Recent News and Articles on the Keywords: osteoporosis + steroid + dose  Related to the article below (Last Update: 12/1/2008)

 News results: Standard Version | Text Version | Image Version Results 1 - 4 of about 9 for osteoporosis steroid dose. (0.18 seconds) 
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Inhaled steroids up pneumonia risk in lung ailment
Reuters - Nov 25, 2008
They also have no greater risk of bone fractures, which had been a concern because certain oral steroids are known to increase of osteoporosis and fracture ...
Treatment of Chronic Inflammatory Demyelinating Polyneuropathy ...
Archives of Neurology - Nov 10, 2008
Pulsed steroids have nongenomic actions not seen with low-dose steroids, including rapid inhibition of arachidonic acid release and of calcium and sodium ...
Asthma Drug can have serious side effects
Times of India, India - Nov 10, 2008
She further added that disturbance in childhood bone acquisition could decrease peak bone mass, thereby triggering lifetime risk of osteoporosis. ...
Rodman & Renshaw Annual Global Investment Conference Presenter ...
TMC Net, CT - Nov 7, 2008
Horizon's lead compound is HZT-501, a novel, proprietary, fixed-dose combination formulation of the world's most prescribed non-steroidal anti-inflammatory ...RODM
Source: Google News

 

Recent News and Articles on the Keywords: osteoporosis + link + steroid  Related to the article below (Last Update: 8/7/2008)

Long acting beta agonists first for COPD
6minutes, Australia - Aug 4, 2008
There was little extra benefit on lung function decline from the combination of steroid and bronchodilator, the study found. Researchers said FEV1 decline ...
Amgen, Inc. Q2 2008 Earnings Call Transcript
Seeking Alpha, NY - Jul 28, 2008
Slide 26 highlights the results of our pivotal phase 3 study in women with post-menopausal osteoporosis. The study was a large international trial that ...AMGN
A hormone that helps you win
Business Day, South Africa - Jul 23, 2008
?Men with elevated SHBG values can have symptoms of osteoporosis, muscle weakness, poor memory, low sex drive, poor erections and poor genital sensation,? ...
Compositions and Products Containing S-Equol, and Methods
FLEXNEWS, France - Jul 8, 2008
Thus far 17 in vitro studies of cultured bone cells, 24 in vivo studies of animal models of postmenopausal osteoporosis, and 17 dietary intervention studies ...
Source: Google News

Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study -
M Luengo, C Picado, L Del Rio, N Guanabens, JM … - British Medical Journal, 1991 - thorax.bmj.com
... E Koshy, M Waker, and CM Goble Access to bone densitometry increases general
practitioners' prescribing for osteoporosis in steroid treated patients Ann Rheum ...

New Developments in the Pathogenesis and Treatment of Steroid-Induced Osteoporosis -
SC Manolagas, RS Weinstein - Journal of Bone and Mineral Research, 1999 - Am Soc Bone Min Res
... Sex-steroid replacement therapy is useful in ... into the pathophysiology of osteoporosis
N Engl J ... OPGL gene promoter: A potential link between osteoblastogenesis ...

[CITATION] Statin Therapy Decreases the Risk of Osteonecrosis in Patients Receiving Steroids. -
JW Pritchett - Clinical Orthopaedics and Related Research, 2001
... KC, Shen WJ: Lipid clearing agents in steroid-induced osteoporosis. ... award: The
pathogenesis and prevention of steroid induced osteonecrosis. ... [Context Link]. 26. ...

Primary and Secondary Osteoporosis' Incidence of Subsequent Vertebral Compression Fractures After … -
JS Harrop, B Prpa, MK Reinhardt, I Lieberman - Spine, 2004 - spinejournal.com
... Am J Respir Crit Care Med 2002;166:691-5. [Context Link]. 35. Ross EJ, Linch DC. ...
vertebral compression fracture; osteoporosis; kyphoplasty; steroids. ...

