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Recent News and Articles on the Keywords: radical prostatectomy + enhance penile + therapy  Related to the article below (Last Update: 7/8/2008)

Comparing Laparoscopic And Open Radical Prostatectomy
Medical News Today (press release), UK - Jul 5, 2008
The 5-year disease-free survival rates for laparoscopic radical prostatectomy are shown below. The warm ischemia time is higher in laparoscopic partial ...
Abstracts Discussing The Treatment Of Peyronie's Disease ... Medical News Today (press release)
all 13 news articles »
Analyzing The Occurrence Of Peyronie's Disease After Radical ...
Medical News Today (press release), UK - Jul 2, 2008
A retrospective review of 589 patients undergoing radical prostatectomy was performed to examine the incidence of PD in this population with a mean age of ...
Take Home Message - Localized Prostate Cancer - Reported From The ... Medical News Today (press release)
Take Home Message - Advanced Prostate Cancer - Reported From The ... Medical News Today (press release)
all 15 news articles »
Positive Surgical Margins During Robotic Radical Prostatectomy: A ...
Medical News Today (press release), UK - Jul 2, 2008
... Liss and colleagues assess the risk factors associated with a positive surgical margin (PSM) that can occur during robotic radical prostatectomy (RARP). ...
Teaching And Mentoring: A Multi-Center Laparoscopic Radical ...
Medical News Today (press release), UK - Jun 30, 2008
... and safety while maintaining acceptable oncological and functional outcomes during the learning curve of a laparoscopic radical prostatectomy (LRP). ...
Penile Rehabilitation In The Radical Prostatectomy Patient
Medical News Today (press release), UK - Jun 28, 2008
A consequence of radical prostatectomy (RP) is ED and its prevalence is reported between 9-93%. How penile rehabilitation is given and whether it works is ...
Study of Urinary Continence After Radical Prostatectomy ...
UroToday, CA - Jun 24, 2008
The objective of this study was to compare the results in terms of continence and quality of life between retropubic radical prostatectomy and laparoscopic ...
Progression Outcomes After Radical Prostatectomy For Men In Their ...
Medical News Today (press release), UK - Jun 21, 2008
There remains a scarcity of data on the biochemical outcome after radical prostatectomy specifically for men in their 30's. These investigators from Johns ...
Radical Prostatectomy For Prostatic Adenocarcinoma: Matched ...
Medical News Today (press release), UK - Jun 22, 2008
... and early oncologic results in a comparative study matching radical retropubic (RRP) and robot assisted laparoscopic prostatectomy (RALP) groups. ...
Functional And Oncologic Outcomes Of Laparoscopic Vs Robotic ...
Medical News Today (press release), UK - Jun 13, 2008
ORLANDO, FL (UroToday.com) - A single surgeon's laparoscopic radical prostatectomy (LRP), experience towards the tail end of his series was directly ...
Extrafacial Versus Interfacial Nerve-Sparing Technique For Robotic ...
Medical News Today (press release), UK - Jun 13, 2008
... of the interfacial (IF) and the extrafacial (EF) never sparing (NSP) techniques for the robotic-assisted laparoscopic radical prostatectomy (RLRP). ...
Source: Google News

Management of erectile dysfunction following radical prostatectomy -
CD Zippe, R Raina, M Thukral, MM Lakin, EA Klein, … - Current Urology Reports, 2001 - Springer
... three times per week for 12 weeks) could enhance recovery of ... function in 12 men who
had undergone nerve-sparing radical, retropubic prostatectomy. ...

… OF SURAL NERVE RESTORES FUNCTION OF CAVERNOUS NERVES RESECTED DURING RADICAL PROSTATECTOMY -
ED KIM, PT SCARDINO, ORI HAMPEL, NL MILLS, TM … - The Journal of Urology, 1999 - Elsevier
... just fluffy.? Nocturnal penile tumescence testing ... that partial erections recovered
after radical prostatectomy. ... as possible to enhance nerve revascularization ...

… therapy responders can potentially switch to sildenafil citrate after radical prostatectomy -
R Raina, MM Lakin, A Agarwal, S Ausmundson, DK … - Urology, 2004 - Elsevier
... Index of Erectile Function; RP = radical prostatectomy. ... should consider promoting
early penile rehabilitation with ... sexually rehabilitate and enhance the return ...

… factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse … -
RS Rogers, TM Graziottin, CS Lin, YW Kan, TF Lue - International Journal of Impotence Research, 2003 - nature.com
... Following radical prostatectomy, approximately 30% of patients have ... also revealed
that penile smooth muscle ... and VEGF treatment enhanced penile smooth cell ...

PENILE ERECTILE FUNCTION AFTER PERMANENT RADIOACTIVE SEED IMPLANTATION FOR TREATMENT OF PROSTATE … -
RG STOCK, J KAO, NN STONE - The Journal of Urology, 2001 - Elsevier
... intimately related to penile erectile function ... with experience and enhanced technology,
higher ... Donker, Impotence following radical prostatectomy: insight into ...

… Future Strategies for Preventing and Managing Erectile Dysfunction Following Radical Prostatectomy -
F Montorsi, A Briganti, A Salonia, P Rigatti, AL … - European Urology, 2004 - Elsevier
... face of nerve injury, particularly after radical prostatectomy. ... interposition grafts
to enhance erectile function ... major neuromediator of penile erection nitric ...

