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Recent News and Articles on the Keywords: neck cancer + chemotherapy reduces + chemotherapy  Related to the article below (Last Update: 7/1/2008)


MLive.com
Cancer zappers
MLive.com, MI - Jun 25, 2008
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Different Type Of Colon Cancer Vaccine Reduces Disease Spread ...
Science Daily (press release) - Jun 24, 2008
"The target populations for such a vaccine are patients who have had surgery and adjuvant chemotherapy and have no evidence of disease. ...
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Advance for Speech-Language Pathologists and Audiologists, PA - Jun 24, 2008
"The chemotherapy and radiation therapy we use to treat this type of cancer is very aggressive. If we can identify those patients most likely to respond, ...
Oral Health in Older Patients is Something to Talk About
Nurse.com, VA -
... of xerostomia in the older adult is 25% to more than 40%, with causes ranging from multiple medications to head-and-neck radiation or chemotherapy. ...

Natural News.com
Acupuncture Reduces Pain Associated With Head and Neck Cancer
Natural News.com, AZ - Jun 17, 2008
Acupuncture is being used in the palliative care of cancer to alleviate pain and chronic fatigue and to reduce postoperative chemotherapy-induced nausea and ...
Acupuncture Reduces Pain After Surgery for Head and Neck Cancer
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Depending on the location and stage of the cancer, treatment may involve surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of ...

Business Wire (press release)
Promising Data on Head and Neck Cancer Announced by DNAR at 2008 ...
Business Wire (press release), CA - Jun 3, 2008
DNA repair pathways correct DNA that has been damaged by many common forms of cancer treatment (eg chemotherapy and radiation) and play a central role in ...
Cancer patients should avoid antioxidants
London Free Press, Canada - Jun 16, 2008
In fact, the effectiveness of radiotherapy and several chemotherapy drugs largely depends on their ability to generate free radicals. ...
ASCO Study Shows UConn?s Virtual Cell Can Model Complications of ...
bio1nf0rm (subscription), NY - Jun 13, 2008
In patients scheduled to receive high-dose head and neck radiation, say, for oral cancer, particularly if they are going to receive chemotherapy ...
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EurekAlert (press release), DC - Jun 2, 2008
CHICAGO, June 2 ? Patients treated for locally advanced head and neck cancer may respond better to treatment with the addition of cetuximab to chemotherapy, ...
Source: Google News

[CITATION] Oral glutamine reduces the duration and severity of stomatitis after cytotoxic cancer chemotherapy -
PM Anderson, G Schroeder, KM Skubitz? - Cancer, 1998
... GI tract, and head and neck have reductions in ... glutamine action relative to control
of cancer. ... the effec- tiveness of chemotherapy against rhabdomyosarcoma and ...

… Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer -
J Bernier, C Domenge, M Ozsahin, K Matuszewska, JL … - The New England Journal of Medicine, 2004 - nejm.org
... from a significant effect on survival indexes, adjuvant chemotherapy and radiotherapy ...
five-year rate of death from head and neck cancer was reduced from 43 ...
-

[CITATION] Adjuvant chemotherapy in head and neck cancer -
PM Stell - Clinical Otolaryngology, 1990 - Blackwell Synergy
... it is hoped that adju- vant chemotherapy might reduce the rate of ... trials with survival
data of adju- vant chemotherapy in head and neck cancer have been ...

Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta- … -
JP Pignon, J Bourhis, C Domenge, L Design? - The Lancet, 2000 - Elsevier
... of effect of chemotherapy in head and neck squamous-cell ... to that observed in
non-small-cell lung cancer. ... analyses of the timing of chemotherapy suggested no ...

… in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy -
KH Chi, CH Chen, WK Chan, KC Chow, SY Chen, SH Yen … - Journal of Clinical Oncology, 1995 - jcojournal.org
... JY Chao, CY Chang and KY Chen Cancer Center, Veterans ... IV squamous cell carcinoma
of head and neck were studied. ... In the first cycle of PFL chemotherapy, GM-CSF ...

