Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California
blank

 

Recent News and Articles on the Keywords: incontinence drug + trospium have + bladder  Related to the article below (Last Update: 7/1/2008)

Do Incontinence Drugs Affect Cognition in the Elderly?
Medscape (subscription) - Jun 10, 2008
Clemett D, Jarvis B. Tolterodine: a review of its use in the treatment of overactive bladder. Drugs Aging. 2001;18:277-304. Abstract Solifenacin (Vesicare) ...
Source: Google News

TROSPIUM CHLORIDE IMPROVES OVERACTIVE BLADDER SYMPTOMS: A MULTICENTER PHASE III TRIAL -
N ZINNER, M GITTELMAN, R HARRIS, J SUSSET, A … - The Journal of Urology, 2004 - Elsevier
... knowledge of the effect of trospium chloride at ... presenting with overactive bladder
associated with urge incontinence. ... and tolerability in this class of drugs. ...

Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: … -
P Herbison, J Hay-Smith, G Ellis, K Moore - BMJ: British Medical Journal, 2003 - pubmedcentral.nih.gov
... the auspices of the Cochrane Incontinence Group ... group of direct antimuscarinic drugs
included emepronium ... bromide, propiverine, tolterodine, and trospium chloride ...

Trospium Chloride in the Management of Overactive Bladder. -
ES Rovner - Drugs, 2004 - drugs.adisonline.com
... studies have suggested that trospium chloride may ... potential for clinically relevant
drug interactions than ... savings regarding overall incontinence management in ...

Preview of new drugs for overactive bladder and incontinence: Darifenacin, solifenacin, trospium, … -
RT Kershen, M Hsieh - Current Urology Reports, 2004 - Springer
... Trospium chloride also has been tested in the ... in micturition frequency, frequency
of incontinence episodes, and ... However, drug-related adverse event rates were ...

Anticholinergic drugs versus placebo for overactive bladder syndrome in adults.
J Hay-Smith, P Herbison, G Ellis, K Moore - Evid Based Nurs, 2003 - ncbi.nlm.nih.gov
... SEARCH STRATEGY: The Cochrane Incontinence Group trials ... that compared an anticholinergic
drug with placebo ... propantheline; tolterodine; and trospium chloride. ...

Antimuscarinics for treatment of overactive bladder -
KE Andersson - Lancet Neurology, 2004 - Elsevier
... drugs, including tolterodine, trospium, propantheline, oxybutynin, and ... between
antimuscarinic drugs and placebo were ... Consultation on Incontinence working groups ...

Drug Treatment of Overactive Bladder: Efficacy, Cost and Quality-of-Life Considerations. -
H Hashim, P Abrams - Drugs, 2004 - drugs.adisonline.com
... was significant reduction in frequency, urgency and urge incontinence episodes in ...
pelvic floor exercise regimen to a drug treatment is ... Trospium Chloride TOP. ...

Trospium chloride-an effective drug in the treatment of overactive bladder and detrusor … -
K H?fner, M Oelke, S Machtens, V Gr?newald - World Journal of Urology, 2001 - Springer
... Among the drugs with an anticholinergic activity, trospium chloride (TCL ... who had
been using pads, incontinence pants or ... Potential cost savings by drug treatment ...

Pharmacological agents for the treatment of urinary incontinence due to overactive bladder -
AJ Wein - eid, 2001 - Expert Opinion
... agents, muscarinic receptor antagonists, overactive bladder, oxybutynin, tolterodine,
trospium chloride, urinary incontinence ... Drugs (2001) 10(1):65-83 ...

The pharmacological treatment of urinary incontinence -
KE Andersson, R Appell, LD Cardozo, C Chapple, HP … - BJU Int, 1999 - ingentaconnect.com
... Trospium chloride has a documented eCect in detrusor ... urinary urgency and urge
incontinence [57?59 ... The drug has no selectivity for muscarinic receptor subtypes ...

Source: Google Scholar
 
 

Trospium, an incontinence drug, could have an additional topical effect on the bladder

 
 
A commonly prescribed incontinence drug may help patients in more than one way, according to research carried out at University of Pittsburgh.

When taken orally, Trospium chloride ( Sanctura ) not only helps control symptoms of overactive bladder systemically, it also may help control symptoms in the bladder itself when it comes into contact with the bladder walls.

" When taken orally, certain classes of drugs can control the muscle contractions that cause conditions like overactive bladder. In this study, we have found one drug, Trospium, reacts with the bladder muscle as urine is stored in the bladder, " said Michael Chancellor, of University of Pittsburgh School of Medicine.

In the study, urine samples from human subjects taking the anti-muscarinic drugs Trospium, Tolterodine LA and Oxybutynin XL and from control subjects were instilled into the bladders of animal models.

Researchers induced bladder overactivity using cCarbachol.

The Trospium bladder did not react to the Carbachol, indicating that the Trospium had a topical effect on controlling the muscle contractions.
In the control, Tolterodine- and Oxybutynin-treated bladders, the length of time between bladder contractions and the bladder's capacity were decreased – representing overactive bladder-type conditions and indicating no topical effect.

Anti-muscarinic drugs block receptors in the bladder responsible for smooth muscle contractions; by easing the muscle contractions, the number of incontinence episodes are reduced and bladder capacity is increased.
Common urologic conditions like overactive bladder are caused by involuntary contractions of the detrusor muscle, which controls the bladder.

More than 17 million Americans suffer from overactive bladder, a condition that significantly affects the patient's quality of life. An estimated 80 percent of these patients do not seek help or treatment for this condition. Overactive bladder is characterized by the following conditions: frequency – urinating more than eight times in a 24 hour period; urgency – the immediate and strong urge to urinate; and urge incontinence – the inability to suppress urgency, resulting in the leaking or loss of urine.

Source: 100th Annual Meeting of the American Urological Association ( AUA ), 2005
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With: News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; Nedws9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page