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Recent News and Articles on the Keywords: pancreatic + cancer + disease  Related to the article below (Last Update: 8/5/2008)

YM BIOSCIENCES REPORTS PHASE II DATA FOR NIMOTUZUMAB IN METASTATIC ...
FOXBusiness -
... a Phase II/III trial as a treatment for pancreatic cancer and the phase II study in colorectal cancer reported on in this release. ...YMI - OTC:CMTX
City doc's in ?5m war on cancer
Liverpool Echo, UK -
He said: "Liverpool is outstanding internationally for biomedical research in pancreatic disease. "This award is highly significant for the pursuit of new ...
Public to pass judgment on Chester hospital parking charges ChesterChronicle.co.uk
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I Had the Same Disease. But I Was Lucky.
Washington Post, United States - Aug 2, 2008
Last March, Pausch testified before a congressional subcommittee about his struggle with pancreatic cancer. Holding up a picture of his soon-to-be-widowed ...
Sorting Out Coffee?s Contradictions
New York Times, United States -
Cancer. Panic swept this coffee-dependent nation in 1981 when a Harvard study tied the drink to a higher risk of pancreatic cancer. ...

ABC News
Vitamin C 'slows cancer growth'
BBC News, UK -
The vitamin may be reacting with cancer cell chemicals to make acid, they add. The jab halved the size of brain, ovarian and pancreatic tumours in mice, ...
Health: Research points to vitamin C role in fighting cancer guardian.co.uk
Vitamin C jabs 'trigger fightback against cancer' Daily Mail
High dose shot of vitamin C halts the spread of cancer News-Medical.net
UK Express - Melbourne Herald Sun
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The Pancreatic Cancer Action Network Mourns The Loss of Carnegie ...
FOXBusiness - Jul 26, 2008
During his nearly two year battle with pancreatic cancer, he helped raise awareness of the disease and the urgent need for additional funding for pancreatic ...
YouTube's Professor With Pancreatic Cancer Dies At Age 47 KNBC.com
The Lustgarten Foundation for Pancreatic Cancer Research Mourns ... FOXBusiness
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TopCancerNews.com
Panel of proteins linked to early development of pancreatic cancer ...
TopCancerNews.com, TX - Jul 31, 2008
Because the disease is asymptomatic in the early stages, most patients are not diagnosed until the cancer has spread beyond the pancreas, which contributes ...

BBC News
Fat stomachs 'raise risk of pancreatic cancer in women'
Telegraph.co.uk, United Kingdom - Jul 15, 2008
Pancreatic cancer is the tenth most common cancer in the UK, with around 7400 cases diagnosed each year. Difficulty in diagnosing the disease means few ...
Obesity In Women Raises Risk Of Pancreatic Cancer RedOrbit
Obesity raises pancreatic cancer risk Irish Health
Slim waists could be linked to a lower risk of pancreatic cancer InTheNews.co.uk
The Press Association - BBC News
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E! Online
Healthy-Looking Swayze, Gaunt Jobs Spark Public Speculation
ABC News - Jul 23, 2008
By ALLYSON T. COLLINS As Patrick Swayze walked through Los Angeles International Airport on Sunday, evidence of the pancreatic cancer diagnosis he received ...
Patrick Swayze smiling again after 'miracle' response to cancer ... Daily Mail
Patrick Swayze says he is a 'miracle' following treatment for ... Telegraph.co.uk
I should be dead, 'miracle' Swayze says Stuff.co.nz
Mirror.co.uk - San Francisco Chronicle
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First comprehensive website on pancreatic cancer launched
Hindu, India - Jul 29, 2008
Mumbai (PTI): To create more awareness on pancreatic cancer, specialists from the Tata Memorial Hospital (TMH) here and Delhi's Sir Gangaram Hospital have ...
Source: Google News

Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis … -
AB Lowenfels - J Natl Cancer I, 1997 - jnci.oxfordjournals.org
... Ninety-nine of the 238 patients without pancreatic cancer and six of the patients
with pancreatic cancer inherited the disease through the paternal side of the ...

… and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West … -
SR Bramhall, WH Allum, AG Jones, A Allwood, C … - Br J Surg, 1995 - ncbi.nlm.nih.gov
... Treatment and survival in 13,560 patients with pancreatic cancer, and incidence
of the disease, in the West Midlands: an epidemiological study. ...

… of vascular endothelial growth factor in human pancreatic cancer correlates with local disease … -
J Itakura, T Ishiwata, H Friess, H Fujii, Y … - Clin Cancer Res, 1997 - ncbi.nlm.nih.gov
Click here to read Enhanced expression of vascular endothelial growth factor in
human pancreatic cancer correlates with local disease progression. ...

The National Cancer Data Base report on pancreatic cancer. -
JE Niederhuber, MF Brennan, HR Menck - Cancer, 1995 - ncbi.nlm.nih.gov
... US The present report, covering one-third of all patients treated in the US in 1991,
confirms the advanced disease status of patients with pancreatic cancer. ...

Pancreatic cancer, alcohol, diabetes mellitus and gall-bladder disease. -
J Cuzick, AG Babiker - Int J Cancer, 1989 - ncbi.nlm.nih.gov
Int J Cancer. 1989 Mar 15;43(3):415-21. Pancreatic cancer, alcohol, diabetes
mellitus and gall-bladder disease. Cuzick J, Babiker AG. ...

Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from … -
SF Sener, A Fremgen, HR Menck, DP Winchester - J Am Coll Surg, 1999 - ncbi.nlm.nih.gov
... Overall survival rates for pancreatic cancer have not changed in 2 decades. A small
minority of patients presented with limited, resectable disease, but the ...

… effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer -
SJ Wigmore, JA Ross, J Stuart Falconer, CE Plester … - Nutrition, 1996 - Elsevier
... We have shown previously that in patients with pancreatic cancer, disease progression
causes a progressive rise in both the incidence and intensity of the ...

… progression model for pancreatic cancer recapitulating the genetic alterations of the human disease -
M Wagner, FR Greten, CK Weber, S Koschnick, T … - Genes & Development, 2001 - Cold Spring Harbor Lab
... Here we show that these mice develop pancreatic cancer similar to the human disease
regarding cellular differentiation, growth characteristics, and genetic ...

Serum Diagnosis of Pancreatic Adenocarcinoma Using Surface-Enhanced Laser Desorption and Ionization … -
J Koopmann, Z Zhang, N White, J Rosenzweig, N … - Clinical Cancer Research, 2004 - AACR
... markers and CA19?9 was superior to CA19?9 alone in distinguishing individuals with
pancreatic cancer from the combined pancreatic disease controls and ...

Cyclooxygenase-2 Expression Is Up-Regulated in Human Pancreatic Cancer 1 -
ON Tucker, AJ Dannenberg, EK Yang, F Zhang, L Teng … - Cancer Research, 1999 - AACR
... 1) . Unfortunately, >90% of pancreatic cancer patients present with metastatic disease
or advanced local disease, precluding a curative surgical resection. ...

Source: Google Scholar
 
 

Disease progression model of pancreatic cancer developed

 
 
Researchers at the University of Pennsylvania - School of Medicine have developed an animal model of pancreatic cancer that closely mimics disease progression in humans.

Advanced pancreatic cancer is among the most lethal of cancers, with a one-year survival rate after chemotherapy of only 17 to 28 percent of patients, according to the National Cancer Institute.

Sunil R. Hingorani and David A. Tuveson, both in the Departments of Medicine and Cancer Biology, and colleagues, engineered mice to express two mutant genes commonly associated with pancreatic cancer: Kras, an oncogene, and p53, a well-studied tumor suppressor.
The investigators linked physiological, cellular, and genomic changes due to mutations in Kras and p53 in the mice to changes similar to that observed in pancreatic cancer patients.
The disease that develops in the Kras and p53 mutant mouse model demonstrates distinct similarities to human pancreatic cancer at multiple levels. " In terms of clinical presentation, metastatic burden, and histological changes in tissue, this model appears to closely mimic the human disease, " says Hingorani.

Clinical symptoms in the mutant mice mirrored those displayed in pancreatic cancer patients, such as abdominal swelling and muscle loss. Similarly, the progression of pancreatic cancer metastases paralleled that seen in the human disease. " In this model, pancreatic cancer metastasizes to the liver, lungs, diaphragm, and adrenal glands, all the same places that human pancreatic cancer metastasizes," says Tuveson.

The frequency of metastases to these various organ sites was also highly similar to that seen in humans.
In human patients, 60 to 80 percent develop metastases to the liver; and 50 to 60 percent develop metastases to the lungs.
In the genetically modified animals, 63 percent displayed liver metastases, and 45 percent displayed lung metastases–further emphasizing the accuracy of this model in mimicking human pancreatic cancer.

To understand the progression of pancreatic cancer, Hingorani and colleagues studied cell lines derived from primary tumor and metastasized cells. From this, the researchers established the occurrence of genomic instability in the mouse model.

Genomic instability–continuous formation of mutated chromosomes–leads to widespread genetic changes throughout the affected cells. Genomic instability is seen in many human epithelial cancers, including pancreatic cancer, and is thought to be a driving force in the transition from local tumor growth to metastases of cancers.

According to Hingorani, " This model may prove useful to understanding human pancreatic and other epithelial cancers because the key event of genomic instability that has been very difficult to model in the mouse appears to be recapitulated here. "

In the pancreatic tumors and metastases from the mouse model, the investigators characterized other molecules implicated in pancreatic cancer. Often, the expression of molecules such as growth factors and their receptors will offer possible targets for treatment. The researchers were surprised to discover a high degree of heterogeneity in expression among these key molecules across the specimens. After ruling out the likelihood that this variability resulted from additional acquired mutations in known key tumor suppressor pathways, Hingorani suggests, " there may actually be unique genetic routes to pancreatic cancer, such that not all pancreatic cancers are equivalent. "

The development of the first animal model for pancreatic cancer that fully imitates the progression of the human condition will likely open many new doors in understanding this disease.

" With a model that can generate the full spectrum of disease, from preinvasive to invasive and metastastic lesions, we can begin to tease out the events that are linked to the progression of pancreatic cancer, " explains Hingorani. " In trying to understand what events are required to create and support invasive and metastatic disease, we hope to translate our findings into better therapies. “

Source: University of Pennsylvania School of Medicine, 2005
 
 
 
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