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Recent News and Articles on the Keywords: control rate + lung cancer + may  Related to the article below (Last Update: 5/12/2008)


Daily Mail
Can sex REALLY give you a heart attack? We expose the truth behind ...
Daily Mail, UK -
FACT: Although smoking is the main cause of lung cancer, one in eight cases are not linked to smoking, explains GP Dr Dawn Harper. ...
Researchers launch lung cancer screening trial
Cancer Research UK - News & Resources, UK - May 9, 2008
However, if some types of lung cancer are detected at an early, operable stage, then a five-year survival rate of up to 80 per cent can be achieved. ...

Sydney Morning Herald
Fast gains found in giving up smoking
Baltimore Sun, United States - May 7, 2008
In just five years, quitters reduced their added risk of dying of a heart attack by 47 percent and of lung cancer by 21 percent. ...
Study: Quitting smoking pays off in 5 years Indianapolis Star
all 500 news articles »
Epigenomics AG Reports First Quarter 2008 Financial Results
FOXBusiness - May 6, 2008
During Q1 2008, Epigenomics also made progress in its prostate and lung cancer screening programs. As an interim result from Epigenomics' prostate cancer ...FRA:ECX
Governor hopefuls urge investigations
The News Journal, DE - May 9, 2008
"The cancer rate in the community here and in Wilmington is higher than other places. There has to be something going on." In response to its recent ...
Epigenomics AG Successfully Validates Optimized Blood-Based ...
ABN Newswire (press release), Australia - Apr 20, 2008
The new assay detected 72 of 97 cancer cases (74% sensitivity) and only 14 of 172 individuals without disease (false positive rate of 8% or 92% specificity) ...FRA:ECX - DGX
Nude Carla Bruni makes MD philanthropist blush
National Review of Medicine, Canada - May 8, 2008
GENEVA ? Common viruses may have a hand in the development of lung cancer, said multiple researchers at the 1st European Lung Cancer Conference last month. ...
Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment ...
RedOrbit, TX - May 3, 2008
Lung cancer has a dismal 5-year survival rate of 15%. Timely detection in individuals at risk could prevent, interrupt, or delay lung cancer progression. ...
Indigenous Polynesian Peoples Have Higher Cancer Mortality Rates
Medical News Today, UK - Apr 28, 2008
Advances such as adjuvant chemotherapy for breast, bowel, and lung cancer have improved survival, but data on treatment by ethnicity are lacking, ...
Effect of Preemptive Epidural Analgesia on Cytokine Response and ...
RedOrbit, TX - May 9, 2008
Furthermore, intraoperative sevoflurane was administered more heavily in the control group, which may have also partly affected the results. ...
Source: Google News

… Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer -
M Fukuoka, S Yano, G Giaccone, T Tamura, K … - Journal of Clinical Oncology, 2003 - jco.ascopubs.org
... RR was 6.7%, and the disease control rate was 42.7 ... The rate of disease-related symptom
improvement was ... of unresectable non- small-cell lung cancer: Adopted on ...

… , and lung cancer in the UK since 1950: combination of national statistics with two case-control -
R Peto, S Darby, H Deo, P Silcocks, E Whitley, R … - BMJ: British Medical Journal, 2000 - pubmedcentral.nih.gov
... If, for example, the male rate of hospital admission for the control diseases was ...
for this would multiply the relative risk of lung cancer in male ...

Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis -
H Yu, MR Spitz, J Mistry, J Gu, WK Hong, X Wu - jnci, 1999 - jnci.oxfordjournals.org
... In this case-control study, we found that higher plasma ... serve as a biomarker for
assessing lung cancer risk. ... IGF-I to maintain their high rate of proliferation ...

… Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non-Small-Cell Lung Cancer -
F Cappuzzo, FR Hirsch, E Rossi, S Bartolini, GL … - jnci, 2005 - jnci.oxfordjournals.org
... in many cancers, including non?small-cell lung cancer (NSCLC ... 16.6 to 50.3; P<.001),
disease control rate (67% versus ... copy number identified by FISH may be an ...

