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Recent News and Articles on the Keywords: cholesterol lowering + artichoke extract + artichoke  Related to the article below (Last Update: 7/1/2008)

The Statin Showdown
Forbes, NY -
Vytorin gets extra cholesterol-lowering oomph by combining Zocor with a newer drug, Zetia. But Liao argues that Zetia might actually make this inflammation ...
Basil Rifkind, 73; Linked Cholesterol, Heart Disease
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Other deaths
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Rifkind was one of the principal figures in a 1984 landmark study that provided the first conclusive evidence that lowering blood cholesterol can prevent ...

Canada.com
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7thSpace Interactive (press release), NY -
For each patient the mean cholesterol level per year was calculated. A patient belonged to the group with lipid-lowering drugs if there was at least one ...
Genzyme, Isis Finalize Partnership For Cholesterol-Lowering Drug
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... Pharmaceuticals said today they have modified some of the terms of their partnership to develop Isis?s mipomersen for patients with high cholesterol. ...
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Study Shows Use Of Cholesterol-Lowering Drugs Rose 156 Percent ...
Therapeutics Daily (subscription) (press release), PA - Jun 26, 2008
... use of cholesterol-lowering drugs called statins rose by 156 percent between 2000 and 2005, with spending jumping from $7.7 billion to $19.7 billion. ...OTC:CMTX
Agency Seeks Views on Proposed Use of Cholesterol-Lowering Ingredient
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Source: Google News

Caffeic acid derivatives in artichoke extract are metabolised to phenolic acids in vivo -
AR Rechner, AS Pannala, CA Rice-Evans - Free Radical Research, 2001 - informaworld.com
... Isl Artichoke extract also inhibited cholesterol biosynthesis in cultured rat hepato-
cytes [61 and showed choleretic and cholesterol lowering properties in ...

[PDF] Artichoke leaf extract for treating hypercholesterolaemia -
MH Pittler, CO Thompson, E Ernst - Cochrane Database Syst Rev, 2002 - sld.cu
... Artichoke leaf extract (ALE), which is available as an over-the-counter
remedy, has been implicated in lowering cholesterol levels. ...

[CITATION] Inhibition of cholesterol biosynthesis in HepG 2 cells by artichoke extracts is reinforced by … -
R Gebhardt - Phytotherapy Research, 2002
... Choleretic and cholesterol lowering properties of two artichoke extracts. ... Effect
of 1,5-dicaffeylquinic acid (cynarine) on cholesterol levels in serum and ...

… activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in … -
T Sa?nz Rodriguez, D Garc?a Gim?nez, R de la … - Phytomedicine, 2002 - Elsevier
... O Reimann HJ (1994) Increase in choleresis by means of artichoke extract. ... Franc 39:
27?35 Lietti A (1977) Choleretic and cholesterol lowering proper- ties of ...

Isolation, characterization and determination of minor artichoke (Cynara scolymus L.) leaf extract … -
J Fritsche, CM Beindorff, M Dachtler, H Zhang, JG … - European Food Research and Technology, 2002 - Springer
... subgroup analys- es revealed a cholesterol lowering effect of ... 18.5% decrease of total
cholesterol after daily ... of 450 mg dry artichoke extract (CY450) compared ...

[CITATION] Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six- … -
G Holtmann, B Adam, S Haag, W Collet, E Grunewald, … - Alimentary Pharmacology & Therapeutics, 2003 - Blackwell Synergy
... exert hepatoprotective 12 lipid-lowering 13 antioxidant ... Inhibition of hepatic
cholesterol biosynthesis by ... Luteolin-rich artichoke extract protects low density ...

Artichoke juice improves endothelial function in hyperlipemia -
G Lupattelli, S Marchesi, R Lombardini, AR Roscini … - Life Sciences, 2004 - Elsevier
... 1996 V. Fintelmann, Antidyspeptic and lipid lowering effect of artichoke leaf extract ...
the concentration of low density lipoprotein cholesterol in plasma ...

Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled … -
MH Pittler, AR White, C Stevinson, E Ernst - Canadian Medical Association Journal, 2003 - Can Med Assoc
... 9:687-93.[Medline]; Fintelmann V. Antidyspeptic and lipid-lowering effect of ... Pittler
MH, Ernst E. Artichoke leaf extract for serum cholesterol reduction ...

Choleretic effects of yarrow (Achillea millefolium sl) in the isolated perfused rat liver -
B Benedek, N Geisz, W J?ger, T Thalhammer, B Kopp - Phytomedicine, 2006 - Elsevier
... L. are reported to have choleretic, hepatoprotective and cholesterol-lowering effects
(Wegener and Fintelmann, 1999). A standardised artichoke extract showed a ...

Long-term administration of an artichoke extract for dyspepsia symptoms.
V Fintelmann, O Petrowicz - Natura med, 1998 - lichtwer.co.uk
... the 6 month therapy using artichoke leaf special ... the present study, the calculated
LDL cholesterol proved to ... characterizing the lipid-lowering effect of the med ...

Source: Google Scholar
 
 

Artichoke leaf extract under study for cholesterol-lowering

UK scientists are hoping to confirm that components in the artichoke can lower cholesterol, a major risk factor for the world’s biggest health problem, heart disease.
 
A recent German clinical trial found that artichoke leaf extract (ALE) significantly reduced levels of ‘bad' cholesterol in people with high cholesterol. However there is little further evidence to confirm the benefits.

Dr Ann Walker, from the University of Reading's Hugh Sinclair Unit of Human Nutrition, said: "We are very keen to extend this work to people with more moderately raised levels. This study ties in well with other studies that we have run at the University which showed that ALE can be helpful for the relief of minor digestive problems."

Sales of foods designed to improve heart health are rapidly growing, and were worth 100.7 stg in the UK alone during 2002, with forecast annual growth of 7.6 per cent to 2007, according to Datamonitor.

A team at the University of Essen recently reported that an ALE preparation was significantly better than placebo in alleviating symptoms of functional dyspepsia.

However a Cochrane review on the extract's effects on hypercholesterolaemia, updated in 2002, found that it was supported by few data from rigorous clinical trials. Beneficial effects are reported, the evidence however is not compelling. More rigorous clinical trials assessing larger patient samples over longer intervention periods are needed to establish whether ALE is an effective and safe treatment option for patients with hypercholesterolaemia, it concluded.

According to the World Health Organisation, almost one fifth (18 per cent) of global stroke events (mostly nonfatal events) and about 56 per cent of global heart disease are attributable to total cholesterol levels above 3.2 mmol/l. This amounts to about 4.4 million deaths (7.9 per cent of the total) and 2.8 per cent of the global disease burden.

Walker and colleagues are recruiting healthy people with raised cholesterol to take part in a 12-week study on the plant extract.

 
 
 
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