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Recent News and Articles on the Keywords: new + cystitis + interstitial  Related to the article below (Last Update: 8/5/2008)

There are a number of treatments for interstitial cystitis, writes ...
Irish Times, Ireland - Jul 28, 2008
Over time, my symptoms have increased and I have been told I have something called interstitial cystitis. Can you tell me what this is? ...
Defining The Urologic Chronic Pelvic Pain Syndromes: A New ...
Medical News Today (press release), UK - Jul 18, 2008
He discussed the classification of bladder pain syndrome put forth by the European Society for the Study of Interstitial Cystitis which classifies patients ...
Treatment Modalities, Health Care Resource Utilization, and Costs ...
UroToday, CA - Jul 28, 2008
Patient cohorts treated with some of the more common oral therapies for interstitial cystitis, including pentosan polysulfate sodium, amitriptyline, ...
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Edmond Sun, OK - Jul 21, 2008
Here?s the kicker ? I?ve been diagnosed with interstitial cystitis (my urologist?s words). My question for you; is it conceivable that this condition is ...
Lyme disease hits close to home
Kings County Record, Canada - Jul 28, 2008
... gastroesophageal reflux disease, interstitial cystitis (urinary bladder disease), chronic fatigue syndrome, early Alzheimer's disease and bi-polar ...
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Seeking Alpha, NY - Jul 29, 2008
We continue to make progress with Accessa, our neuromuscular stimulation device with application in interstitial cystitis and female urge incontinence. ...AMMD
NIDDK Publishes New Resources About Urologic And Kidney Disorders
Medical News Today (press release), UK -
What I need to know about Interstitial Cystitis/Painful Bladder Syndrome. What I need to know about My Child's Urinary Tract Infection. ...

University of Arizona News (press release)
Urologist Specializing in Female Pelvic Disorders Joins UA
University of Arizona News (press release), AZ - Jul 31, 2008
His research interests include incontinence treatment, urodynamics, interstitial cystitis and outcomes research in incontinence and pelvic reconstructive ...
Men sought for bladder research
Iowa City Press Citizen, IA - Jul 22, 2008
Men with a history of interstitial cystitis or prostate cancer are not eligible. The study will involve about five visits to University Hospitals over 13 ...
MediciNova to Present At the 4th Annual Collins Stewart Growth ...
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MediciNova's pipeline includes six clinical-stage compounds for the treatment of status asthmaticus, multiple sclerosis, asthma, interstitial cystitis, ...NJM:4875 - LON:CLST - MNOV
Source: Google News

… interstitial cystitis: previously unrecognized urologic and gynecologic cases identified using a new … -
CL Parsons, J Dell, EJ Stanford, M Bullen, BS Kahn … - Urology, 2002 - ncbi.nlm.nih.gov
... here to read Increased prevalence of interstitial cystitis: previously unrecognized
urologic and gynecologic cases identified using a new symptom questionnaire ...

Interstitial Cystitis: A Critique of Current Concepts With a New Proposal for Pathologic Diagnosis … -
A Elbadawi - The Journal of Urology, 1998 - Elsevier
... the advantages and disadvantages of the animal models, and the so-called standard
and new pathological conditions of interstitial cystitis, culminating in a ...

The Interstitial Cystitis Symptom Index and Problem Index -
MP O'Leary, GR Sant, FJ Fowler, KE Whitmore, J … - The Journal of Urology, 1998 - Elsevier
... Editorial Comment: New therapies continually become available for interstitial
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Interstitial Cystitis: Unexplained Associations With Other Chronic Disease and Pain Syndromes -
M Alagiri, S Chottiner, V Ratner, D Slade, PM … - The Journal of Urology, 1998 - Elsevier
... Hanno a a Department of Urology, Temple University School of Medicine, Philadelphia,
Pennsylvania and the Interstitial Cystitis Association, New York, New York ...

Epidemiology of Interstitial Cystitis -
CA Jones, L Nyberg - The Journal of Urology, 1998 - Elsevier
... was the lead article in a supplement to Urology entitled Interstitial Cystitis:
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… INTERSTITIAL CYSTITIS REVISITED: LESSONS LEARNED FROM THE NATIONAL INSTITUTES OF HEALTH INTERSTITIAL … -
PM HANNO, JR LANDIS, Y MATTHEWS-COOK, J KUSEK, L … - The Journal of Urology, 1999 - jurology.com
... Parsons, CL: New concepts in interstitial cystitis. ... Interstitial Cystitis and Chronic
Pelvic Pain: New Insights in Neuropathology, Diagnosis, and Treatment. ...

