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Recent News and Articles on the Keywords: single inhaler + asthma control + asthma  Related to the article below (Last Update: 7/1/2008)

Atlanta's infamous smog terrorizes asthma sufferers
Atlanta Journal Constitution,  USA - Jun 16, 2008
The US Food and Drug Administration recently discontinued the manufacture and sale of albuterol (a quick-acting drug that opens airways) asthma inhalers ...
Inhaler Devices Are Still a Major Hurdle in Asthma and COPD Treatment
RedOrbit, TX - Jun 5, 2008
There are two main types of portable inhaler devices used in the treatment of asthma and COPD: metered dose inhalers (MDIs), including pressurized MDIs ...
What is the Real Cost of Fossil Fuels?
InvestorIdeas.com (press release), WA - Jun 13, 2008
Now, I see 25% to 50% of the kids in my daughter?s high school with inhalers. Asthma cases have increased 160% over the past 15 years and over 5 million ...
Analysis Showed No Increased Risk of Hospitalization in Patients ...
Earthtimes (press release), UK - Jun 2, 2008
Advair Diskus(R), a fixed-dose treatment, combines two medications in one device to help prevent and control asthma symptoms. Advair(R) contains both the ...
What Ails You: Many conditions contribute to that ?run down? feeling
Desert Dispatch, CA - Jun 2, 2008
Asthma is a condition that causes chronic inflammation in the lungs. Even when you think you are feeling well, the inflammation is there. ...

FWWeekly
Hear No Evil, Smell No Evil
FWWeekly, TX - Jun 11, 2008
Sulfur dioxide air pollution, as environmentalists, regulators, and TXU officials have known for many years, helps trigger asthma attacks and other ...
NC wildfire sends up smoke, 50 homes evacuated
WAVY-TV, VA - Jun 11, 2008
Darlene King who lives in southern Chesapeake says her "son had to use his inhaler this morning." She says he has asthma. Tim Aydlett of Elizabeth City says ...
Orji Kalu should be granted leave to travel
Daily Sun, Nigeria - Jun 4, 2008
According to respected medical journals, asthma is a complex and very serious terminal condition. Third, you weigh the merits of EFCC's argument that ...
Smoke from wildfire at NC refuge making its way to Hampton Roads
WAVY-TV, VA - Jun 10, 2008
Darlene King who lives in southern Chesapeake says her "son had to use his inhaler this morning." She says he has asthma. Tim Aydlett of Elizabeth City says ...

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Source: Google News

Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide … -
O Zetterstrom, R Buhl, H Mellem, M Perpina, J … - European Respiratory Journal, 2001 - Eur Respiratory Soc
... J. Malolepszy, D. Kozma, K. Krofta, J. Ankerst, B. Johansen, and NC Thomson Budesonide
and Formoterol in a Single Inhaler Improves Asthma Control Compared With ...

Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study -
KF Rabe, PA Vermeire, JB Soriano, WC Maier - European Respiratory Journal, 2000 - Eur Respiratory Soc
... and D. S Postma Obtaining optimal control in mild ... Gibson Teaching old drugs new tricks:
asthma therapy adjusted ... Home page PJ Barnes A Single Inhaler for Asthma ...

… /formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma -
R Scicchitano, R Aalbers, D Ukena, A Manjra, L … - Curr Med Res Opin, 2004 - medscape.com
... Overall, budesonide/formoterol single inhaler therapy gave 31 more asthma control
days (a night and day with no asthma symptoms and no as-needed medication use ...

Budesonide and Formoterol in a Single Inhaler Improves Asthma Control Compared With Increasing the … -
UG Lalloo, J Malolepszy, D Kozma, K Krofta, J … - Chest, 2003 - Am Coll Chest Phys
... treatment with low-dose budes- onide/formoterol in a single inhaler improved lung
function and provided greater overall asthma control than increasing the dose ...

Fluticasone propionate/salmeterol combination provides more effective asthma control than low-dose … -
HS Nelson, WW Busse, E Kerwin, N Church, A Emmett, … - The Journal of Allergy and Clinical Immunology, 2000 - Elsevier
... salmeterol were combined in a single formula- tion (FP/Salm Combo in the Diskus
powder inhaler). The ICS FP has been shown to improve asthma control in adult ...

[CITATION] … /formoterol in a single inhaler versus inhaled corticosteroids alone in the treatment of asthma -
A Tal, G Simon, JH Vermeulen, V Petru, N Cobos, ML … - Pediatric Pulmonology, 2002
... potential to provide both anti-inflammatory control and fast ... In order to simplify
asthma therapy and to ... have been combined in a single inhaler, the Symbicort 1 ...

