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Recent News and Articles on the Keywords: depression + fatty + linked  Related to the article below (Last Update: 8/5/2008)

A Mechanism For The Development Of Obesity-associated Conditions
Science Daily (press release) - Aug 2, 2008
They also exhibited less severe high fat diet?induced fatty liver, something that increases the risk of developing cirrhosis of the liver. ...
Cancer Center to Use Wellness Professionals(TM) Ximega(TM) Omega-3 ...
MarketWatch - Jul 28, 2008
CAMBRIDGE, MA, Jul 28, 2008 (MARKET WIRE via COMTEX) -- Numerous studies have shown the benefits of omega-3 fatty acids for everything from decreasing joint ...
The Right Way to Get Your Omega-3s and -6s
U.S. News & World Report, DC - Aug 1, 2008
Marketers have taken health research on the fatty acids and run with it, but there's more to the omega story than is apparent on food packaging. ...
Integrative Way: Omega-3? Not all fish are equal The Olympian
all 4 news articles »

eFluxMedia
Japanese Fishy Diet & Omega-3 Fatty Acids, the Secret to a Healthy ...
eFluxMedia - Jul 29, 2008
Previous studies suggest that that omega-3s can also help with major depression, schizophrenia, and postpartum depression. Eating fish is also a good way to ...
Scientists Learn How Food Affects The Brain: Omega 3 Especially ...
Science Daily (press release) - Jul 9, 2008
Antidepressants elevate BDNF levels, and most treatments for depression and schizophrenia stimulate BDNF. Here, too, omega-3 fatty acids are beneficial, ...
YourHealth: Fat head and the fishy truth
New Straits Times, Malaysia - Jul 26, 2008
... depression, bipolar disorder and schizophrenia. Omega-3 polyunsaturated fatty acids are complex molecules that enhance electrical conductivity. ...

Gather.com
8 Dangerous 'Un'Healthy Excuses You Don't Want to Make
Gather.com, MA - Aug 3, 2008
The National Institutes of Health recommends consumption of fish oil or other sources of omega-3 fatty acids for elevated triglycerides, ...

Oneindia
Balanced Diet Helps Maintain
Oneindia, India - Jul 11, 2008
He said that omega-3 fatty acids might also help fight against mental disorders like depression, mood disorders, schizophrenia, and dementia. ...
A balanced diet can improve your thinking Economic Times
Omega-3 fatty acids best from food United Press International
Brain Foods: More Good Press for Omega 3 Keep the Doctor Away
all 27 news articles »
Seaweed and a smile could open the door to long-term happiness
New Zealand Herald, New Zealand - Jul 29, 2008
In Beating Stress, Anxiety and Depression, Plant and Stephenson urge a radical overhaul of the way the UK's health service (NHS) treats the soaring number ...

MSNBC
Whole grain cereal and other 'healthy' foods that fool
MSNBC - Jul 23, 2008
This fat lowers heart disease, and it potentially lowers the risk for depression, asthma, post-partum depression, dementia, and possibly even Alzheimer?s ...
Source: Google News

Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism … -
DF Horrobin, CN Bennett - Prostaglandins, Leukotrienes & Essential Fatty Acids, 1999 - Elsevier
... This paper examines the evidence and suggests that the missing factors in the
understanding of depression relate to disturbed fatty acid and phospholipid ...

[PDF] Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study -
H Tiemeier, HR van Tuijl, A Hofman, AJ Kiliaan, MM … - Am J Clin Nutr, 2003 - jerrycott.com
... this result was not secondary to smoking or cardiovascular disease risk factors
and that fatty acid composition is not linked to depression by atherosclerosis ...
-

[PDF] … aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression -
AC Logan - Altern Med Rev, 2003 - thorne.com
... system. Investigations have linked omega-3 fatty acids to a number of
neuropsychiatric disorders, including depression. The purpose ...
-

Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute … -
N Frasure-Smith, F Lesp?rance, P Julien - Biological Psychiatry, 2004 - Elsevier
... or adipose tissues), two patterns of fatty acids were ... least a trend for a
depression-related reduction ... Second, although not consistently linked to increased ...

Diet-Induced Milk Fat Depression in Dairy Cows Results in Increased trans-10, cis-12 CLA in Milk Fat … -
DG Peterson, EA Matitashvili, DE Bauman - Journal of Nutrition, 2003 - Am Soc Nutrition
... of transcription factors (27), and we have recently linked alterations in ... will be
useful in fully characterizing diet-induced milk fat depression, a phenomenon ...

