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Recent News and Articles on the Keywords: heart attack + received approval + diovan  Related to the article below (Last Update: 7/1/2008)

Drug Makers Say FDA Safety Focus
Wall Street Journal -
The wave of post-Vioxx drug scares included concerns that GlaxoSmithKline PLC's widely used diabetes drug, Avandia, could raise heart-attack risk, ...
Looking back at the first season of 'Mad Men'
Chicago Tribune, United States -
Later in the season, when Roger Sterling (John Slattery) finally returned to his ad agency, Sterling Cooper, after a heart attack, no one was more glad to ...
Business Topics
Sun-Sentinel.com, FL -
Israel-based Teva received Food and Drug Administration approval for a generic version of the blockbuster drug, used to treat schizophrenia and bipolar ...OTC:BRDCY - OTC:DNZOY - PINK:DNZOF
FDA now emphasizes safety rather than speed
The News Journal, DE - 47 minutes ago
A year earlier Merck & Co. pulled Vioxx, a painkiller used by millions of Americans, most unnecessarily, off the market, due to discoveries of heart attack ...
Acusphere Announces FDA Acceptance of
Ad-Hoc-News (Pressemitteilung), Germany -
The reduced blood flow can cause chest pain, and if the plaque ruptures, it may cause a heart attack. The American Heart Association estimates that the ...ACUS
From the Wire
AlterNet, CA - Jun 29, 2008
The proposed deal also needs the approval of the Lebanese militant group's secretive, decision-making Shura Council. The agreement had sparked a fierce ...
Israel: 2 Soldiers Captured by Hezbollah Dead, Approves Prisoner Deal FOXNews
Israel, Hezbollah agree on swap Toronto Star
all 1,332 news articles »
Key moments
Globe and Mail, Canada -
1975 In March, Dr. Morgentaler's sentence begins but is completed in a clinic after he suffers a heart attack. Toronto becomes the latest stage for the ...
Iran ready to strike at Israel?s nuclear heart
Times Online, UK - Jun 28, 2008
This intensified speculation that Israel was seeking US approval for a possible attack on Iran. ?Although the visit had been planned well in advance, ...
Cardiac 'wrap' treatments vie for patients' hearts
Pioneer Press, MN - Jun 23, 2008
After suffering a heart attack just over two years ago, Russell has a new lease on life when she received an experimental device called HeartNet, ...
Diabetes Drugs Face Tougher Rules
Wall Street Journal - Jun 27, 2008
But a study last year suggested that Avandia patients' life span didn't improve, because their risk for heart attack increased. No drug that regulates sugar ...
Source: Google News

… of Candesartan on the Development of a New Diagnosis of Diabetes Mellitus in Patients With Heart … -
S Yusuf, JB Ostergren, HC Gerstein, MA Pfeffer, K … - Circulation, 2005 - Am Heart Assoc
... the data, preparation, review, and approval of the ... speakers? bureaus of and/or received
honoraria from ... Lowering Treatment to Prevent Heart Attack Trial (ALLHAT ...

… Pressure Medicine in a Decade, Provides Additional Blood Pressure Reduction When Used With Diovan
FIP Releases - medscape.com
... Tekturna received approval in March 2007 from the US ... Diovan is available for the
treatment of high ... countries, for the treatment of heart attack survivors in ...
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Transplanted kidney structure and function improved with sirolimus-based therapy -
A Options, TOC Latest - Therapy, 2005 - ingentaconnect.com
... glucose concentrations were randomized to receive 10 mg ... drug at preventing death
in heart attack survivors. ... cardio- protective benefits, the approval in Sweden ...

[CITATION] US drug and biologic approvals in 1996
JF Beary, LE Robillard, GR Woollett, JD Siegfried, … - Drug Development Research, 1997
... b sodium (S) Description: the first oral medication approval for use in interstitial
cystitis. ... received approved ... Scintigraphic imaging of the heart 6/7/93 ...

[PDF] DIABETES IN CONTROL. com Newsletter
HNEW YEAR - Newsletter, 2007 - diabetesincontrol.com
... sign for the development of heart disease ... its Exforge antihypertensive medication
had received approval from the ... announced the US regulatory approval of Exforge ...

[PDF] Diovan? the first blood pressure medication in a large-scale clinical trial to lower C-reactive …
P Shelby, J Gilardi - dominoext.novartis.com
... Seven out of 10 people who receive treatment to lower high blood pressure aren?t
maintained in the target zone of 120 ... attack, stroke, heart failure or ...

… Enzyme Inhibitor in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial -
FHH Leenen, CE Nwachuku, HR Black, WC Cushman, BR … - Hypertension, 2006 - Am Heart Assoc
... data; or the preparation or approval of the ... 2. Received February 20, 2006; first
decision March 13 ... Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT ...

Outcomes in Hypertensive Black and Nonblack Patients Treated With Chlorthalidone, Amlodipine, and … -
JT Wright, JK Dunn, JA Cutler, BR Davis, WC … - JAMA, 2005 - Am Med Assoc
... obtained institutional review board approval, and the ... this report were randomized
to receive chlorthalidone, amlodipine ... Treatment to Prevent Heart Attack Trial. ...

[PDF] Recent New Drug Application (NDA) Approvals
T Pharmaceutical, V Pharmaceuticals - caremark.com
... The Final Approval Date is ... receive an annual flu shot ... are associated with high blood
pressure, as well as cardiovascular events (eg, heart attack, stroke ...

Pharmacist interventions to improve the management of coronary artery disease. -
NRM Chapman, MA Fotis, PR Yarnold, M Gheorghiade - American Journal of Health-System Pharmacy, 2004 - pt.wkhealth.com
... This study received approval from the Northwestern University ... of patients were eligible
to receive these drugs ... as alternative for congestive heart failure (see ...

Source: Google Scholar
 
 

Diovan receives EU approval to treat people after heart attacks

 
 
Diovan ( Valsartan ) received European Union ( EU ) approval for the treatment of heart attack survivors.

Diovan is now indicated as a potentially life-saving therapy for the more than 750,000 people in the EU who are at risk of a recurrent heart attack or other serious outcomes such as cardiovascular mortality, hospitalization for heart failure, resuscitated cardiac arrest or stroke.

This approval provides physicians with a proven life-saving treatment for these high-risk patients who have suffered a heart attack. Despite continual improvements, mortality after heart attack is still high.
Diovan can help prolong the life of these high-risk heart attack survivors in addition to providing them with excellent blood pressure lowering efficacy.

The post-heart attack indication for Diovan is based on the positive results of the 14,703 patient trial known as VALIANT ( VALsartan In Acute myocardial infarction ) which was one of the largest long-term studies ever conducted in people who have survived a heart attack.
VALIANT demonstrated that Diovan preserved the benefit of Captopril, which is one essential component of the currently recommended standard of care in these patients, meaning it reduced death to the same degree as the proven treatment.
This finding can translate into a 25% reduction in premature death by Diovan in patients at high risk following a heart attack.
Diovan is the only cardiovascular agent ever demonstrated by a head-to-head trial to have matched the proven benefits of an ACE inhibitor in these patients.
VALIANT also showed that Diovan is well-tolerated in post-heart attack patients.
Adverse events were generally related to the underlying disease. The percentage of permanent discontinuations due to adverse events was statistically higher in the Captopril-treated ( 7.7% ) patients than in the Valsartan-treated ( 5.8%) patients [ p<0.05 ].

Source: Novartis, 2005
 
 
 
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