Iconocast Logo

Welcome To Iconocast

How to add a URL link from your web site to the Iconocast web sites

Virtual tour of Southern California

 

Recent News and Articles on the Keywords: jet lag + neurotransmitter gaba + gaba  Related to the article below (Last Update: 7/8/2008)

Talking travel with jetlag guru Ted Ray (plus anti-jetlag formula ...
Gadling, CA - Jul 7, 2008
He's a licensed acupuncturist and herbalist who's a travel consultant to high-powered Silicon Valley execs, especially on how to get over jet lag. ...
Making plans to keep travel stress free
Irish Times, Ireland -
JET LAG and travel fatigue are integral parts of travelling. There are a number of simple strategies you can put in place to make sure that the transition ...

Gather.com
Ways to minimize jet lag
Gather.com, MA - Jul 1, 2008
But even a seasoned traveler like me can use some tips on how to conquer jet lag. I learned a lot from this article, first published in the Harvard Women's ...
Vodafone rolls out iPhone 3G details, draws lines
Macworld, CA -
And a wicked case of jetlag. If you?re curious about what New Zealanders will be paying to take home an iPhone 3G, you can check out Vodafone's website or ...VOD

Yahoo! Eurosport
Golf-Jimenez fights jet lag at BMW International Open
Reuters UK, UK - Jun 18, 2008
By Norman Dabel MUNICH, June 18 (Reuters) - Miguel Angel Jimenez will fight jet lag on Thursday at the BMW International Open starting on Thursday after his ...
Miguel Angel Jimenez rejects chance to take a breather in the BMW ... Telegraph.co.uk
JIMENEZ NOW A REALISTIC MAJOR CONTENDER Sportinglife.co.za
all 21 news articles »
Condes not worried by jetlag; still in top form
Inquirer.net, Philippines - Jun 9, 2008
IN HIS first trip to the United States, IBF minifly king Florante ?The Little Pacquiao? Condes remains in top shape and it seems jet lag will not come into ...
Just A Little Jet Lag
The Ledger, FL - Jun 30, 2008
It was already after 7 pm We had been circling over the Atlantic, waiting for weather to clear in Orlando. The pilot announced that the airport was still ...
Dunn to compete on world stage
Dubbo Daily Liberal, Australia - 23 minutes ago
?I don?t travel well and I think it was a combination of the flight and jetlag,? Dunn said. ?I had a really strong training session on Monday so I am ...
Orioles overcome jet lag
Redwood City Daily News, CA - Jun 26, 2008
Perhaps the concern wasn't whether the Orioles' pitching would come through, but more of whether the offense was still suffering from jet lag. ...
Ponting steps off plane and into surgery
Sydney Morning Herald, Australia - Jul 7, 2008
On top of what's likely to be a massive case of jetlag, Australian cricket captain Ricky Ponting has begun recuperating after wrist surgery. ...
Source: Google News

Circadian Rhythms, Jet Lag, and Chronobiotics: An Overview -
P Redfern, D Minors, J Waterhouse - Chronobiology International, 1994 - informaworld.com
... The idea of a ?jet lag pill,? a wonder drug that ... will depend on a knowledge of
neurotransmitter mechanisms in ... Y (NPY) and y-aminobutyric acid (GABA) (39). ...

A benzodiazepine used in the treatment of insomnia phase-shifts the mammalian circadian clock -
FW Turek, S Losee-Olson - Nature, 1986 - nature.com
... workers) and travel schedules (for example, jet lag) 1,3 ... act by potentiating the
action of the neurotransmitter -aminobutyric acid (GABA), a widely ...

Come Together, Right? Now: Synchronization of Rhythms in a Mammalian Circadian Clock -
SJ Aton, ED Herzog - Neuron, 2005 - Elsevier
... ?Jet lag? seems a likely consequence of this environmentally imposed internal ... A putative
neurotransmitter synchronizing signal within the SCN must ... GABA. ...

Glutamate and GABA mediate suprachiasmatic nucleus inputs to spinal-projecting paraventricular … -
LN Cui, E Coderre, LP Renaud - American Journal of Physiology- Regulatory, Integrative and …, 2001 - Am Physiological Soc
... our ability to cope with environmental challenges such as shift work and jet lag,
situations that may ... GABA is the principal neurotransmitter of the ...

Adaptation of circadian rhythmicity to shift in light-dark cycle accelerated by a benzodiazepine -
O van Reeth, FW Turek - American Journal of Physiology- Regulatory, Integrative and …, 1987 - Am Physiological Soc
... mental and physical disorders (eg, the ?jet lag? syn- drome ... poten- tiating the action
of the neurotransmitter y-aminobu- tyric acid (GABA) (8)) the ...

Neurotransmitters of the suprachiasmatic nuclei -
V Reghunandanan, R Reghunandanan - Journal of Circadian Rhythms, 2006 - jcircadianrhythms.com
... Problems of shift-work insomnia and ill effects of jet lag are among the clock ... Most
SCN neurons express the neurotransmitter GABA and are thus GABAergic [12]. ...

