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Recent News and Articles on the Keywords: cognitive improvement + quetiapine + schizophrenia  Related to the article below (Last Update: 7/1/2008)

Antipsychotics May Improve Psychiatric Symptoms In Alzheimer's Disease
Medical News Today (press release), UK - Jun 5, 2008
Patients were randomly assigned to masked treatment with one of three second-generation antipsychotic medications (olanzapine, quetiapine, risperidone) or ...
New Treatments In Pediatric and Adolescent Patients With Bipolar ...
Medscape (subscription) - Jun 18, 2008
Those approvals are probably coming down the plank for quetiapine, olanzapine, and ziprasidone as well. And overall it is looking like the atypical ...
Pharmacologic Options for Treatment-Resistant Depression: Charles ...
Medscape (subscription) - Jun 9, 2008
This is not without some ambiguity because, for instance, quetiapine is a second-generation antipsychotic (SGA) that actually has antidepressant properties ...
Source: Google News

Neuropsychological change in patients with schizophrenia after treatment with quetiapine or … -
SE Purdon, A Malla, A Labelle, W Lit - Journal of Psychiatry and Neuroscience, 2001 - pubmedcentral.nih.gov
... Lussier I, Babai M, Fabian JL, Link C. Seroquel and cognitive improvement in patients ...
Attentional improvement following quetiapine fumarate treatment ...

Cognitive improvement in schizophrenia with novel antipsychotic medications -
SE Purdon - Schizophrenia Research, 1999 - Elsevier
... of a positive change from treatment with clozapine, risperidone, olanzapine, and
perhaps quetiapine. The improvement in cognitive skills?including ability ...

Does cognitive function improve with quetiapine in comparison to haloperidol? -
DI Velligan, J Newcomer, J Pultz, J Csernansky, AL … - Schizophrenia Research, 2002 - Elsevier
... Cognitive function has been found to be related to ... the improvements in cognition
with quetiapine are accompanied by an improvement in community ...

The Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia -
HY Meltzer, SR McGurk - Schizophrenia Bulletin, 1999 - MPRC
... they cause selective impairment of some cognitive functions, particu ... Transient
improvement in VLL-IR was noted ... Olanzapine, quetiapine, low-dose risperidone, and ...

… of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia -
ND Woodward, SE Purdon, HY Meltzer, DH Zald - The International Journal of Neuropsychopharmacology, 2005 - Cambridge Univ Press
... available evidence supporting cognitive improvement with atypical ... prospectively examined
cognitive change to ... clozapine, olanzapine, quetiapine, and risperidone ...

Improvement in cognitive functioning in patients with first-episode psychosis during treatment with … -
KP GOOD, I KISS, C BUITEMAN, H WOODLEY, Q RUI, D … - The British Journal of Psychiatry, 2002 - RCP
... Method Cognitive testing was performed before quetiapine was initiated and ... Results
Statistically significant improvement was noted on measures of ...

Cognitive and Behavioral Effects of Quetiapine in Alzheimer Disease Patients. -
DW Scharre, SI Chang - Alzheimer Disease and Associated Disorders, 2002 - alzheimerjournal.com
... cognitive improvement in patients with schizophrenia. Biol Psychiatry 1996;
40:434-5. ... 10. Tariot PN, Salzman C, Yeung PP, et al. Long-term use of quetiapine ...

Effects of quetiapine on cognitive functions in schizophrenia -
BB Kivircik Akdede, K Alptekin, A Kitis, H Arkar, … - Progress in Neuropsychopharmacology & Biological Psychiatry, 2005 - Elsevier
... An open label study investigating cognitive effects of quetiapine in schizophrenia
reported improvement in attention (Sax et al., 1998). ...

Clinical predictors of acute response with quetiapine in psychotic mood disorders -
CA Zarate, A Rothschild, KE Fletcher, A Madrid, J … - European Neuropsychopharmacology, 2000 - Elsevier
... describe dramatic improvements in cognitive performance and ... observed, with trends
towards improvement on tests ... ef- fects of 6 months? quetiapine treatment in ...

Measuring neuropsychological change in schizophrenia with novel antipsychotic medications. -
SE Purdon - Journal of Psychiatry and Neuroscience, 2000 - pubmedcentral.nih.gov
... Lussier I, Babai M, Fabian JL, Link C. Seroquel and cognitive improvement in patients ...
Attentional improvement following quetiapine fumarate treatment ...

Source: Google Scholar
 
 

Schizophrenia, improvement in compliance and cognition with Quetiapine

 
 
Patients with schizophrenia who are treated with the atypical antipsychotic Quetiapine ( Seroquel ) show significantly superior rates of treatment compliance compared to patients treated with other atypical and typical antipsychotics.

The findings show Quetiapine to have the highest compliance rate of both typicals and atypicals, which was significantly ( p<0.05 ) greater than that of Risperidone ( 6% greater ) and Olanzapine ( 4% greater ).

" Compliance with medication is fundamental to a successful treatment outcome in schizophrenia. However, all too often patients have to struggle with medications that cause distressing side effects such as extrapyramidal symptoms ( EPS ), increased prolactin levels leading to galactorroeha and sexual dysfunction, which makes complying with treatment a challenge many patients find too difficult to overcome " commented Michael Riedel from the Munich University Hospital, Germany.
" Two other studies compared the cognitive benefits of Quetiapine and Risperidone in patients with schizophrenia, demonstrating improvements in cognitive function among Seroquel-treated patients.

In a randomized, double-blind study of 44 patients, both Quetiapine and Risperidone improved cognition in patients with schizophrenia over a 6-week period.
However, Quetiapine ( at a mean dose of 566.7 mg/day ) produced significantly greater improvements in working and verbal memory than Risperidone ( p<0.01 and p<0.05 vs Risperidone, respectively ), with a significantly lower incidence of EPS, a highly distressing treatment-induced side effect.

In an 8-week, double-blind, flexible-dose, parallel study randomizing 673 patients with schizophrenia, cognitive benefits of Quetiapine ( mean modal dose of 530 mg/day ) and Risperidone were compared. Both medications were associated with overall improvements in cognitive functioning ( p<0.01 ) versus baseline.

"It is encouraging to see that Quetiapine appears to be at least as effective as Risperidone in improving cognitive function while also demonstrating a superior side effect profile in terms of extrapyramidal symptoms " continued Riedel. " Cognitive impairment is a serious symptom but one which is sometimes perceived as less important than some other symptoms of schizophrenia, such as hallucinations. However, recent studies have found that cognitive function is directly related to many areas of social interaction, and can limit an individual from being able to benefit fully from rehabilitation programmes. That is why treating these symptoms effectively is so important."

Quetiapine has been licensed for the treatment of schizophrenia since 1997 and is available in 82 countries for the treatment of this condition.
Results of recent studies show that 600mg/day is an efficacious Quetiapine dose in patients with schizophrenia.
Quetiapine is also licensed in 63 countries for the treatment of mania associated with bipolar disorder, including the US, Canada and several European countries.

Source: American Psychiatry Association ( APA ) Annual Meeting, 2005
 
 
 
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