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Recent News and Articles on the Keywords: premature ejaculation + treat premature + dapoxetine  Related to the article below (Last Update: 7/8/2008)


TheMedGuru
Premature Ejaculation (PE) : Causes And Treatments
TheMedGuru, India - Jul 4, 2008
These are some of the questions men with premature ejaculation asks themselves every day. Premature ejaculation or PE is most common sexual problem faced by ...
New definition for premature ejaculation
United Press International - Jun 23, 2008
SAN FRANCISCO, June 23 (UPI) -- An International Society for Sexual Medicine panel of world experts presented a new definition of premature ejaculation at a ...
Plethora completes European Phase III premature ejaculation trial ...
Pharmaceutical Business Review - Jun 20, 2008
... dispensed by a metered dose aerosol developed for the treatment of premature ejaculation, a disorder affecting up to 30% of men in Europe and the US, ...

AsiaOne
Anti-climax
AsiaOne, Singapore - Jun 27, 2008
D's husband has a condition called premature ejaculation (PE). An occasional instance of PE might not be cause for concern, but if the problem occurs with ...

Nigerian Tribune
Infertility: The way out
Nigerian Tribune, Nigeria - Jun 28, 2008
Infertility can also be caused by absence of ovaries or its infections, premature ovarian failure, meaning failure of the ovary to produce female hormones ...
US approves Lupin's anti-depressant drug
Economic Times, India - Jun 16, 2008
Lupin claimed the introduction of the drug would strengthen its base in the treatment of depression, anxiety and premature ejaculation. ...BOM:500257

Canada.com
Want better sex? Savour the experience
Canada.com, Canada - Jun 27, 2008
"Anorgasmia and premature ejaculation are often a result of people not giving themselves enough time to get into their sexual feelings and enjoy them, ...
PDE5 Inhibitors: A New Tool In The Hands Of Urologists
Medical News Today (press release), UK - Jun 27, 2008
For premature ejaculation, 83% of clinical trials have shown benefit. The combination of paroxitene with sildenafil was superior to paroxitene alone. ...
Doctor's Advice: Bladder blues
Jamaica Gleaner, Jamaica - Jun 20, 2008
I suggest you begin by typing the words 'premature' and 'ejaculation' into Google. Then you will be able to see what the various treatment options are. ...
Plethora Solutions completes recruitment for European Phase III ...
Interactive Investor, UK - Jun 19, 2008
... it has completed recruiting for the European arm of a Phase III study of its PSD502 complex, used to treat premature ejaculation, on time and in budget. ...LON:PLE
Source: Google News

… and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two …
JL Pryor, SE Althof, C Steidle, RC Rosen, WJG … - The Lancet, 2006 - Elsevier
... Men with moderate-to-severe premature ejaculation in stable, heterosexual ... mg dapoxetine
(874), or 60 mg dapoxetine (870) on ... done on an intention-to-treat basis. ...

[CITATION] … Demand SSRI Treatment of Premature Ejaculation: Pharmacodynamic Limitations for Relevant Ejaculation …
MD Waldinger, DH Schweitzer, B Olivier - The Journal of Sexual Medicine, 2005 - Blackwell Synergy
... (2008) Tramadol HCL has Promise in On-Demand Use to Treat Premature Ejaculation. ...
(2007) Premature Ejaculation. ... (2007) Dapoxetine, a novel selective serotonin ...

[CITATION] Lifelong premature ejaculation: from authority-based to evidence-based medicine -
MD Waldinger - BJU International, 2004 - Blackwell Synergy
... to develop drug strategies to treat PE ... IV View Toward an Evidence-Based Definition
of Premature Ejaculation. ... and pharmacodynamic features of dapoxetine, a novel ...

[CITATION] Tramadol HCL has Promise in On-Demand Use to Treat Premature Ejaculation -
EA Salem, SK Wilson, NK Bissada, JR Delk, WJ … - Journal of Sexual Medicine, 2007 - Blackwell Synergy
... Premature ejaculation has been classified as either primary (lifelong ... these patients
had delayed ejaculation or anejaculation ... 50 mg Tramadol to treat PE showing ...

Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions … -
MJ Dresser, D Desai, S Gidwani, AD Seftel, NB Modi - International Journal of Impotence Research, 2006 - nature.com
... Premature ejaculation (PE) is a common form of male sexual ... are commonly used to treat
the condition ... A new serotonin transporter inhibitor, dapoxetine, has been ...

… of Dapoxetine Hydrochloride, a Novel Agent for the Treatment of Premature Ejaculation -
NB Modi, MJ Dresser, M Simon, D Lin, D Desai, S … - The Journal of Clinical Pharmacology, 2006 - jcp.sagepub.com
... which are sometimes used to treat PE, exhibit ... The pharmacokinetic characteristics
of dapoxetine suggest that ... Self-reported premature ejaculation and aspects of ...

