Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: noninvasive coronary + artery disease + disease  Related to the article below (Last Update: 8/5/2008)

Non-invasive cardiac assessment in high risk patients (the ground ...
7thSpace Interactive (press release), NY - Aug 1, 2008
... most of these patients will die from coronary artery disease (CAD). Screening for silent CAD has become an option with recent non-invasive developments ...
Peripheral Arterial Disease (PAD) Affects One in Three People with ...
Diabetes Health (press release), CA - Jul 17, 2008
These devices have shown clinical effectiveness in treating coronary artery disease. An investigational device for PAD with this characteristic is the new ...
Fish-filled diet might stave off clogged arteries, study finds
Milwaukee Journal Sentinel, WI - Jul 28, 2008
Since World War II, a massive experiment has been going on in Japan: Diet and lifestyle have become more westernized, yet, so far, coronary heart disease ...
What's the right test for heart disease?
Cincinnati.com, OH - Jul 14, 2008
The current gold standard for diagnosing significant arterial blockages is a coronary angiogram, in which dye is injected in a coronary artery, ...
Triple Rule-Out' CT Scan For Acute Coronary Syndrome
eMaxHealth.com, NC - Jul 21, 2008
With regards to coronary artery disease, five percent of patients had severe disease and six percent had moderate disease that was immediately recognized by ...

SeniorJournal.com
Fighting for Your Legs: Peripheral Arterial Disease on Rise for ...
SeniorJournal.com, TX - Jul 10, 2008
These devices have shown clinical effectiveness in treating coronary artery disease, and are currently being studied in the leg arteries. ...
An Assessment of the Potential Use of Transthoracic Impedance ...
RedOrbit, TX - Aug 2, 2008
Extravascular lung water (EVLW) and index (EVLWI) were measured in 23 patients undergoing elective coronary artery bypass graft surgery at 3 time points ...OTC:NIMU
Carotid artery distension predicts coronary events
Reuters India, India - Jul 15, 2008
The mechanical properties of arteries appear to be intrinsically involved with coronary artery health. To assess the predictive value of carotid wall ...
BG Medicine Announces Publication of Biomarker Signature of ...
FOXBusiness - Jul 25, 2008
The biomarker set was further tested on a validation series of patients with peripheral atherosclerotic lesions, coronary artery disease and healthy ...
A bridge too far: Too soon to consider CTA for screening of ...
TheHeart.Org, NY - Jul 21, 2008
Coronary computed tomography angiography as a screening tool for the detection of occult coronary artery disease in asymptomatic individuals. ...
Source: Google News

… an invasive compared with a non-invasive strategy in unstable coronary-artery disease: the FRISC II … -
L Wallentin, B Lagerqvist, S Husted, F Kontny, E … - The Lancet, 2000 - Elsevier
... Articles. Outcome at 1 year after an invasive compared with a non-invasive strategy
in unstable coronary-artery disease: the FRISC II invasive randomised trial. ...

… in patients with coronary artery disease. A potential noninvasive marker of healing coronary … -
KL Gould, JP Martucci, DI Goldberg, MJ Hess, RP … - Circulation, 1994 - Am Heart Assoc
... of perfusion abnormalities by positron emission tomography after dipyridamole in
patients with coronary artery disease. A potential noninvasive marker of ...

… in Patients With Unstable Coronary Artery Disease Effects of an Early Invasive or Noninvasive … -
E Lindmark, E Diderholm, L Wallentin, A Siegbahn - JAMA, 2001 - Am Med Assoc
... During Instability in Coronary Artery Disease II (FRISC II) trial. We also investigated
the effects of an invasive vs a noninvasive treatment strategy and ...

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1 H-NMR … -
JT Brindle, H Antti, E Holmes, G Tranter, JK … - Nature Medicine, 2002 - med.ic.ac.uk
... these measures, singly or in combination, are insufficiently pow- erful to provide
a reliable, noninvasive diagnosis of the presence of coronary heart disease. ...

Reliable Noninvasive Coronary Angiography With Fast Submillimeter Multislice Spiral Computed … -
K Nieman, F Cademartiri, PA Lemos, R Raaijmakers, … - Circulation, 2002 - Am Heart Assoc
... EE van der Wall Noninvasive Angiography and ... Claussen, and AF Kopp Non-invasive
evaluation of ... Detect Significant Obstructive Coronary Artery Disease in Patients ...

… left ventricular function at rest and during exercise in patients with coronary-artery disease. -
JS Borer, SL Bacharach, MV Green, KM Kent, SE … - N Engl J Med, 1977 - ncbi.nlm.nih.gov
... in the noninvasive evaluation of global and regional left ventricular function at
rest and during exercise in patients with coronary-artery disease. ...

… Disease Risk Assessment in Asymptomatic People Role of Traditional Risk Factors and Noninvasive … -
P Greenland, SC Smith Jr, SM Grundy - Circulation, 2001 - Am Heart Assoc
... It must be understood clearly that an abnormal noninvasive test result in an ... for
diagnosis of the presence or absence of angiographic coronary artery disease. ...

