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Recent News and Articles on the Keywords: prostate cancer + risk factor + obesity  Related to the article below (Last Update: 7/1/2008)

Prostate Cancer: Why Every Man Ought To Be Concerned!
Modern Ghana, Ghana - Jun 27, 2008
Additionally, it is believed that obesity and diets high in animal products may increase prostate cancer risk. Family history of the disease also increases ...
Obesity, Lifestyle & Heart Disease; Effects of Lifestyle ...
Men's News Daily, CA - Jun 22, 2008
There have been numerous studies on the effects of various nutritional supplements on prostate cancer cells growing in a Petri dish in the laboratory, ...
Infection and Cancer - Intervention is Key
AllAfrica.com, Washington - Jun 16, 2008
Obesity is another factor that visualizes a chronic energy imbalance and is an independent predictor of an increased cancer risk, particularly for ...
Your Lifestyle, Your Genes, And Cancer
Newsweek - Jun 14, 2008
The Western diet had somehow stimulated the growth of these small deposits of residual cancer cells. Obesity is the second most important factor in causing ...
Nigeria: Why Cancer is on the Rise in Nigeria
AllAfrica.com, Washington - Jun 17, 2008
... the number of prostate cancer cases has increased. But there is argument that known risk factors probably contribute to a varying degree. ...
Main Street Mile is 'a mile for men's health'
IdahoStatesman.com, ID - Jun 21, 2008
Williams said prostate cancer trends toward older men, but family history, African-American heritage and unhealthy habits also are risk factors. ...
Vitamin D & Prostate Cancer Risk; Radiofrequency Ablation (RFA) of ...
Men's News Daily, CA - Jun 8, 2008
Also, obesity and a high-fat diet have been linked to an increased risk of developing prostate cancer. Exercise, eat well, and get screened ever year, ...
How men can outsmart the top 5 causes of death
Dallas Morning News, TX - Jun 2, 2008
Prostate cancer. This is No. 2 behind lung cancer in men's cancer deaths, as well as the most diagnosed cancer in men. Risk factors include increasing age, ...
Lifestyle Interventions to Reduce Cancer Risk and Improve Outcomes
RedOrbit, TX - Jun 3, 2008
Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional ...
Probe into household cancer risks
Independent Online, South Africa - Jun 7, 2008
It estimates the total cancer risk involving industrial chemicals, infections, dietary contamination, obesity and ultraviolet light account for 60 percent ...
Source: Google News

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study. -
JM Chan, MJ Stampfer, E Giovannucci, PH Gann, J Ma … - The Journal of Urology, 1998 - jurology.com
... Insulin-Like Growth Factors and Coronary Heart Disease. ... SPECIFIC ANTIGEN GENE ON
THE RISK, TUMOR VOLUME AND PATHOLOGICAL STAGE OF PROSTATE CANCER. ...

Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001 -
AH Mokdad, ES Ford, BA Bowman, WH Dietz, F Vinicor … - JAMA, 2003 - Am Med Assoc
... disability, physical activity, prostate cancer screening, colorectal cancer screening,
and ... Adults by State, Behavioral Risk Factor Surveillance System ...

DIET, OBESITY, AND RISK OF FATAL PROSTATE CANCER 1 -
DA SNOWDON, RL PHILLIPS, W CHOI - American Journal of Epidemiology, 1984 - Oxford Univ Press
... The results of this study and others suggest that animal product consumption
and obesity may be risk factors for fatal prostate cancer. ...

… Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk … -
P Stattin, A Bylund, S Rinaldi, C Biessy, H … - jnci, 2000 - jnci.oxfordjournals.org
... is characterized by an energy-dense diet and an increased risk of prostate cancer. ...
Identification of the nutritional and genetic factors that may cause the ...

Is obesity a risk factor for prostate cancer, and does it even matter? A hypothesis and different … -
MA Moyad - Urology, 2002 - ncbi.nlm.nih.gov
2002 Apr;59(4 Suppl 1):41-50. Click here to read Is obesity a risk factor for prostate
cancer, and does it even matter? A hypothesis and different perspective. ...

… Obesity on Biochemical Control After Radical Prostatectomy for Clinically Localized Prostate Cancer … -
SJ Freedland, WJ Aronson, CJ Kane, JC Presti Jr, … - Journal of Clinical Oncology, 2004 - jcojournal.org
... J Natl Cancer Inst 90:911-915, 1998 [Abstract/Free Full Text]; Moyad MA: Is obesity
a risk factor for prostate cancer, and does it even matter? ...

Risk Factors for Prostate Cancer -
KJ Pienta, PS Esper - Annals of Internal Medicine, 1993 - annals.highwire.org
... It is difficult to determine whether benign prostatic hyperplasia is a risk factor
for prostate cancer because both are common diseases in men as they age. ...

