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Recent News and Articles on the Keywords: liver cancer + target probiotic + probiotics  Related to the article below (Last Update: 7/8/2008)

Primovist Approved in the US for the Detection and ...
PharmaLive.com (press release), PA -
"Bayer is now in the unique position of offering Primovist for diagnosing patients with liver cancer and Nexavar for treating hepatocellular carcinoma - the ...
FDA Approves EOVIST(R) to Detect and Characterize Focal Liver Lesions SunHerald.com
Bayer says FDA approves Primovist agent for detection of liver ... Interactive Investor
Bayer's liver agent approved by FDA Hays Pharma
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More accurate prognosis for liver cancer victims
The Standard, Hong Kong - Jul 7, 2008
A new method of prognosis may pinpoint the life expectancy of advanced primary liver cancer patients with up to 80 percent accuracy, its developers claim. ...
I just couldn't believe it when I heard the word 'cancer' again
Irish Independent, Ireland -
Liver cancer has one of the lowest survival rates out of all cancers, largely because it's usually diagnosed once it's past its early stages. ...
A boy's life (AUDIO)
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Patient deserves the money
Toronto Star,  Canada - Jul 7, 2008
Adolfo Flora was diagnosed with liver cancer in 1999, having contracted cirrhosis from a tainted blood transfusion in 1973, resulting in this cancer. ...
Study: drinking coffee lowers liver cancer risk
Tehran Times, Iran - Jun 30, 2008
BEIJING (Xinhuanet) -- Coffee drinkers may be at less risk of liver cancer -- the third most common cause of cancer deaths worldwide -- based on a ...
Watchdog: GP's care of pensioner inadequate
New Zealand Herald, New Zealand -
Advanced cancer was found in her liver in July 2003 and she died two months later, aged 80. The primary site of the cancer was never found. ...
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Inventorspot
Drink Up! More Coffee May Lower Risk For Liver Cancer
Inventorspot - Jul 4, 2008
Researchers have found that drinking more coffee may decrease your risk of liver cancer. Researchers at the University of Helsinki have found that drinking ...
Cancer Nanotech: Government Spending Done Right
Wired News -
When I reported yesterday on drug-infused nanoparticles that stopped mouse liver and kidney cancers from spreading, some commenters why I was still covering ...
Coffee seems to protect against liver cancer, study reveals
CBC.ca, Canada - Jun 26, 2008
The more coffee a person drinks, the lower their risk of developing liver cancer, suggests a large study. University of Helsinki researchers found that ...
Source: Google News

Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics -
GR Gibson, MB Roberfroid - Journal of Nutrition, 1995 - Am Soc Nutrition
... Diarrhea/constipation Infections Liver damage Cancer Encephalopathy ... The prebiotics
must directly target the colon, have a selective fermentation and ...

Selection criteria for probiotic microorganisms -
PL Conway - Asia Pacific J. Clin. Nutr, 1996 - elecpress.monash.edu.au
... characterised, able to survive the rigours of the digestive tract and possibly colonise,
biologically active against the target as well as ... Liver damage. ... Cancer. ...
-

Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic … -
A Takagi, T Matsuzaki, M Sato, K Nomoto, M … - Carcinogenesis, 2001 - Oxford Univ Press
... 44.Storkus,WJ and Dawson,JR (1991) Target structures involved in natural ... Cancer Lett.,
61, 177?183. ... of mutations in Ki-ras and INK4a in liver tumors of mice ...

Probiotics and colon cancer -
J Rafter - Best Practice & Research Clinical Gastroenterology, 2003 - Elsevier
... glucuronide formation in the liver before entering ... possible that different strains
target different mechanisms. ... lactic cultures for human cancer suppression is ...

Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus … -
K KAILASAPATHY, J CHIN - Immunology & Cell Biology, 2000 - pt.wkhealth.com
... and biologically active against the identified target. ... 42 Bifidobacterium longum
inhibits liver tumours in ... increasing potential for cancer chemoprevention.44. ...