… ultrastructural pathology of nonulcerative interstitial cystitis: new observations and their … -
AE Elbadawi, JK Light - Urol Int, 1996 - ncbi.nlm.nih.gov
Distinctive ultrastructural pathology of nonulcerative interstitial cystitis: new
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Analysis of Long-Term Elmiron Therapy for Interstitial Cystitis -
PM Hanno - The Journal of Urology, 1998 - Elsevier
... Patients with diagnosed interstitial cystitis who met the study entry criteria received ...
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Mast cell involvement in interstitial cystitis: a review of human and experimental evidence. -
TC Theoharides, D Kempuraj, GR Sant - Urology, 2001 - ncbi.nlm.nih.gov
... Tufts University School of Medicine and New England Medical Center, Boston,
Massachusetts, USA. theoharis.theoharides@tufts.edu Interstitial cystitis (IC) is ...

New agents for the medical treatment of interstitial cystitis -
TC Theoharides, GR Sant - eid, 2001 - Expert Opinion
Page 1. Theoharides & Sant New agents for the medical treatment of interstitial
cystitis New agents for the medical treatment of interstitial cystitis ...

Source: Google Scholar
 
 

Interstitial cystitis biomarkers could lead to the first test and new therapies

 
 
Researchers at University of Pittsburgh have isolated two biomarkers for interstitial cystitis ( IC ).

According to the National Institute of Diabetes and Digestive and Kidney Diseases, 700,000 Americans have interstitial cystitis; 90 percent are women.
Interstitial cystitis is one of the chronic pelvic pain disorders, defined by recurring discomfort or pain in the bladder and surrounding pelvic region.
Symptoms vary and can include any combination of mild to severe pain, pressure and tenderness in the bladder and pelvic area; and an urgent and/or frequent need to urinate.
In interstitial cystitis, the bladder wall may become scarred or irritated, and pinpoint bleeding may appear on the bladder wall.

The discovery of these biomarkers could lead to a definitive test for interstitial cystitis and have the potential to lead to new therapies.

" Finding a marker for interstitial cystitis can not only make developing an early test, but it can lead to new targeted molecular therapies for the condition," said Fernando de Miguel, at University of Pittsburgh - School of Medicine.

In the first study, titled " Identification of Nuclear Proteins in the Chronic Cystitic Rat Model ", researchers used a proteomic approach to identify specific markers related to interstitial cystitis.
By comparing protein expression in the bladder tissue of two animal models of interstitial cystitis to expression in the tissue of a normal animal, the researchers found three nuclear proteins that were unique to the animals with interstitial cystitis .
Using protein mass fingerprinting, the proteins were identified as transgelin ( SM-22 ), ras suppressor protein ( RSU-1 ) and GAPDH.

In the second study, titled " Time-point Study of the Regulation of Nuclear Protein SM-22 ( Transgelin ) in the Rat Cystitis Model ",the researchers expanded their investigation into the expression of SM-22 in both normal and IC-model bladders.
The bladders were instilled with hydrochloric acid; tissue was analyzed at one, four, seven, 13 and 28 days after instillation. After day one and day four, there was a noticeable down-regulation of SM-22 in the IC-model bladders; by day 28, there was a reduction by 31 percent of the SM-22 in the diseased models.

The early down-regulation of SM-22, evident as early as day one, shows that the absence of SM-22 can potentially be used as an early diagnostic marker for interstitial cystitis.
Researchers plan to conduct more research into SM-22 to determine the protein's functional role, which could lead the way to future molecular-targeted therapies.

According to the National Institute of Diabetes and Digestive and Kidney Diseases, 700,000 Americans have interstitial cystitis; 90 percent are women.
Interstitial cystitis is one of the chronic pelvic pain disorders, defined by recurring discomfort or pain in the bladder and surrounding pelvic region.
Symptoms vary and can include any combination of mild to severe pain, pressure and tenderness in the bladder and pelvic area; and an urgent and/or frequent need to urinate.
In interstitial cystitis, the bladder wall may become scarred or irritated, and pinpoint bleeding may appear on the bladder wall.

Source: 100th Annual Meeting of the American Urological Association ( AUA ), 2005
 
 
 
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