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Recent News and Articles on the Keywords: rheumatoid arthritis + sex hormone + role  Related to the article below (Last Update: 5/12/2008)

New Study Shows How Genes Control Blood Proteins Important To Health
Science Daily (press release) - May 10, 2008
As an example, the group identified variations in genes that influence "Sex hormone binding globulin," a protein that controls how much testosterone is ...
Source: Google News

Sex Hormones and Pregnancy in Rheumatoid Arthritis and Systemic Lupus Erythematosus -
M OSTENSEN - Annals of the New York Academy of Sciences, 1999 - Blackwell Synergy
... 1 Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE ... However, they differ
in their response to sex hormones. ... with an emphasis on the role of sex ...

The role of pregnancy in the course and aetiology of rheumatoid arthritis -
JAP Silva, TD Spector - Clinical Rheumatology, 1992 - Springer
... with the pi-egnancy-induced remission of rheumatoid arthritis (Abstract ... Arthritis
Rheum 1990, 33 (9 Suppl): S10 ... James, WH Sex ratios and hormones in HLA-related ...

The role of sex hormones in systemic lupus erythematosus. -
RG Lahita - Current Opinion in Rheumatology, 1999 - co-rheumatology.com
... In a recent paper, such changes were used to explain the improvement of patients
with rheumatoid arthritis and multiple ... The role of sex hormones in systemic ...

Sex hormones and rheumatoid arthritis -
M Cutolo, B Villaggio, C Craviotto, C Pizzorni, B … - Autoimmunity Reviews, 2002 - Elsevier
... Accardo , Sex hormones, HLA and rheumatoid arthritis. Clin Exp Rheumatol 9 (1991),
pp. 641?648. 2. M. Cutolo, B. Seriolo, C. Pizzorni and A. Sulli , The role ...

Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis -
PN Sambrook, JA Eisman, GD Champion, NA Pocock - Arthritis Rheum, 1988 - doi.wiley.com
... estrogens, adrenal androgens play a role in the ... a well-recognized complication of
rheumatoid arthritis (RA) and ... is any disturbance of sex hormone metabolism in ...

Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone … -
ZM Sthoeger - The Journal of Immunology, 1988 - Am Assoc Immnol
... Recent aspects of gonadal hormone and neurotransmitter ... immune cells: implications
in rheumatoid arthritis Ann Rheum ... Bland, and IH Chaudry Sex steroids regulate ...

The Pathophysiologic Roles of Interleukin-6 in Human Disease -
DA Papanicolaou, RL Wilder, SC Manolagas, GP … - Annals of Internal Medicine, 1998 - annals.highwire.org
... inhibits thyroid-stimulating hormone secretion, and ... in several inflammatory diseases,
such as rheumatoid arthritis. ... resorption, such as sex-steroid deficiency ...

Sex hormones and rheumatoid arthritis: cause or effect relationships in a complex pathophysiology? -
AT Masi - Clin Exp Rheumatol, 1995 - ncbi.nlm.nih.gov
... to contribute to the risk of rheumatoid arthritis (RA) because ... Hypotheses of sex
hormone contributions to RA are tested by ... in men further support a role of sex ...

INCIDENCE OF RHEUMATOID ARTHRITIS: DO THE OBSERVED AGE-SEX INTERACTION PATTERNS SUPPORT A ROLE OF … -
AT MASI - Rheumatology, 1994 - Br Soc Rheumatology
... RHEUMATOID arthritis is a highly complex, systemic inflammatory ... neurohormonal systems
and sex hormones (eg preg ... 4] reveal significant age-sex interaction pat ...

SEX HORMONE ADJUVANT THERAPY IN RHEUMATOID ARTHRITIS -
M Cutolo - Rheumatic Disease Clinics of NOrth America, 2000 - Elsevier
... increased attention, particularly regarding their role in preclinical ... phases and
in active rheumatoid arthritis, with sex hormone adjuvant (replacement ...

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Rheumatoid arthritis, role of TNF on sex hormone production

 
 
Drugs blocking the action of TNF ( Tumor Necrosis Factor ) have shown promise in the early treatment of rheumatoid arthritis.

To expand the understanding of TNF's function in chronic inflammatory diseases, researchers at University Hospital Regensburg in Germany and the National Institute of Rheumatic Diseases in the Slovak Republic decided to take a closer look at this cytokine's impact on androgen production.

Androgens are thought to play a critical anti-inflammatory role in rheumatic diseases, including various forms of arthritis and lupus, based on extensive clinical trials and animal models.

For their study, the researchers investigated the role of TNF in the conversion of biologically inactive DHEAS--dehydroepiandrosterone sulfate--to biologically active DHEA, the steroid hormone parent of androgen, estrogen, and testosterone.

To get a clear picture of how TNF affects hormone production and regulation, the research team analyzed samples of inflamed synovial tissue--obtained immediately after opening the knee joint capsules of 37 patients who underwent elective joint replacement surgery. 15 of the patients had a longstanding history of rheumatoid arthritis, with disease duration averaging 15 years. 22 of the patients were osteoarthritis sufferers.

Using tools for biochemical analysis, the team assessed the process of converting DHEAS to DHEA.

The results revealed marked differences in the cellular activity of rheumatoid arthritis and osteoarthritis patients.

On the evidence of both synovial cell and synovial fluid analysis, levels of DHEA from DHEAS were significantly lower among rheumatoid arthritis patients than osteoarthritis patients. In addition, researchers found a negative correlation between converted DHEA and markers of inflammation among rheumatoid arthritis patients but not in patients with osteoarthritis. They also found evidence that TNF inhibits the activity of steroid sulfatase, the key enzyme in DHEAS-to-DHEA conversion.

" This is the first study to demonstrate that the conversion of DHEAS to DHEA is decreased in patients with rheumatoid arthritis as compared with that in patients with osteoarthritis," notes leading contributor Claudia Weidler. " In the present study, we were fortunate to demonstrate that TNF is also a strong inhibitor of the conversion of DHEAS to DHEA in synovial cells from patients with rheumatoid arthritis but absolutely not in patients with osteoarthritis."

Providing the full picture of androgen deficiency in rheumatoid arthritis, this study affirms the need for further research into early anti-TNF antibody therapy in the treatment of this particular inflammatory disease.

Source: Arthritis & Rheumatism, 2005
 
 
 
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