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Recent News and Articles on the Keywords: more effective + healing erosive + esomeprazole  Related to the article below (Last Update: 7/1/2008)

The GI Company Reports Additional Phase II Clinical Data of ...
Market Wire (press release) -
The GI Company also has pre-clinical development projects in enteritis / proctitis, inflammatory bowel disease, erosive gastroesophageal reflux disease, ...CLDA

Malaysia Star
Not just any pain ...
Malaysia Star, Malaysia - Jun 28, 2008
She tried everything that came her way ? drinking thick black medicated oil, healing magnets, massages, even sinsehs who told her she was cursed. ...

Earthtimes (press release)
The GI Company Reports Significant Reduction in Occurrence of Oral ...
Earthtimes (press release), UK - Jun 2, 2008
The GI Company also has pre-clinical development projects in Enteritis/Proctitis, Inflammatory Bowel Disease, Erosive Gastroesophageal Reflux Disease, ...
Glossary of Terms and Definitions
National Fibromyalgia Association, CA - Jun 12, 2008
Research has shown that people who react in an active way to the consequences of their disease, are more effective than people who react in a passive way. ...
Source: Google News

[CITATION] Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis -
DO Castell, PJ Kahrilas, JE Richter, NB Vakil, DA … - American Journal of Gastroenterology, 2002 - Blackwell Synergy
... CONCLUSIONS: Esomeprazole (40 mg) is more effective than lansoprazole (30
mg) in healing erosive esophagitis and resolving heartburn. ...

[CITATION] Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux … -
PJ Kahrilas, GW Falk, DA Johnson, C Schmitt, DW … - Alimentary Pharmacology & Therapeutics, 2000 - Blackwell Synergy
... differences in symptom relief and healing esophagitis between ... in erosive GERD and
provides more rapid heartburn ... Rabeprazole is as effective as omeprazole in ...

[CITATION] Efficacy and safety of esomeprazole compared with omeprazole in GERD patients with erosive … -
JE Richter, PJ Kahrilas, J Johanson, P Maton, JR … - American Journal of Gastroenterology, 2001 - Blackwell Synergy
... (23), both dosages of esomeprazole were significantly more effective than omeprazole
for healing of erosive esophagitis, with esomeprazole 40 mg providing the ...

[CITATION] Esomeprazole once daily for 6 months is effective therapy for maintaining healed erosive esophagitis … -
DA Johnson, SB Benjamin, NB Vakil, JL Goldstein, M … - American Journal of Gastroenterology, 2001 - Blackwell Synergy
... At month 6, more than 70% of patients being ... Conclusions Esomeprazole is effective
and well tolerated in the maintenance of a healing erosive esophagitis. ...

[CITATION] A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg for healing erosive … -
J Labenz, D Armstrong, K Lauritsen, P Katelaris, S … - Alimentary Pharmacology & Therapeutics, 2005 - Blackwell Synergy
... Esomeprazole 40 mg provides more effective acid control than pantoprazole 40 mg. ...
J. Does baseline Hp status impact erosive oesophagitis (EE) healing rates? ...

[CITATION] Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a … -
P Miner, PO Katz, Y Chen, M Sostek - American Journal of Gastroenterology, 2003 - Blackwell Synergy
... acid exposure and healing of erosive esophagitis (6, 15). The more effective gastric
acid?suppressive pharmacodynamics of esomeprazole might contribute to ...

[CITATION] … inhibitor esomeprazole is effective as a maintenance therapy in GERD patients with healed erosive … -
NB Vakil, R Shaker, DA Johnson, T Kovacs, RD Baerg … - Alimentary Pharmacology & Therapeutics, 2001 - Blackwell Synergy
... therapy with a proton pump inhibitor is significantly more effective than standard ...
40 mg and 20 mg were highly effective for maintaining healing of erosive ...

