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Recent News and Articles on the Keywords: cystic fibrosis + help treat + turmeric  Related to the article below (Last Update: 7/1/2008)


The Plain Dealer - cleveland.com
Spices delivering more quality to life
The Plain Dealer - cleveland.com, OH - Jun 9, 2008
Turmeric: Its active ingredient is curcumin, used in traditional medicine to treat ailments from gallstones to anemia, to heal wounds and treat arthritis. ...
Source: Google News

Rescue of ?F508-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) by Curcumin: Involvement … -
J Lipecka, C Norez, N Bensalem, M Baudouin-Legros, … - Journal of Pharmacology and Experimental Therapeutics, 2006 - ASPET
... the cftr gene product, the Cystic Fibrosis Transmembrane Conductance ... a condiment
and spice, turmeric has been ... traditional Oriental medicine to treat a number ...

Some like it hot: curcumin and CFTR -
PB Davis, ML Drumm - Trends in Molecular Medicine, 2004 - Elsevier
... and function, and its rescue in cystic fibrosis (CF). ... a herbal therapy that is used
to treat cancer and ... conditions, is derived from the spice turmeric and has ...

The spice of life for cystic fibrosis -
NM Croft - Gastroenterology, 2004 - Elsevier
... This report might help us to communicate again. ... on the function of the cystic fibrosis
transmembrane regulator ... includes groups of drugs that treat the effects ...
-

The epithelium as a target for therapy in cystic fibrosis -
WR Thelin, RC Boucher - Current Opinion in Pharmacology, 2007 - Elsevier
... a viable therapeutic strategy with which to treat CF ... to move into clinical trials
(Cystic Fibrosis Foundation: http ... a component of the spice turmeric, could also ...

Rescue of ?F508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by … -
F Van Goor, KS Straley, D Cao, J Gonzalez, S … - American Journal of Physiology- Lung Cellular and Molecular …, 2006 - Am Physiological Soc
... Rescue of F508-CFTR trafficking and gating in human cystic fibrosis airway
primary cultures by small molecules. Fredrick Van Goor ...

New pulmonary therapies for cystic fibrosis. -
F Ratjen - Current Opinion in Pulmonary Medicine, 2007 - co-pulmonarymedicine.com
... the end of 2007 and will help to clarify ... and change the way we treat cystic fibrosis
lung disease ... Evidence of CFTR function in cystic fibrosis after systemic ...

[CITATION] Correction of the CF defect by curcumin: hypes and disappointments -
M Mall, K Kunzelmann - BioEssays, 2005 - John Wiley and Sons, Inc New York, USA
... Since curcumin treat- ment failed to correct abnormal ... the DF508 protein and help
it escape ... just another panacea treatment for cystic fibrosis, which ultimately ...

Advances in cystic fibrosis therapies. -
SM Rowe, JP Clancy - Current Opinion in Pediatrics, 2006 - co-pediatrics.com
... This review describes recent developments in cystic fibrosis pulmonary therapies
intended to treat various facets of the disease, including several treatments ...

Chronic Pseudomonas aeruginosa infection in cystic fibrosis airway -
SS Yoon, DJ Hassett - Expert Rev. Anti-infect. Ther, 2004 - Future Drugs
... infection in cystic fibrosis airway disease: metabolic changes that ... Page 3. Pseudomonus
aeruginosa infection in cystic fibrosis www.future-drugs.com 613 ...

Recent Advances in Cystic Fibrosis -
LA Whittaker, JR Curtis - chestnet.org
... to CF affects the cystic fibrosis transmembrane conductance ... a component of the spice
turmeric, to accomplish ... antibiotics are used to treat bacterial infection ...

Source: Google Scholar
 
 

Turmeric could help treat cystic fibrosis

A compound in the curry spice turmeric appears to correct the cystic fibrosis defect in mice, report Canadian scientists today, demonstrating the potential for treating the disease in humans.

 
The study is the latest to highlight the medicinal value of curcumin, which gives turmeric, or Curcuma longa , its yellow colour and bright taste.

Previous trials suggest that the spice could prevent the onset of alcoholic liver disease, may slow down the blood cancer multiple myeloma and multiple sclerosis, and could be an inexpensive, well-tolerated, treatment for inflammatory bowel disease.

While the current trial, and most of the earlier studies, only tested cells in a lab, researchers believe that there is enough evidence to progress to a human clinical trial.

Cystic fibrosis is a fatal genetic disease affecting around 30,000 people in the US and another 30,000 around the world. One person in 25 carries the defective gene that causes the disease in which thick mucous clogs the lungs and the pancreas due to problems with the secretion of ions and fluid by cells of the airways and gastrointestinal tract. Normal secretion depends upon the function of a protein called CFTR (cystic fibrosis transmembrane conductance regulator), which was discovered at the Toronto-based Hospital for Sick Children in 1989.

Mutations in the gene encoding CFTR are responsible for cystic fibrosis. In the most common form of cystic fibrosis, the CFTR protein is trapped inside the cell, and is therefore unable to carry out its proper function at the cell surface.

Marie Egan and Michael Caplan from Yale University School of Medicine, and Gergely Lukacs from Sick Kids report in today's issue of Science (pp600-602) that curcumin treatment in a mouse model can release the mutant CFTR protein from this inappropriate compartment inside the cell and allow it to reach its proper destination, where it is able to function.

"We were able to prove at the cellular level what the Yale group observed in the mouse model of the disease," said Dr Lukacs. "After having received curcumin treatment, mice with the genetic defect that causes CF survived at a rate almost equal to normal mice. The CFTR protein also functioned normally in the cells lining the nose and rectum, which are areas of the body affected by cystic fibrosis."

Dr Caplan added: "In the next phase of this research, we will work to determine precisely how curcumin is achieving these effects and to optimize its potential as a possible drug."

Cystic Fibrosis Foundation Therapeutics, the nonprofit drug discovery and development affiliate of the Cystic Fibrosis Foundation charity, is currently working with Seer Pharmaceuticals on a Phase I clinical trial of curcumin to assess safety and dosage parameters in humans.

The trial will be conducted in four to six sites and will include approximately 25 patients.

 
 
 
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