The Role of Probiotic Cultures in the Control of Gastrointestinal Health 1 -
RD Rolfe - Journal of Nutrition, 2000 - Am Soc Nutrition
... microorganisms are usually required at the target site in ... However, in patients with
liver failure, the blood ... leads to a reduced incidence of cancer is unknown. ...

Probiotics and colon cancer prevention -
GH McIntosh - Asia Pacific J. Clin. Nutr, 1996 - elecpress.monash.edu.au
... They have a significant target, gastrointestinal disturbances and ... or one third the
colon cancer incidence and ... a direct inhibitory effect on liver tumours in ...
-

Probiotics: Considerations for Human Health -
ME Sanders - Nutrition Reviews, 2003 - ingentaconnect.com
... play a role in the genesis of colon cancer. ... Human Subjects for Probiotic Studies
Target Proposed Mechanisms ... Endotoxemia associated with alcoholic liver disease ...

New Scientific Paradigms for Probiotics and Prebiotics. -
G Reid, ME Sanders, HR Gaskins, GR Gibson, A … - Journal of Clinical Gastroenterology, 2003 - jcge.com
... infections such as endocarditis, septicemia, or liver abscess ... need not be confined
to colorectal cancer, and indeed ... the normal flora of the target region using ...

Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene … -
DR Mack, S Michail, S Wei, L McDougall, MA … - American Journal of Physiology- Gastrointestinal and Liver …, 1999 - Am Physiological Soc
Am J Physiol Gastrointest Liver Physiol 276: G941-G950 ... to a nonintestinal epithelial
cell target (HEp-2 ... expression in human normal intestine and colon cancer. ...

Source: Google Scholar
 
 

Probiotics could target causes of liver cancer

A daily supplement of probiotics could reduce the risk of liver cancer caused by fungal toxins in foods, a leading cause of the disease in some of the world’s most populous countries.
 
“Probiotic-based food products may be an effective dietary prevention that could be implemented in many regions of the world to prevent the development of liver cancer or other environmentally induced cancers,” wrote the researchers in The American Journal of Clinical Nutrition (Vol. 83, pp. 1199-1203).

Liver cancer is the sixth most commonly diagnosed cancer in the world, and third most common cause of death from cancer, according to Cancer Research UK. Despite these figures, the cancer remains relatively rare, with 18,500 new cases in the US every year, and about 3,000 in the UK.

The highest incidences of the disease are in east and Southeast Asia, particularly China, and for this reason the current researchers looked at the effects of probiotic supplements on markers for the disease.

The biggest risk factor for the disease is said to be chronic hepatitis B virus infection, but consumption of foods contaminated with aflatoxins are also established causes of liver cancer.

The researchers, led by Hannu Mykkänen from the University of Kuopio and supported by grants from the Academy of Finland and Valio, selected 90 male students from the Guangdong province where food ingested exposure to aflotoxins is said to be common.

The double-blind, placebo-controlled trial with two parallel groups randomly assigned the volunteers to either the intervention group – two probiotic capsules per day containing a mixture of the strains Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii ssp. shermanii, (Valio's commercial Bioprofit product), or placebo (cellulose).

The strains were present in equal weight concentrations with a dose of 2-5 x1010 colony-forming units per day.

At the start of the intervention period, both groups had similar urine concentrations of AFB-N7-guanine, a metabolite of aflotoxin M1.

“Probiotic administration led to a statistically significant decrease in the level of urinary excretion of AFB-N7-guanine. The reduction was 36 per cent at week three and 55 per cent at week five, but disappeared during the five-week post-intervention period,” wrote lead author Hani El-Nezami.

The reduction in excretion levels of the aflotoxin metabolite indicates that the concentration within the body of carcinogens was decreasing.

“The results of the present probiotic intervention are encouraging for additionally studies on an approach of probiotic use that can beneficially influence the toxicokinetics of unavoidable exposures to aflotoxins and other natural and environmental carcinogens,” concluded the researchers.

 
 
 
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