Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California
blank

 

Recent News and Articles on the Keywords: sleep apnea + risk factor + liver  Related to the article below (Last Update: 7/1/2008)

Is gastric bypass a cure for Type 2 diabetes?
Greensboro News Record, NC - Jun 4, 2008
Sleep apnea doesn't just cause poor sleep. It also puts people at increased risk for heart attacks, strokes, high blood pressure, obesity and diabetes. ...
Source: Google News

Elevated C-Reactive Protein in Patients With Obstructive Sleep Apnea -
ASM Shamsuzzaman, M Winnicki, P Lanfranchi, R Wolk … - Circulation, 2002 - Am Heart Assoc
... Key Words: sleep ? inflammation ? cardiovascular disease ? risk factors. ... Obstructive
sleep apnea (OSA) has been increasingly ... from the liver and regulated ...

Obstructive Sleep Apnea Is Independently Associated with Insulin Resistance -
MSM IP, B LAM, MMT NG, WAHKIT LAM, KWT TSANG, KSL … - American Journal of Respiratory and Critical Care Medicine, 2002 - Am Thoracic Soc
... are ligands of hepatic nuclear factor-4 . Nature ... Lombardi, and K. Narkiewicz Sleep
apnea: epidemiology, pathophysiology ... and relation to cardiovascular risk Am J ...

[CITATION] Chronic liver injury during obstructive sleep apnea. -
F Tanne, F Gagnadoux, O Chazouilleres, B Fleury, D … - Hepatology (Baltimore), 2005 - John Wiley & Sons, Inc. Hoboken, USA
... Patients with obstructive sleep apnea (OSA) are at risk for the development of ... data
suggest that OSA per se could be a risk factor of liver injury; ischemic ...

Health Consequences of Obesity in Youth: Childhood Predictors of Adult Disease -
WH Dietz - Pediatrics, 1998 - Am Acad Pediatrics
... A, Tsunamoto K, Furukawa N, Fatty liver and its ... Lauer RM, Clarke WR Childhood risk
factors for high ... in morbidly obese children with obstructive sleep apnea. ...

3. Role of Adipocytokines on the Pathogenesis of Atherosclerosis in Visceral Obesity -
T FUNAHASHI, T NAKAMURA, I SHIMOMURA, K MAEDA, H … - Internal Medicine, 1999 - Journal@rchive
... activation and aggregation during obstructive sleep apnea and its ... syndrome" as a
multiple risk factor clustering syndrome ... located upstream of the liver via the ...

Occult Sleep-Disordered Breathing in Stable Congestive Heart Failure -
S Javaheri, TJ Parker, L Wexler, SE Michaels, E … - Annals of Internal Medicine, 1995 - annals.highwire.org
... no information was sought about symptoms or risk factors for sleep apnea. ... and forced
vital capacity < 68%); intrinsic renal and liver disorders; untreated ...

Multivariate Analysis of Risk Factors for Death Following Gastric Bypass for Treatment of Morbid … -
AZ Fernandez Jr, EJ Demaria, DS Tichansky, JM … - Annals of Surgery, 2004 - annalsofsurgery.com
... as specific as possible in determining risk factors for mortality ... in this group,
for example, obstructive sleep apnea increases the risk of intestinal ...

Selective Activation of Inflammatory Pathways by Intermittent Hypoxia in Obstructive Sleep Apnea … -
S Ryan, CT Taylor, WT McNicholas - Circulation, 2005 - Am Heart Assoc
... cardiac enzymes, and was assessed for cardiovascular risk factors. ... of respiratory
effort during apnea or hypopnea ... All sleep studies were performed in the sleep ...

Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes -
K Spiegel, K Knutson, R Leproult, E Tasali, EV … - Journal of Applied Physiology, 2005 - Am Physiological Soc
... depends on the balance between glucose production by the liver and glucose ... K, and
Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. ...

Liver Pathology and the Metabolic Syndrome X in Severe Obesity -
P Marceau, S Biron, FS Hould, S Marceau, S Simard, … - Journal of Clinical Endocrinology & Metabolism, 1999 - Endocrine Soc
... cardiopulmonary pathology (6%), osteo-arthritis (11%), or documented sleep apnea
(3%). Diabetes ... 1997 The metabolic syndrome as risk factor for liver disease ...

Source: Google Scholar
 
 

Obstructive sleep apnea may be a risk factor for liver damage

 
 
Patients with obstructive sleep apnea ( OSA ) are at risk for the development of fatty liver as a result of being overweight.
Several data suggest that OSA per se could be a risk factor of liver injury; ischemic hepatitis during OSA has been reported, and OSA is an independent risk factor for insulin resistance.

Researchers led by Lawrence Serfaty, at the Hepatology Department at Saint-Antoine Hospital in Paris ( France ), tested liver function in patients being evaluated for OSA in order to determine if sleep apnea by itself was a risk factor for liver disease and if so, the mechanism involved.

The study included 163 patients who were referred to the Sleep Unit of Saint-Antoine Hospital between September 2000 and May 2001 to undergo evaluation for OSA.

Blood levels of liver enzymes were measured in the morning after sleeping at the clinic, and patients with elevated levels underwent liver biopsies, also in the morning.

Patients were categorized into groups according to the level of severity of OSA: severe ( 44 patients ), moderate ( 84 patients ), or non-existent ( 35 patients ). This last group, who did not have OSA, was used as the control group.

Elevated liver enzymes were found in 32 patients, 29 of whom were in the severe or moderate group.

Liver biopsies were performed in 18 patients: 9 with severe OSA, 6 with moderate OSA and 3 with no OSA.

Patients with severe OSA had a significantly higher percentage of steatosis ( fatty liver disease ), lobular necrosis and fibrosis ( two signs of liver damage ) than patients in the other two groups, regardless of body mass index ( BMI ), which itself is a known risk factor for fatty liver disease. They also had significantly higher levels of insulin and were more insulin resistant than the other patients.

Although the authors note that the results should be considered with caution due to the limited number of patients who underwent liver biopsy, they conclude that severe OSA, independent of being overweight, is a risk factor for liver disease.
In addition, they postulate that OSA may contribute to insulin resistance and fatty liver disease, since insulin responsiveness improves after treating OSA.
They suggest that the striking relationship between the severity of sleep apnea and liver damage indicates that OSA may play a role in how fatty liver disease develops.

According to authors, " OSA is a risk factor for abnormal liver enzymes independently from BMI, and should be investigated in patients without other cause of liver disease."

Source: Hepatology, 2005
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With: News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page