Mechanisms of glucocorticoid-induced osteoporosis. -
E Canalis - Current Opinion in Rheumatology, 2003 - co-rheumatology.com
... Sanchez S, Modin GW, et al.: Parathyroid hormone treatment can reverse
corticosteroid-induced osteoporosis: results of ... Steroids 1997, 62:77-82. ... Context Link]. ...

STEROID-FREE IMMUNOSUPPRESSION IN RENAL TRANSPLANTATION: A LONG-TERM FOLLOW-UP OF 100 CONSECUTIVE … -
SA Birkeland - Transplantation, 2001 - transplantjournal.com
... No steroid-induced side effects (4) were observed, including diabetes, osteoporosis,
body disfigurement, and growth retardation in children, who all evidenced ...

Glucocorticoid-induced osteoporosis. -
JA Clowes, N Peel, R Eastell, FM Sci - Current Opinion in Rheumatology, 2001 - co-rheumatology.com
... of steroid-induced osteoporosis. J Bone Miner Res 1999, 14:1061-1066. [Context Link].
5. Bland R: Steroid hormone receptor expression and action in bone. ...

Genetics of osteoporosis: role of steroid hormone receptor gene polymorphisms -
L Gennari, L Becherini, A Falchetti, L Masi, F … - Journal of Steroid Biochemistry and Molecular Biology, 2002 - Elsevier
... Cite or Link Using DOI (Opens New Window) Copyright ? 2002 Elsevier Science Ltd.
All rights reserved. Review. Genetics of osteoporosis: role of steroid hormone ...

Osteoporosis after organ transplantation -
C Ponticelli, A Aroldi - The Lancet, 2001 - Elsevier
... at least in kidney transplantation, steroid-free immunosuppression ... patients at higher
risk of osteoporosis, such as ... SummaryPlus | Full Text + Links | PDF (99 K ...

Osteoporosis prophylaxis during corticosteroid treatment: failure to prescribe. -
SR Hart, B Green - Postgraduate Medical Journal, 2002 - pt.wkhealth.com
... 7. Peat ID, Healy S, Reid D, et al. Prevention of steroid induced osteoporosis.
A missed opportunity? J Rheum Dis 1995;54:66-8. [Context Link]. 8. Stevenson JC. ...

Source: Google Scholar
 
 

Understanding High-Dose Steroid Link to Osteoporosis

WEDNESDAY, Aug. 2 (HealthDay News) -- U.S. scientists have learned more about why high doses of the steroid cortisone -- used to treat asthma, rheumatoid arthritis and other inflammatory and autoimmune diseases -- weaken bones and cause osteoporosis.

A team at Washington University School of Medicine in St. Louis conducted studies with mice and identified osteoclasts (cells that dismantle old bone) as the essential link between cortisone and osteoporosis.

The researchers found that when they gave cortisone to genetically modified mice whose bone-dismantling osteoclasts lacked cortisone receptors, the bone-weakening effects of cortisone were blocked.
 

They also found that cortisone inhibited the ability of osteoclasts to dismantle old bone in normal mice. This impairment of the regular skeletal renewal process results in dramatic age and stress-related weakening of bones.

Blocking osteoclast activity may also trigger a chain reaction that slows the activity of bone-building osteoblasts, the researchers said.

The findings were published in the August issue of the Journal of Clinical Investigation.

Learning more about this cortisone-osteoclast connection may help scientists identify targets for therapy to prevent cortisone from weakening bones, the researchers said.

"High-dose cortisone is the second most common cause of osteoporosis, and we currently have no real treatment for this serious side effect. Given how frequently these drugs are used to treat many different conditions, that's a major clinical problem," study senior author Dr. Steven L. Teitelbaum, professor of pathology and immunology, said in a prepared statement.

More information

The American College of Rheumatology has more about glucocorticoid-induced osteoporosis.
 
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