[CITATION] Proposal for a Definition of Lifelong Premature Ejaculation Based on Epidemiological Stopwatch Data -
MD Waldinger, AH Zwinderman, B Olivier, DH … - Journal of Sexual Medicine, 2005 - Blackwell Synergy
... men, the question arises whether we should treat a normal ... (2007) Dapoxetine, a novel ...
serotonin transport inhibitor for the treatment of premature ejaculation. ...

[CITATION] Self-reported Premature Ejaculation and Aspects of Sexual Functioning and Satisfaction
D Rowland, M Perelman, S Althof, J Barada, A … - The Journal of Sexual Medicine, 2004 - Blackwell Synergy
... a tool that allows clinicians to better recognize and treat this common ... (2007)
Identification and diagnosis of premature ejaculation. ... 2007) Dapoxetine, a novel ...

[CITATION] … features of dapoxetine, a novel drug for'on-demand'treatment of premature ejaculation -
KE ANDERSSON, JP MULHALL, MG WYLLIE - BJU International, 2006 - Blackwell Synergy
... Premature ejaculation (PE), also commonly known as rapid or early ... or recurrent onset
of orgasm and ejaculation with minimal ... 5], and efforts to treat PE should ...

[CITATION] A New Combination Treatment for Premature Ejaculation: A Sex Therapist's Perspective -
MA Perelman - Journal of Sexual Medicine, 2006 - Blackwell Synergy
... the three major medications used to treat ED?Viagra ... in development such as dapoxetine
[53] have ... Premature ejaculation is a common sexual dysfunction that has ...

Source: Google Scholar
 
 

Dapoxetine developed to treat premature ejaculation

 
 
A Phase III clinical trial demonstrated that men taking Dapoxetine for the treatment of premature ejaculation ( PE ) experienced significant improvements in sexual function, including ejaculatory control, satisfaction with sexual intercourse for men and their partners, and increases in intravaginal ejaculatory latency time ( IELT ).

According to the American Urological Association, premature ejaculation may be the most common male sexual disorder.
It is estimated that PE may affect 27 percent to 34 percent of men across all age ranges, in contrast to erectile dysfunction, which is estimated to affect 10 percent to 12 percent of all men, who are usually older in age.

The phase III clinical trials studied 2,614 men with premature ejaculation aged 18-77 in monogamous sexual relationships of greater than six months.

Premature ejaculation was defined as persistent or recurrent ejaculation sooner than desired either before or shortly after penetration, typically reflecting an IELT of two minutes or less, over which the sufferer has minimal or no control.

Men in the studies were randomized to receive 30 mg or 60 mg of Dapoxetine over 12 weeks in two identical, double-blind, placebo-controlled, multicenter trials. Patients were asked to take study medication one-to-three hours before intercourse.
Participants had IELT of two minutes or less in at least 75 percent of intercourse episodes occurring during the two-week baseline run-in period prior to treatment.

The studies examined changes from baseline for mean IELT as monitored by a stopwatch; measured the subject's ejaculatory control and sexual satisfaction on a five-point scale from "very poor to very good" and measured the partner's satisfaction with sexual intercourse from "very poor to very good."

The results showed:

- Men taking Dapoxetine 30 mg and 60 mg experienced more than a three-to-four fold increase in mean IELT compared with placebo ( P < 0.0001 at 30 mg and 60 mg ). IELT increased significantly with the first dose of Dapoxetine, and increases in IELT were maintained over the 12-week study period.

- The percentage of men rating control over ejaculation as "fair to very good" increased dramatically for Dapoxetine 30 mg ( 2.5 percent to 51.8 percent ) and 60 mg ( 3.3 percent to 58.4 percent ) compared to placebo ( 3.5 percent to 26.4 percent ).

- The percentage of men rating sexual satisfaction as "good to very good" almost doubled with Dapoxetine 30 mg ( 20.2 percent to 38.7 percent ) and 60 mg ( 22.3 percent to 46.5 percent ), respectively, in comparison to placebo ( 21.6 percent to 24.6 percent ).

- The percentage of partners rating sexual satisfaction as "good to very good" almost doubled with Dapoxetine 30 mg ( 20.4 percent to 39 percent ) and 60 mg ( 24.8 percent to 47.4 percent ), respectively, compared to placebo ( 20.1 percent to 25.2 percent ).

The study also found that Dapoxetine was generally well tolerated, with most side effects of mild-to-moderate severity.
The most common adverse events reported with both 30 mg and 60 mg doses of Dapoxetine were nausea, followed by headache.

An observational study published in 2005 in The Journal of Sexual Medicine found that patient-reported outcome measures ( PROs ), such as control over ejaculation, satisfaction with sexual intercourse and distress are important factors in assessing the benefit of treatments for premature ejaculation in clinical studies. The study found that men with premature ejaculation and their partners reported higher ratings for interpersonal difficulty, lack of control over ejaculation and dissatisfaction with sexual intercourse.

Source: 100th Annual Meeting of the American Urological Association ( AUA ), 2005
 
 
 
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