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Recent News and Articles on the Keywords: gum + guar + inflammation  Related to the article below (Last Update: 8/5/2008)


Daily Mail
It's NOT all hokum! A new book reveals which herbal remedies work ...
Daily Mail, UK -
BENEFICIAL: Two remedies shown to help are guar gum, which comes from the Indian cluster bean, and the herb psyllium. Both are sources of soluble fibre, ...
Source: Google News

Studies of Guar Gum Compression-Coated 5-Aminosalicylic Acid Tablets for Colon-Specific Drug … -
YSR Krishnaiah, S Satyanarayana, YVR Prasad - Drug Development and Industrial Pharmacy, 1999 - informaworld.com
... Inflammation of the colon is usually treated topically by enema administration ... sulfate
(16), amylose (17), inulinHP (18), chitosan (19,20), and guar gum (21?25 ...

Potential of Guar Gum Microspheres for Target Specific Drug Release to Colon -
MK Chourasia, SK Jain - Journal of Drug Targeting, 2004 - ingentaconnect.com
... YSR and Satyanarayana, S. (1998) ?In vitro evaluation of guar gum as a ... lated cellulosic
cores: evaluation of the efficacy against colonic inflammation in rats ...

Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome -
EG Giannini, C Mansi, P Dulbecco, V Savarino - Nutrition, 2006 - Elsevier
... of peripheral stimuli, and non-specific psychological disturbances [5]. Recently,
subclinical inflammation of the enteric ... PHGG, partially hydrolyzed guar gum. ...

Partially hydrolyzed guar gum down-regulates colonic inflammatory response in dextran sulfate sodium … -
Y Naito, T Takagi, K Katada, K Uchiyama, M Kuroda, … - The Journal of Nutritional Biochemistry, 2006 - Elsevier
... by a controlled partial enzymatic hydrolysis of guar gum beans, has ... Colonic mucosal
inflammation was evaluated clinically, biochemically and histologically. ...

Nasal Inflammation in Patients With Obstructive Sleep Apnea. -
I Rubinstein - The Laryngoscope, 1995 - laryngoscope.com
... We suggest that nasal inflammation plays a role in up- per airway obstruction in ...
Ob- structive Sleep Apnea Caused by Occupational Exposure to Guar Gum Dust. ...

A fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative modification of LDL induced … -
N Venkatesan, SN Devaraj, H Devaraj - Molecular and Cellular Biochemistry, 2007 - Springer
Page 1. A fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative
modification of LDL induced by an atherogenic diet in rats ...

Inflammation in the Uvula Mucosa of Patients With Obstructive Sleep Apnea. -
M Sekosan, M Zakkar, BL Wenig, CO Olopade, I … - The Laryngoscope, 1996 - laryngoscope.com
... Rubinstein I. Nasal inflammation in patients with obstructive sleep apnea ... V. Reversible
obstructive sleep apnea caused by occupational exposure to guar gum dust ...

Partially Hydrolyzed Guar Gum Attenuates the Severity of Pouchitis in a Rat Model of Ileal J Pouch- …
K Atila, C Terzi, AE Canda, ST Akhisaroglu, HS … - Dig Dis Sci, 2008 - ncbi.nlm.nih.gov
... 2002]; Partially hydrolyzed guar gum down-regulates colonic inflammatory response
in ... 1 receptor antagonist reduces an ongoing ileal pouch inflammation and the ...

[PDF] The use of Partially Hydrolyzed Guar Gum (PHGG)-containing formulas in the treatment of Inflammatory … -
AM DE LA TORRE, BDEM SILLERAS - Rivista Italiana di Nutrizione Parenterale ed Enterale/Anno - wichtig.it
... Dietary fiber, Partially Hydrolyzed Guar Gum (PHGG), Short ... alimentare, Gomma di Guar
parzialmente idrolizzata ... diseases present with inflammation and ulceration ...

AQUEOUS BASE LIQUID PHARMACEUTICAL COMPOSITIONS IN SUSPENSION FORM FOR THE ORAL ADMINISTRATION OF … -
RANA JIMENEZ, AL BERGES - EP Patent 1,452,169, 2004 - freepatentsonline.com
... for the treatment of joint pain, inflammation, fever, swelling from ... hydroxiethyl
cellulose, hydroxypropyl methylcellulose, xanthan gum, guar gum, tragacanth gum ...
-

Source: Google Scholar
 
 

Guar gum derivative could reduce gut inflammation

Increasing intake of foods with a functional partially hydrolysed guar gum (PHGG) ingredient could reduce gut inflammation by over 20 per cent, according to a Japanese study with mice.
 
Guar gum,, a water-soluble dietary fibre, is obtained from the seeds of the guar plant found on the Indian sub-continent and the US. Because of its high viscosity, the gum can be hydrolysed so that it can be used in quantities that infer a physiological effect, and is widely used in this form in beverages.

The new study, published in the Journal of Nutritional Biochemistry (Vol. 17, pp. 402-409) looked at the effects of a PHGG supplement to the diet of female mice with inflamed colons.

The researchers, led by Yoji Naito from the Kyoto Prefectural University of Medicine in Japan, added dextran sulphate sodium (DSS) to the drinking water of nine-week old mice to induce colitis. The mice were then divided into two groups – a control group, and atest group with the control diet supplemented with 5, 10, or 15 per cent PHGG (SunFiber, provided by Taiyo Kaguku).

After three weeks the scientists found that DSS ingestion had resulted in a shortening of the colon length in both control and test groups. However mice supplemented with PHGG had 15 per cent longer colons than the control mice.

Levels of the inflammatory marker, TNF-alpha, were also significantly reduced in the test group, compared to the control group. Supplementation with 5 per cent PHGG reduced TNF-alpha levels by 23 per cent. No significant difference was observed between the supplementation doses so the researchers concentrated their observations to the lowest dose group.

“Inhibition of TNF-alpha by PHGG-supplemented diet was accompanied by significant suppression of intestinal inflammation in vivo,” wrote Naito.

“These data suggest that oral administration of PHGG may be an additional therapeutic strategy for inflammatory bowel disease,” concluded the researchers.

The researchers said the further studies were needed to elucidate the underlying mechanism, but noted that previous suggestions of increased levels of Bacteroides in the gut were not observed in this study – other studies had identified PHGG as a prebiotic, boosting beneficial intestinal microflora populations.

In Europe and Japan, soluble fibre has the greater market share than insoluble. In the US, where the entire fibre market was worth $192.8m (€m) in 2004, insoluble fibre dominates the market with $176.2m (€m), and $16.6m (€m) soluble.

But while Frost and Sullivan predicts overall growth in the US to $470m (€m) by 2011, the soluble fibre sector is expected to increase by almost twice the compound annual growth rate (CAGR) compared to insoluble fibre – 26.3 per cent compared to 13.1 per cent.

 
 
 
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