Pract, 1996 - ncbi.nlm.nih.gov
... adverse reactions, including myocardial infarction. We report two cases
of myocardial infarction in young men on anabolic steroids. ...

… and Anabolic Steroids: A Previously Unreported Cause of Myocardial Infarction With Normal Coronary … -
DR GOLDSTEIN, T DOBBS, B KRULL, VJ PLUMB - Southern Medical Journal, 1998 - smajournalonline.com
... Various mechanisms have been proposed to account for the association between anabolic
steroids and myocardial infarction, though there is no direct evidence. ...

Cardiovascular effects of androgenic-anabolic steroids. -
RB MELCHERT, AA WELDER - Medicine & Science in Sports & Exercise, 1995 - acsm-msse.org
... accumulated over the past several years which associates androgenic-anabolic steroid
(AAS) use with sudden cardiac death, myocardial infarction, altered scrum ...

Tumor Necrosis Factor and Steroid Metabolism in Chronic Heart Failure: Possible Relation to Muscle … -
SD Anker, AL Clark, M Kemp, C Salsbury, MM … - Journal of the American College of Cardiology, 1997 - Elsevier
... are increased after acute myocardial infarction [9]. Some ... cortisol and the anabolic
hormone, dehydroepiandrosterone (DHEA ... this change in steroid metabolism is ...

Source: Google Scholar
 
 

Anabolic steroids increase myocardial infarction risk and cause liver damage

 
 
A study that measured the effects of anabolic steroids on men with HIV wasting disease found that anabolic steroids cause decreased levels of HDL-cholesterol, increased levels of LDL-cholesterol, and serious liver toxicity within 12 weeks.

The results have implications for athletes who take anabolic steroids to enhance performance, says principal investigator Carl Grunfeld, at the San Francisco VA Medical Center.

The study is published in the Journal of Acquired Immune Deficiency Syndromes.

The researchers found that as expected, anabolic steroids lead to gains in both lean body mass and fat in men with HIV wasting.

he randomized, double-blind trial among 262 HIV-positive men was the largest study of its type on men with HIV-associated weight loss.

For the first 12 weeks of the trial, the men were randomly assigned to receive daily doses of either 20, 40, or 80 milligrams of the anabolic steroid Oxandrolone or a placebo.
They were allowed to receive open-label Oxandrolone for the second 12-week period.

Grunfeld says the adverse effects of the steroids predispose people to an increased risk of myocardial infarction. Furthermore, they found grade III and grade IV liver toxicity in some men, which means a very significant risk of serious liver damage." The men's testosterone levels were also depressed. These effects were not seen in men taking placebo, according to Grunfeld.

The researchers observed that in men with the most wasting, the 20 milligram dose was more effective than higher doses in promoting weight gain. Subjects who weighed more and were healthier – and were therefore more like athletes who use the drugs, observes Grunfeld – required higher doses to gain weight. This is significant, he says, because it demonstrates in healthy people, "you need a higher dose to get a benefit – and the higher the dose, the more the toxicity."

Based on observed changes in HDL and LDL, Grunfeld estimates that myocardial infarction risk would be increased 58 percent among men taking 20 milligrams of Oxandrolone per day, two-fold with a 40 milligram daily dose, and three-fold with 80 milligrams. "Add smoking or hypertension, and the risk becomes really serious," he says.

The ability to promote gains in both muscle and fat makes these drugs unique among the medications used for HIV wasting disease, notes Grunfeld. He says that among patients with serious wasting illnesses, the benefits of immediate weight gain could still potentially outweigh the risks of longer-term heart and liver damage. For these patients, he says, it is important to have a store of fat as well as muscle mass, because "opportunistic infections burn up muscle if there's no fat there. The more fat you have, the less muscle you burn."

Nonetheless, he notes, " We would still stop the drug among anyone who has grade III or grade IV liver toxicity."

Source: University of California - San Francisco, 2006
 
 
 
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