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Recent News and Articles on the Keywords: breast cancer + may affect + risk  Related to the article below (Last Update: 5/12/2008)

TYKERB(R) (Lapatinib) to be Investigated in Landmark Early Breast ...
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By Ben Wasserman FRIDAY April 25, 2008 (foodconsumer.org) -- Bisphenol A may affect aggressiveness of breast cancer, according to a new study published in ...
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Source: Google News

The effect of raloxifene on risk of breast cancer in postmenopausal women -
SR Cummings, S Eckert, KA Krueger, D Grady, TJ … - feedback, 2005 - biomedcentral.com
... Any effect of raloxifene is therefore likely to represent suppression or regression
of subclinical cancer. Raloxifene may reduce the risk of breast cancer more ...

[PDF] Circulating concentrations of insulin-like growth factor-I and risk of breast cancer -
SE Hankinson, WC Willett, GA Colditz, DJ Hunter, … - Lancet, 1998 - mcgill.ca
... find out whether known risk factors for breast cancer are acting ... risk between
premenopausal and postmenopausal women may reflect an important effect of the ...
-

Physical Activity and the Risk of Breast Cancer -
I Thune, T Brenn, E Lund, M Gaard - New England Journal of Medicine, 1997 - content.nejm.org
... activity may affect hormonal concentrations and energy balance, we decided to
investigate whether everyday exercise is related to the risk of breast cancer. ...

Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers -
TR Rebbeck, AM Levin, A Eisen, C Snyder, P Watson, … - jnci, 1999 - jnci.oxfordjournals.org
... with menopause may also substantially affect quality of ... is some concern that this
therapy may be contraindicated ... if HRT increases the risk of breast cancer. ...

Effect of Hormone Replacement Therapy on Breast Cancer Risk: Estrogen Versus Estrogen Plus Progestin -
RK Ross, A Paganini-Hill, PC Wan, MC Pike - jnci, 2000 - jnci.oxfordjournals.org
... would argue that the adverse effect on the breast may outweigh the beneficial effect
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Endogenous Hormones and Breast Cancer Risk -
L Bernstein, RK Ross - Epidemiologic Reviews, 1993 - Soc Epidemiolc Res
... There is currently insufficient evidence to conclude that dietary fat may affect
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… of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk. -
HL Bradlow, DL Davis, G Lin, D Sepkovic, R Tiwari - Environmental Health Perspectives, 1995 - pubmedcentral.nih.gov
... Abstract. Xenobiotic estrogens are external compounds with estrogenic activity
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Breast Cancer Epidemiology -
JL Kelsey, GS Berkowitz - Cancer Research, 1988 - AACR
... have suggested that lactation may have an inde pendent protective effect against
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… and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk -
CB Ambrosone - Cancer Research, 1995 - AACR
... GSTM1 may affect the mutagenic potential of polycyclic aromatic hydrocarbons. We
examined polymorphisms in GSTM1 and CYP1A1 in relation to breast cancer risk. ...

Modification of BRCA1-Associated Breast Cancer Risk by the Polymorphic Androgen-Receptor CAG Repeat -
TR Rebbeck, PW Kantoff, K Krithivas, S Neuhausen, … - The American Journal of Human Genetics, 1999 - Elsevier
... these hypotheses was limited, and we cannot rule out the possibility that endocrine
or paracrine effects of androgens may affect breast cancer risk in BRCA1 ...

Source: Google Scholar
 
 

Birth weight and breastfeeding may affect breast cancer risk

 
 
A research found that premenopausal women who were heavier than average at birth or had not been breastfed as infants appear to be at increased risk for developing breast cancer.

Results of the study, carried out by epidemiologists at the University at Buffalo's School of Public Health and Health Professions, showed no association between birth weight and breastfeeding in infancy and postmenopausal breast-cancer risk.

" The intrauterine and neonatal life periods have been suggested as critical windows in mammary gland development, " said Maddalena Barba of UB Department of Social and Preventive Medicine and lead researcher on the study. " In utero and early childhood exposures might affect breast cancer risk by altering the hormonal environment of the developing fetus and young infant through mechanisms not yet completely clarified. "

Researchers analyzed data collected from 2,382 women participating in the Western New York Exposures and Breast Cancer Study conducted from 1996-2001 during in-person, computer-assisted interviews.
Complete information on the exposures of interest was available for 845 participants newly diagnosed with breast cancer during the study period who served as cases, and for 1,573 matched controls.

Researchers compared cases and controls, taking into consideration already well-recognized breast-cancer risk factors such as age, education, body-mass index, history of benign breast disease, family history of cancer, months of lactation, age at first menstrual period, age at first pregnancy, number of pregnancies and age at menopause for postmenopausal women.

Results showed that premenopausal women whose birth weight was greater than 8.5 pounds, and premenopausal women who had not been breast fed as infants, had an almost two-fold risk of developing breast cancer when compared to premenopausal women whose weight at birth was 5.5-7 pounds ( reference category ) and who had been breast fed.

None of these variables showed a relationship with postmenopausal breast cancer. Birth order was not associated with breast cancer risk in pre- or postmenopausal women.

" Our results support the hypothesis that early life events impact women's breast-cancer risk later in life, " said Barba. " Further research based on targeted studies is needed to reach a deeper understanding of the underlying biological mechanisms. "

The research was supported in part by grants from the U.S. Army and the American-Italian Cancer Foundation.

Source: University at Buffalo, 2005
 
 
 
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