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Recent News and Articles on the Keywords: human trials + alzheimer's prevention + curcumin  Related to the article below (Last Update: 7/1/2008)

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Source: Google News

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic … -
GP Lim, T Chu, F Yang, W Beech, SA Frautschy, GM … - Journal of Neuroscience, 2001 - neuroscience.org
... This model, which carries a human familial AD ... a promising agent for controlled clinical
trials to establish ... prevention or treatment of Alzheimer's and possibly ...

[CITATION] NSAID and Antioxidant Prevention of Alzheimer's Disease: Lessons from In Vitro and Animal Models -
GM COLE, T MORIHARA, GP LIM, F YANG, A BEGUM, SA … - Annals of the New York Academy of Sciences, 2004 - Blackwell Synergy
... oxidative damage can induce BACE1 in human neuronal NT2 ... by our colleagues at the
UCLA Alzheimer Center (Drs ... Clinical trials are the final judge and jury for any ...

Antioxidant strategies for Alzheimer's disease -
M Grundman, P Delaney - Proc Nutr Soc, 2002 - ingentaconnect.com
... the brains of patients with Alzheimer?s disease ... of these agents for AD prevention
and treatment ... will remain so until properly designed human trials have been ...

A Potential Role of the Curry Spice Curcumin in Alzheimer?s Disease -
JM Ringman, SA Frautschy, GM Cole, DL Masterman, … - Current Alzheimer research, 2005 - pubmedcentral.nih.gov
... key processes involved in the pathogenesis of Alzheimer?s disease ... in the prevention
and treatment of human AD ... At least one clinical trial suggested a possible ...

Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions -
GM Cole, GP Lim, F Yang, B Teter, A Begum, Q Ma, … - Neurobiology of Aging, 2005 - Elsevier
... in AD pathogenesis, curcumin is now in clinical trials in mild ... an FDA approved IND
by the UCLA Alzheimer Center. ... AD pathogenesis in mice with a human AD gene ...

A rationale for curcuminoids for the prevention or treatment of Alzheimer's disease
GM Cole, F Yang, GP Lim, JL Cummings, DL Masterman … - Curr. Med. Chem-Immun. Endoc. Metab. Agents, 2003 - ingentaconnect.com
... Like heart disease, Alzheimer's Disease (AD) is a chronic ... inhibition, limits their
widespread use for AD prevention. ... In short term human trials, 500 mg per day ...

Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease … -
RW Stackman, F Eckenstein, B Frei, D Kulhanek, J … - Experimental Neurology, 2003 - Elsevier
... Alzheimer's disease (AD) is characterized clinically by cognitive ... trained for 16
trials (4 trials/day) in ... Ginkgo biloba has benefits for human subjects with AD ...

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's … -
L Baum - Journal of Alzheimer's Disease, 2004 - IOS Press
... Keywords: Curcumin, desferrioxamine, copper, iron, zinc, metal, Alzheimer?s disease,
AD ... and it has slowed AD progression in a human clinical trial [17 ...

Curcumin, A Multi-Functional Chemopreventive Agent, Blocks Growth of Colon Cancer Cells by Targeting … -
S Narayan - Journal of Molecular Histology, 2004 - Springer
... effective approach for colon cancer prevention and is ... by inhibiting hyaluronidase
activity) to Alzheimer?s disease ... least six phase I human trials showing the ...

Polymeric nanoparticle-encapsulated curcumin (?nanocurcumin?): a novel strategy for human cancer … -
S Bisht, G Feldmann, S Soni, R Ravi, C Karikar, A … - Journal of Nanobiotechnology, 2007 - jnanobiotechnology.com
... as well as other human maladies like Alzheimer disease [48 ... Phase I clinical trial
of curcumin ... and IL-6-inducible STAT3 phosphorylation in human multiple myeloma ...

Source: Google Scholar
 
 

Curcumin under human trials for Alzheimer's prevention

Curcumin, the yellow pigment in curry spice, is to be investigated for its potential in prevention of Alzheimer’s disease after tests on mice found it to be more effective than drugs currently being investigated for treatment.

 
A dietary staple of India, where Alzheimer's disease rates are reportedly among the world's lowest, curcumin appears to block and break up brain plaques that cause the disease.

The spice has also been found to correct the cystic fibrosis defect in mice, prevent the onset of alcoholic liver disease and may slow down the blood cancer multiple myeloma as well as multiple sclerosis.

Reporting in the 7 December online edition of the Journal of Biological Chemistry, researchers from the University of California Los Angeles also revealed that curcumin is more effective in inhibiting formation of the protein fragments than many other drugs being tested as Alzheimer's treatments.

The researchers found the low molecular weight and polar structure of curcumin allow it to penetrate the blood-brain barrier effectively and bind to beta amyloid (which form the disease-causing plaques).

In earlier studies published during 2001, the same research team found curcumin has powerful antioxidant and anti-inflammatory properties, which scientists believe help ease Alzheimer's symptoms caused by oxidation and inflammation.

The body of research has prompted the UCLA Alzheimer's Disease Research Center (ADRC) to begin human clinical trials to further evaluate its protective and therapeutic effects.

"The prospect of finding a safe and effective new approach to both prevention and treatment of Alzheimer's disease is tremendously exciting," said principal investigator Gregory Cole, professor of medicine and neurology at the David Geffen School of Medicine at UCLA and associate director of the UCLA Alzheimer's Disease Research Center.

"Curcumin has been used for thousands of years as a safe anti-inflammatory in a variety of ailments as part of Indian traditional medicine," Cole added.

"Recent successful studies in animal models support a growing interest in its possible use for diseases of ageing involving oxidative damage and inflammation like Alzheimer's, cancer and heart disease. What we really need, however, are clinical trials to establish safe and effective doses in aging patients."

Alzheimer's disease is the most common form of dementing illness among middle and older adults, affecting more than 4 million Americans and many millions worldwide. The prevalence of Alzheimer's among adults aged 70-79 in India, however, is 4.4 times less than the rate in the United States.

 
 
 
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