Obesity as a risk factor for certain types of cancer -
KK Carroll - Lipids, 1998 - Springer
... Obesity does not appear to be an important risk factor for prostate cancer (4).
Although some cohort studies have shown a positive association with overweight ...

… Rates As Related to Obesity and Race in Men With Prostate Cancer Undergoing Radical Prostatectomy -
CL Amling, RH Riffenburgh, L Sun, JW Moul, RS … - Journal of Clinical Oncology, 2004 - jco.ascopubs.org
... Cantobelli S, et al: Effect of obesity and body ... globulins in relation to lifestyle
factors in older ... BE: Do diet and androgens alter prostate cancer risk via a ...

Prostate Cancer Risk and Serum Levels of Insulin and Leptin: a Population-Based Study -
AW Hsing, S Chua, YT Gao, E Gentzschein, L Chang, … - jnci, 2001 - jnci.oxfordjournals.org
... was reported (5) to be a strong risk factor for prostate cancer among Chinese men
in the same case?control study. Abdominal obesity, especially visceral fat ...

Source: Google Scholar
 
 

Obesity is risk factor for aggressive prostate cancer

 
 
Obesity appears to increase the risk of prostate cancer, particularly aggressive form.
Smaller prostates also increase the risk of aggressive disease.

The study examined the association between body mass index ( BMI ) and prostate cancer in 787 men undergoing biopsy due to an elevated tumor marker in the blood or an abnormal physical exam at a Veterans Affairs hospital in California between 1998 and 2002.

It indicated that obesity increases the risk of prostate cancer, particularly in young men, as well as the risk of aggressive disease in all men.

“ The exact relationship between obesity and prostate cancer is still very much a point of controversy and debate in urology,” says Martha K. Terris, at the Veterans Affairs Medical Center in Augusta and the Medical College of Georgia.

“ One consensus that seems to be evolving is that obese men have an increased risk of more aggressive, and therefore potentially more deadly, disease,” she says. “ The take-home message for men and for all of us really is that we should try to maintain a healthy weight for a variety of health reasons. ”

It may be difficult to find prostate cancer in presence of obesity.
Fat makes estrogen-like compounds, which lowers circulating levels of prostate specific antigen, or PSA, a marker for prostate cancer. If PSA levels are lower due to hormone changes from obesity, the prostate cancer is less likely to be detected at an early stage.

Hormone changes observed with obesity also cause decreased levels of the male hormone testosterone. Since testosterone feeds prostate cancer, obesity could, in theory at least, reduce the risk of prostate cancer. This reasoning remains controversial, however since the current study and others suggest that obese men actually may be at increased risk for prostate cancer. However, researchers are more convinced of the link between obesity and aggressive prostate cancers that do not rely on testosterone to grow.

“ Hormone balance has potent effects on the prostate and prostate cancer,” Terris says. “ Most prostate cancer researchers have accepted the suggestion that higher estrogen and lower testosterone suppress prostate cancer growth with the exception of those cancers that are not sensitive to testosterone. However, when we adjusted for age in this study, we didn’t necessarily find less cancer. We did find that men with a higher body mass index did indeed have higher-grade, more aggressive-appearing cancer .”

A study published in February 2004 in Journal of Clinical Oncology also found higher rates of aggressive cancer in obese men as well as higher recurrence rates after surgery.
That study looked at 1,106 men who had cancerous prostate glands.
The 1,106 men included 330 of normal weight, 528 considered overweight and 214 mildly, moderately or severely obese.

“ Obesity was associated with higher-grade tumors, increased risk of positive surgical margins, and higher biochemical failure rates among men with clinically localized prostate cancer treated with ( radical prostatectomy ),” the study authors concluded. “ Severely and moderately obese patients were at higher risk of failure than mildly obese patients,” with risks two to three times that of slimmer patients.

The new study exploring the relationship between the size of the prostate gland and severity of disease.

“ Men with smaller prostates tend to have smaller cancers than men with larger prostates. But this is not as good as it sounds,” says Terris. “ If you have a large prostate, cancer can grow to a fairly large size before it outgrows the surrounding prostate and spreads out into other areas of the body. However, if the prostate containing the cancer is small, the cancer does not have to grow very much before it is big enough to spread outside the gland.” But this story gets more complicated. Men with larger prostates naturally have higher PSA levels, which means they may be more closely followed so their cancers are caught earlier. Also, the size of the prostate is linked to genetic and testosterone levels.

“ Similar to the findings in obese men with prostate cancer, the explanation may be differences in hormone levels,” says Terris. “ If you have estrogen or less testosterone in your system, your prostate will not be as large as a man with a high testosterone because these hormone affect both benign prostate growth and cancer. As a result, the same hormone balance that result in a small prostate gives hormone insensitive tumors more chance to grow. ”

Source: 100th Annual Meeting of the American Urological Association ( AUA ), 2005
 
 
 
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