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Recent News and Articles on the Keywords: heart + metabolism + linked Related to the article below (Last Update: 8/7/2008)
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ST. LOUIS, Aug. 8 (UPI) -- The heart is an energy-hungry organ, and defects in its energy metabolism contribute to heart disease, according to U.S. researches.
Washington University researchers have shown that hearts of non-diabetics with muscle thickening due to high blood pressure have an energy metabolism skewed away from the use of fat for energy, according to the study published in the Journal of Nuclear Cardiology.
"The heart has to be able to choose the energy source, either fats or glucose, most appropriate for its current energy needs and the availability of fuel," says Dr. Lisa de las Fuentes, co-director of the Cardiovascular Imaging and Clinical Research Core Laboratory at Washington University School of Medicine in St. Louis.
Hearts with muscle thickening, or hypertrophy, get less energy because of their reduced fat metabolism, which leads them to rely more heavily on carbohydrates.
"Carbohydrates produce less energy per molecule than fatty acids," she says. "With hypertrophy, the heart has a higher energy demand because there's more muscle to feed."
The metabolic abnormality can eventually lead to impaired contraction of the heart and to heart failure; however, not everyone who has high blood pressure will develop hypertrophy, and not everyone with hypertrophy has long-term problems, according to de las Fuentes.
