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Recent News and Articles on the Keywords: pacific islanders + heirs study + iron  Related to the article below (Last Update: 7/1/2008)

Television movies for the week of June 22
Pittsburgh Post Gazette, PA - Jun 21, 2008
Following the death of his parents, young heir Bruce Wayne becomes a masked avenger who fights the forces of evil in Gotham City. (PG-13) (2:30) FX: Thu. ...
Television movies for the week of June 15
Pittsburgh Post Gazette, PA - Jun 14, 2008
Two heirs try to wrest control of a corporation by dashing the merger between an American tycoon and his girlfriend. (2:00) ABCFAM: Sat. ...
Source: Google News

Hemochromatosis and Iron Overload Screening (HEIRS) Study Design for an Evaluation of 100,000 … -
CE McLaren, JC Barton, PC Adams, EL Harris, RT … - The American Journal of the Medical Sciences, 2003 - amjmedsci.com
... in Hispanics, Asians, and Pacific Islanders indicate that the HEIRS Study screening
strategy will identify persons with HFE-associated iron overload in these ...

Hemochromatosis and Iron-Overload Screening in a Racially Diverse Population -
PC Adams, DM Reboussin, JC Barton, CE McLaren, JH … - New England Journal of Medicine, 2005 - content.nejm.org
... Serum Ferritin and Transferrin Saturation in Asians and Pacific Islanders. ... Diabetes
in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.. ...

Liver Diseases in the Hemochromatosis and Iron Overload Screening Study
PC Adams, L Passmore, S Chakrabarti, DM Reboussin, … - Clinical Gastroenterology and Hepatology, 2006 - Elsevier
... weight) then the liver iron concentration was ... Asians, 13% Hispanics, .7% Pacific
Islanders, .7% Native ... phenotypic characteristics of the HEIRS study group have ...

… and Self-Reported Diabetes in the Hemochromatosis and Iron Overload Screening (HEIRS) Study -
RT Acton, JC Barton, LV Passmore, PC Adams, MR … - Diabetes Care, 2006 - Am Diabetes Assoc
... In a pilot study of iron status and glycemic control ... highest prevalence of diabetes
in the HEIRS study was observed in Pacific Islanders (20.06%), a ...

… in Hfe Mutation Frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study -
RT Acton, JC Barton, BM Snively, CE McLaren, PC … - Ethnicity & Disease, 2006 - apt.allenpress.com
... in the Hemochromatosis and Iron Overload Screening ... groups and among the HEIRS Study
field centers ... field centers in Native Americans and Pacific Islanders. ...

… in patients with indeterminate results: The hemochromatosis and iron overload screening study. -
RT Anderson, L Wenzel, AP Walker, A Ruggiero, RT … - Genetics in Medicine, 2006 - geneticsinmedicine.org
... prior to their participation in HEIRS and were ... presents the demographic characteristics
of study participants ... and nearly 10% as Asian/Pacific Islander (40.7% of ...

Concerns in a primary care population about genetic discrimination by insurers. -
MA Hall, JE McEwen, JC Barton, AP Walker, EG Howe, … - Genetics in Medicine, 2005 - geneticsinmedicine.org
... participants: If you have iron overload or ... Hispanic, Asian, Native Hawaiian/Pacific
Islander, American Indian ... a different component of the HEIRS Study asked 440 ...

[CITATION] … genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study -
JC Barton, RT Acton, L Lovato, MR Speechley, CE … - Clinical Genetics, 2006 - Blackwell Synergy
... Native Hawaiian or other Pacific Islander (706), or ... SF, and calculated total
iron-binding capacity ... The HEIRS Study defined these initial screening phenotypes ...

[CITATION] A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study -
RT Acton, BM Snively, JC Barton, CE McLaren, PC … - Clinical Genetics, 2007 - Blackwell Synergy
... probands was conducted at all HEIRS Study Field Centers ... years of age were also available
for study. ... groups (white, black, Asian, Pacific Islander, and Native ...

Serum Ferritin and Transferrin Saturation in Asians and Pacific Islanders -
EL Harris, CE McLaren, DM Reboussin, VR Gordeuk, … - Archives of Internal Medicine, 2007 - archinte.highwire.org
... Background Asians and Pacific Islanders in the Hemochromatosis and Iron Overload
Screening (HEIRS) Study had the highest prevalence of elevated serum ferritin ...
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Source: Google Scholar
 
 

HEIRS study, Asians and Pacific Islanders have the highest levels of iron

 
 
Results of the largest and most diverse screening study of hemochromatosis and iron overload ever conducted ( HEIRS Study ), show that Asians and Pacific Islanders have the highest mean levels of iron in their blood of all other ethnic groups involved in the study – African Americans, Caucasians, Hispanics, and Native Americans. Elevated iron levels in the blood are sometimes associated with accumulations of iron in vital body organs, which can lead to an increased risk of diabetes, arthritis, sexual dysfunction, liver disease and liver cancer, and heart disease.

At the start of the study in 1999, it was known that most cases of hemochromatosis in Caucasians resulted from mutations in the HFE gene ( known as C282Y ), which was first discovered in 1996.
Little was known about iron overload in other racial and ethnic groups. Surprisingly, results of the HEIRS Study show that Asians and Pacific Islanders had the highest blood iron levels but the lowest prevalence of HFE genetic mutations.

The study has been published in the New England Journal of Medicine.

“ Hemochromatosis is one of the most common inherited disorders,” says John Eckfeldt, at the University of Minnesota, HEIRS central laboratory director, and the HEIRS Study steering committee chair. “ It can lead to iron overload, which if detected early, can be treated easily through regular blood draws. The problem is that it is difficult to diagnose early before severe complications have occurred. When the HEIRS Study is completed, we hope to have answers to the key questions that will help policymakers decide who should be screened for hemochromatosis and iron overload, when should they be screened, and what screening methods should be used.”

The findings about hemochromatosis and iron overload in Caucasians confirm findings from previous studies. The high levels of iron in the blood of Asians and Pacific Islanders is surprising because they had the lowest prevalence of the HFE C282Y/C282Y genotype.

The HEIRS Study recruited more than 100,000 participants in primary care settings and blood drawing laboratories at five field centers in the United States and Canada. The five-year study is funded by the National Heart, Lung, and Blood Institute and the National Human Genome Research Institute.

Other major findings of the study include the following:

- Caucasians had the highest prevalence of the HFE C282Y/C282Y genotype ( 4.4 per 1,000 people ).

- HFE C282Y/C282Y prevalence rates in other ethnic groups were: Native Americans ( 1.1 per 1,000 ), Hispanics ( 2.7 per 10,000 ), African Americans ( 1.4 per 10,000 ), Pacific Islanders ( 1.2 per 10,000 ), and Asians ( 3.9 per 10 million ).

- Most participants with the HFE C282Y/C282Y genotype had elevated levels of iron in the blood ( measured by serum ferritin and transferrin saturation ).

- Men with the HFE C282Y/C282Y genotype were more likely to report a history of liver disease than participants without HFE mutations.

Source: University of Minnesota, 2005
 
 
 
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