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Recent News and Articles on the Keywords: sodium nitrite + heart attack + attack  Related to the article below (Last Update: 7/1/2008)

High input costs hit chemical industry
Sify, India - Jun 7, 2008
Consider this: Sodium nitrite which was being sold at Rs 26 per kg in April, is Rs 40 per kg now. Sulphuric acid was Rs 3 per kg six months back, ...
Spam a lot
San Diego CityBEAT, CA - Jun 3, 2008
Spam is made of the shoulders and legs of dead pigs, ground up and mixed together with salt, sugar, water and sodium nitrite. It?s packed in a gelatinous ...
A new and better hot dog?
HeraldNet, WA - Jun 12, 2008
... flavor, sodium lactate, corn syrup, sodium phosphates, dextrose, sodium diacetate, sodium erythorbate and sodium nitrite. Hallmark moment: A Washington, ...
Get a clear answer on what's in your water
Grand Traverse Herald, MI - Jun 24, 2008
The partial chemistry test conducted by the Health Department will give the iron content along with nitrate, nitrite, hardness, sulfate, chloride, sodium ...
So it?s come down to this ? SPAM
Buffalo News,  United States - Jun 4, 2008
The SPAM ?Classic? combination of ham, pork, sugar, salt, water, modified potato starch and sodium nitrite has become sort of a national institution by now, ...
TABLE-India Chemicals Prices - Delhi - Jun 9
Reuters India, India - Jun 9, 2008
... 300-350 Soda Hydro Sulphate (one kg) 90-100 90-100 Boric Acid technical 4500-4600 4500-4600 Borax Granular 1400-1500 1400-1500 Sodium Nitrite 2000-2500 ...
Full of bologna
Schenectady Gazette, NY - Jun 17, 2008
... some sugar and salt and pepper and other spices, and of course some chemicals like good old sodium nitrite to keep it from spoiling too quickly. ...
Spam: The Ultimate Survivor
AdAge.com (subscription) - Jun 15, 2008
By Matthew Creamer NEW YORK (AdAge.com) -- By all rights, something should have happened to Spam the brand that a dose of sodium nitrite prevents from ...
Beeler Pork launches gluten free pork products
PigProgress.net, Netherlands - Jun 19, 2008
Heluka products are made without adding artificial ingredients or preservatives, including msg, sodium nitrites or nitrates, phosphates, glutens or binders. ...
Causitc Soda prices move higher in India...
Chemical Explorer (subscription), India - Jun 2, 2008
... ash (50 kg) (Birla) 940 Sodium Nitrite (50 kg) 1400-1550 Sodium silicate (Qtl) 950-1100 stable bleaching powder (shriram) (25 kg) 320 stable bleaching ...
Source: Google News

[CITATION] A Short History Of Nitroglycerine And Nitric Oxide In Pharmacology And Physiology -
N Marsh, A Marsh - Clinical and Experimental Pharmacology and Physiology, 2000 - Blackwell Synergy
... the time of returning to work: the 'Sunday Heart Attack' 30 (RC ... Other experimenters
produced equally spectacular effects with sodium nitrite, for example, the ...

[PDF] Recent chemical studies of sodium nitroprusside relevant to its hypotensive action
AR Butler, C Glidewell - Chemical Society Reviews, 1987 - xlink.rsc.org
... failure conditions.' '-- Sodium nitroprusside is thus an effective drug for the
treatment of two conditions, high blood pressure and heart attack, which are ...

The physiological role of nitric oxide -
AR Butler, DLH Williams - Chemical Society Reviews, 1993 - rsc.org
... a major blood vessel coming direct from the heart) and found ... formed by way of free
radical attack by NO ... and a reducing agent or from sodium nitrite and nitric ...

[CITATION] Fos expression in the midbrain periaqueductal grey after trigeminovascular stimulation -
KL HOSKIN, DCE BULMER, M LASALANDRA, A JONKMAN, PJ … - Journal of Anatomy, 2001 - Blackwell Synergy
... including recur- rence after acute attack treatment (Ferrari ... Blood pressure and heart
rate were stable and ... 1000 IU heparin and 1% sodium nitrite) followed by 2 ...

Chronic exercise and cardiac vascularization -
GD Tharp, CT Wagner - European Journal of Applied Physiology, 1982 - Springer
... of ischemia such as occurs during a heart attack. ... and capillaries of the heart, heart
chambers and ... Inc.) and Locke's solution containing 0.02% sodium nitrite. ...

The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning -
SI Baskin, AM Horowitz, EW Nealley - The Journal of Clinical Pharmacology, 1992 - jcp.sagepub.com
... sions, and unconsciousness, that could result in death may be alleviated by sodium
nitrite and so- ... gans have been proposed to be the brain and heart; ...