Viability and Safety of Combination Drug Therapies for Erectile Dysfunction -
WD STEERS - The Journal of Urology, 2003 - Elsevier
... 18 This strategy may enhance efficacy and ... outcomes with sildenafil after radical
retropubic prostatectomy ... injections in patients after prostatectomy as opposed ...

… and Survival of Patients With Positive Lymph Nodes After Radical Prostatectomy. Is there a Chance … -
PIA BADER, FC BURKHARD, R MARKWALDER, URSE STUDER - The Journal of Urology, 2003 - Elsevier
... Sogani and WF Whitmore Jr., Penile cancer: relation ... and DF Paulson, Does radical
prostatectomy in the ... of positive pelvic lymph nodes enhance survival?, World J ...

Early use of vacuum constriction device following radical prostatectomy facilitates early sexual … -
R Raina, A Agarwal, S Ausmundson, M Lakin, KC … - International Journal of Impotence Research, 2006 - nature.com
... aids have been proposed to enhance recovery of ... Erectile dysfunction after radical
prostatectomy. ... E1 injection therapy for post-prostatectomy impotence: an ...

Future Options for Combination Therapy in the Management of Erectile Dysfunction in Older Men. -
F Sommer, U Engelmann - Drugs & Aging, 2004 - aging.adisonline.com
... with ED after bilateral nerve sparing radical retropubic prostatectomy found sildenafil
to ... to reduce adverse effects and enhance penile rigidity.[30 ...

Source: Google Scholar
 
 

Muse therapy following radical prostatectomy enhances penile recovery

 
 
A study evaluated the effects of the early use of Alprostadil ( Muse ) urethral suppository on erectile dysfunction ( ED ) subsequent to a bilateral nerve-sparing radical prostatectomy ( RP ) in men with prostate cancer.

A total of 91 preoperatively sexually active patients who developed erectile dysfunction due to a bilateral nerve-sparing radical prostatectomy were enrolled in the study.
A single surgeon performed the radical prostatectomy for all study patients.

Fifty-six patients were treated with Alprostadil, three times per week for six months.
Treatment was initiated approximately three weeks after surgery with 125 mcg of Alprostadil; after 6 weeks, the dose of Alprostadil was either increased to 250 mcg or was maintained at 125 mcg for an additional 4 months.
The remaining 35 patients received no treatment and comprised the control group.
Both groups had similar baseline levels of erectile function before surgery.

Thirty-eight patients in the Alprostadil-treated group continued treatment for the duration of the study, and of these, 39% were able to achieve natural erections sufficient for intercourse without the use of erectogenic agents. In contrast, only 11% of subjects in the observational control group were able to achieve erections sufficient for intercourse without treatment six months after surgery.

Erectile function was assessed before and at six months after surgery in both groups using the Sexual Health Inventory for Men ( SHIM ), a patient questionnaire that determines the degree of erectile dysfunction in which higher scores indicate better function.

The six-month SHIM scores for the Alprostadil-treated group was 18.9 ( baseline of 21.2 ) compared to the score of 12.1 ( baseline of 22.0 ) for the control group ( p<0.05 ).

The study also showed that 74% of patients who completed six months of Alprostadil treatment were able to resume sexual activity.

" Results from this study suggest that early treatment with Muse after a radical prostatectomy may improve penile function recovery," commented Raina, lead author of the study. " The approximate four-fold improvement in the ability to have natural erections without the use of erectogenic aids in the Muse group is clinically significant in this group of subjects.
As erectile dysfunction associated with a radical prostatectomy can persist for 12 to 24 months, any treatment that would reduce this time would be of significant benefit to the patient."

A total of 18 men in the Muse group discontinued treatment prior to the end of the study, nine for insufficient erections, five for reduced sexual interest and four for local pain/burning.

According to the American Cancer Society, more than 230,000 men were diagnosed with prostate cancer in 2004. Research from the 2002 National Hospital Discharge Survey found that 195,000 prostatectomy procedures were performed in 2002 as a means of treating prostate cancer.
Sexual dysfunction is a frequent consequence of this type of surgery, most likely due to damage to local nerves and blood vessels.

Muse ( Alprostadil ) is a medicated pellet that is placed in the urinary opening using a disposable plastic applicator.
Muse was approved by the FDA in 1997 for the treatment of erectile dysfunction.
It has not been approved by the FDA for the recovery of normal erectile function following radical prostatectomy.
Muse should not be used by men who have sickle cell anemia or trait, leukemia or tumor of the bone marrow, allergy to Alprostadil ( the active ingredient in Muse ), or abnormal penile anatomy.
Muse should not be used in men for whom sexual activity is inadvisable due to cardiac fitness.
Muse should not be used for intercourse with a pregnant woman without a condom.
Muse does not protect against sexually transmitted diseases.
Because of the potential for symptomatic hypotension and syncope, which occurred in 3% and 0.4%, respectively, of patients during in-clinic dosing, Muse titration should be carried out under medical supervision.
During post-marketing surveillance syncope occurring within one hour of administration has been reported. Patients should be cautioned to avoid activities such as driving or hazardous tasks, where injury could result if hypotension or syncope were to occur after Muse administration.
Side effects can include penile pain.

Source: 100th Annual Meeting of the American Urological Association ( AUA ), 2005
 
 
 
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