JET-LAG: Symptoms and Treatment -
C Desynchronization, RJ Lag - sportsci.org
... tranquilizers, benzodiaepines, affect neurotransmitters that have ... acetylcholine and
gamma-aminobutyric acid (GABA). ... reduction in jet-lag symptoms, improvements ...

Cellular Interactions in the Suprachiasmatic Nucleus. -
A Van Den Pol - NASA, 1997 - stinet.dtic.mil
... SCN cells to the fast-acting neurotransmitters GABA and glutamate ... neurons is modulated
by neurotransmitters, we may ... during what is commonly known as "jet lag". ...
-

Cellular Interactions in the Suprachiasmatic Nucleus. -
AVANDEN Pol - 2000 - stormingmedia.us
... SCN cells to the fast-acting neurotransmitters GABA and glutamate ... neurons is modulated
by neurotransmitters, we may ... during what is commonly known as "jet lag". ...

Sleep Disorders?No Failed Antihistamines Need Apply
EME TECHNOLOGIES - ingentaconnect.com
... 3M Pharmaceuticals (St. Paul, MN) is developing a melatonin patch for sleep disorders,
seasonal disorders, and jet lag. ... GABA 3 1 4 ... Other neurotransmitter 1 1 ...

Source: Google Scholar
 
 

Neurotransmitter GABA involved in jet lag

 
 
A new study demonstrates that the brain’s central timekeeper -- the biological clock that regulates waking and sleeping cycles -- has two parts that fall out of synchrony during light schedule shifts of six hours, the time it takes to fly across the Atlantic.

The finding may explain, at least in part, why transmeridian travelers suffer from jet lag, the malaise experienced after crossing several time zones. The new understanding could eventually lead to the development of medicines that would “reset” the biological clock so travelers could adjust much more quickly to rapid time zone changes. Most people require about two-and-a-half days to adjust to a six-hour flight from Europe to the United States, and even longer after an eastbound trans-Atlantic flight. The study also has implications for ways to treat shift workers — health care providers, factory employees, truck drivers, etc. — who encounter alertness problems, and those with sleep disorders.

A team of researchers at the University of Virginia and at Leiden University Medical Center in the Netherlands found that the dorsal and ventral sections of the suprachiasmatic nucleus ( SCN ), the brain’s central timekeeper, adjust to shifts in light schedules at vastly different rates, potentially causing the difficult period of adjustment that most people experience after air travel across several time zones.

The researchers found that the ventral part of the SCN, which is directly connected by a nerve to the light-sensing retina, synchronizes rapidly with a new light schedule, even a radically shifted schedule. But the dorsal part of the clock requires several additional days to adjust. This results in complex signaling patterns that may adversely affect the functioning of tissues and organs throughout the body for a period of several days.

Importantly, the study identifies the neurotransmitter GABA ( gamma-aminobutyric acid ) as the link between the two clock parts that eventually pulls them back into synchronization.

Block likens GABA to a weak rubber band linking pendulums swinging at different rates. If the “rubber band” could be made stronger, such as using a drug to enhance GABA, the ventral and dorsal parts of the central timekeeper could more quickly move back into harmony. The symptoms of jet lag would then be reduced or eliminated.

“ The key here is, we now know what the ‘rubber band’ is: the neurotransmitter GABA that ultimately brings the clock back into synch,” Block said. “ This could lead to future therapies for jet lag. This is the first time that we have a mechanistic understanding of the systematic coupling of the different parts of the clock. We are now on our way to suggesting strategies for shifting the clock more quickly in response to unnatural light cycle changes.”

Block said that future therapies, using this new knowledge, might also benefit shift workers and older people who suffer from sleep disorders.

In nature, day and night cycles shift slowly as the seasons change. The body is able to adjust to the slow changes and is in fact adapted to these seasonal cycles. But transmeridian flight is an unnatural manipulation of the light cycles, forcing the body to try to rapidly adjust to abrupt light cycle shifts. This sudden disruption in the normal pattern can compromise the normal function of organs. The result often is sleeplessness or sleepiness, reduced alertness, indigestion, fatigue and possibly ulcers.

“ This new finding adds support to the emerging view that the central timekeeper, the SCN, is more complex than previously thought, and in fact adjusts to light cycle shifts at a different rate within its own structure,” Block said. “ Most importantly, the new research identifies the mechanism that couples the two parts of the SCN clock.”

He suggested that the differing rates of synchronization that occurs in the central clock may be part of a complex evolutionary adaptation to seasonal light changes, but the mechanism, in effect, becomes confused when confronted with unnatural and dramatic shifts in light schedules.

Source: University of Virginia, 2005
 
 
 
Google
Web www.iconocast.com
 
 
 

 

Continue News With: News7 ; News8 ; News9 ; News9A


ADVERTISEMENT

Iconocast is about learning and teaching without borders; we offer eMarketing, Internet Advertising, Internet Marketing, Search Engine Optimization, Search Engine Marketing, Online Branding, and eMarketing News Services. Home

 © 2002-2006

Keywords::

Contact Iconocast

Home Page