… chemotherapy--results of a multicentric randomized German trial in advanced head-and-neck cancer. -
S Staar, V Rudat, H Stuetzer, A Dietz, P Volling, … - Int J Radiat Oncol Biol Phys, 2001 - ncbi.nlm.nih.gov
... of treatment for advanced unresectable head-and-neck cancer. ... benefit of simultaneously
given chemotherapy, a two ... regression), and resulted in reduced LRC (log ...

… dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. -
A Eisbruch, T Lyden, CR Bradford, LA Dawson, MJ … - Int J Radiat Oncol Biol Phys, 2002 - ncbi.nlm.nih.gov
... aspiration after radiation concurrent with chemotherapy for head ... Stage IV
head-and-neck cancer participated in ... high rate of mucosal toxicity, reduced drug ...

… induced by adjuvant cyclophosphamide, methotrexate, and fluorouracil chemotherapy causes rapid bone … -
T Saarto, C Blomqvist, M Valimaki, P Makela, S … - Journal of Clinical Oncology, 1997 - jco.ascopubs.org
... and 4.6% in the femoral neck, while in ... CONCLUSION: Chemotherapy-induced ovarian failure
causes rapid bone loss in premenopausal breast cancer patients. ...

Induction Chemotherapy followed by Concomitant TFHX Chemoradiotherapy with Reduced Dose Radiation in … -
DJ Haraf, FR Rosen, K Stenson, A Argiris, BB … - Clinical Cancer Research, 2003 - AACR
... Clinical Trials. Induction Chemotherapy followed by Concomitant TFHX Chemoradiotherapy
with Reduced Dose Radiation in Advanced Head and Neck Cancer. ...

… Disorders in Head and Neck Cancer Patients Treated With Radiotherapy and Adjuvant Chemotherapy. -
CL Lazarus, JA Logemann, BR Pauloski, LA Colangelo … - The Laryngoscope, 1996 - laryngoscope.com
... Also, the clinical judgment of reduced tongue base ... function in radiated head and
neck cancer patients will ... Also, the effects of chemotherapy on oropharyngeal ...

Source: Google Scholar
 
 

Head and neck cancer: Docetaxel combined with standard chemotherapy reduces mortality by nearly 30 percent

 
 
Researchers from Dana-Farber Cancer Institute in Boston found that the addition of Docetaxel ( Taxotere ) to an initial chemotherapy regimen for inoperable head and neck cancers reduces mortality by nearly 30 percent over three years following treatment compared to the standard two-drug combination.

The survival advantage emerged from an international clinical trial of more than 500 patients with squamous cell carcinoma of the head and neck treated with a sequential regimen that included induction chemotherapy and chemoradiotherapy, explains Marshall R. Posner, at Dana-Farber.

In recent years, Posner and colleagues at Dana-Farber have developed a multi-modality therapy for inoperable, locally advanced head and neck cancers that can reduce the need to remove critical organs while giving the patient good odds of survival. The first phase is induction chemotherapy with a combination of drugs followed by simultaneous fractionated radiation therapy and weekly treatment with Carboplatin ( Paraplatin ) chemotherapy. Patients then have surgery if needed.

A combination of Cisplatin and Fluorouracil ( 5-FU ) has been used for the induction chemotherapy. Posner's team has added Docetaxel as a third drug, and the clinical trial compared the three-drug versus the two-drug regimen.
From 1999 to 2003, a total of 538 patients were randomized to the two treatments; 501 patients were evaluable. The patients were followed for at least two years, and 79 percent were followed for three years.

Survival estimates for three years showed that the addition of Docetaxel reduced the risk of mortality by 30 percent: Survival at three years was 62 percent with the three-drug combination compared to 48 percent on the standard regimen. The safety profiles were similar in both arms of the study, says Posner.

Almost 40,000 cases of head and neck cancers will be diagnosed in 2006, according to the American Cancer Society, and an estimated 7,400 deaths.

Source: Dana-Farber Cancer Institute, 2006
 
 
 
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