DOCOSAHEXANOIC ACID AND ?-3 FATTY ACIDS IN DEPRESSION -
D Mischoulon, M Fava - Psychiatric Clinics of North America, 2000 - Elsevier
... for Omega-6 and Omega-3 Fatty Acids 50 ... DHA is high are associated with decreased
rates of depression. ... and the postpartum period, also are linked with depression ...

[PDF] A Placebo-Controlled Trial of Omega-3 Fatty Acid(Ethyl Eicosapentaenoic Acid) Supplementation for … -
WS Fenton? - American Journal of Psychiatry, 2001 - niaaa.nih.gov
... Prostaglandins Leukot Essent Fatty Acids 1996; 55:71 ... SA, ?sberg M: A new depression
scale designed to ... Influence of Serotonin-Transporter-Linked Promoter Region ...
-

Mammary Lipogenic Enzyme Activity, trans Fatty Acids and Conjugated Linoleic Acids Are Altered in … -
LS Piperova, BB Teter, I Bruckental, J Sampugna, … - Journal of Nutrition, 2000 - Am Soc Nutrition
... The RNA was cross-linked to the membrane (40 s at ... RA, Douglass LW, Teter BB Milk
fat depression, the glycogenic theory, and trans-18:1 fatty acids. ...

Do Plasma Polyunsaturates Predict Hostility and Depression? -
JR Hibbeln, JC Umhau, DT George, N Salem Jr - content.karger.com
... on the influence of dietary polyun- saturated fatty acids on hostility and depression
and discuss ... function, measures which are closely linked to aggression ...

… of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin- … -
J Covault, H Pettinati, D Moak, T Mueller, HR … - American Journal of Medical Genetics Part B, 2004 - doi.wiley.com
... for depression demonstrated clinically significant reductions in symptoms ... 3 and encodes
long-chain fatty acid-CoA ... gene result in X-linked mental retardation ...

Source: Google Scholar
 
 

Brain fatty acid levels linked to depression

 
 
Researchers discovered that rats exhibiting the signs of depression have increased levels of the omega-6 fatty acid, arachidonic acid, in their brains.

During recent years, omega-3 fatty acids have enjoyed increased popularity as numerous studies have shown that supplementing diets with fish oil ( a natural source of this polyunsaturated fatty acid ) does everything from reducing the risk of heart disease to preventing arthritis.
There is also evidence that depression may be associated with a dietary deficiency in omega-3 fatty acids.
This " phospholipid hypothesis " of depression has been supported by research showing that omega-3 fatty acid concentration in the blood of depressed patients is lower than that in control patients.

" The "phospholipid hypothesis" of depression postulates that decreased omega-3 fatty acid intake, and hence, perhaps decreased brain omega-3 fatty acid content, could be responsible for the disease," explains Pnina Green of Tel Aviv University. " In humans, because of high dietary variability and the obvious inability to examine brain tissue, the theory is backed up mainly by indirect evidence. The availability of the Flinders Sensitive Line rat, an animal model of depression, overcomes both these obstacles. "

Green in collaboration with Gal Yadid of Bar-Ilan University, Ramat Gan, used the Flinders Sensitive Line rats to investigate the link between omega-3 fatty acids and depression.
They examined the brains of the depressed rats and compared them with brains from normal rats.
Surprisingly, they found that the main difference between the two types of rats was in omega-6 fatty acid levels and not omega-3 fatty acid levels.
Specifically, they discovered that brains from rats with depression had higher concentrations of arachidonic acid, a long-chain unsaturated metabolite of omega-6 fatty acid.

Arachidonic acid is found throughout the body and is essential for the proper functioning of almost every body organ, including the brain. It serves a wide variety of purposes, from being a purely structural element in phospholipids to being involved in signal transduction and being a substrate for a host of derivatives involved in second messenger function.

" The finding that in the depressive rats the omega-3 fatty acid levels were not decreased, but arachidonic acid was substantially increased as compared to controls is somewhat unexpected," admits Green. " But the finding lends itself nicely to the theory that increased omega-3 fatty acid intake may shift the balance between the two fatty acid families in the brain, since it has been demonstrated in animal studies that increased omega-3 fatty acid intake may result in decreased brain arachidonic acid. "

Although far less attention has been paid to dietary requirements for omega-6 fatty acids, which can be found in most edible oils and meat, perhaps in the future depression may be controlled by increasing omega-3 fatty acid intake and decreasing omega-6 fatty acid intake.

Source: Journal of Lipid Research, 2005
 
 
 
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