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Recent News and Articles on the Keywords: cancer therapy + promising new + cancer  Related to the article below (Last Update: 7/8/2008)


Cancer Monthly
DCA - a Cancer Treatment?
Cancer Monthly, NC -
Now a new study in the journal Gynecoogic Oncology finds that DCA might also be a promising therapy for endometrial cancer. Endometrial cancer, which ...
Nanoparticle 'smart bomb' homes in on cancer
New Scientist (subscription), UK -
While the researchers haven't tested the homing nanoparticles in humans, their approach looks promising as a potential cancer treatment, ...
Pricey Drugs Put Squeeze on Doctors
Wall Street Journal -
In 2005, Medicare limited doctors to a 6% markup on intravenous drugs, which account for a large share of new cancer drugs. Private insurers followed. ...
Polish researchers reveal revolutionary chemotherapy procedure for ...
Polish Radio External Service, Poland -
She is one of 12000 Polish women with newly diagnosed breast cancer: 'When I was going for chemo therapy treatment I was thinking will I return home or not. ...
Cancer Nanotech: Government Spending Done Right
Wired News -
By Brandon Keim July 08, 2008 | 10:18:14 AMCategories: Cancer, Government, Nanotechnology The promising field of cancer nanotherapies provide a perfect ...
New Drug for Advanced Thyroid Cancer
Ivanhoe, FL -
?This is the first of the various thyroid cancer trials to identify specific mutations that might allow us to individualize or personalize therapy. ...
New Treatment Approach Promising For Lymphoma Patients In ...
Science Daily (press release) - Jul 6, 2008
In the developed world, CHOP is administered in combination with an antibody therapy called rituximab. But many patients in developing countries, ...
New targeted treatment promising in breast cancer
Reuters India, India - Jul 1, 2008
The combination therapy has "potent anti-tumor activities" in breast cancer cells that produce the Her2 protein as well as in those that do not. ...

InTheNews.co.uk
Cancer patients with depression could be helped by a new care system
InTheNews.co.uk, UK - Jul 6, 2008
"This new treatment could substantially improve the way we manage depression in people with cancer and also in people with other serious medical conditions. ...

India New England
Dr. Who?
India New England, MA -
A spokesperson for Menon and his company first approached INDIA New England in early June with the news of Cellceutix?s promising new cancer-treating ...
Source: Google News

Gemcitabine: a promising new agent in the treatment of advanced urothelial cancer -
MJ Moore, IF Tannock, DS Ernst, S Huan, N Murray - Journal of Clinical Oncology, 1997 - jco.ascopubs.org
... of Clinical Oncology. ARTICLES. Gemcitabine: a promising new agent in the
treatment of advanced urothelial cancer. MJ Moore, IF Tannock ...

Photodynamic therapy: a promising new modality for the treatment of cancer -
JJ Schuitmaker, P Baas, H van Leengoed, FW van der … - Journal of Photochemistry & Photobiology, B: Biology, 1996 - Elsevier
... Therefore it seems legitimate to ask whether PDT can still be described
as "'a promising new therapy in the treatment of cancer". ...

Promising new agents under development by the Division of Cancer Treatment, Diagnosis, and Centers … -
MC Christian, JM Pluda, PT Ho, SG Arbuck, AJ Murgo … - Semin Oncol, 1997 - ncbi.nlm.nih.gov
1997 Apr;24(2):219-40. Promising new agents under development by the Division of
Cancer Treatment, Diagnosis, and Centers of the National Cancer Institute. ...

Claudin-4: A New Target for Pancreatic Cancer Treatment Using Clostridium perfringens Enterotoxin -
P Michl, M Buchholz, M Rolke, S Kunsch, M L?hr, B … - Gastroenterology, 2001 - Elsevier
... Our findings suggest that targeting claudin- 4?expressing tumors with CPE represents
a promising new treatment modality for pancreatic cancer and other solid ...

The Hypoxic Cell A Target for Selective Cancer Therapy-Eighteenth Bruce F. Cain Memorial Award … -
JM Brown - Cancer Research, 1999 - AACR
... among basic researchers has waxed and waned as promising new directions emerged ... creating
a poorer prognosis irrespective of which cancer treatment is used. ...

[PDF] NEW FUNCTIONS FOR THE MATRIX METALLOPROTEINASES IN CANCER PROGRESSION -
M Egeblad, Z Werb - Nature Reviews Cancer, 2002 - microarray.princeton.edu
... surprising.To better target MMPs for cancer treatment, an appreciation ... acting in
opposing directions in cancer progression ? is ... NEW FUNCTIONS FOR THE MATRIX ...
-

Promising new developments in cancer chemotherapy -
K Ferrante - Cancer Chemotherapy and Pharmacology, 1999 - Springer
... With such innovative and promising develop- ments in cancer chemotherapy there is
greater potential now than ever before to advance the treatment of ma ...

Claudin Proteins in Human Cancer: Promising New Targets for Diagnosis and Therapy -
PJ Morin - Cancer Research, 2005 - AACR
... Cancer Research Reviews. Claudin Proteins in Human Cancer: Promising New Targets
for Diagnosis and Therapy. Patrice J. Morin Laboratory ...

Epidermal Growth Factor Receptor Inhibition in Cancer Therapy: Biology, Rationale and Preliminary … -
SM Huang, PM Harari - Investigational New Drugs, 1999 - Springer
... rituxan), EGFR blockade plus radiation therapy in squamous cell car- cinomas of
the head and neck represents a promising new molecular cancer therapy approach. ...

… Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer -
M Fukuoka, S Yano, G Giaccone, T Tamura, K … - Journal of Clinical Oncology, 2003 - jco.ascopubs.org
... factor receptor (EGFR) is a promising target for ... New blinded treatment supplies,
decreasing the dose ... the Functional Assessment of Cancer Therapy ? Lung (FACT ...

Source: Google Scholar
 
 

ABT-737, a promising new approach in cancer therapy

 

 
An experimental compound, ABT-737, that blocks the action of a class of proteins known as the Bcl-2 family, may prove to be a valuable tool in the fight against cancer.

The Bcl-2 family of proteins plays a central role in regulating apoptosis and, consequently, in tumor formation, tumor growth and resistance to treatment.
These proteins are often overexpressed in solid tumors. Researchers have been interested in the Bcl-2 proteins since their role in preventing apoptosis was proven more than a decade ago.
Pioneering work in structural biology at Abbott established how the Bcl-2 family of proteins interacts with one another.

This protein-protein interaction involves a large surface area and has presented significant difficulty in identifying a small-molecule candidate that would potently inhibit the function of these proteins.
Using SAR by NMR ( structure-activity relationships by nuclear magnetic resonance ), a proprietary technology developed by an Abbott team led by the head of Cancer Research, Stephen Fesik, as well as other methods, Abbott researchers created three-dimensional maps of these intricate proteins and discovered small molecules that bound tightly to the Bcl-2 family of proteins and demonstrated greater potency than any previously discovered compounds.

The data show that ABT-737 binds to the Bcl-2 proteins, and, in effect, restores cell death to cancerous cells.
ABT-737 was found to effectively kill certain cancer cell lines, including lymphoma and small cell lung carcinoma.
Additionally, Abbott Bcl-2 family inhibitors were found to enhance the effects of chemotherapy and radiation in other types of cancer, such as non-small cell lung cancer.

These discoveries are the result of a scientific collaboration between Abbott and Idun Pharmaceuticals focused on developing small-molecule treatments for cancer specifically targeting the apoptotic pathway.

Source: Abbott, 2005
 
 
 
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