Budesonide/Formoterol in a Single Inhaler for Maintenance and Relief in Mild-to-Moderate Asthma* A … -
KF Rabe, E Pizzichini, B Stallberg, S Romero, AM … - Chest, 2006 - Am Coll Chest Phys
... 323-330[CrossRef][ISI][Medline]; Lalloo, UG, Malolepszy, J, Kozma, D, et al Budesonide
and formoterol in a single inhaler improves asthma control compared with ...

Is overall asthma control being achieved? A hypothesis-generating study -
ED Bateman, J Bousquet, GL Braunstein - European Respiratory Journal, 2001 - Eur Respiratory Soc
... The new single inhaler product containing both budesonide/formoterol improves
asthma control in adults. Eur Respir J 2000;16:Suppl. 31455. ...

Budesonide/Formoterol Combination Therapy as Both Maintenance and Reliever Medication in Asthma -
PM O'Byrne, H Bisgaard, PP Godard, M Pistolesi, M … - American Journal of Respiratory and Critical Care Medicine, 2005 - 171.66.122.149
... Home page, Eur Respir J Home page PJ Barnes Scientific rationale for using a single
inhaler for asthma control Eur. Respir. J., March 1, 2007; 29(3): 587 - 595. ...

Measuring compliance with inhaled medication in asthma -
JA Coutts, NA Gibson, JY Paton - Archives of Disease in Childhood, 1992 - fetalneonatal.com
... M. Perpina, J. Hedman, S. O'Neill, and T. Ekstrom Improved asthma control with
budesonide/formoterol in a single inhaler, compared with budesonide alone Eur. ...

Source: Google Scholar
 
 

Symbicort Single Inhaler Therapy gives greater improvement in asthma control than Seretide

 
 
Results from the COSMOS trial demonstrated that Symbicort Single Inhaler Therapy, ( Budesonide / Formoterol maintenance and reliever therapy ), reduces the risk of severe asthma attack by 25 per cent ( primary endpoint ) and the total number of severe asthma attacks by 22 per cent, when compared to Seretide ( Fluticasone / Salmeterol ).

COSMOS is the first ‘real-life,’ head-to-head trial of the two commonly used combination treatments and studied 2,143 patients with moderate to severe asthma in 16 countries.

The study was open label to allow for clinician choice in treatment, and compared Symbicort Single Inhaler Therapy with a titrated dose of Seretide ( as judged appropriate by the treating physician: 100/50, 250/50 and/or 500/50 BID ).
COSMOS examined the benefits of using the same single inhaler for maintenance and relief or multiple maintenance and reliever inhalers.
Throughout the one-year study, clinicians were given the freedom to adjust the maintenance dose in both treatment groups.

The COSMOS study showed that patients using Symbicort Single Inhaler Therapy experienced fewer severe asthma attacks and required less rescue medication compared to patients taking Seretide.
Less than four inhalations of rescue medication per week indicates good asthma control and at the end of the COSMOS study, more Symbicort Single Inhaler Therapy patients demonstrated good control of their symptoms by using low levels of rescue therapy ( 76 per cent compared to 66 per cent of Seretide patients ).

The traditional fixed dosing treatment approach used for Seretide in the COSMOS study requires the use of separate maintenance and reliever inhalers.
In contrast, Symbicort Single Inhaler Therapy combines two key components of asthma therapy in one inhaler - Formoterol, a unique rapid and long lasting bronchodilator, which can be used both as maintenance and reliever medication; and Budesonide, an inhaled corticosteroid that provides an additional anti-inflammatory effect.

Throughout the COSMOS study, Symbicort Single Inhaler Therapy patients managed their asthma using the same single inhaler for both maintenance and relief.
In contrast, 55 per cent of the Seretide patients required at least three different inhalers to manage their asthma ( i.e. different Seretide inhaler strengths along with an additional Salbutamol inhaler used as rescue medication ).

International asthma guidelines clearly indicate that compliance amongst patients is negatively affected by complex treatment regimens resulting in poor asthma control.
Symbicort Single Inhaler Therapy not only offers a more effective treatment option than Seretide, but as it requires fewer inhalers, it is also simpler for patients to use.

Additional benefits observed in the COSMOS trial for patients treated within the Symbicort Single Inhaler Therapy group, versus the Seretide group, were as follows:

· The full effect on the exacerbation burden was exemplified by a 34 per cent reduction in oral steroid days and a 37 per cent reduction in hospital days · Significantly less need for rescue medication throughout the year ( 38 per cent )

· Significantly higher maximum lung function ( FEV1 ) following bronchodilation at the clinic

· At the end of the study more patients were able to manage their asthma with a reduced dose of regular combination treatment compared to their initial maintenance dose ( 31 per cent with Symbicort Single Inhaler Therapy vs. 14 per cent for Seretide )

Source: 101st International Conference of the American Thoracic Society ( ATS ), 2005
 
 
 
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