Noninvasive definition of anatomic coronary artery disease by ultrafast computed tomographic … -
DB Simons, RS Schwartz, WD Edwards, PF Sheedy, JF … - Journal of the American College of Cardiology, 1992 - Am Coll Cardio Found
... Noninvasive definition of anatomic coronary artery disease by ultrafast ... Department
of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester ...

Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction -
JA Suwaidi, S Hamasaki, ST Higano, RA Nishimura, … - Circulation, 2000 - Am Heart Assoc
... Division of Cardiovascular Diseases, and Department of ... the frequency of abnormal
noninvasive tests among ... absence of obstructive coronary artery disease may not ...

… in the Noninvasive Evaluation and Management of Patients with Suspected Coronary Artery Disease -
LJ Shaw, DD Miller, JC Romeis, D Kargl, LT Younis, … - Annals of Internal Medicine, 1994 - annals.highwire.org
... resources use and cardiac event rates in relatively low-risk patients referred for
the noninvasive stress evaluation of suspected coronary artery disease. ...

Source: Google Scholar
 
 

MSCT for noninvasive detection of coronary artery disease

 
 
Multislice computed tomography ( MSCT ) provides high accuracy for noninvasive detection of suspected obstructive coronary artery disease, and this technology has potential to complement diagnostic invasive coronary angiography in routine clinical care.

Invasive coronary angiography is currently the diagnostic standard for clinical evaluation of known or suspected coronary artery disease ( CAD ).
The risk of adverse events is small, but serious and potentially life-threatening events may occur, including arrhythmia, stroke, coronary artery dissection, and access site bleeding ( total complication rate, 1.8 percent; death rate, 0.1 percent ). Furthermore, angiography catheterization induces some discomfort and mandates routine follow-up care.
Guidelines recommend that conventional invasive diagnostic angiography be restricted to stringent clinical indications.

A recently developed procedure that may potentially complement invasive coronary angiography is multislice computed tomography, which may achieve a high level of reliability and accuracy in the visualization of the coronary arteries.

MSCT is a sophisticated x-ray imaging technique, in which a CT tube and multiple layered detector rows rotate around the patient, taking numerous images of the body in seconds.
A computer processes the information into three-dimensional images composing volumetric representations of anatomy.
The coronary arteries can be extracted from these images and are presented in arbitrarily oriented sectional cuts.
This procedure eliminates much of the risk and discomfort associated with invasive coronary artery catheterization, although it retains the risks inherent in radiation exposure and use of contrast agents.

Martin H. K. Hoffmann, of University Hospital, Ulm, Germany and colleagues assessed the diagnostic accuracy of 16-slice MSCT scanning vs. invasive coronary angiography in a large group of patients with known or suspected CAD.
The study, which included 103 patients ( average age, 61.5 years ), was conducted from November 2003-August 2004.
The patients underwent both invasive coronary angiography and MSCT using a scanner with 16 detector rows.

The researchers found that compared with invasive coronary angiography for detection of significant lesions ( greater than 50 percent stenosis ), segment-based sensitivity, specificity, and positive and negative predictive values of MSCT were 95 percent, 98 percent, 87 percent, and 99 percent, respectively.
Quantitative comparison of MSCT and invasive coronary angiography showed good correlation, with MSCT systematically measuring greater-percentage stenoses.
Per-patient based analysis indicated high discriminative power to identify patients who might be candidates for revascularization.

“ We found that MSCT shows reasonably high accuracy for detecting significant obstructive CAD when assessed at a patient level. At its current stage of development, it may therefore be used to substantially reduce likelihood of clinically important CAD in patients with suspected disease. The appeal of MSCT compared with conventional coronary angiography is that it is noninvasive, avoiding most catheter-associated risks and discomforts with the exception of exposure to iodinated contrast agents and radiation. With rapidly improving technology, MSCT may well evolve from a useful complement to invasive angiography to a clinically viable alternative,” the authors conclude.

In an accompanying editorial, Mario J. Garcia, of the Cleveland Clinic Foundation, comments on the findings by Hoffmann et al.

“Despite these promising results, several important limitations of MSCT must be considered. First, MSCT requires ionizing radiation,” Garcia writes. “ This dose [ in this study ] is equivalent to 2 to 3 times the dose typically administered during a diagnostic invasive angiogram. Although the long-term risks associated with this level of radiation exposure are relatively low, it raises a concern about repetitive use or use in younger individuals and women of childbearing age. ”
“Second, the extent and severity of coronary calcifications in the population studied by Hoffmann et al is not known definitively.”

“Despite [ these and other limitations ], there is an important segment of the population at risk for heart disease in whom MSCT angiography could provide coronary anatomic information with sufficient diagnostic quality. Indeed, MSCT may offer another advantage over conventional angiography, which is the potential ability to detect and quantify atherosclerotic plaques in the coronary vessel walls. Nevertheless, in the absence of outcome and cost analysis studies, it is not yet clear how MSCT coronary angiography should be integrated in the clinical practice. Should it be used as a first test for the evaluation of chest pain or as a complementary test in patients with equivocal stress test results ? In either case, adequate patient selection will be critically important.”

Source: Journal of the American Medical Association, 2005
 
 
 
Google
Web www.iconocast.com
 
 
 

 

ALL THE NEWS : News1 ; News2 ; News3 ; News4 ; News5 ; News6 ; News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page