[PDF] Ea rly Lung Cancer Action Project: overall design and findings from baseline screening -
CI Henschke, DI McCauley, DF Yankelevitz, DP … - THE LANCET, 1999 - newportbodyscan.com
... against radiographic screening for lung cancer were predominantly ... by the investigators
themselves; the rate of adherence to ... and about 50% in the control group. ...
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A case-control study of lung cancer with special reference to the effect of air pollution in Poland -
W Jedrychowski, H Becher, J Wahrendorf, Z Basa- … - British Medical Journal, 1990 - jech.bmj.com
... The study was a retrospective case-control survey of ... rate 73.5%; females n = 198,
response rate 64.0 ... MAIN RESULTS--Lung cancer risk was found to depend strongly ...

… radiation therapy and concurrent chemotherapy in limited small-cell lung cancer: a randomized study -
B Jeremic, Y Shibamoto, L Acimovic, S … - Journal of Clinical Oncology, 1997 - jcojournal.org
... C/E seems to produce better local control and survival rates than delayed ... Blood
Hematopoietic Progenitors in Better-Prognosis Small-Cell Lung Cancer J Natl ...

[PDF] … between probability of pathologic tumor control and glucose metabolic rate measured with FDG PET … -
NC Choi, AJ Fischman, A Niemierko, JS Ryu, T Lynch … - Int J Radiat Oncol Biol Phys, 2002 - mips.stanford.edu
... effectiveness in improving locoregional tumor control with concurrent ... in glucose
metabolism in lung cancer as a ... measurement of the metabolic rate of glucose (MR ...

Akt Phosphorylation and Gefitinib Efficacy in Patients With Advanced Non-Small-Cell Lung Cancer -
F Cappuzzo, E Magrini, GL Ceresoli, S Bartolini, E … - jnci, 2004 - jnci.oxfordjournals.org
... of unselected non?small-cell lung cancer (NSCLC) patients ... a better response rate,
disease control rate, and time ... tumors, suggesting that gefitinib may be most ...

Dose Escalation in Non-Small-Cell Lung Cancer Using Three-Dimensional Conformal Radiation Therapy: … -
JA Hayman, MK Martel, RK Ten Haken, DP Normolle, … - Journal of Clinical Oncology, 2001 - jco.ascopubs.org
... PURPOSE: High-dose radiation may improve outcomes in non ... locally advanced
non?small-cell lung cancer (NSCLC) each ... they reported a local control rate of only ...

Source: Google Scholar
 
 

Non-small cell lung cancer: disease control rate may be a more powerful predictor of survival than tumor shrinkage

 

 
Researchers evaluate the effectiveness of a new antitumoral therapy by looking at how tumors respond to it. But in the case of advanced non-small cell lung cancer ( NSCLC ), there may be a better way to assess effectiveness. A new Southwest Oncology Group ( SWOG ) study, led by a team of researchers at University of California Davis Cancer Center, suggests that an alternative measurement – " disease control rate " – may be a more powerful predictor of survival than tumor shrinkage.

" If validated, this 'early look' statistical measure could enhance efficacy assessment, with broad implications for the design of future cancer clinical trials for advanced non-small cell lung cancer," said Primo N. Lara, at UC Davis Cancer Center and lead author of the new study.

Lara and his colleagues defined the disease control rate as the percentage of patients who have a partial or complete response to an investigational treatment plus those whose disease stabilizes.

" In the past, we have used the complete response rate plus the partial response rate, or CR + PR, as our sole efficacy measure," Lara said. " The disease control rate, DCR, is the complete response rate plus the partial response rate plus the rate of patients with stabilized disease, or DCR = CR + PR + SD. This measure may better predict how a new drug will affect survival."

In their study, the investigators pooled data from 984 patients with advanced non-small cell lung cancer who participated in three randomized SWOG trials of Platinum-based chemotherapy regimens.

Of the 886 patients who were alive two months after beginning treatment, 62 percent had stable disease, meaning their cancer had not progressed since entering the clinical trial. Another 19 percent had a complete or partial response, meaning their tumors had disappeared or reduced in size. Adding the two measures together yielded a disease control rate of 81 percent.

When Lara and his colleagues compared the disease control rate to the standard measure ( CR+PR ), they found that the disease control rate had a much stronger association with survival.

Lung cancer is the leading cause of cancer death among both men and women in the United States. According to the American Cancer Society, an estimated 174,470 people will get lung cancer this year, and 162,460 will die from it. Non-small cell lung cancer accounts for about 80 percent of lung cancer cases.

Source: University of California, Davis - Health System, 2006
 
 
 
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