Dihydrolipoic acid protects pancreatic islet cells from inflammatory attack -
V Burkart, T Koike, HH Brenner, Y Imai, H Kolb - Inflammation Research, 1993 - Springer
... dihydrolipoic acid suppressed the production of nitrite as a ... of homogenates of rat
liver and heart to lipid ... 1 (Serva GmbH, Heidelberg, FRG), sodium pyruvate 1 ...

[CITATION] Urinary nitric oxide metabolites and lipid peroxidation by-products in migraine -
I Ciancarelli, M Tozzi-Ciancarelli, C Di Massimo, … - Cephalalgia, 2003 - Blackwell Synergy
... with known concentrations of sodium nitrite (excitation wavelength ... Srimal RC, Dikshit
M. Blood nitrite levels in ... 2007) Migraine and ischaemic heart disease and ...

[PDF] Chemical agent terrorism -
FR Sidell - Ann Emerg Med, 1996 - rke.vaems.org
... Sodium nitrite and sodium thiosulfate, both ... produces many effects similar to those
of atropine, such as mydriasis, drying of secretions, heart rate changes ...
-

Medication News
M Mayhew - Journal for Nurse Practitioners, 2005 - Elsevier
... On April 14, 2005, the study ?Sodium Nitrite for Heart Attack and Organ Damage?
was released by the National Heart, Lung and Blood Institute (NHLBI). ...

Source: Google Scholar
 
 

Sodium Nitrite might be used to protect tissue after heart attack

 
 
Sodium Nitrite, a naturally occurring chemical and common meat preservative, is only used medically to treat cyanide poisoning. But if the results of a new animal study hold up under further research in people, the chemical may one day be used to protect and preserve tissue and organ function after heart attack, high risk abdominal surgery, and organ transplantation.

The new study was conducted by scientists with the National Heart, Lung, and Blood Institute ( NHLBI ) of the National Institutes of Health ( NIH ) in collaboration with investigators supported by the National Institute of Diabetes and Digestive and Kidney Diseases at Louisiana State University Health Sciences Center and published in The Journal of Clinical Investigation.

The scientists found that low concentrations of Sodium Nitrite had a strong protective effect — preventing cell death in the hearts and livers of mice undergoing experimental heart attack and liver injury. In the heart study, nitrite reduced the size of the area of dead tissue known as an infarct by 67 percent compared to control animals given nitrate, another nitrogen compound. This potent protective effect was observed at concentrations of nitrite in blood that were only slightly higher than the physiological normal levels in blood.

The study, led by David Lefer, of Louisiana State University Health Sciences Center in Shreveport and Mark Gladwin, Head of the Vascular Therapeutics Section of the NHLBI’s Cardiovascular Branch, follows another study conducted by the NIH research team that found that infusions of sodium nitrite into the human circulation leads to the production of nitric oxide ( NO ), a strong blood vessel dilating molecule that increases blood flow. The conversion of nitrite to NO will occur only in tissue or blood that is very low in oxygen. It was this finding that triggered the team’s interest in sodium nitrite as a treatment / preventive for the tissue damage and cell death that can occur in conjunction with organ transplantation, heart attack, and treatment of a heart attack.

In both the liver and heart components of the current study, the research team compared the effects of both lower and higher concentrations of nitrite versus control treatments of saline or nitrate, a chemical compound that is related to nitrite but cannot convert to NO in the blood. Surprisingly, they found that only low concentrations of nitrite provided protection against injury.

The investigators are currently studying the mechanism for the protective effect of Sodium Nitrite and they believe it is related in some way to the conversion of nitrite to nitric oxide.

“ The remarkable thing about nitrite is that it is only converted to nitric oxide in the organs and tissues with the lowest oxygen levels, allowing for targeted NO delivery — and thus improved blood flow — to tissues under stress. More research is needed to look at the effectiveness of nitrite in various organs and disease states in humans, ” said NHLBI’s Gladwin who is also an investigator in the Critical Care Medicine Department, NIH Clinical Center.

Gladwin is currently studying the use of Sodium Nitrite as a way to help adults with sickle cell disease. It is hoped that this treatment will reverse the effect of decreased blood flow due to the patients’ “sickled” blood cells. Patients with sickle cell disease have abnormal hemoglobin molecules in their red blood cells. The molecules damage the red cells, causing them to change into a crescent or sickle shape and stick to blood vessel walls. This can lead to narrowed, or blocked, blood vessels leading to pain, damage, and anemia.

Further studies either underway or in planning translate the new findings to humans. These studies evaluate Sodium Nitrite’s effect on heart attacks, kidney failure, solid organ transplantation, cerebral vasospasm ( a complication of a ruptured aneurysm leading to reduced blood flow and possible stroke ), and high blood pressure in the lungs in babies.

Source: NIH, 2005
 
 
 
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