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Recent News and Articles on the Keywords: corneal transplant + corneal transplants + rejection  Related to the article below (Last Update: 7/8/2008)

Dying for a transplant
Health24.com, South Africa - Jul 7, 2008
This, however includes cornea transplants, which means that there are currently roughly 1 500 people waiting for solid organ transplants, which include ...
Mother of 8 battles failing health, Medicaid
Atlanta Journal Constitution,  USA - Jun 11, 2008
Georgia Medicaid allows transplants of kidney, liver, bone marrow and cornea for adults, according to the rejection letter sent to Katz. ...
Five years later...
Tunica Times, MS - Jul 3, 2008
... corneas, and kidneys. The call came early in the afternoon, as Shawnee and his wife were returning home from his cardiologist?s office. The transplant ...

Business Wire (press release)
Lux Biosciences Names Brett Skolnik Chief Financial Officer
Business Wire (press release), CA - Jun 19, 2008
... as well as the LUCIDA pivotal clinical program with LX201 for the prevention of corneal transplant rejection were initiated in early 2007 and include ...

Business Wire (press release)
Jefferies 2nd Annual Healthcare Conference
Business Wire (press release), CA - Jun 18, 2008
... as well as the LUCIDA pivotal clinical program with LX201 for the prevention of corneal transplant rejection were initiated in early 2007 and include ...JEF
Source: Google News

Clinical types of corneal transplant rejection. Their manifestations, frequency, preoperative … -
OC Alldredge, JH Krachmer - Archives of Ophthalmology, 1981 - Am Med Assoc
... Clinical types of corneal transplant rejection. Their manifestations, frequency,
preoperative correlates, and treatment. OC Alldredge and JH Krachmer. ...

TOPICAL INTERLEUKIN 1 RECEPTOR ANTAGONIST PROMOTES CORNEAL TRANSPLANT SURVIVAL 1. -
MR Dana, J Yamada, JW Streilein - Transplantation, 1997 - transplantjournal.com
... of graft recipients whose transplants reject (2 ... costs associated with transplant
rejection, host immune ... cumulative problem of corneal transplant rejections is ...

Effect of factors unrelated to tissue matching on corneal transplant endothelial rejection. -
HM Boisjoly, PM Bernard, I Dube, PA Laughrea, R … - Am J Ophthalmol, 1989 - ncbi.nlm.nih.gov
... The variables studied included primary diagnosis, number of previous corneal
transplants, previous transplant failures from rejection episodes, transplant size ...

Differential Chemokine Gene Expression in Corneal Transplant Rejection -
S Yamagami, D Miyazaki, SJ Ono, MR Dana - Investigative Ophthalmology & Visual Science, 1999 - ARVO
... Differential Chemokine Gene Expression in Corneal Transplant Rejection. ... Orthotopic
mouse corneal transplantation was ... and syngeneic transplants (isografts) as ...

… of Microbial Keratitis, Peripheral Ulcerative Keratitis, and Corneal Transplant Rejection. -
MR Dana, Y Qian, P Hamrah - Cornea, 2000 - corneajrnl.com
... different from that developed in response to low-risk transplants? ... The process of
corneal transplant rejection can be conceptualized as being similar to the ...

Conclusions of the corneal transplant follow up study. -
A Vail, SM Gore, BA Bradley, DL Easty, CA Rogers, … - British Journal of Ophthalmology, 1997 - pt.wkhealth.com
... Armitage WJ, Nicholls S, et al. Negative effect of HLA-DR matching on corneal
transplant rejection. Transpl Proc 1995;27:1392-4. [Context ...

Corneal transplant allograft reaction: possible predisposing factors. -
JJ Arentsen - Transactions of the American Ophthalmological Society, 1983 - pubmedcentral.nih.gov
... rejection of epithelium in experimental corneal transplants. ... the corneal endothelium
during graft rejection. ... a probable sign of corneal transplant rejection. ...

Treatment of corneal transplant rejection in humans with anti-interferon-? antibodies -
S Skurkovich, A Kasparov, N Narbut, B Skurkovich - American Journal of Ophthalmology, 2002 - Elsevier
... All rights reserved. Brief report. Treatment of corneal transplant rejection
in humans with anti-interferon-? antibodies *1. Simon ...

A subconjunctival degradable implant for cyclosporine delivery in corneal transplant therapy -
A Apel, C Oh, R Chiu, B Saville, YL Cheng, D … - Current Eye Research, 1995 - informaworld.com
... used successfully for many years to prevent rejection of solid organ transplants. ...
corticosteroids, to reduce the rate of corneal transplant rejection in high ...

Corneal Lymphangiogenesis: Evidence, Mechanisms, and Implications for Corneal Transplant Immunology. -
C Cursiefen, L Chen, MR Dana, JW Streilein - Cornea, 2003 - corneajrnl.com
... dictating the outcome of corneal graft survival has recently been elucidated by
several articles (for reviews of immunobiology of transplant rejection, see refs ...

Source: Google Scholar
 
 

Allergies increase risk for corneal transplant rejection

 
 
Corneal transplant patients who suffer from eye allergies are at a significantly higher risk of transplant failure than those without allergies.

" We found that the immune system's response to corneal transplants was profoundly elevated in mice with allergic eye disease, resulting in the rejection of 100 percent of the corneal grafts. This was in sharp contrast to the 50 percent rejection rate that occurred in the mice without allergic eye disease, " said Jerry Niederkorn, University of Texas Southwestern Medical Center.

The immune system is programmed to react to organ transplants by producing a specific pattern of proteins that promote a destructive immune response, which culminates in graft rejection.
The immune system responds in a markedly different manner when confronted with allergens, producing an opposing pattern of proteins.

Proteins associated with allergic responses are known to inhibit immune cells and thus, were previously believed to prevent graft rejection.

In this study, published in Journal of Immunology, researchers applied ragweed pollen for several days to the right eyes of mice awaiting corneal transplantation, inducing allergic eye disease similar to that found in patients with ocular allergies.
Another group of mice served as a control group, and corneal grafts were rejected in 50 percent of them; however, all of the grafts were rejected in mice with ocular ragweed allergy.

The allergic mice also had a rejection rate twice as fast as the control group.

Researchers then performed additional experiments to determine if the increased graft rejection was simply due to the inflammation and irritation in the eye produced by the allergic response to ragweed pollen.
In these experiments, ragweed pollen was applied to the right eye of the mice but the cornea was transplanted to the left eye, which was free of local allergic responses. All of the corneal transplants were still rejected.

" These findings demonstrate that the presence of eye allergies can have a profound effect on the immune system that reaches beyond the local site of an allergic response, in this case, the eye," Niederkorn said. " The results offer hope for improving the success of corneal transplants in patients with allergic eye diseases. "

The study was funded by the National Institutes of Health and Research to Prevent Blindness.

Source: University of Texas Southwestern, 2005
 
 
 
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