Esomeprazole 40 mg provides more effective intragastric acid control than lansoprazole 30 mg, … -
K R?hss, T Lind, C Wilder-Smith - European Journal of Clinical Pharmacology, 2004 - Springer
... mg may, therefore, translate into more effective symptom resolution ... patients,
esomeprazole provided significantly greater healing of erosive oesophagitis [23 ...

[CITATION] Efficacy of esomeprazole 40 mg vs. lansoprazole 30 mg for healing moderate to severe erosive … -
MB Fennerty, JF Johanson, C Hwang, M Sostek - Alimentary Pharmacology & Therapeutics, 2005 - Blackwell Synergy
... indicated that esomeprazole was more effective than lansoprazole and omeprazole
in healing moderate or severe (Los Angeles grades C or D) erosive oesophagitis ...

… for Therapeutic Equivalence of Lansoprazole 30mg and Esomeprazole 40mg in the Treatment of Erosive … -
CW Howden, EDB II, W Robieson - Clinical Drug Investigation, 2002 - druginvestigation.adisonline.com
... et al. Esomeprazole provides more effective healing than lansoprazole in
GERD patients with erosive esophagitis [abstract]. Am J ...

Source: Google Scholar
 
 

Esomeprazole more effective than Lansoprazole in maintaining healing of erosive esophagitis

 
 
A new study, involving more than 1,000 patients with healed erosive esophagitis, has shown that Esomeprazole ( Nexium ) is more effective than Lansoprazole ( Prevacid ) in preventing a recurrence and is equally effective in reducing its associated symptoms.

Esomeprazole and Lansoprazole are proton pump inhibitors ( PPIs ).

An estimated one in three people with acid reflux disease develop erosive esophagitis, in which stomach acid begins to wear away, or erode, the inner lining of the esophagus.
Acid reflux disease is a condition in which the valve between the esophagus and stomach doesn't close properly, allowing acid to leak back into the esophagus. Symptoms of acid reflux disease and erosive esophagitis are similar and may include persistent heartburn, acid regurgitation, bitter taste in the mouth, and difficulty swallowing.

The trial was a randomized, double-blind, parallel-group study to compare the endoscopic and symptomatic remission rates of Esomeprazole with those of Lansoprazole in patients with healed grade A-D erosive esophagitis.

Patients had been treated and healed ( no endoscopic evidence of erosive esophagitis ) with Esomeprazole 40 mg or Lansoprazole 30 mg once daily ( patients with Los Angeles grades C and D erosive esophagitis at baseline ) or Esomeprazole 40 mg ( patients with Los Angeles grades A and B erosive esophagitis at baseline ) and had no heartburn or acid regurgitation symptoms during the previous week.

A total of 1,026 patients were randomized to once-daily therapy with either Esomeprazole 20 mg ( n=512 ) or Lansoprazole 15 mg ( n=514 ) for up to 6 months.

An esophagogastroduodenoscopy ( EGD ) was performed at 3 and 6 months to determine the relative remission rates of both treatment groups.

The estimated endoscopic/symptomatic remission rate during a period of 6 months was significantly higher ( P = .0007 ) for patients who received Esomeprazole 20 mg once daily ( 84.8% ) compared with those who received Lansoprazole 15 mg ( 75.9% ).

Most patients had no heartburn or acid regurgitation symptoms at 6 months, and there were no significant differences between treatments.

Both treatments were well-tolerated.

“ The challenge in treating erosive esophagitis is that many patients who are successfully treated with an acid-suppressing medication, such as a PPI, will commonly relapse within a year if that medication is discontinued. Reflux symptoms are chronic in many patients, particularly those with erosive esophagitis," said Kenneth DeVault, at Mayo Clinic College of Medicine, Jacksonville, Florida, and the lead study investigator.

“ The study showed that Esomeprazole was more effective than Lansoprazole in meeting one of the important yardsticks for clinical success - maintaining healing of erosive esophagitis," added DeVault.

Source: Clinical Gastroenterology and Hepatology, 2006
 
 
 
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