Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary … -
L Serfaty - Hepatology, 2003 - doi.wiley.com
... that linked the use of UDCA to a lower rate of colorectal dysplasia, based ... 24 It
is unclear how UDCA might inhibit the growth of adenoma and possibly ...

Phase III Trial of Ursodeoxycholic Acid To Prevent Colorectal Adenoma Recurrence -
DS Alberts, ME Martinez, LM Hess, JG Einspahr, SB … - jnci, 2005 - jnci.oxfordjournals.org
... for the overall relatively low level of chemopreventive activity against sporadic
colorectal adenoma recurrence shown by UDCA in this study may be related to ...

Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of … -
PR Debruyne, EA Bruyneel, IM Karaguni, X Li, G … - Oncogene, 2002 - nature.com
... invasive phenotype, during the adenoma/adenocarcinoma transition ... receptor co-activators
in colorectal cancer cells ... LCA), but not UDCA, may stimulate invasion ...

Primary chemoprevention strategies for colorectal cancer: Ursodeoxycholic acid and other agents -
TA Brasitus - Gastroenterology, 1995 - Elsevier
... or promote the development of colorectal cancer must ... and/or drugs and colonic adenoma
and cancer ... supplementa- tion with ursodeoxycholic acid (UDCA) (0.4%), the ...

High-Dose Ursodeoxycholic Acid in Primary Sclerosing Cholangitis: A 5-Year Multicenter, Randomized, … -
R Olsson, KM Boberg, O Schaffalitsky de Muckadell, S … - Gastroenterology, 2005 - Elsevier
... Since the first demonstration that UDCA may be an effective treatment of primary
biliary cirrhosis, 9 several studies have been published investigating the ...

Results of a Phase I Multiple-Dose Clinical Study of Ursodeoxycholic Acid -
LM Hess, MF Krutzsch, J Guillen, HH Chow, J … - Cancer Epidemiology Biomarkers & Prevention, 2004 - AACR
... In the AOM rat model, treatment with UDCA resulted in a significant
decrease in adenoma formation and colorectal cancer. ...

Options for Treatment of Primary Biliary Cirrhosis. -
YH Oo, J Neuberger - Drugs, 2004 - drugs.adisonline.com
... sclerosing cholangitis and PBC.[8]UDCA treatment reduces intracellular hydrophobic
bile acid levels and thereby may have a ... UDCA and Colorectal Adenoma TOP. ...

[CITATION] Colorectal cancer chemoprevention -
PJ Limburg, JC Kolars - Chinese Journal of Digestive Diseases, 2004 - Blackwell Synergy
... on premalignant tissues, and may beneficially modulate cell ... Clinical trial data for
UDCA chemoprevention of ... Dietary fiber and distal colorectal adenoma in men. ...

Does Ursodeoxycholic Acid Change the Proliferation of the Colorectal Mucosa?. A Randomized, Placebo- … -
T Ochsenkuhn, I Marsteller, U Hay, J Diebold, G … - Digestion, 2003 - content.karger.com
... at the University of Arizona (USA), analyzing adenoma recurrence in ... shed more light
on the role of UDCA in chemoprevention of colorectal cancer ...

[CITATION] Chemoprevention of colorectal cancer -
K Gwyn, FA Sinicrope - American Journal of Gastroenterology, 2002 - Blackwell Synergy
... plus difluoromethylornithine, sulindac sulfone, UDCA, and folic ... and costly studies
with adenoma recurrence as ... in patients with prior colorectal adenomas and ...