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Recent News and Articles on the Keywords: 0.17 + web + human  Related to the article below (Last Update: 8/4/2008)

Geron Corporation Reports 2008 Second Quarter Financial Results ...
MarketWatch - Jul 30, 2008
For the second quarter of 2008, the company reported a net loss of $13.6 million, or $(0.17) per share, compared to $14.0 million, or $(0.19) per share, ...GERN
Illumina Reports Financial Results for Second Quarter 2008
FOXBusiness - Jul 23, 2008
Illumina's technology will be used as part of the project to identify the genetic variants responsible for disease and human diversity. ...ILMN
Amgen's Second Quarter 2008 Adjusted Earnings Per Share Increased ...
Trading Markets (press release), CA - Jul 28, 2008
Amgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies ...AMGN
Source: Google News

Five Psychometric Scales for Online Measurement of the Quality of Human-Computer Interaction in Web … -
P van Schaik, J Ling - International Journal of Human-Computer Interaction, 2005 - Lawrence Earlbaum
... key constructs previously investigated in mainstream human?com- puter ... Psychometric
Scales for Web Site Evaluation 317 ... 0.81 4.76 0.80 < 1 ns ?0.17 0.37 0.06 ...

The Interactive Minority Game: a Web-based investigation of human market interactions -
P Laureti, P Ruch, J Wakeling, YC Zhang - Physica A: Statistical Mechanics and its Applications, 2004 - Elsevier
... Trader 4 0.17 Symmetric 1.46 9,400 ... When observed elsewhere in human eco- nomic
decision-making, repetitive ... Department for providing us with a web server and ...

[PDF] A DNA polymorphism discovery resource for research on human genetic variation -
FS Collins, LD Brooks, A Chakravarti? - Genome Res, 1998 - udl.es
... Risks, considers the material in the DNA Polymorphism Discovery Re- source to be
in the category of human subjects, for ... African?American 0.17 120 20 100 0 0 ...
-

… Analyzer: An Automatic Classification Approach to Facilitating Collaborative Commerce on the Web -
W Chung - Hawaii International Conference on System Sciences, Island …, 2005 - doi.ieeecomputersociety.org
... Based on the approach, we developed Business Stakeholder Analyzer, a system that
incorporates both human knowledge and business Web site content, and ...

[PDF] World Wide Web Navigation Aid -
M Head, N Archer, Y Yuan - 2000 - business.mcmaster.ca
... Nielsen (1990b) suggests that this is one of the major usability problems with large
scale hypermedia environments such as the Web. Human limitations on short ...
-

[PDF] Customer needs in Web Based Interaction: A Macro view of Usability
R Goonetilleke, C Duffy, D Jacques - Human-Computer Interaction, 2001 - www-ieem.ust.hk
... 14 - safe 0.18 0.70 -0.16 -0.26 15- trust website 0.17 0.86 0.13 -0.08 ... Human Factors
& Web Development, Mahwah, NJ: Lawrence Erlbaum Associates, pp. ...

Thieno-triazolo-1, 4-diazepines as antagonists of platelet-activating factor: Present status -
J Casals-Stenzel - Lipids, 1991 - Springer
... 0.54 WEB 2086 0.17 WEB 2170 0.32 WEB 2347 0.30 ... 1.3 48 740 RP 48.7 aInhibition
of PAF (5 X 10-SM)-induced human platelet aggre- gation. ...

… Factor Play an Important Role in Early Atherogenesis In Vitro and In Vivo Inhibition by WEB 2086 -
G Subbanagounder, N Leitinger, PT Shih, KF Faull, … - Circulation Research, 1999 - Am Heart Assoc
... were rinsed twice with medium, and a suspension of human monocytes (2 ... L) was much
higher than the IC 50 value (0.17 ?mol/L) reported for WEB 2086 inhibition ...

The Sequence of the Human Genome -
JC Venter, MD Adams, EW Myers, PW Li, RJ Mural, GG … - Science, 2001 - sciencemag.org
... We also describe our preliminary analysis of the human genetic code on the basis
of ... with this issue; files for each chromosome can be found in Web fig. ...

Does ?authority? mean quality? predicting expert quality ratings of Web documents -
B Amento, L Terveen, W Hill - Proceedings of the 23rd annual international ACM SIGIR …, 2000 - portal.acm.org
... with the expert ratings, we had to analyze the web neighborhood surrounding ... 4.3 Can
We Predict Human Quality Judgements? ... 41 15 0.37 39 10 0.26 41 7 0.17 42 13 ...

Source: Google Scholar
 
 

Leprosy microbes provide insights into human immune responses

 
 
With the unusual opportunity that human leprosy infections provide for study of human immune responses, scientists have discovered how the body's early warning system prompts a rapid immune response by two separate armies of defensive cells.
The finding helps explain why, when threatened by microbes like the leprosy bug, this initial defense sometimes succeeds in limiting the damage, but in other cases yields to a dangerous, spreading infection.

The researchers ,led by Stephan R. Krutzik of UCLA, isolated immune cells in blood samples from healthy people and exposed the cells to a component of mycobacteria. The large white blood cells known as monocytes rapidly differentiated into the two distinct cell types, forming the body's emergency response to the detection of foreign bacteria. One category of defensive cells, macrophages, seek out and engulf the infectious bugs. The other group consists of dendritic, or "antigen-presenting" cells ( APC ), which seize distinctive pieces of the enemy and use them to "educate" and stir up a second immune response, known as "adaptive" immunity.

Until now, laboratory dish experiments hadn't revealed that the instantaneous or "innate" immune reaction-discovered less than 10 years ago-is mounted by two differently-specialized cells. It had been thought that the initially responding cells were uniformly macrophages, equipped for the two roles. The innate response swings into action when invading microbes are detected by molecules called Toll-like receptors ( TLRs ) that stick out of the cell's outer membrane, serving as a trip-wire to raise the alarm. The TLRs spur the monocytes to differentiate into the two rapid response cell types.

Why this matters became strikingly clear when the scientists studied different forms of leprosy for the presence of the two cell types.
One of the types, the microbe-eating macrophages, is labeled DC-SIGN+, while the other, the antigen-presenting dendritic cells, are termed CD1b+.
In people who have the form of leprosy known as tuberculoid, or T-lep, the body has made a strong immune response and the infection stays localized to the skin.
In patients with lepromatous leprosy, or L-lep, the bacteria have overwhelmed the immune defenses and can spread along nerves throughout the body and may cause blindness.

The scientists found DC-SIGN+ macrophages in both types of leprosy infections. The CD1b+ cells were present only in the milder form, indicating a successful battle against the leprosy bacterium. They were missing, however, in the more severe leprosy infections, meaning that the monocytes hadn't succeeded in producing those key anti-bacterial fighters.

" The logic here is that because their monocytes are unable to produce the ( CD1b+ ) cells that can mobilize T-cells, these people don't respond well and become much sicker," commented Bloom. " This research gives us insights about how the body develops protective immunity against bugs that invade our cells-or fails to. Now we know the players, and we would love to look at them in other diseases such as tuberculosis in the lungs and juvenile diabetes."

Source: Harvard School of Public Health, 2005
 
 
 
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