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Recent News and Articles on the Keywords: acne drug + blood fat + blood  Related to the article below (Last Update: 5/12/2008)

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Source: Google News

Dehydroepiandrosterone Replacement in Aging Humans 1 -
MA Flynn, D Weaver-Osterholtz, KL Sharpe-Timms, S … - Journal of Clinical Endocrinology & Metabolism, 1999 - Endocrine Soc
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significant blood changes were seen, but ... The effects of the drug, such as a ...

… of Hypertriglyceridemia during 13-cis Retinoic Acid Therapy for Acne: A Pharmacogenetic Study -
N Rodondi, R Darioli, AA Ramelet, D Hohl, V Lenain … - Annals of Internal Medicine, 2002 - annals.highwire.org
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Olestra increases faecal excretion of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. -
A Geusau, E Tschachler, M Meixner, S Sandermann, O … - Lancet, 1999 - ncbi.nlm.nih.gov
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EFFECT OF SYSTEMIC ADMINISTRATION OF ISOTRETINOIN ON BLOOD LIPIDS AND FATTY ACIDS IN ACNE PATIENTS. -
LS Ostlere, D Harris - International Journal of Dermatology, 1996 - pt.wkhealth.com
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Oral Isotretinoin as Part of the Treatment of Cutaneous Aging -
E Hernandez-Perez, HA Khawaja, TYM Alvarez - Dermatologic Surgery, 2000 - Blackwell Synergy
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… the Plasma Levels of Isotretinoin and 4-Oxo-Isotretinoin A Useful Tool for Management of Severe Acne -
H Topic - Logo, 1998 - content.karger.com
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of 13-cis-retinoic acid in human blood. Drug Metab Dispos 1981;9:515-520 ...

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WA Colburn, DM Gibson, RE Wiens, JJ Hanigan - The Journal of Clinical Pharmacology, 1983 - jcp.sagepub.com
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Source: Google Scholar
 
 

Acne drug tied to blood fat abnormalities

 

 

NEW YORK (Reuters Health) - Lipid disturbances arising from the acne treatment isotretinoin, more familiarly known as Accutane, may be more common than initially thought.

Findings from a new study show that 44 percent of patients who begin oral isotretinoin treatment for acne will develop abnormal triglyceride levels. By contrast, the information leaflet included with Accutane, the Roche brand of isotretinoin, notes that approximately 25 percent of patients can expect to develop a high triglyceride level.

The results, which appear in the Archives of Dermatology for August, indicate that abnormal total cholesterol and liver enzyme levels are also fairly common.

The good news is that the moderate-to severe abnormalities were usually transient and reversible.

Dr. Lee T. Zane, from the University of California at San Francisco, and colleagues assessed the rate of abnormal lab test results among 13,772 isotretinoin users, between 13 and 50 years of age.

In addition to abnormal triglyceride levels, abnormal total cholesterol and liver enzyme levels developed in 31 percent and 11 percent of patients, respectively.

"The incidence of abnormally high serum lipid levels during isotretinoin treatment may be greater than previously estimated," the authors conclude. However, the clinical significance of these abnormalities remains to be determined.

SOURCE: Archives of Dermatology, August 2006.

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