Siemens: Ask the Ultimate Power in Imaging MarketWatch - Nov 30, 2008 "By dovetailing our technological expertise and engineering excellence with our deep clinical insights and a fundamental understanding of the business needs ...
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Price mayor is man for his time Salt Lake Tribune, United States - Nov 30, 2008 His words carried insight and a calm, steady philosophy. Everyone would have to pull together to help raise the children of the fallen miners, he said. ...
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New insights into mouth cancers
Mouth cancer develops in two distinct ways which determine the seriousness of the disease, scientists said on Tuesday, a finding that could lead to new ways of preventing and treating it.
In laboratory experiments using healthy, early and advanced cancer cells, the researchers discovered differences in the cells that determined the aggressiveness of the cancer.
"The data we collected provide strong evidence for the first time that some mouth cancer tumors are more aggressive than others and therefore linked to poor patient survival," said Professor Paul Harrison of the Beatson Institute for Cancer Research in Glasgow, Scotland.
Oral cancer often develops from pre-cancerous lesions, changes or patches in the mouth, that could be early signs of the disease. Knowing which pre-cancerous changes are more likely to develop into aggressive tumors would enable doctors to determine the best treatment.
"Our work suggests it may be possible to identify in advance, by these molecular approaches, which of these pre-cancers are likely to progress and which need to be taken seriously at the outset," Harrison explained in an interview.
The scientists found that faults in the p53 gene, which stops damaged cells from dividing, and in the p16 gene, which helps to regulate and prevent cancer from developing, were two changes linked to more aggressive tumors.
The faults could form the basis of a diagnostic test for the illness, but Harrison said other so-called molecular signatures would be needed to make it a reliable test.
Smoking, other types of tobacco use such as chewing tobacco and heavy alcohol consumption are leading causes of mouth cancer. Smoking and drinking are a particularly dangerous combination.
"Cigarette smoke contains carcinogens which cause mutations and changes in cells which generate the cancer formation," said Harrison, who reported his finding in the journal Cancer Research.
Like lung cancer, oral cancer usually develops in people in their 50s or older.
"The best thing to do with any cancer is to prevent it, if possible. In mouth cancer we know two of the major players. Smoking is a major factor but not everyone appreciates that heavy drinking is also a risk factor," Harrison added.
New insights into aggressive mouth cancers
August 1, 2006 01:49:20 AM PST
Mouth cancer develops in two distinct ways which determine the seriousness of the disease, scientists said on Tuesday, a finding that could lead to new ways of preventing and treating it.
In laboratory experiments using healthy, early and advanced cancer cells, the researchers discovered differences in the cells that determined the aggressiveness of the cancer.
"The data we collected provide strong evidence for the first time that some mouth cancer tumors are more aggressive than others and therefore linked to poor patient survival," said Professor Paul Harrison of the Beatson Institute for Cancer Research in Glasgow, Scotland.
Oral cancer often develops from pre-cancerous lesions, changes or patches in the mouth, that could be early signs of the disease. Knowing which pre-cancerous changes are more likely to develop into aggressive tumors would enable doctors to determine the best treatment.
"Our work suggests it may be possible to identify in advance, by these molecular approaches, which of these pre-cancers are likely to progress and which need to be taken seriously at the outset," Harrison explained in an interview.
The scientists found that faults in the p53 gene, which stops damaged cells from dividing, and in the p16 gene, which helps to regulate and prevent cancer from developing, were two changes linked to more aggressive tumors.
The faults could form the basis of a diagnostic test for the illness, but Harrison said other so-called molecular signatures would be needed to make it a reliable test.
Smoking, other types of tobacco use such as chewing tobacco and heavy alcohol consumption are leading causes of mouth cancer. Smoking and drinking are a particularly dangerous combination.
"Cigarette smoke contains carcinogens which cause mutations and changes in cells which generate the cancer formation," said Harrison, who reported his finding in the journal Cancer Research.
Like lung cancer, oral cancer usually develops in people in their 50s or older.
"The best thing to do with any cancer is to prevent it, if possible. In mouth cancer we know two of the major players. Smoking is a major factor but not everyone appreciates that heavy drinking is also a risk factor," Harrison added.
