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Recent News and Articles on the Keywords: cut risk + colorectal cancer + cancer  Related to the article below (Last Update: 7/8/2008)

Oily Fish Can Help Cut Colorectal Cancer Risk
The Healthier Life, UK - Jun 25, 2008
A new study has found that regular and long-term consumption of omega-3 fatty acids and oily fish can slash the risk of developing colorectal cancer by up ...
KRAS Dx Market Emerges In US as ASCO Data Support Companion ...
Pharmacogenomics Reporter (subscription), NY - Jul 2, 2008
?KRAS testing should be routinely conducted in all colorectal cancer patients immediately after diagnosis to ensure the best treatment strategies for the ...
PROFNET EXPERT ALERTS: Health & Living
StreetInsider.com (subscription), MI - Jun 27, 2008
... of Harvard University and the Dana-Farber Cancer Institute stating that daily vitamin D intake reduces the risk of heart disease and colorectal cancer ...
Health services must balance books or outside administrator will ...
Owen Sound Sun Times, Canada - Jun 21, 2008
It will include reports from the hospital chief executive officer and board chair and a presentation on colorectal cancer by Dr. Jonathon Caulfeild. ...
Social conditions worsen area's health disparities
Daily Press, VA - Jun 18, 2008
African-Americans have a higher death rate from breast, lung and colorectal cancer than any other racial or ethnic group. ? African-Americans have a higher ...
Source: Google News

… C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in … -
R Kaaks, P Toniolo, A Akhmedkhanov, A Lukanova, C … - jnci, 2000 - jnci.oxfordjournals.org
... IGF-I, and IGFBP-1, -2, and -3. Quintile cut points were ... were associated with
statistically significant increases in the risk of colorectal cancer (P trend ...

C-Reactive Protein and the Risk of Incident Colorectal Cancer -
TP Erlinger, EA Platz, N Rifai, KJ Helzlsouer - JAMA, 2004 - Am Med Assoc
... Matched odds ratios (ORs) for colorectal cancer, calculated as an estimate of the
relative risk, and corresponding ... Quartile cut points for CRP were based on ...

Fruit, Vegetables, Dietary Fiber, and Risk of Colorectal Cancer -
P Terry, E Giovannucci, KB Michels, L Bergkvist, H … - jnci, 2001 - jnci.oxfordjournals.org
... of exposure quartiles, we also examined the risk of colorectal cancer among individuals
who ... logarithm-transformed calories, with the use of cut points of ...

Physical activity and reduced risk of colon cancer: implications for prevention -
GA Colditz, CC Cannuscio, AL Frazier - Cancer Causes and Control, 1997 - Springer
... others report results for tertiles defined by unspecified cut-points, and ... the magnitude
of the relation between physical activity and risk of colon cancer. ...

Meat, Fish, and Colorectal Cancer Risk: The European Prospective Investigation into Cancer and … -
T Norat, S Bingham, P Ferrari, N Slimani, M Jenab, … - jnci, 2005 - jnci.oxfordjournals.org
... Cut points for fish intake were the same for men and women, with low ... low fiber intake
could partially explain the increase in colorectal cancer risk in high ...

Intake of selected micronutrients and risk of colorectal cancer -
C La Vecchia, C Braga, E Negri, S Franceschi, A … - International Journal of Cancer, 1997 - doi.wiley.com
... model, with unit set as the difference between the upper cut-point of ... for a protec-
tive effect of several micronutrients on colorectal cancer risk and some ...

… colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial -
AM Lacy, JC Garc?a-Valdecasas, S Delgado, A … - The Lancet, 2002 - Elsevier
... For continuous variables, the cut-off level chosen ... 30 days of surgery (relative risk
of perioperative ... both open and closed colorectal cancer resection seems to ...

Calcium Intake and Risk of Colon Cancer in Women and Men -
K Wu, WC Willett, CS Fuchs, GA Colditz, EL … - jnci, 2002 - jnci.oxfordjournals.org
... The upper cut point depended on the range of intake ... statistically significant,
associations between calcium intake and risk of colorectal cancer in these ...

The relationship between dietary fat intake and risk of colorectal cancer: evidence from the … -
GR Howe, KJ Aronson, E Benito, R Castelleto, J … - Cancer Causes and Control, 1997 - Springer
... Fat and colorectal cancer ... for all analyses permits the direct comparison of risk
estimates for a ... Cut-points for quintiles of the variables used in the present ...

Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis -
RW Stephens, HJ Nielsen, IJ Christensen, O … - jnci, 1999 - jnci.oxfordjournals.org
... level independently predicted survival of patients with colorectal cancer. ... plasma
suPAR measurements and cut points in identifying high-risk patients among ...

Source: Google Scholar
 
 

Statins cut the risk of colorectal cancer

 
 
The use of statins is associated with a 47 percent relative reduction in the risk of colorectal cancer after adjustment for other known risk factors.

Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and effective lipid-lowering agents.

“ This is an important piece of the puzzle. This piece helps bring together evidence that statins may have the potential to prevent chronic diseases other than heart disease, and helps us consider ways to study these powerful drugs for more than one purpose,” says study author Stephen Gruber, at the University of Michigan - School of Public Health.

Data was based on the Molecular Epidemiology of Colorectal Cancer study, a population-based case-control study of colorectal cancer in northern Israel.
The researchers analyzed 1,953 people with colorectal cancer and 2,015 control subjects who did not have colon cancer. All study participants were asked to recall every medication they had used for at least five years. Statin use was determined based on this list and validated against prescription records from the health care provider.

The people without colon cancer were nearly twice as likely to report taking statins for at least five years, compared to the people with a history of colon cancer, 11.6 percent vs. 6.1 percent.

Researchers analyzed the data taking into account increased or decreased risk associated with demographic factors such as age, sex and ethnic background, and with lifestyle factors such as taking aspirin, participating in sports and eating vegetables. They also considered family history of colon cancer, which increases a person’s risk.

Even considering all these additional factors, statins were still associated with a 47 percent reduced risk of colorectal cancer.

It’s not known or well understood why statins show a protective effect against cancer. Recent research has suggested a similar connection between statins and other types of cancer, including breast, prostate, pancreatic and esophageal cancers. Researchers suspect something in the cholesterol pathway may affect a person’s risk of colon cancer.

“ Statins also have anti-inflammatory properties that might be relevant for cancer. That may explain why they appear to work in other cancers besides colon cancer,” says study lead author Jenny Poynter, at University of Michigan - School of Public Health.

Researchers caution, it’s not advisable for everyone to begin taking statins to prevent cancer.

“ We are now working to identify those groups who are likely to benefit most. In order to proceed to clinical trials, it is important to know who is most likely to benefit, and who isn't,” says Gruber, co-director of the biomedical prevention program at the University of Michigan - Comprehensive Cancer Center.

Nearly 105,000 people will be diagnosed with colon cancer in the United States this year, according to the American Cancer Society, and some 56,000 will die from the disease.

Funding for the study is from the National Cancer Institute, the Ravitz Foundation and the National Institutes of Health.

Source: The New England Journal of Medicine, 2005
 
 
 
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